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Select item 108077101.

HNF1α maintains pancreatic α and β cell functions in primary human islets

Mollie F. Qian, Romina J. Bevacqua, Vy M.N. Coykendall, Xiong Liu, Weichen Zhao, Charles A. Chang, Xueying Gu, Xiao-Qing Dai, Patrick E. MacDonald, Seung K. Kim

JCI Insight. 2023 Dec 22; 8(24): e170884. Published online 2023 Dec 22. doi: 10.1172/jci.insight.170884

PMCID:: PMC10807710

Article PDF–2.3M

Select item 106279202.

Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes

Pernille Svalastoga, Alba Kaci, Janne Molnes, Marie H. Solheim, Bente B. Johansson, Lars Krogvold, Torild Skrivarhaug, Eivind Valen, Stefan Johansson, Anders Molven, Jørn V. Sagen, Eirik Søfteland, Lise Bjørkhaug, Erling Tjora, Ingvild Aukrust, Pål R. Njølstad

Diabetologia. 2023; 66(12): 2226–2237. Published online 2023 Oct 5. doi: 10.1007/s00125-023-06012-4

PMCID:: PMC10627920

Article PDF–1.5M

Select item 104804453.

Single cell multiomic analysis reveals diabetes-associated β-cell heterogeneity driven by HNF1A

Chen Weng, Anniya Gu, Shanshan Zhang, Leina Lu, Luxin Ke, Peidong Gao, Xiaoxiao Liu, Yuntong Wang, Peinan Hu, Dylan Plummer, Elise MacDonald, Saixian Zhang, Jiajia Xi, Sisi Lai, Konstantin Leskov, Kyle Yuan, Fulai Jin, Yan Li

Nat Commun. 2023; 14: 5400. Published online 2023 Sep 5. doi: 10.1038/s41467-023-41228-3

PMCID:: PMC10480445

Article PDF–8.5M

Select item 103131204.

Molecular characterization and re-interpretation of HNF1A variants identified in Indian MODY subjects towards precision medicine

Babu Kavitha, Sampathkumar Ranganathan, Sundaramoorthy Gopi, Umashankar Vetrivel, Nagarajan Hemavathy, Viswanathan Mohan, Venkatesan Radha

Front Endocrinol (Lausanne) 2023; 14: 1177268. Published online 2023 Jun 16. doi: 10.3389/fendo.2023.1177268

PMCID:: PMC10313120

Article PDF–3.3M

Select item 99805775.

HNF1A regulates the crosstalk between innate immune responses and MAFLD by mediating autophagic degradation of TBK1

Yunfei Qin, Dongbo Qiu, Qi Zhang

Autophagy. 2023; 19(3): 1026–1027. Published online 2022 Aug 11. doi: 10.1080/15548627.2022.2110728

PMCID:: PMC9980577

Article PDF–362K

Select item 97291316.

The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations

Lauren A. Stalbow, Michael H. Preuss, Roelof A. J. Smit, Nathalie Chami, Lise Bjørkhaug, Ingvild Aukrust, Anna L. Gloyn, Ruth J. F. Loos

Diabetologia. 2023; 66(1): 116–126. Published online 2022 Oct 11. doi: 10.1007/s00125-022-05806-2

PMCID:: PMC9729131

Article PDF–1.2M

Select item 89880107.

Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants

Laura Kind, Arne Raasakka, Janne Molnes, Ingvild Aukrust, Lise Bjørkhaug, Pål Rasmus Njølstad, Petri Kursula, Thomas Arnesen

J Biol Chem. 2022 Apr; 298(4): 101803. Published online 2022 Mar 4. doi: 10.1016/j.jbc.2022.101803

PMCID:: PMC8988010

Article PDF–3.1M

Select item 89487208.

HNF1A Mutations and Beta Cell Dysfunction in Diabetes

Yasutaka Miyachi, Takashi Miyazawa, Yoshihiro Ogawa

Int J Mol Sci. 2022 Mar; 23(6): 3222. Published online 2022 Mar 16. doi: 10.3390/ijms23063222

PMCID:: PMC8948720

Article PDF–772K

Select item 89214769.

HNF1A：From Monogenic Diabetes to Type 2 Diabetes and Gestational Diabetes Mellitus

Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun

Front Endocrinol (Lausanne) 2022; 13: 829565. Published online 2022 Mar 1. doi: 10.3389/fendo.2022.829565

PMCID:: PMC8921476

Article PDF–2.5M

Select item 890508810.

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

Ana-Maria Cujba, Mario E. Alvarez-Fallas, Sergio Pedraza-Arevalo, Anna Laddach, Maggie H. Shepherd, Andrew T. Hattersley, Fiona M. Watt, Rocio Sancho

Cell Rep. 2022 Mar 1; 38(9): 110425. Published online 2022 Mar 1. doi: 10.1016/j.celrep.2022.110425

PMCID:: PMC8905088

Article PDF–6.2M

Select item 889416011.

A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY

Jarno L. T. Kettunen, Elina Rantala, Om P. Dwivedi, Bo Isomaa, Leena Sarelin, Paula Kokko, Liisa Hakaste, Päivi J. Miettinen, Leif C. Groop, Tiinamaija Tuomi

Diabetologia. 2022; 65(4): 632–643. Published online 2021 Dec 24. doi: 10.1007/s00125-021-05631-z

Correction in:: Diabetologia. 2022; 65(5): 912.

PMCID:: PMC8894160

Article PDF–787K

Select item 864574312.

The prognostic value of TCF1+CD8+T in primary small cell carcinoma of the esophagus

Lin Ma, Lijun Sun, Kaikai Zhao, Zhengxin Dong, Zhaoqin Huang, Xiangjiao Meng

Cancer Sci. 2021 Dec; 112(12): 4968–4976. Published online 2021 Oct 25. doi: 10.1111/cas.15167

PMCID:: PMC8645743

Article PDF–1.2M

Select item 840557813.

VARIANTS IN MYCOPHENOLATE AND CMV ANTIVIRAL DRUG PHARMACOKINETIC AND PHARMACODYNAMIC GENES AND LEUKOPENIA IN HEART TRANSPLANT RECIPIENTS

Kris Oreschak, Laura M. Saba, Nicholas Rafaels, Amrut V. Ambardekar, Kimberly M. Deininger, Robert L. Page, II, JoAnn Lindenfeld, Christina L. Aquilante

J Heart Lung Transplant. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: J Heart Lung Transplant. 2021 Sep; 40(9): 917–925. Published online 2021 Jun 12. doi: 10.1016/j.healun.2021.05.020

PMCID:: PMC8405578

Article PDF–103K

Select item 811630114.

Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods

Daniel Demus, Bas C. Jansen, Richard A. Gardner, Paulina A. Urbanowicz, Haiyang Wu, Tamara Štambuk, Agata Juszczak, Edita Pape Medvidović, Nathalie Juge, Olga Gornik, Katharine R. Owen, Daniel I. R. Spencer

Glycoconj J. 2021; 38(3): 375–386. Published online 2021 Mar 25. doi: 10.1007/s10719-021-09992-w

PMCID:: PMC8116301

Article PDF–734K

Select item 799546715.

Integrated bioinformatic analysis of HNF1A in human cancers

Enfan Zhang, Xi Huang, Jingsong He

J Int Med Res. 2021 Mar; 49(3): 0300060521997326. Published online 2021 Mar 22. doi: 10.1177/0300060521997326

PMCID:: PMC7995467

Article PDF–1.6M

Select item 767887116.

Hepatocyte nuclear factor 1 alpha influences pancreatic cancer growth and metastasis

Ramadevi Subramani, Joshua Medel, Kristina Flores, Courtney Perry, Adriana Galvez, Mayra Sandoval, Servando Rivera, Diego A. Pedroza, Elizabeth Penner, Mahika Chitti, Rajkumar Lakshmanaswamy

Sci Rep. 2020; 10: 20225. Published online 2020 Nov 19. doi: 10.1038/s41598-020-77287-5

PMCID:: PMC7678871

Article PDF–4.9M

Select item 753657917.

Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation

Sara Althari, Laeya A. Najmi, Amanda J. Bennett, Ingvild Aukrust, Jana K. Rundle, Kevin Colclough, Janne Molnes, Alba Kaci, Sameena Nawaz, Timme van der Lugt, Neelam Hassanali, Anubha Mahajan, Anders Molven, Sian Ellard, Mark I. McCarthy, Lise Bjørkhaug, Pål Rasmus Njølstad, Anna L. Gloyn

Am J Hum Genet. 2020 Oct 1; 107(4): 670–682. Published online 2020 Sep 9. doi: 10.1016/j.ajhg.2020.08.016

PMCID:: PMC7536579

Article PDF–1.7M

Select item 717041218.

New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population

Yumin Ma, Siqian Gong, Xirui Wang, Xiaoling Cai, Xinhua Xiao, Weijun Gu, Jinkui Yang, Liyong Zhong, Jianzhong Xiao, Meng Li, Wei Liu, Simin Zhang, Xianghai Zhou, Yufeng Li, Lingli Zhou, Yu Zhu, Yingying Luo, Qian Ren, Xiuting Huang, Xueying Gao, Xiuying Zhang, Rui Zhang, Ling Chen, Fang Wang, Qiuping Wang, Mengdie Hu, Xueyao Han, Linong Ji

BMJ Open Diabetes Res Care. 2020; 8(1): e000745. Published online 2020 Mar 31. doi: 10.1136/bmjdrc-2019-000745

PMCID:: PMC7170412

Article PDF–596K

Select item 708071619.

Response to multiple glucose-lowering agents in a sib-pair with a novel HNF1α (MODY3) variant

Clara S. H. Tan, Su Fen Ang, Su Chi Lim

Eur J Hum Genet. 2020 Apr; 28(4): 518–520. Published online 2019 Dec 16. doi: 10.1038/s41431-019-0561-8

PMCID:: PMC7080716

Article PDF–295K

Select item 691944420.

Prognostic and clinical significance of long non-coding RNA HNF1A-AS1 in solid cancers: A systematic review and meta-analysis

Xi Zhou, Yang-Hua Fan, Yan Wang, Yong Liu

Medicine (Baltimore) 2019 Dec; 98(49): e18264. Published online 2019 Dec 10. doi: 10.1097/MD.0000000000018264

PMCID:: PMC6919444

Article PDF–1.1M

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