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Select item 111614741.

Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model

Jinxiang Wu, Pin Wang, Xinyu Xie, Xiaoqi Yang, Shuangmei Tang, Jiping Zhao, Tian Liu, Junfei Wang, Jintao Zhang, Tongliang Xia, Xin Feng

Cell Death Dis. 2024 Jun; 15(6): 400. Published online 2024 Jun 7. doi: 10.1038/s41419-024-06777-5

PMCID:: PMC11161474

Abstract Article PDF–6.2M

Select item 106360522.

Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection

Sarah Rosli, Christopher M. Harpur, Maggie Lam, Alison C. West, Christopher Hodges, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate

Cell Death Dis. 2023 Nov; 14(11): 727. Published online 2023 Nov 9. doi: 10.1038/s41419-023-06258-1

PMCID:: PMC10636052

Abstract Article PDF–3.3M

Select item 105882533.

Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration

Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man, Riccardo Natoli

J Neuroinflammation. 2023; 20: 239. Published online 2023 Oct 20. doi: 10.1186/s12974-023-02927-2

PMCID:: PMC10588253

Abstract Article PDF–13M

Select item 105299244.

Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens

Liam B. Healy, Gang Du, Hao Wu

Trends Immunol. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Trends Immunol. 2023 Aug; 44(8): 571–573. Published online 2023 Jul 4. doi: 10.1016/j.it.2023.06.006

PMCID:: PMC10529924

Abstract Article PDF–339K

Select item 104860515.

GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice

Naga Venkata Divya Challa, Shaoyi Chen, Huijun Yuan, Matthew R. Duncan, William Javier Moreno, Helen Bramlett, W. Dalton Dietrich, Merline Benny, Augusto F. Schmidt, Karen Young, Shu Wu

J Neuroinflammation. 2023; 20: 205. Published online 2023 Sep 7. doi: 10.1186/s12974-023-02878-8

PMCID:: PMC10486051

Abstract Article PDF–3.1M

Select item 104642946.

GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice

Xiaoxia Yang, Qingqing Cao, Yi Guo, Jingchuan He, Demei Xu, Aolei Lin

J Neuroinflammation. 2023; 20: 193. Published online 2023 Aug 23. doi: 10.1186/s12974-023-02876-w

PMCID:: PMC10464294

Abstract Article PDF–12M

Select item 99473017.

Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice

C. Alicia Traughber, Gauravi M. Deshpande, Kalash Neupane, Nilam Bhandari, Mariam R. Khan, Megan R. McMullen, Shadi Swaidani, Emmanuel Opoku, Santoshi Muppala, Jonathan D. Smith, Laura E. Nagy, Kailash Gulshan

iScience. 2023 Feb 17; 26(2): 106076. Published online 2023 Jan 31. doi: 10.1016/j.isci.2023.106076

PMCID:: PMC9947301

Abstract Article PDF–3.7M

Select item 99292708.

Gasdermin D Deficiency in Vascular Smooth Muscle Cells Ameliorates Abdominal Aortic Aneurysm Through Reducing Putrescine Synthesis

Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng

Adv Sci (Weinh) 2023 Feb; 10(5): 2204038. Published online 2022 Dec 25. doi: 10.1002/advs.202204038

PMCID:: PMC9929270

Abstract Article PDF–4.9M

Select item 98131399.

GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice

Sarah Sonny, Huijun Yuan, Shaoyi Chen, Matthew R. Duncan, Pingping Chen, Merline Benny, Karen Young, Kevin K. Park, Augusto F. Schmidt, Shu Wu

Sci Rep. 2023; 13: 143. Published online 2023 Jan 4. doi: 10.1038/s41598-022-27201-y

PMCID:: PMC9813139

Abstract Article PDF–19M

Select item 961465810.

Gasdermin D protects against Streptococcus equi subsp. zooepidemicus infection through macrophage pyroptosis

Guobin Xu, Zheng Guo, Yuxuan Liu, Yalin Yang, Yongjin Lin, Chunliu Li, Yunfei Huang, Qiang Fu

Front Immunol. 2022; 13: 1005925. Published online 2022 Oct 14. doi: 10.3389/fimmu.2022.1005925

PMCID:: PMC9614658

Abstract Article PDF–5.7M

Select item 960275511.

Multi-Omics Analysis Reveals the Protection of Gasdermin D in Concanavalin A-Induced Autoimmune Hepatitis

Kaicen Wang, Wenrui Wu, Xianwan Jiang, Jiafeng Xia, Longxian Lv, Shengjie Li, Aoxiang Zhuge, Zhengjie Wu, Qiangqiang Wang, Shuting Wang, Lanjuan Li

Microbiol Spectr. 2022 Sep-Oct; 10(5): e01717-22. Published online 2022 Aug 16. doi: 10.1128/spectrum.01717-22

PMCID:: PMC9602755

Abstract Article PDF–6.1M

Select item 954677612.

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

Xiaomiao Ye, Peng Zhang, Yuting Zhang, Jingyun Luan, Caili Xu, Zhengyu Wu, Dianwen Ju, Wei Hu

Front Immunol. 2022; 13: 893914. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.893914

PMCID:: PMC9546776

Abstract Article PDF–6.1M

Select item 953580613.

GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv Chauhan, Dieter Demon, Lieselotte Vande Walle, Oonagh Paerewijck, Annalisa Zecchin, Leslie Bosseler, Karin Santoni, Rémi Planès, Silvia Ribo, Amelie Fossoul, Amanda Gonçalves, Hanne Van Gorp, Nina Van Opdenbosch, Filip Van Hauwermeiren, Etienne Meunier, Andy Wullaert, Mohamed Lamkanfi

EMBO Rep. 2022 Oct; 23(10): e54277. Published online 2022 Jul 28. doi: 10.15252/embr.202154277

PMCID:: PMC9535806

Abstract Article PDF–3.4M

Select item 944062714.

Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation

Eun Bi Ma, Hafiz Muhammad Ahmad Javaid, Do-Hyeon Jung, Jong-Hwan Park, Joo Young Huh

Mediators Inflamm. 2022; 2022: 7853482. Published online 2022 Aug 26. doi: 10.1155/2022/7853482

PMCID:: PMC9440627

Abstract Article PDF–2.6M

Select item 936003915.

GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy

Yujia Wang, Yinshuang Li, Zhimin Chen, Ying Yuan, Qinglin Su, Keng Ye, Caiming Chen, Guoping Li, Yankun Song, Hong Chen, Yanfang Xu

Cell Death Dis. 2022 Aug; 13(8): 693. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05138-4

PMCID:: PMC9360039

Abstract Article PDF–11M

Select item 918983616.

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression

Tingting Lv, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Qin He

J Immunother Cancer. 2022; 10(6): e004763. Published online 2022 Jun 10. doi: 10.1136/jitc-2022-004763

PMCID:: PMC9189836

Abstract Article PDF–11M

Select item 884175717.

Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice

Jie Wang, Ke Shi, Ning An, Shuaifei Li, Mei Bai, Xudong Wu, Yan Shen, Ronghui Du, Jingcai Cheng, Xuefeng Wu, Qiang Xu

Front Immunol. 2022; 13: 825428. Published online 2022 Jan 31. doi: 10.3389/fimmu.2022.825428

PMCID:: PMC8841757

Abstract Article PDF–23M

Select item 860270418.

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Xionghui Ding, Hiroto Kambara, Rongxia Guo, Apurva Kanneganti, Maikel Acosta-Zaldívar, Jiajia Li, Fei Liu, Ting Bei, Wanjun Qi, Xuemei Xie, Wenli Han, Ningning Liu, Cunling Zhang, Xiaoyu Zhang, Hongbo Yu, Li Zhao, Fengxia Ma, Julia R. Köhler, Hongbo R. Luo

Nat Commun. 2021; 12: 6699. Published online 2021 Nov 18. doi: 10.1038/s41467-021-27034-9

PMCID:: PMC8602704

Abstract Article PDF–4.4M

Select item 859422919.

Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes

Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen, Gabriel Mbalaviele

Arthritis Res Ther. 2021; 23: 286. Published online 2021 Nov 16. doi: 10.1186/s13075-021-02668-8