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Select item 112845581.

A model organism pipeline provides insight into the clinical heterogeneity of TARS1 loss-of-function variants

Rebecca Meyer-Schuman, Allison R. Cale, Jennifer A. Pierluissi, Kira E. Jonatzke, Young N. Park, Guy M. Lenk, Stephanie N. Oprescu, Marina A. Grachtchouk, Andrzej A. Dlugosz, Asim A. Beg, Miriam H. Meisler, Anthony Antonellis

HGG Adv. 2024 Jul 18; 5(3): 100324. Published online 2024 Jul 2. doi: 10.1016/j.xhgg.2024.100324

PMCID:: PMC11284558

Abstract Article PDF–840K

Select item 66989362.

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype

Arjan F. Theil, Elena Botta, Anja Raams, Desiree E.C. Smith, Marisa I. Mendes, Giuseppina Caligiuri, Sarah Giachetti, Silvia Bione, Roberta Carriero, Giordano Liberi, Luca Zardoni, Sigrid M.A. Swagemakers, Gajja S. Salomons, Alain Sarasin, Alan Lehmann, Peter J. van der Spek, Tomoo Ogi, Jan H.J. Hoeijmakers, Wim Vermeulen, Donata Orioli

Am J Hum Genet. 2019 Aug 1; 105(2): 434–440. Published online 2019 Aug 1. doi: 10.1016/j.ajhg.2019.06.017

PMCID:: PMC6698936

Abstract Article PDF–976K

Select item 41550843.

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer

Theresa L Wellman, Midori Eckenstein, Cheung Wong, Mercedes Rincon, Takamaru Ashikaga, Sharon L Mount, Christopher S Francklyn, Karen M Lounsbury

BMC Cancer. 2014; 14: 620. Published online 2014 Aug 27. doi: 10.1186/1471-2407-14-620

PMCID:: PMC4155084

Abstract Article PDF–2.3M

Select item 35782234.

Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis

Tamara F. Williams, Adam C. Mirando, Barrie Wilkinson, Christopher S. Francklyn, Karen M. Lounsbury

Sci Rep. 2013; 3: 1317. Published online 2013 Feb 21. doi: 10.1038/srep01317

PMCID:: PMC3578223

Abstract Article PDF–868K

Select item 3629735.

Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines.

K J Kontis, S M Arfin

Mol Cell Biol. 1989 May; 9(5): 1832–1838. doi: 10.1128/mcb.9.5.1832

PMCID:: PMC362973

Summary Page Browse PDF–1.8M

Select item 92924026.

Contribution of upregulated aminoacyl‐tRNA biosynthesis to metabolic dysregulation in gastric cancer

Xiaoling Gao, Rui Guo, Yonghong Li, Guolan Kang, Yu Wu, Jia Cheng, Jing Jia, Wanxia Wang, Zhenhao Li, Anqi Wang, Hui Xu, Yanjuan Jia, Yuanting Li, Xiaoming Qi, Zhenhong Wei, Chaojun Wei

J Gastroenterol Hepatol. 2021 Nov; 36(11): 3113–3126. Published online 2021 Aug 1. doi: 10.1111/jgh.15592

PMCID:: PMC9292402

Abstract Article PDF–25M

Select item 57997957.

Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration

Seung Jae Jeong, Jong Hyun Kim, Beom Jin Lim, Ina Yoon, Ji-Ae Song, Hee-sun Moon, Doyeun Kim, Dong Ki Lee, Sunghoon Kim

Exp Mol Med. 2018 Jan; 50(1): e424. Published online 2018 Jan 12. doi: 10.1038/emm.2017.231

PMCID:: PMC5799795

Abstract Article PDF–2.6M

Select item 43892578.

Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam Mirando, Kaige Chen, Xin Chen, Sunghoon Kim, Christopher S. Francklyn, Min Guo

Nat Commun. 2015 Mar 31; 6: 6402. Published online 2015 Mar 31. doi: 10.1038/ncomms7402

PMCID:: PMC4389257

Abstract Article PDF–1.5M

Select item 64308109.

A threonyl-tRNA synthetase-mediated translation initiation machinery

Seung Jae Jeong, Shinhye Park, Loi T. Nguyen, Jungwon Hwang, Eun-Young Lee, Hoi-Khoanh Giong, Jeong-Soo Lee, Ina Yoon, Ji-Hyun Lee, Jong Hyun Kim, Hoi Kyoung Kim, Doyeun Kim, Won Suk Yang, Seon-Young Kim, Chan Yong Lee, Kweon Yu, Nahum Sonenberg, Myung Hee Kim, Sunghoon Kim

Nat Commun. 2019; 10: 1357. Published online 2019 Mar 22. doi: 10.1038/s41467-019-09086-0

PMCID:: PMC6430810

Abstract Article PDF–2.6M

Select item 634487110.

ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response

Lufen Chang, Lei Shen, Hu Zhou, Jing Gao, Hangyi Pan, Li Zheng, Brian Armstrong, Yang Peng, Guang Peng, Binhua P Zhou, Steven T Rosen, Binghui Shen

Nucleic Acids Res. 2019 Jan 25; 47(2): 824–842. Published online 2018 Dec 4. doi: 10.1093/nar/gky1199

PMCID:: PMC6344871

Abstract Article PDF–6.8M

Select item 470715811.

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

Ming Wang, Jing Sang, Yanhua Ren, Kejia Liu, Xinyi Liu, Jian Zhang, Haolu Wang, Jian Wang, Amir Orian, Jie Yang, Jing Yi

Protein Cell. 2016 Jan; 7(1): 63–77. Published online 2015 Oct 28. doi: 10.1007/s13238-015-0216-7

PMCID:: PMC4707158

Abstract Article PDF–1.3M

Select item 587388512.

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

Omar M. Khan, Joana Carvalho, Bradley Spencer-Dene, Richard Mitter, David Frith, Ambrosius P. Snijders, Stephen A. Wood, Axel Behrens

J Clin Invest. 2018 Apr 2; 128(4): 1326–1337. Published online 2018 Feb 26. doi: 10.1172/JCI97325

PMCID:: PMC5873885

Abstract Article PDF–16M

Select item 637646813.

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway

Yin-Li Zheng, Lei Li, Yong-Xun Jia, Bao-Zhu Zhang, Jiang-Chao Li, Ying-Hui Zhu, Meng-Qing Li, Jiao-Zi He, Ting-Ting Zeng, Xiao-Jiao Ban, Yun-Fei Yuan, Yan Li, Xin-Yuan Guan

Theranostics. 2019; 9(3): 796–810. Published online 2019 Jan 24. doi: 10.7150/thno.28992

PMCID:: PMC6376468

Abstract Article PDF–2.3M

Select item 117742714.

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways

Chen Zhao, Carilee Denison, Jon M. Huibregtse, Steven Gygi, Robert M. Krug

Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29): 10200–10205. Published online 2005 Jul 11. doi: 10.1073/pnas.0504754102

PMCID:: PMC1177427

Abstract Article PDF–470K

Select item 730831315.

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, Mingming Xiao, Baicai Yang, Guoxuan Qin, Ruirui Kong, Ruibing Chen, Ning Zhang

Nat Commun. 2020; 11: 3162. Published online 2020 Jun 22. doi: 10.1038/s41467-020-16966-3

PMCID:: PMC7308313

Abstract Article PDF–2.9M

Select item 1085081816.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 630048717.

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

Tabish Hussain, Jaeho Lee, Martin C. Abba, Junjie Chen, C. Marcelo Aldaz

Front Oncol. 2018; 8: 591. Published online 2018 Dec 13. doi: 10.3389/fonc.2018.00591

PMCID:: PMC6300487

Abstract Article PDF–1.8M

Select item 682384618.

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion

Calvin J. Chan, Roberta Le, Kaylan Burns, Khadra Ahmed, Etienne Coyaud, Estelle M. N. Laurent, Brian Raught, Paul Melançon

Mol Cell Proteomics. 2019 Nov; 18(11): 2285–2297. Published online 2019 Sep 13. doi: 10.1074/mcp.RA119.001645

PMCID:: PMC6823846

Abstract Article PDF–2.2M

Select item 425650719.

The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets

Maria Katsogiannou, Claudia Andrieu, Virginie Baylot, Anaïs Baudot, Nelson J. Dusetti, Odile Gayet, Pascal Finetti, Carmen Garrido, Daniel Birnbaum, François Bertucci, Christine Brun, Palma Rocchi

Mol Cell Proteomics. 2014 Dec; 13(12): 3585–3601. Published online 2014 Oct 1. doi: 10.1074/mcp.M114.041228