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Select item 103198391.

Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

Fubiao Shi, Flaviane de Fatima Silva, Dianxin Liu, Hari U. Patel, Jonathan Xu, Wei Zhang, Clara Türk, Marcus Krüger, Sheila Collins

Mol Metab. 2023 Aug; 74: 101753. Published online 2023 Jun 13. doi: 10.1016/j.molmet.2023.101753

PMCID:: PMC10319839

Abstract Article PDF–2.9M

Select item 93040532.

The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia

Ke Wang, Chenran Wang, Di Chen, Yichen Huang, Jiaying Li, Pengju Wei, Ziyu Shi, Yue Zhang, Yanqin Gao

Cell Mol Life Sci. 2022 Aug; 79(8): 439. Published online 2022 Jul 21. doi: 10.1007/s00018-022-04465-1

PMCID:: PMC9304053

Abstract Article PDF–18M

Select item 61871923.

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

Takato Honda, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa

Proc Natl Acad Sci U S A. 2018 Oct 9; 115(41): 10458–10463. Published online 2018 Sep 25. doi: 10.1073/pnas.1810823115

PMCID:: PMC6187192

Abstract Article PDF–970K

Select item 33606054.

Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice

Tatsuya Uebi, Yumi Itoh, Osamu Hatano, Ayako Kumagai, Masato Sanosaka, Tsutomu Sasaki, Satoru Sasagawa, Junko Doi, Keita Tatsumi, Kuniko Mitamura, Eiichi Morii, Katsuyuki Aozasa, Tomohiro Kawamura, Meinoshin Okumura, Jun Nakae, Hajime Takikawa, Toshio Fukusato, Minako Koura, Mayumi Nish, Anders Hamsten, Angela Silveira, Alejandro M. Bertorello, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Takeshi Tomonaga, Tetsuji Naka, Shigeo Ikegawa, Noriyuki Tsumaki, Junichiro Matsuda, Hiroshi Takemori

PLoS One. 2012; 7(5): e37803. Published online 2012 May 25. doi: 10.1371/journal.pone.0037803

PMCID:: PMC3360605

Abstract Article PDF–1.5M

Select item 100892105.

SIK3–HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice

Fuyuki Asano, Staci J. Kim, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Nodoka Asama, Kanako Iwasaki, Miyo Kakizaki, Seiya Mizuno, Michihiro Mieda, Fumihiro Sugiyama, Satoru Takahashi, Shoi Shi, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa

Proc Natl Acad Sci U S A. 2023 Mar 14; 120(11): e2218209120. Published online 2023 Mar 6. doi: 10.1073/pnas.2218209120

PMCID:: PMC10089210

Abstract Article PDF–3.1M

Select item 84119106.

Salt-inducible kinase 3 promotes vascular smooth muscle cell proliferation and arterial restenosis by regulating AKT and PKA-CREB signaling

Yujun Cai, Xue-Lin Wang, Jinny Lu, Xin Lin, Jonathan Dong, Raul J Guzman

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Sep; 41(9): 2431–2451. Published online 2021 Jul 1. doi: 10.1161/ATVBAHA.121.316219

PMCID:: PMC8411910

Abstract Article PDF–4.8M

Select item 75814307.

Secondary ossification center induces and protects growth plate structure

Meng Xie, Pavel Gol'din, Anna Nele Herdina, Jordi Estefa, Ekaterina V Medvedeva, Lei Li, Phillip T Newton, Svetlana Kotova, Boris Shavkuta, Aditya Saxena, Lauren T Shumate, Brian D Metscher, Karl Großschmidt, Shigeki Nishimori, Anastasia Akovantseva, Anna P Usanova, Anastasiia D Kurenkova, Anoop Kumar, Irene Linares Arregui, Paul Tafforeau, Kaj Fried, Mattias Carlström, András Simon, Christian Gasser, Henry M Kronenberg, Murat Bastepe, Kimberly L Cooper, Peter Timashev, Sophie Sanchez, Igor Adameyko, Anders Eriksson, Andrei S Chagin

eLife. 2020; 9: e55212. Published online 2020 Oct 16. doi: 10.7554/eLife.55212

PMCID:: PMC7581430

Abstract Article PDF–15M

Select item 57475178.

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

Naoto Hayasaka, Arisa Hirano, Yuka Miyoshi, Isao T Tokuda, Hikari Yoshitane, Junichiro Matsuda, Yoshitaka Fukada

eLife. 2017; 6: e24779. Published online 2017 Dec 11. doi: 10.7554/eLife.24779

Correction in:: eLife. 2021; 10: e66683.

PMCID:: PMC5747517

Abstract Article PDF–4.6M

Select item 48208109.

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki

Nat Commun. 2016; 7: 10959. Published online 2016 Mar 24. doi: 10.1038/ncomms10959

Correction in:: Nat Commun. 2016; 7: 12117.

PMCID:: PMC4820810

Abstract Article PDF–3.0M

Select item 427692810.

Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line

Ayako Kumagai, Akira Fujita, Tomoki Yokoyama, Yuki Nonobe, Yasuhiro Hasaba, Tsutomu Sasaki, Yumi Itoh, Minako Koura, Osamu Suzuki, Shigeki Adachi, Haruko Ryo, Arihiro Kohara, Lokesh P. Tripathi, Masato Sanosaka, Toshiki Fukushima, Hiroyuki Takahashi, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Kenji Mizuguchi, Taisei Nomura, Junichiro Matsuda, Toshihide Tabata, Hiroshi Takemori

Genes (Basel) 2014 Dec; 5(4): 1095–1114. Published online 2014 Dec 11. doi: 10.3390/genes5041095

PMCID:: PMC4276928

Abstract Article PDF–6.2M

Select item 400130811.

Salt-inducible kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutic-mediated cell death

H Chen, S Huang, X Han, J Zhang, C Shan, Y H Tsang, H T Ma, R Y C Poon

Cell Death Dis. 2014 Apr; 5(4): e1177. Published online 2014 Apr 17. doi: 10.1038/cddis.2014.154

PMCID:: PMC4001308

Abstract Article PDF–2.5M

Select item 801873812.

Induction of Mutant Sik3^Sleepy Allele in Neurons in Late Infancy Increases Sleep Need

Kanako Iwasaki, Tomoyuki Fujiyama, Shinya Nakata, Minjeong Park, Chika Miyoshi, Noriko Hotta-Hirashima, Aya Ikkyu, Miyo Kakizaki, Fumihiro Sugiyama, Seiya Mizuno, Manabu Abe, Kenji Sakimura, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa

J Neurosci. 2021 Mar 24; 41(12): 2733–2746. doi: 10.1523/JNEUROSCI.1004-20.2020

PMCID:: PMC8018738

Abstract Article PDF–6.5M

Select item 682554713.

Pablo E. Hollstein, Lillian J. Eichner, Sonja N. Brun, Anwesh Kamireddy, Robert U. Svensson, Liliana I. Vera, Debbie S. Ross, T.J. Rymoff, Amanda Hutchins, Hector M. Galvez, April E. Williams, Maxim N. Shokhirev, Robert A. Screaton, Rebecca Berdeaux, Reuben J. Shaw

Cancer Discov. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Cancer Discov. 2019 Nov; 9(11): 1606–1627. Published online 2019 Jul 26. doi: 10.1158/2159-8290.CD-18-1261

PMCID:: PMC6825547

Abstract Article PDF–3.0M

Select item 529048514.

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Nicola J. Darling, Rachel Toth, J. Simon C. Arthur, Kristopher Clark

Biochem J. 2017 Feb 15; 474(4): 521–537. Prepublished online 2016 Dec 5. Published online 2017 Feb 3. doi: 10.1042/BCJ20160646

PMCID:: PMC5290485

Abstract Article PDF–1.6M

Select item 442739115.

Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice

Masato Sanosaka, Minoru Fujimoto, Tomoharu Ohkawara, Takahiro Nagatake, Yumi Itoh, Mai Kagawa, Ayako Kumagai, Hiroyuki Fuchino, Jun Kunisawa, Tetsuji Naka, Hiroshi Takemori

Immunology. 2015 Jun; 145(2): 268–278. Published online 2015 May 7. doi: 10.1111/imm.12445

PMCID:: PMC4427391

Abstract Article PDF–535K

Select item 607622516.

Forward genetic analysis of sleep in randomly mutagenized mice

Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Shin Nakane, Jun Tomita, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Seiya Mizuno, Shinichi Miyazaki, Linzi Connor, Vivek Kumar, Ikuo Miura, Tomohiro Suzuki, Atsushi Watanabe, Manabu Abe, Fumihiro Sugiyama, Satoru Takahashi, Kenji Sakimura, Yu Hayashi, Qinghua Liu, Kazuhiko Kume, Shigeharu Wakana, Joseph S Takahashi, Masashi Yanagisawa

Nature. Author manuscript; available in PMC 2018 Aug 4.

Published in final edited form as: Nature. 2016 Nov 17; 539(7629): 378–383. Published online 2016 Nov 2. doi: 10.1038/nature20142

PMCID:: PMC6076225

Abstract Article PDF–4.4M

Select item 604447617.

Mutant GNAS drives pancreatic tumorigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

Krushna C. Patra, Yasutaka Kato, Yusuke Mizukami, Sebastian Widholz, Myriam Boukhali, Iulia Revenco, Elizabeth A. Grossman, Fei Ji, Ruslan I. Sadreyev, Andrew S. Liss, Robert A. Screaton, Kei Sakamoto, David P. Ryan, Mari Mino-Kenudson, Carlos Fernandez-del Castillo, Daniel K. Nomura, Wilhelm Haas, Nabeel Bardeesy

Nat Cell Biol. Author manuscript; available in PMC 2018 Dec 25.

Published in final edited form as: Nat Cell Biol. 2018 Jul; 20(7): 811–822. Published online 2018 Jun 25. doi: 10.1038/s41556-018-0122-3

PMCID:: PMC6044476

Abstract Article PDF–2.9M

Select item 1014594818.

A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

Sung-Hee Yoon, Mark B. Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S. Wang, Christian D. Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A. Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B. Sundberg, Ramnik J. Xavier, Charles H. Adelmann, Daniel J. Brooks, Anthony Anselmo, Ruslan I. Sadreyev, Ivy A. Rosales, David E. Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J. Wesley Pike, Michael Mannstadt, Marc N. Wein

J Clin Invest. 2023 May 1; 133(9): e163627. Published online 2023 May 1. doi: 10.1172/JCI163627

PMCID:: PMC10145948

Abstract Article PDF–13M

Select item 856646219.

Salt inducible kinases 2 and 3 are required for thymic T cell development

Meriam Nefla, Nicola J. Darling, Manuel van Gijsel Bonnello, Philip Cohen, J. Simon C. Arthur

Sci Rep. 2021; 11: 21550. Published online 2021 Nov 3. doi: 10.1038/s41598-021-00986-0

PMCID:: PMC8566462

Abstract Article PDF–13M

Select item 728662020.

Salt-inducible Kinases Are Critical Determinants of Female Fertility

Marah Armouti, Nicola Winston, Osamu Hatano, Elie Hobeika, Jennifer Hirshfeld-Cytron, Juergen Liebermann, Hiroshi Takemori, Carlos Stocco

Endocrinology. 2020 Jul; 161(7): bqaa069. Published online 2020 Apr 28. doi: 10.1210/endocr/bqaa069

PMCID:: PMC7286620

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