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Select item 98380411.

Lower SLC7A2 expression is associated with enhanced multidrug resistance, less immune infiltrates and worse prognosis of NSCLC

Shanshan Jiang, Junrong Zou, Jianyu Dong, Huimian Shi, Jie Chen, Yan Li, Xianglong Duan, Wensheng Li

Cell Commun Signal. 2023; 21: 9. Published online 2023 Jan 13. doi: 10.1186/s12964-022-01023-x

PMCID:: PMC9838041

Abstract Article PDF–6.1M

Select item 81900732.

SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells

Suhong Xia, Jingwen Wu, Wangdong Zhou, Mingyu Zhang, Kai Zhao, Jingmei Liu, Dean Tian, Jiazhi Liao

Cell Death Dis. 2021 Jun; 12(6): 570. Published online 2021 Jun 2. doi: 10.1038/s41419-021-03853-y

PMCID:: PMC8190073

Abstract Article PDF–15M

Select item 73778493.

SLC7A2 serves as a potential biomarker and therapeutic target for ovarian cancer

Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang

Aging (Albany NY) 2020 Jul 15; 12(13): 13281–13296. Published online 2020 Jul 9. doi: 10.18632/aging.103433

PMCID:: PMC7377849

Abstract Article PDF–1.9M

Select item 55830314.

Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps

Pin Sun, Xiangzhu Zhu, Martha J Shrubsole, Reid M Ness, Elizabeth A Hibler, Qiuyin Cai, Jirong Long, Zhi Chen, Guoliang Li, Lifang Hou, Walter E Smalley, Todd L. Edwards, Edward Giovannucci, Wei Zheng, Qi Dai

J Nutr Biochem. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: J Nutr Biochem. 2017 Sep; 47: 35–40. Published online 2017 May 5. doi: 10.1016/j.jnutbio.2017.04.016

PMCID:: PMC5583031

Abstract Article PDF–87K

Select item 37985055.

Identification of Cysteine Residues in Human Cationic Amino Acid Transporter hCAT-2A That Are Targets for Inhibition by N-Ethylmaleimide

Sarah R. Beyer, Robert T. Mallmann, Isabel Jaenecke, Alice Habermeier, Jean-Paul Boissel, Ellen I. Closs

J Biol Chem. 2013 Oct 18; 288(42): 30411–30419. Published online 2013 Sep 9. doi: 10.1074/jbc.M113.490698

PMCID:: PMC3798505

Abstract Article PDF–1.6M

Select item 109007106.

Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington’s disease

Ian D. Gaudet, Hongyuan Xu, Emily Gordon, Gianna A. Cannestro, Michael L. Lu, Jianning Wei

J Neuroinflammation. 2024; 21: 59. Published online 2024 Feb 28. doi: 10.1186/s12974-024-03038-2

PMCID:: PMC10900710

Abstract Article PDF–4.0M

Select item 107786487.

Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation

Tiane Huang, Jing Zhou, Benhui Wang, Xiang Wang, Wanli Xiao, Mengqi Yang, Yan Liu, Qiquan Wang, Yang Xiang, Xinqiang Lan

Int J Mol Sci. 2024 Jan; 25(1): 95. Published online 2023 Dec 20. doi: 10.3390/ijms25010095

PMCID:: PMC10778648

Abstract Article PDF–4.1M

Select item 55005098.

The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B

Anja Chafai, Martin F. Fromm, Jörg König, Renke Maas

Sci Rep. 2017; 7: 4767. Published online 2017 Jul 6. doi: 10.1038/s41598-017-04965-2

PMCID:: PMC5500509

Abstract Article PDF–2.0M

Select item 34363289.

A Chimera Carrying the Functional Domain of the Orphan Protein SLC7A14 in the Backbone of SLC7A2 Mediates Trans-stimulated Arginine Transport

Isabel Jaenecke, Jean-Paul Boissel, Matthias Lemke, Johanna Rupp, Bruno Gasnier, Ellen I. Closs

J Biol Chem. 2012 Aug 31; 287(36): 30853–30860. Published online 2012 Jul 11. doi: 10.1074/jbc.M112.350322

PMCID:: PMC3436328

Abstract Article PDF–996K

Select item 296761410.

Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production

Rupesh Chaturvedi, Mohammad Asim, Svea Hoge, Nuruddeen D. Lewis, Kshipra Singh, Daniel P. Barry, Thibaut de Sablet, M. Blanca Piazuelo, Aditya R. Sarvaria, Yulan Cheng, Ellen I. Closs, Robert A. Casero, Jr., Alain P. Gobert, Keith T. Wilson

Gastroenterology. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Gastroenterology. 2010 Nov; 139(5): 1686–1698.e6. Published online 2010 Jul 1. doi: 10.1053/j.gastro.2010.06.060

PMCID:: PMC2967614

Abstract Article PDF–2.3M

Select item 412386211.

Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids within the CHARGE Consortium

Weihua Guan, Brian T. Steffen, Rozenn N. Lemaitre, Jason H.Y. Wu, Toshiko Tanaka, Ani Manichaikul, Millennia Foy, Stephen S. Rich, Lu Wang, Jennifer A. Nettleton, Weihong Tang, Xiangjun Gu, Stafania Bandinelli, Irena B. King, Barbara McKnight, Bruce M. Psaty, David Siscovick, Luc Djousse, Yii-Der Ida Chen, Luigi Ferrucci, Myriam Fornage, Dariush Mozafarrian, Michael Y. Tsai, Lyn M. Steffen

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Jun; 7(3): 321–331. Published online 2014 May 13. doi: 10.1161/CIRCGENETICS.113.000208

PMCID:: PMC4123862

Abstract Article PDF–430K

Select item 633509912.

Blood-Brain Barrier: From Physiology to Disease and Back

Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, Berislav V. Zlokovic

Physiol Rev. 2019 Jan 1; 99(1): 21–78. Published online 2018 Oct 3. doi: 10.1152/physrev.00050.2017

PMCID:: PMC6335099

Abstract Article

Select item 352727613.

A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells

Li Xie, Claude Gazin, Sung Mi Park, Lihua J. Zhu, Marie-anne Debily, Ellen L. W. Kittler, Maria L. Zapp, David Lapointe, Stephane Gobeil, Ching-Man Virbasius, Michael R. Green

PLoS Genet. 2012 Dec; 8(12): e1003151. Published online 2012 Dec 20. doi: 10.1371/journal.pgen.1003151

PMCID:: PMC3527276

Abstract Article PDF–1.8M

Select item 733229314.

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson

eLife. 2020; 9: e57306. Published online 2020 Jul 2. doi: 10.7554/eLife.57306

PMCID:: PMC7332293

Abstract Article PDF–2.2M

Select item 612890515.

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

Hema Adhikari, Christopher M. Counter

Nat Commun. 2018; 9: 3646. Published online 2018 Sep 7. doi: 10.1038/s41467-018-05692-6

PMCID:: PMC6128905

Abstract Article PDF–2.2M

Select item 903755416.

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy

Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M. N. Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter K. Kim, Brian Raught, John H. Brumell

Autophagy. 2022; 18(4): 829–840. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1960116

PMCID:: PMC9037554

Abstract Article PDF–4.1M

Select item 1064152417.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 638658818.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 904055619.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 917141120.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

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