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Select item 88353061.

Somatostatin Receptor Splicing Variant sst5TMD4 Overexpression in Glioblastoma Is Associated with Poor Survival, Increased Aggressiveness Features, and Somatostatin Analogs Resistance

Antonio C. Fuentes-Fayos, Miguel E. G-García, Jesús M. Pérez-Gómez, Annabel Peel, Cristóbal Blanco-Acevedo, Juan Solivera, Alejandro Ibáñez-Costa, Manuel D. Gahete, Justo P. Castaño, Raúl M. Luque

Int J Mol Sci. 2022 Feb; 23(3): 1143. Published online 2022 Jan 20. doi: 10.3390/ijms23031143

PMCID:: PMC8835306

Abstract Article PDF–2.5M

Select item 88073622.

Epigenetic and post‐transcriptional regulation of somatostatin receptor subtype 5 (SST₅) in pituitary and pancreatic neuroendocrine tumors

Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Ricardo Blázquez‐Encinas, Miguel R. Branco, Mari C. Vázquez‐Borrego, Aura D. Herrera‐Martínez, Eva Venegas‐Moreno, Raquel Serrano‐Blanch, Álvaro Arjona‐Sánchez, María A. Gálvez‐Moreno, Marta Korbonits, Alfonso Soto‐Moreno, Manuel D. Gahete, Marika Charalambous, Raúl M. Luque, Justo P. Castaño

Mol Oncol. 2022 Feb; 16(3): 764–779. Published online 2021 Oct 26. doi: 10.1002/1878-0261.13107

PMCID:: PMC8807362

Abstract Article PDF–2.6M

Select item 54168073.

Phosphorylation of Threonine 333 Regulates Trafficking of the Human sst₅ Somatostatin Receptor

Aline Petrich, Anika Mann, Andrea Kliewer, Falko Nagel, Anne Strigli, Jan Carlo Märtens, Florian Pöll, Stefan Schulz

Mol Endocrinol. April 1, 2013; 27(4): 671–682. Published online 2013 Feb 15. doi: 10.1210/me.2012-1329

PMCID:: PMC5416807

Abstract Article

Select item 53123724.

The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients

Manuel D. Gahete, David Rincón-Fernández, Mario Durán-Prado, Marta Hergueta-Redondo, Alejandro Ibáñez-Costa, Alejandro Rojo-Sebastián, Francisco Gracia-Navarro, Michael D. Culler, Oriol Casanovas, Gema Moreno-Bueno, Raúl M. Luque, Justo P. Castaño

Oncotarget. 2016 Sep 13; 7(37): 60110–60122. Published online 2016 Aug 5. doi: 10.18632/oncotarget.11076

PMCID:: PMC5312372

Abstract Article PDF–6.8M

Select item 48727355.

Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors

Miguel Sampedro-Núñez, Raúl M. Luque, Ana M. Ramos-Levi, Manuel D. Gahete, Ana Serrano-Somavilla, Alicia Villa-Osaba, Magdalena Adrados, Alejandro Ibáñez-Costa, Elena Martín-Pérez, Michael D. Culler, Mónica Marazuela, Justo P. Castaño

Oncotarget. 2016 Feb 9; 7(6): 6593–6608. Published online 2015 Dec 11. doi: 10.18632/oncotarget.6565

PMCID:: PMC4872735

Abstract Article PDF–2.9M

Select item 48308976.

Analysis of transmission of novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene in patients with autism

Marlene Lauritsen, Mette Nyegaard, Catalina Betancur, Catherine Colineaux, Trine Josiassen, Torben Kruse, Marion Leboyer, Henrik Ewald

Am J Med Genet B Neuropsychiatr Genet. Author manuscript;

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2003 Aug; 121(1): 100–104. doi: 10.1002/ajmg.b.20050

PMCID:: PMC4830897

Abstract Article

Select item 43782697.

Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas

Raúl M. Luque, Alejandro Ibáñez-Costa, Leonardo Vieira Neto, Giselle F. Taboada, Daniel Hormaechea-Agulla, Leandro Kasuki, Eva Venegas-Moreno, Alberto Moreno-Carazo, María Ángeles Gálvez, Alfonso Soto-Moreno, Rhonda D. Kineman, Michael D. Culler, Manuel D. Gahete, Mônica R. Gadelha, Justo P. Castaño

Cancer Lett. Author manuscript; available in PMC 2016 Apr 10.

Published in final edited form as: Cancer Lett. 2015 Apr 10; 359(2): 299–306. Published online 2015 Jan 28. doi: 10.1016/j.canlet.2015.01.037

PMCID:: PMC4378269

Abstract Article PDF–2.4M

Select item 41379698.

The Hypofunctional Effect of P335L Single Nucleotide Polymorphism on SSTR5 Function

Guisheng Zhou, Marie-Claude Gingras, Shi-He Liu, Donghui Li, Zhijun Li, Robbi L. Catania, Kelly M. Stehling, Min Li, Giovanni Paganelli, Richard A Gibbs, Franco DeMayo, William E. Fisher, F. Charles Brunicardi

World J Surg. Author manuscript; available in PMC 2014 Aug 19.

Published in final edited form as: World J Surg. 2011 Aug; 35(8): 1715–1724. doi: 10.1007/s00268-010-0939-9

PMCID:: PMC4137969

Abstract Article PDF–1.6M

Select item 38974529.

The Truncated Isoform of Somatostatin Receptor5 (sst5TMD4) Is Associated with Poorly Differentiated Thyroid Cancer

Manel Puig-Domingo, Raúl M. Luque, Jordi L. Reverter, Laura M. López-Sánchez, Manuel D. Gahete, Michael D. Culler, Gonzalo Díaz-Soto, Francisco Lomeña, Mattia Squarcia, José Luis Mate, Mireia Mora, Laureano Fernández-Cruz, Oscar Vidal, Antonio Alastrué, Jose Balibrea, Irene Halperin, Dídac Mauricio, Justo P. Castaño

PLoS One. 2014; 9(1): e85527. Published online 2014 Jan 21. doi: 10.1371/journal.pone.0085527

PMCID:: PMC3897452

Abstract Article PDF–894K

Select item 317891410.

Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly

Darja Ciganoka, Inga Balcere, Ivo Kapa, Raitis Peculis, Andra Valtere, Liene Nikitina-Zake, Ieva Lase, Helgi B Schiöth, Valdis Pirags, Janis Klovins

Eur J Endocrinol. 2011 Oct; 165(4): 517–525. doi: 10.1530/EJE-11-0416

PMCID:: PMC3178914

Abstract Article PDF–169K

Select item 313572011.

Association between Somatostatin Receptor 5 Gene Polymorphisms and Pancreatic Cancer Risk and Survival

Donghui Li, Motofumi Tanaka, F. Charles Brunicardi, William E. Fisher, Richard A. Gibbs, Marie-Claude Gingras

Cancer. Author manuscript; available in PMC 2012 Jul 10.

Published in final edited form as: Cancer. 2011 Jul 1; 117(13): 2863–2872. Published online 2011 Jan 10. doi: 10.1002/cncr.25858

PMCID:: PMC3135720

Abstract Article PDF–484K

Select item 270354912.

Characterization of Intracellular Signaling Mediated by Human Somatostatin Receptor 5: Role of the DRY Motif and the Third Intracellular Loop

Erika Peverelli, Andrea G. Lania, Giovanna Mantovani, Paolo Beck-Peccoz, Anna Spada

Endocrinology. 2009 Jul; 150(7): 3169–3176. Published online 2009 Apr 2. doi: 10.1210/en.2008-1785

PMCID:: PMC2703549

Abstract Article

Select item 541939713.

Cell Growth Inhibition and Functioning of Human Somatostatin Receptor Type 2 Are Modulated by Receptor Heterodimerization

Michael Grant, Haydar Alturaihi, Philippe Jaquet, Brian Collier, Ujendra Kumar

Mol Endocrinol. October 1, 2008; 22(10): 2278–2292. doi: 10.1210/me.2007-0334

PMCID:: PMC5419397

Abstract Article

Select item 281750614.

Differential between Protein and mRNA Expression of CCR7 and SSTR5 Receptors in Crohn's Disease Patients

Nathalie Taquet, Serge Dumont, Jean-Luc Vonesch, Didier Hentsch, Jean-Marie Reimund, Christian D. Muller

Mediators Inflamm. 2009; 2009: 285812. Published online 2010 Feb 1. doi: 10.1155/2009/285812

PMCID:: PMC2817506

Abstract Article PDF–2.7M

Select item 34550215.

Primary structure of the gene encoding rat preprosomatostatin.

M R Montminy, R H Goodman, S J Horovitch, J F Habener

Proc Natl Acad Sci U S A. 1984 Jun; 81(11): 3337–3340. doi: 10.1073/pnas.81.11.3337

PMCID:: PMC345502

Summary Page Browse PDF–989K

Select item 623744616.

Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function

Masaaki Yamamoto, Anat Ben-Shlomo, Hiraku Kameda, Hidenori Fukuoka, Nan Deng, Yan Ding, Shlomo Melmed

JCI Insight. 2018 Oct 4; 3(19): e122932. Published online 2018 Oct 4. doi: 10.1172/jci.insight.122932

PMCID:: PMC6237446

Abstract Article PDF–5.2M

Select item 793393117.

Predictive and prognostic significance of tumour subtype, SSTR1‐5 and e‐cadherin expression in a well‐defined cohort of patients with acromegaly

Jiri Soukup, Helena Hornychova, Monika Manethova, Kvetoslava Michalova, Ludmila Michnova, Lenka Popovska, Veronika Skarkova, Tomas Cesak, David Netuka, Ales Ryska, Jan Cap, Václav Hána, Václav Hána, Jr, Michal Kršek, Eva Dvořáková, Michal Krčma, Ivica Lazurova, Věra Olšovská, Karel Starý, Peter Vaňuga, Filip Gabalec

J Cell Mol Med. 2021 Mar; 25(5): 2484–2492. Published online 2021 Jan 24. doi: 10.1111/jcmm.16173

PMCID:: PMC7933931

Abstract Article PDF–551K

Select item 461880418.

Immunohistochemical Detection and Localization of Somatostatin Receptor Subtypes in Prostate Tissue from Patients with Bladder Outlet Obstruction

Rodolfo Montironi, Liang Cheng, Roberta Mazzucchelli, Doriana Morichetti, Daniela Stramazzotti, Alfredo Santinelli, Gianluca Moroncini, Andrea B. Galosi, Giovanni Muzzonigro, Giancarlo Comeri, Jon Lovisolo, Sergio Cosciani-Cunico, Aldo V. Bono

Cell Oncol. 2008; 30(6): 473–482. Published online 2008 Oct 14. doi: 10.3233/CLO-2008-0433

PMCID:: PMC4618804

Abstract PDF–3.5M

Select item 4821419.

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

Y Yamada, S R Post, K Wang, H S Tager, G I Bell, S Seino

Proc Natl Acad Sci U S A. 1992 Jan 1; 89(1): 251–255. doi: 10.1073/pnas.89.1.251

PMCID:: PMC48214

Summary Page Browse PDF–1.2M

Select item 298940420.

Eighteen Insulin-like Growth Factor (IGF) pathway genes, circulating levels of IGF-1 and its binding protein (IGFBP-3), and risk of prostate and breast cancer

Fangyi Gu, Fredrick R. Schumacher, Federico Canzian, Naomi E. Allen, Demetrius Albanes, Christine D Berg, Sonja I. Berndt, Heiner Boeing, H. Bas Bueno-de-Mesquita, Julie E. Buring, Nathalie Chabbert-Buffet, Stephen J. Chanock, Françoise Clavel-Chapelon, Vanessa Dumeaux, J. Michael Gaziano, Edward L. Giovannucci, Christopher A. Haiman, Susan E. Hankinson, Richard B. Hayes, Brian E. Henderson, David J. Hunter, Robert N. Hoover, Mattias Johansson, Timothy J. Key, Kay-Tee Khaw, Laurence N. Kolonel, Pagona Lagiou, I-Min Lee, Loic LeMarchand, Eiliv Lund, Jing Ma, N. Charlotte Onland-Moret, Kim Overvad, Laudina Rodriguez, Carlotta Sacerdote, Maria-José Sánchez, Meir J. Stampfer, Pär Stattin, Daniel O. Stram, Gilles Thomas, Michael J. Thun, Anne Tjønneland, Dimitrios Trichopoulos, Rosario Tumino, Jarmo Virtamo, Stephanie J. Weinstein, Walter C. Willett, Meredith Yeager, Shumin M. Zhang, Rudolf Kaaks, Elio Riboli, Regina G. Ziegler, Peter Kraft

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11): 2877–2887. Published online 2010 Sep 1. doi: 10.1158/1055-9965.EPI-10-0507

PMCID:: PMC2989404

Abstract Article PDF–108K

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