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Select item 110112981.

Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation

Andrea Vergaro, Monika Pankievic, Jana Jedlickova, Lubica Dudakova, Marie Vajter, Michel Michaelides, Martin Meliska, Pavel Nemec, Daniela Babincova, Bohdan Kousal, Petra Liskova

Int J Mol Sci. 2024 Apr; 25(7): 3744. Published online 2024 Mar 27. doi: 10.3390/ijms25073744

PMCID:: PMC11011298

Abstract Article PDF–1.5M

Select item 110060112.

Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy

Jacob H. J. Betts, Linda Troeberg

Mol Vis. 2024; 30: 74–91. Published online 2024 Mar 3.

PMCID:: PMC11006011

Abstract Article PDF–2.3M

Select item 101718303.

Circulating levels of tissue inhibitor of metalloproteinase (TIMP)-3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia

Ana C Palei, Juliana de O Cruz, João Leandro Chaguri, José Carlos Peraçoli, Mariana Romão-Veiga, Vanessa R Ribeiro-Vasques, Ricardo C Cavalli, Priscila R Nunes, Marcelo R Luizon, Valéria C Sandrim

Int J Gynaecol Obstet. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Int J Gynaecol Obstet. 2023 May; 161(2): 544–551. Published online 2022 Nov 21. doi: 10.1002/ijgo.14552

PMCID:: PMC10171830

Abstract Article PDF–687K

Select item 98195704.

Impact of Clinicopathological Characteristics and Tissue Inhibitor of Metalloproteinase-3 Polymorphism Rs9619311 on Biochemical Recurrence in Taiwanese Patients with Prostate Cancer

Chun-Yu Hsieh, Chia-Yen Lin, Shian-Shiang Wang, Ying-Erh Chou, Ming-Hsien Chien, Yu-Ching Wen, Ming-Ju Hsieh, Shun-Fa Yang

Int J Environ Res Public Health. 2023 Jan; 20(1): 306. Published online 2022 Dec 25. doi: 10.3390/ijerph20010306

PMCID:: PMC9819570

Abstract Article PDF–326K

Select item 97357535.

TIMP3 Gene Polymorphisms of -1296 T > C and -915 A > G Increase the Susceptibility to Arsenic-Induced Skin Cancer: A Cohort Study and In Silico Analysis of Mutation Impacts

Meei-Maan Wu, Chi-Wei Chen, Chiu-Yi Chen, Chih-Hung Lee, Mark Chou, Ling-I Hsu, Te-Chang Lee, Chien-Jen Chen

Int J Mol Sci. 2022 Dec; 23(23): 14980. Published online 2022 Nov 29. doi: 10.3390/ijms232314980

PMCID:: PMC9735753

Abstract Article PDF–2.1M

Select item 96961766.

Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy

Jian Hua Qi, Bela Anand-Apte

Int J Mol Sci. 2022 Nov; 23(22): 14231. Published online 2022 Nov 17. doi: 10.3390/ijms232214231

PMCID:: PMC9696176

Abstract Article PDF–2.4M

Select item 92543697.

Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan

Jui-Fu Chung, Chia-Lin Chen, Yasser Nassef, Bei-Hao Shiu, Chun-Hao Wang, Fu-Hsuan Kuo, Yi-Hsuan Hsiao, Shun-Fa Yang, Po-Hui Wang

Int J Med Sci. 2022; 19(6): 1013–1022. Published online 2022 May 29. doi: 10.7150/ijms.72378

PMCID:: PMC9254369

Abstract Article PDF–627K

Select item 91855178.

Early-Onset TIMP3-Related Retinopathy Associated With Impaired Signal Peptide

Bin Guan, Laryssa A. Huryn, Andrew B. Hughes, Zhiyu Li, Chelsea Bender, Delphine Blain, Amy Turriff, Catherine A. Cukras, Robert B. Hufnagel

JAMA Ophthalmol. 2022 Jul; 140(7): 730–733. Published online 2022 Jun 9. doi: 10.1001/jamaophthalmol.2022.1822

PMCID:: PMC9185517

Abstract Article

Select item 82745329.

Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer

Sahar Hakamy, Mourad Assidi, Mohammad A. Jafri, Taoufik Nedjadi, Heba Alkhatabi, Abrar Al-Qahtani, Jaudah Al-Maghrabi, Khalid Sait, Mohammed Al-Qahtani, Abdelbaset Buhmeida, Adeel Chaudhary

Libyan J Med. 2021; 16(1): 1937866. Published online 2021 Jul 9. doi: 10.1080/19932820.2021.1937866

PMCID:: PMC8274532

Abstract Article PDF–1.9M

Select item 811814310.

A novel TIMP3 mutation associated with a retinitis pigmentosa-like phenotype

Meghan J. DeBenedictis, Yosef Gindzin, Enrico Glaab, Bela Anand-Apte

Ophthalmic Genet. Author manuscript; available in PMC 2021 May 13.

Published in final edited form as: Ophthalmic Genet. 2020 Oct; 41(5): 480–484. Published online 2020 Jul 27. doi: 10.1080/13816810.2020.1795889

PMCID:: PMC8118143

Abstract Article PDF–605K

Select item 809465911.

Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas

Dimitri Barski, Marietta Wolter, Guido Reifenberger, Markus J. Riemenschneider

Brain Pathol. 2010 May; 20(3): 623–631. Published online 2009 Oct 6. doi: 10.1111/j.1750-3639.2009.00340.x

PMCID:: PMC8094659

Abstract Article PDF–734K

Select item 786531712.

Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site

Mohammed S. Aldughaim, Fatimah Alsaffar, Michael D. Barker

Molecules. 2021 Feb; 26(3): 625. Published online 2021 Jan 25. doi: 10.3390/molecules26030625

PMCID:: PMC7865317

Abstract Article PDF–2.6M

Select item 786216913.

Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy

Viviana Casagrande, Giulia Iuliani, Stefano Menini, Giuseppe Pugliese, Massimo Federici, Rossella Menghini

Clin Transl Med. 2021 Feb; 11(2): e305. Published online 2021 Feb 4. doi: 10.1002/ctm2.305

PMCID:: PMC7862169

Abstract Article PDF–11M

Select item 784840914.

TIMP-3 Increases the Chemosensitivity of Laryngeal Carcinoma to Cisplatin via Facilitating Mitochondria-Dependent Apoptosis

Xiaohui Shen, Xia Gao, Hui Li, Yajun Gu, Junguo Wang

Oncol Res. 2018; 27(1): 73–80. Published online 2018 Dec 27. doi: 10.3727/096504018X15201099883047

PMCID:: PMC7848409

Abstract Article PDF–9.7M

Select item 779576215.

Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil^®) to Tumour Cells Using a Novel TIMP3 Peptide

Mohammed S. Aldughaim, Munitta Muthana, Fatimah Alsaffar, Michael D. Barker

Molecules. 2021 Jan; 26(1): 100. Published online 2020 Dec 28. doi: 10.3390/molecules26010100

PMCID:: PMC7795762

Abstract Article PDF–2.7M

Select item 714045616.

Role of FGF and Hyaluronan in Choroidal Neovascularization in Sorsby Fundus Dystrophy

Alyson Wolk, Dilara Hatipoglu, Alecia Cutler, Mariya Ali, Lestella Bell, Jian Hua Qi, Rupesh Singh, Julia Batoki, Laura Karle, Vera L. Bonilha, Oliver Wessely, Heidi Stoehr, Vincent Hascall, Bela Anand-Apte

Cells. 2020 Mar; 9(3): 608. Published online 2020 Mar 4. doi: 10.3390/cells9030608

PMCID:: PMC7140456

Abstract Article PDF–5.2M

Select item 677123917.

TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis

Han-Li Huang, Yi-Min Liu, Ting-Yi Sung, Tsui-Chin Huang, Ya-Wen Cheng, Jing-Ping Liou, Shiow-Lin Pan

Theranostics. 2019; 9(22): 6676–6689. Published online 2019 Sep 18. doi: 10.7150/thno.34020

Correction in:: Theranostics. 2021; 11(5): 2079.

PMCID:: PMC6771239

Abstract Article PDF–2.3M

Select item 659413718.

The N‐terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond

Sarah Naessens, Julie De Zaeytijd, Delfien Syx, Roosmarijn E. Vandenbroucke, Frédéric Smeets, Caroline Van Cauwenbergh, Bart P. Leroy, Frank Peelman, Frauke Coppieters

Hum Mutat. 2019 May; 40(5): 539–551. Published online 2019 Feb 6. doi: 10.1002/humu.23713