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Select item 83462111.

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells

Cecilia Pessoa Rodrigues, Asifa Akhtar

Sci Adv. 2021 Aug; 7(32): eabi5987. Published online 2021 Aug 6. doi: 10.1126/sciadv.abi5987

PMCID:: PMC8346211

Abstract Article PDF–3.9M

Select item 40598882.

Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation

Sarina Ravens, Marjorie Fournier, Tao Ye, Matthieu Stierle, Doulaye Dembele, Virginie Chavant, Làszlò Tora

eLife. 2014; 3: e02104. Published online 2014 Jun 4. doi: 10.7554/eLife.02104

PMCID:: PMC4059888

Abstract Article PDF–2.0M

Select item 34131703.

The Histone Acetyltransferase MOF is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network

Xiangzhi Li, Li Li, Ruchi Pandey, Jung S. Byun, Kevin Gardner, Zhaohui Qin, Yali Dou

Cell Stem Cell. Author manuscript; available in PMC 2013 Aug 3.

Published in final edited form as: Cell Stem Cell. 2012 Aug 3; 11(2): 163–178. doi: 10.1016/j.stem.2012.04.023

PMCID:: PMC3413170

Abstract Article PDF–2.7M

Select item 25196974.

Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture

Tim Thomas, Mathew P. Dixon, Andrew J. Kueh, Anne K. Voss

Mol Cell Biol. 2008 Aug; 28(16): 5093–5105. Published online 2008 Jun 9. doi: 10.1128/MCB.02202-07

PMCID:: PMC2519697

Abstract Article PDF–1.2M

Select item 106873395.

Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

Xinghong Guo, Kai Liang, Longqing Xia, Xu Zhang, Jinbo Liu, Chuan Wang, Jinquan Li, Xiangzhi Li, Xinguo Hou, Li Chen

iScience. 2023 Dec 15; 26(12): 108446. Published online 2023 Nov 14. doi: 10.1016/j.isci.2023.108446

PMCID:: PMC10687339

Abstract Article PDF–9.8M

Select item 84238206.

MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness

Yahui Liu, Juan Du, Xinnan Liu, Lingbiao Wang, Yichao Han, Chunrong Huang, Rui Liang, Fang Zheng, Guochao Shi, Bin Li

Signal Transduct Target Ther. 2021; 6: 321. Published online 2021 Sep 8. doi: 10.1038/s41392-021-00667-4

PMCID:: PMC8423820

Article PDF–1.0M

Select item 79485727.

Dysregulation of intercellular signaling by MOF deletion leads to liver injury

Hongwei Lei, Aaron D. denDekker, Guobing Li, Zhiguo Zhang, Liang Sha, Matthew A. Schaller, Steven L. Kunkel, Liangyou Rui, Kaixiong Tao, Yali Dou

J Biol Chem. 2021 Jan-Jun; 296: 100235. Published online 2021 Jan 7. doi: 10.1074/jbc.RA120.016079

PMCID:: PMC7948572

Abstract Article PDF–4.4M

Select item 71413888.

TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF

Aaron D. denDekker, Frank M. Davis, Amrita D. Joshi, Sonya J. Wolf, Ronald Allen, Jay Lipinski, Brenda Nguyen, Joseph Kirma, Dylan Nycz, Jennifer Bermick, Bethany B. Moore, Johann E. Gudjonsson, Steven L. Kunkel, Katherine A. Gallagher

JCI Insight. 2020 Mar 12; 5(5): e132306. Published online 2020 Mar 12. doi: 10.1172/jci.insight.132306

PMCID:: PMC7141388

Abstract Article PDF–1.9M

Select item 60198199.

MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice

Hanwei Jiang, Qian Gao, Wei Zheng, Shi Yin, Liu Wang, Liangwen Zhong, Asim Ali, Teka Khan, Qiaomei Hao, Hui Fang, Xiaoling Sun, Peng Xu, Tej K. Pandita, Xiaohua Jiang, Qinghua Shi

PLoS Genet. 2018 May; 14(5): e1007300. Published online 2018 May 24. doi: 10.1371/journal.pgen.1007300

PMCID:: PMC6019819

Abstract Article PDF–29M

Select item 550129310.

Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis

Daria G. Valerio, Haiming Xu, Chun-Wei Chen, Takayuki Hoshii, Meghan E. Eisold, Christopher Delaney, Monica Cusan, Aniruddha J. Deshpande, Chun-Hao Huang, Amaia Lujambio, George Zheng, Johannes Zuber, Tej K. Pandita, Scott W. Lowe, Scott A. Armstrong

Cancer Res. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Cancer Res. 2017 Apr 1; 77(7): 1753–1762. Published online 2017 Feb 15. doi: 10.1158/0008-5472.CAN-16-2374

PMCID:: PMC5501293

Abstract Article PDF–1.6M

Select item 548299311.

Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels

Shi Yin, Xiaohua Jiang, Hanwei Jiang, Qian Gao, Fang Wang, Suixing Fan, Teka Khan, Nazish Jabeen, Manan Khan, Asim Ali, Peng Xu, Tej K. Pandita, Heng-Yu Fan, Yuanwei Zhang, Qinghua Shi

Development. 2017 Jun 15; 144(12): 2165–2174. doi: 10.1242/dev.149518

PMCID:: PMC5482993

Abstract Article

Select item 521626412.

Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice

Daria G. Valerio, Haiming Xu, Meghan E. Eisold, Carolien M. Woolthuis, Tej K. Pandita, Scott A. Armstrong

Blood. 2017 Jan 5; 129(1): 48–59. Prepublished online 2016 Nov 8. doi: 10.1182/blood-2016-05-714568

PMCID:: PMC5216264

Abstract Article

Select item 363052013.

T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice

Arun Gupta, Clayton R. Hunt, Raj K. Pandita, Juhee Pae, K. Komal, Mayank Singh, Jerry W. Shay, Rakesh Kumar, Kiyoshi Ariizumi, Nobuo Horikoshi, Walter N. Hittelman, Chandan Guha, Thomas Ludwig, Tej K. Pandita

Mutagenesis. 2013 May; 28(3): 263–270. Published online 2013 Feb 5. doi: 10.1093/mutage/ges080

PMCID:: PMC3630520

Abstract Article PDF–3.4M

Select item 304812414.

Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice

Rakesh Kumar, Clayton R. Hunt, Arun Gupta, Suraj Nannepaga, Raj K. Pandita, Jerry W. Shay, Robert Bachoo, Thomas Ludwig, Dennis K. Burns, Tej K. Pandita

Proc Natl Acad Sci U S A. 2011 Mar 1; 108(9): 3636–3641. Published online 2011 Feb 14. doi: 10.1073/pnas.1016524108

PMCID:: PMC3048124

Abstract Article PDF–787K

Select item 731455515.

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate

Cecilia Pessoa Rodrigues, Josip Stefan Herman, Benjamin Herquel, Claudia Isabelle Keller Valsecchi, Thomas Stehle, Dominic Grün, Asifa Akhtar

Sci Adv. 2020 May; 6(21): eaaz4815. Published online 2020 May 20. doi: 10.1126/sciadv.aaz4815

PMCID:: PMC7314555

Abstract Article PDF–3.2M

Select item 489363416.

MOF maintains transcriptional programs regulating cellular stress response

B N Sheikh, W Bechtel-Walz, J Lucci, O Karpiuk, I Hild, B Hartleben, J Vornweg, M Helmstädter, A H Sahyoun, V Bhardwaj, T Stehle, S Diehl, O Kretz, A K Voss, T Thomas, T Manke, T B Huber, A Akhtar

Oncogene. 2016 May; 35(21): 2698–2710. Published online 2015 Sep 21. doi: 10.1038/onc.2015.335

PMCID:: PMC4893634

Abstract Article PDF–3.6M

Select item 366279617.

Upregulation of the mammalian X chromosome is associated with enhanced transcription initiation, MOF-mediated H4K16 acetylation, and longer RNA half-life

Xinxian Deng, Joel B. Berletch, Wenxiu Ma, Di Kim Nguyen, William S. Noble, Jay Shendure, Christine M. Disteche

Dev Cell. Author manuscript; available in PMC 2014 Apr 15.

Published in final edited form as: Dev Cell. 2013 Apr 15; 25(1): 55–68. Published online 2013 Mar 21. doi: 10.1016/j.devcel.2013.01.028

PMCID:: PMC3662796

Abstract Article PDF–4.2M

Select item 297637618.

MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

Xiangzhi Li, Callie Ann Sprunger Corsa, Patricia W. Pan, Lipeng Wu, David Ferguson, Xiaochun Yu, Jinrong Min, Yali Dou

Mol Cell Biol. 2010 Nov; 30(22): 5335–5347. Published online 2010 Sep 13. doi: 10.1128/MCB.00350-10

PMCID:: PMC2976376

Abstract Article PDF–2.9M

Select item 644688019.

KAT8 selectively inhibits antiviral immunity by acetylating IRF3

Wanwan Huai, Xingguang Liu, Chunmei Wang, Yunkai Zhang, Xi Chen, Xiang Chen, Sheng Xu, Tim Thomas, Nan Li, Xuetao Cao

J Exp Med. 2019 Apr 1; 216(4): 772–785. Published online 2019 Mar 6. doi: 10.1084/jem.20181773

Correction in:: J Exp Med. 2019 Apr 1; 216(4): 1001.

PMCID:: PMC6446880

Abstract Article PDF–2.9M

Select item 1122241420.

KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2

Shilei Bi, Lijun Huang, Yongjie Chen, Zhenhua Hu, Shanze Li, Yifan Wang, Baoying Huang, Lizi Zhang, Yuanyuan Huang, Beibei Dai, Lili Du, Zhaowei Tu, Yijing Wang, Dan Xu, Xiaotong Xu, Wen Sun, Julia Kzhyshkowska, Haibin Wang, Dunjin Chen, Fengchao Wang, Shuang Zhang

Nat Commun. 2024; 15: 5602. Published online 2024 Jul 3. doi: 10.1038/s41467-024-49930-6