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Select item 108911681.

Comprehensive analyses of solute carrier family members identify SLC12A2 as a novel therapy target for colorectal cancer

Dan-yang Chen, Yang-yang Zhang, Hai-hang Nie, Hai-zhou Wang, Pei-shan Qiu, Fan Wang, Ya-nan Peng, Fei Xu, Qiu Zhao, Meng Zhang

Sci Rep. 2024; 14: 4459. Published online 2024 Feb 23. doi: 10.1038/s41598-024-55048-y

PMCID:: PMC10891168

Abstract Article PDF–11M

Select item 97137172.

Cryo‐EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

Caroline Neumann, Lena Lindtoft Rosenbæk, Rasmus Kock Flygaard, Michael Habeck, Jesper Lykkegaard Karlsen, Yong Wang, Kresten Lindorff‐Larsen, Hans Henrik Gad, Rune Hartmann, Joseph Anthony Lyons, Robert A Fenton, Poul Nissen

EMBO J. 2022 Dec; 41(23): e110169. Published online 2022 Oct 14. doi: 10.15252/embj.2021110169

PMCID:: PMC9713717

Abstract Article PDF–3.9M

Select item 86129233.

Further confirmation of the association of SLC12A2 with non-syndromic autosomal-dominant hearing impairment

Samuel M. Adadey, Isabelle Schrauwen, Elvis Twumasi Aboagye, Thashi Bharadwaj, Kevin K. Esoh, Sulman Basit, Anushree Acharya, Liz M. Nouel-Saied, Khurram Liaqat, Edmond Wonkam-Tingang, Shaheen Mowla, Gordon A. Awandare, Wasim Ahmad, Suzanne M. Leal, Ambroise Wonkam

J Hum Genet. 2021; 66(12): 1169–1175. Published online 2021 Jul 5. doi: 10.1038/s10038-021-00954-6

PMCID:: PMC8612923

Abstract Article PDF–3.0M

Select item 77272754.

NKCC1: Newly Found as a Human Disease-Causing Ion Transporter

Rainelli Koumangoye, Lisa Bastarache, Eric Delpire

Function (Oxf) 2021; 2(1): zqaa028. Published online 2020 Nov 3. doi: 10.1093/function/zqaa028

PMCID:: PMC7727275

Abstract Article PDF–947K

Select item 74475145.

SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect

Alisdair McNeill, Emanuela Iovino, Luke Mansard, Christel Vache, David Baux, Emma Bedoukian, Helen Cox, John Dean, David Goudie, Ajith Kumar, Ruth Newbury-Ecob, Chiara Fallerini, Alessandra Renieri, Diego Lopergolo, Francesca Mari, Catherine Blanchet, Marjolaine Willems, Anne-Francoise Roux, Tommaso Pippucci, Eric Delpire

Brain. 2020 Aug; 143(8): 2380–2387. Published online 2020 Jul 13. doi: 10.1093/brain/awaa176

Correction in:: Brain. 2023 Apr; 146(4): e26.

PMCID:: PMC7447514

Abstract Article PDF–442K

Select item 74164336.

A mutation in the Na-K-2Cl cotransporter-1 leads to changes in cellular metabolism

Salma Omer, Rainelli Koumangoye, Eric Delpire

J Cell Physiol. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: J Cell Physiol. 2020 Oct; 235(10): 7239–7250. Published online 2020 Feb 10. doi: 10.1002/jcp.29623

PMCID:: PMC7416433

Abstract Article PDF–2.1M

Select item 71591867.

Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans

Hideki Mutai, Koichiro Wasano, Yukihide Momozawa, Yoichiro Kamatani, Fuyuki Miya, Sawako Masuda, Noriko Morimoto, Kiyomitsu Nara, Satoe Takahashi, Tatsuhiko Tsunoda, Kazuaki Homma, Michiaki Kubo, Tatsuo Matsunaga

PLoS Genet. 2020 Apr; 16(4): e1008643. Published online 2020 Apr 15. doi: 10.1371/journal.pgen.1008643

PMCID:: PMC7159186

Abstract Article PDF–2.6M

Select item 70353138.

Structure of the human cation–chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy

Xiaoyong Yang, Qinzhe Wang, Erhu Cao

Nat Commun. 2020; 11: 1016. Published online 2020 Feb 21. doi: 10.1038/s41467-020-14790-3

Correction in:: Nat Commun. 2020; 11: 2359.

PMCID:: PMC7035313

Abstract Article PDF–2.4M

Select item 40519249.

Role of the Na⁺/K⁺/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

Atsushi Shiozaki, Yoshito Nako, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yoshinori Marunaka, Eigo Otsuji

World J Gastroenterol. 2014 Jun 14; 20(22): 6844–6859. Published online 2014 Jun 14. doi: 10.3748/wjg.v20.i22.6844

PMCID:: PMC4051924

Abstract Article PDF–1.6M

Select item 395327010.

Molecular Motions Involved in Na-K-Cl Cotransporter-mediated Ion Transport and Transporter Activation Revealed by Internal Cross-linking between Transmembrane Domains 10 and 11/12

Michelle Y. Monette, Suma Somasekharan, Biff Forbush

J Biol Chem. 2014 Mar 14; 289(11): 7569–7579. Published online 2014 Jan 22. doi: 10.1074/jbc.M113.542258

PMCID:: PMC3953270

Abstract Article PDF–2.2M

Select item 391997411.

Direct control of Na⁺-K⁺-2Cl⁻-cotransport protein (NKCC1) expression with aldosterone

Bo Ding, Robert D. Frisina, Xiaoxia Zhu, Yoshihisa Sakai, Bernd Sokolowski, Joseph P. Walton

Am J Physiol Cell Physiol. 2014 Jan 1; 306(1): C66–C75. Published online 2013 Oct 30. doi: 10.1152/ajpcell.00096.2013

PMCID:: PMC3919974

Abstract Article

Select item 385534012.

Functional Expression of Human NKCC1 from a Synthetic Cassette-Based cDNA: Introduction of Extracellular Epitope Tags and Removal of Cysteines

Suma Somasekharan, Michelle Y. Monette, Biff Forbush

PLoS One. 2013; 8(12): e82060. Published online 2013 Dec 5. doi: 10.1371/journal.pone.0082060

PMCID:: PMC3855340

Abstract Article PDF–1.2M

Select item 372742413.

Decreased NKCC1 Activity in Erythrocytes From African Americans With Hypertension and Dyslipidemia

Sergei N. Orlov, Francis Gossard, Zdenka Pausova, Olga A. Akimova, Johanne Tremblay, Clarence E. Grim, Jane M. Kotchen, Theodore A. Kotchen, Daniel Gaudet, Allen W. Cowley, Pavel Hamet

Am J Hypertens. Author manuscript; available in PMC 2013 Jul 30.

Published in final edited form as: Am J Hypertens. 2010 Mar; 23(3): 321–326. Published online 2009 Dec 31. doi: 10.1038/ajh.2009.249

PMCID:: PMC3727424

Abstract Article PDF–1.2M

Select item 336678514.

Loop Diuretic and Ion-binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (TM3) of Na-K-Cl Cotransporter (NKCC1)

Suma Somasekharan, Jessica Tanis, Biff Forbush

J Biol Chem. 2012 May 18; 287(21): 17308–17317. Published online 2012 Mar 21. doi: 10.1074/jbc.M112.356014

PMCID:: PMC3366785

Abstract Article PDF–1.7M

Select item 300244315.

Cotransport of water by the Na⁺ −K⁺ −2Cl⁻ cotransporter NKCC1 in mammalian epithelial cells

Steffen Hamann, José J Herrera-Perez, Thomas Zeuthen, Francisco J Alvarez-Leefmans

J Physiol. 2010 Nov 1; 588(Pt 21): 4089–4101. Published online 2010 Sep 6. doi: 10.1113/jphysiol.2010.194738

PMCID:: PMC3002443

Abstract Article PDF–524K

Select item 957617016.

Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression

Rainelli Koumangoye, Parker Penny, Eric Delpire

Am J Physiol Cell Physiol. 2022 Oct 1; 323(4): C1251–C1263. Published online 2022 Aug 15. doi: 10.1152/ajpcell.00334.2022

PMCID:: PMC9576170

Abstract Article

Select item 788988517.

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel, Wei Zhuo, Suma Somasekharan, Kasturi Roy, Laixing Zhang, Yang Liu, Xianbin Meng, Haiteng Deng, Wenwen Zeng, Guohui Li, Biff Forbush, Maojun Yang

Commun Biol. 2021; 4: 226. Published online 2021 Feb 17. doi: 10.1038/s42003-021-01750-w

PMCID:: PMC7889885

Abstract Article PDF–5.5M

Select item 761299718.

Genome-Wide Association Study Identifies LINC01184/SLC12A2 As Novel Risk Locus for Skin and Soft Tissue Infections

Tormod Rogne, Kristin V Liyanarachi, Humaira Rasheed, Laurent F Thomas, Helene M Flatby, Jørgen Stenvik, Mari Løset, Dipender Gill, Stephen Burgess, Cristen J Willer, Kristian Hveem, Bjørn O Åsvold, Ben M Brumpton, Andrew T DeWan, Erik Solligård, Jan K Damås

J Invest Dermatol. Author manuscript; available in PMC 2022 Jul 6.

Published in final edited form as: J Invest Dermatol. 2021 Aug 1; 141(8): 2083–2086.e8. Published online 2021 Mar 1. doi: 10.1016/j.jid.2021.01.020

PMCID:: PMC7612997

Article PDF–626K

Select item 695784519.

Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation

Rainelli Koumangoye, Salma Omer, Mustafa H. Kabeer, Eric Delpire

Cell Mol Gastroenterol Hepatol. 2020; 9(2): 239–255. Published online 2019 Oct 23. doi: 10.1016/j.jcmgh.2019.10.006

PMCID:: PMC6957845

Abstract Article PDF–9.8M

Select item 551443420.

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin

Paula Schiapparelli, Hugo Guerrero-Cazares, Roxana Magaña-Maldonado, Susan M. Hamilla, Sara Ganaha, Eric Goulin Lippi Fernandes, Chuan-Hsiang Huang, Helim Aranda-Espinoza, Peter Devreotes, Alfredo Quinones-Hinojosa

EBioMedicine. 2017 Jul; 21: 94–103. Published online 2017 Jun 21. doi: 10.1016/j.ebiom.2017.06.020

PMCID:: PMC5514434

Abstract Article PDF–1.3M

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