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Select item 108875631.

STAT4 Gene Variant rs7574865 Is Associated with Rheumatoid Arthritis Activity and Anti-CCP Levels in the Western but Not in the Southern Population of Mexico

Karla Mayela Bravo-Villagra, José Francisco Muñoz-Valle, Christian Johana Baños-Hernández, Sergio Cerpa-Cruz, José Eduardo Navarro-Zarza, Isela Parra-Rojas, José Alonso Aguilar-Velázquez, Samuel García-Arellano, Andres López-Quintero

Genes (Basel) 2024 Feb; 15(2): 241. Published online 2024 Feb 14. doi: 10.3390/genes15020241

PMCID:: PMC10887563

Abstract Article PDF–391K

Select item 105566352.

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation

Gianluca Scarno, Julija Mazej, Mattia Laffranchi, Chiara Di Censo, Irene Mattiola, Arianna M. Candelotti, Giuseppe Pietropaolo, Helena Stabile, Cinzia Fionda, Giovanna Peruzzi, Stephen R. Brooks, Wanxia Li Tsai, Yohei Mikami, Giovanni Bernardini, Angela Gismondi, Silvano Sozzani, James P. Di Santo, Christian A. J. Vosshenrich, Andreas Diefenbach, Massimo Gadina, Angela Santoni, Giuseppe Sciumè

Proc Natl Acad Sci U S A. 2023 Oct 3; 120(40): e2306761120. Published online 2023 Sep 27. doi: 10.1073/pnas.2306761120

PMCID:: PMC10556635

Abstract Article PDF–1.7M

Select item 103925713.

Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome

Hratch Baghdassarian, Sarah A. Blackstone, Owen S. Clay, Rachael Philips, Brynja Matthiasardottir, Michele Nehrebecky, Vivian K. Hua, Rachael McVicar, Yang Liu, Suzanne M. Tucker, Davide Randazzo, Natalie Deuitch, Sofia Rosenzweig, Adam Mark, Roman Sasik, Kathleen M. Fisch, Pallavi Pimpale Chavan, Elif Eren, Norman R. Watts, Chi A. Ma, Massimo Gadina, Daniella M. Schwartz, Anwesha Sanyal, Giffin Werner, David R. Murdock, Nobuyuki Horita, Shimul Chowdhury, David Dimmock, Kristen Jepsen, Elaine F. Remmers, Raphaela Goldbach-Mansky, William A. Gahl, John J. O’Shea, Joshua D. Milner, Nathan E. Lewis, Johanna Chang, Daniel L. Kastner, Kathryn Torok, Hirotsugu Oda, Christopher D. Putnam, Lori Broderick

N Engl J Med. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: N Engl J Med. 2023 Jun 15; 388(24): 2241–2252. Published online 2023 May 31. doi: 10.1056/NEJMoa2202318

PMCID:: PMC10392571

Abstract Article PDF–2.4M

Select item 102513694.

STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion

Wei Wang, Si Liu, Funian Lu, Bin Yang, Xucui Zhuang, Jingjing Yin, Gang Chen, Chaoyang Sun

Oncol Rep. 2023 Jul; 50(1): 140. Published online 2023 May 31. doi: 10.3892/or.2023.8577

PMCID:: PMC10251369

Abstract Article PDF–3.3M

Select item 92838585.

T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation

Yihan Chen, Bao Zhang, Tianliang Liu, Xiaoping Chen, Yaning Wang, Hongbo Zhang

Front Immunol. 2022; 13: 895762. Published online 2022 Jul 1. doi: 10.3389/fimmu.2022.895762

PMCID:: PMC9283858

Abstract Article PDF–6.4M

Select item 88263716.

Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway

Caie Wang, Na Gao, Lukui Yang, Yuanyuan Guo, Yan Fang, Tong Wang, Chen Xu, Gui fang Li, Jun Zhou, Yunfei Zhang, Qiang Wen, Hailing Qiao

Cell Death Dis. 2022 Feb; 13(2): 130. Published online 2022 Feb 8. doi: 10.1038/s41419-022-04584-4

PMCID:: PMC8826371

Abstract Article PDF–5.3M

Select item 83144317.

A new discovery of STAT4 single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Chinese Han population: a case–control study

Xu Chao, Jieqiong Wu, Wei Zhang, Xuesong Feng, Luyan Zhao, Feng Huang, Chao Jiang

Biosci Rep. 2021 Jul 30; 41(7): BSR20210124. Published online 2021 Jul 26. doi: 10.1042/BSR20210124

PMCID:: PMC8314431

Abstract Article PDF–894K

Select item 82375038.

Association between STAT4 gene polymorphism and type 2 diabetes risk in Chinese Han population

Jiaqi Cui, Rui Tong, Jing Xu, Yanni Tian, Juan Pan, Ning Wang, Huan Chen, Yanqi Peng, Sijia Fei, Wang Ling, Chaoying Guo, Juanchuan Yao, Wei Cui

BMC Med Genomics. 2021; 14: 169. Published online 2021 Jun 27. doi: 10.1186/s12920-021-01000-2

PMCID:: PMC8237503

Abstract Article PDF–1017K

Select item 70979189.

STAT4: an immunoregulator contributing to diverse human diseases

Chou Yang, Haoming Mai, Jinxin Peng, Bin Zhou, Jinlin Hou, Deke Jiang

Int J Biol Sci. 2020; 16(9): 1575–1585. Published online 2020 Mar 5. doi: 10.7150/ijbs.41852

PMCID:: PMC7097918

Abstract Article PDF–849K

Select item 613119910.

Polymorphisms of the STAT4 gene in the pathogenesis of tuberculosis

Shouquan Wu, Minggui Wang, Yu Wang, Miaomiao Zhang, Jian-Qing He

Biosci Rep. 2018 Aug 31; 38(4): BSR20180498. Published online 2018 Aug 29. doi: 10.1042/BSR20180498

PMCID:: PMC6131199

Abstract Article PDF–336K

Select item 602964311.

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE

Niklas Hagberg, Martin Joelsson, Dag Leonard, Sarah Reid, Maija-Leena Eloranta, John Mo, Magnus K Nilsson, Ann-Christine Syvänen, Yenan T Bryceson, Lars Rönnblom

Ann Rheum Dis. 2018 Jul; 77(7): 1070–1077. Published online 2018 Feb 23. doi: 10.1136/annrheumdis-2017-212794

PMCID:: PMC6029643

Abstract Article PDF–3.6M

Select item 584494812.

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

James J. Gilchrist, Anna Rautanen, Benjamin P. Fairfax, Tara C. Mills, Vivek Naranbhai, Holly Trochet, Matti Pirinen, Esther Muthumbi, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Chisomo L. Msefula, Esther N. Gondwe, Jenny M. MacLennan, Stephen J. Chapman, Malcolm E. Molyneux, Julian C. Knight, Chris C. A. Spencer, Thomas N. Williams, Calman A. MacLennan, J. Anthony G. Scott, Adrian V. S. Hill

Nat Commun. 2018; 9: 1014. Published online 2018 Mar 9. doi: 10.1038/s41467-017-02398-z

PMCID:: PMC5844948

Abstract Article PDF–1.1M

Select item 537644913.

Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation

Anca D. Dobrian, Kaiwen Ma, Lindsey M. Glenn, Margaret A. Hatcher, Bronson A. Haynes, Eric J. Lehrer, Mark H. Kaplan, Jerry L. Nadler

Mediators Inflamm. 2017; 2017: 5420718. Published online 2017 Mar 16. doi: 10.1155/2017/5420718

PMCID:: PMC5376449

Abstract Article PDF–3.3M

Select item 492868314.

STAT4-mediated transcriptional repression of the IL5 gene in human memory Th2 cells

Sarah R. Gonzales-van Horn, Leonardo D. Estrada, Nicolai S. C. van Oers, J. David Farrar

Eur J Immunol. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Eur J Immunol. 2016 Jun; 46(6): 1504–1510. Published online 2016 Apr 8. doi: 10.1002/eji.201546050

PMCID:: PMC4928683

Abstract Article PDF–992K

Select item 464663515.

The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

Amalia Lamana, Mercedes López-Santalla, Raquel Castillo-González, Ana María Ortiz, Javier Martín, Rosario García-Vicuña, Isidoro González-Álvaro

PLoS One. 2015; 10(11): e0142683. Published online 2015 Nov 16. doi: 10.1371/journal.pone.0142683

PMCID:: PMC4646635

Abstract Article PDF–644K

Select item 463372216.

Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis

De-Ke Jiang, Xiao-Pin Ma, Xiaopan Wu, Lijun Peng, Jianhua Yin, Yunjie Dan, Hui-Xing Huang, Dong-Lin Ding, Lu-Yao Zhang, Zhuqing Shi, Pengyin Zhang, Hongjie Yu, Jielin Sun, S. Lilly Zheng, Guohong Deng, Jianfeng Xu, Ying Liu, Jinsheng Guo, Guangwen Cao, Long Yu

Sci Rep. 2015; 5: 16278. Published online 2015 Nov 5. doi: 10.1038/srep16278

PMCID:: PMC4633722

Abstract Article PDF–401K

Select item 461438817.

Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines

Ivan V Litvinov, Brendan Cordeiro, Simon Fredholm, Niels Ødum, Hanieh Zargham, Yuanshen Huang, Youwen Zhou, Kevin Pehr, Thomas S Kupper, Anders Woetmann, Denis Sasseville

Cell Cycle. 2014 Sep 15; 13(18): 2975–2982. Published online 2014 Oct 30. doi: 10.4161/15384101.2014.947759

PMCID:: PMC4614388

Abstract Article PDF–600K

Select item 438554718.

Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma

Gang Wang, Jia-Hui Chen, Yong Qiang, Dong-Zhi Wang, Zhong Chen

World J Gastroenterol. 2015 Apr 7; 21(13): 3983–3993. Published online 2015 Apr 7. doi: 10.3748/wjg.v21.i13.3983

PMCID:: PMC4385547

Abstract Article PDF–1.7M

Select item 421879819.

Association of HLA-DP/DQ and STAT4 Polymorphisms with HBV Infection Outcomes and a Mini Meta-Analysis

Yun Liao, Bei Cai, Yi Li, Jie Chen, Chuanmin Tao, Hengjian Huang, Lanlan Wang

PLoS One. 2014; 9(11): e111677. Published online 2014 Nov 3. doi: 10.1371/journal.pone.0111677

PMCID:: PMC4218798

Abstract Article PDF–357K

Select item 413984420.

Association between STAT4 Gene Polymorphisms and Autoimmune Thyroid Diseases in a Chinese Population

Ni Yan, Shuai Meng, Jiaozhen Zhou, Jian Xu, Fatuma Said Muhali, Wenjuan Jiang, Liangfeng Shi, Xiaohong Shi, Jinan Zhang

Int J Mol Sci. 2014 Jul; 15(7): 12280–12293. Published online 2014 Jul 11. doi: 10.3390/ijms150712280

PMCID:: PMC4139844

Abstract Article PDF–163K

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