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Select item 88073901.

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

Yana Pikman, Nicole Ocasio-Martinez, Gabriela Alexe, Boris Dimitrov, Samuel Kitara, Frances F. Diehl, Amanda L. Robichaud, Amy Saur Conway, Linda Ross, Angela Su, Frank Ling, Jun Qi, Giovanni Roti, Caroline A. Lewis, Alexandre Puissant, Matthew G. Vander Heiden, Kimberly Stegmaier

Leukemia. 2022; 36(2): 348–360. Published online 2021 Aug 2. doi: 10.1038/s41375-021-01361-8

PMCID:: PMC8807390

Abstract Article PDF–5.8M

Select item 82928702.

The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke

Junnan Wang, Junqing Gu, Yi Huang, Yuanjian Fang, Jinghui Lin

Bosn J Basic Med Sci. 2021 Aug; 21(4): 454–460. doi: 10.17305/bjbms.2020.5188

PMCID:: PMC8292870

Abstract Article PDF–1.1M

Select item 68185783.

Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension

Guodong Xu, Changyi Wang, Xiuru Ying, Fanqian Kong, Huihui Ji, Jinshun Zhao, Xiaohong Zhang, Shiwei Duan, Liyuan Han, Li Li

J Clin Lab Anal. 2019 Mar; 33(3): e22712. Published online 2018 Nov 9. doi: 10.1002/jcla.22712

PMCID:: PMC6818578

Abstract Article PDF–586K

Select item 66156944.

A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

Sakunrat Ubonprasert, Juthamas Jaroensuk, Wichai Pornthanakasem, Nuntaporn Kamonsutthipaijit, Peerapong Wongpituk, Pitchayathida Mee-udorn, Thanyada Rungrotmongkol, Onuma Ketchart, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen, Somchart Maenpuen

J Biol Chem. 2019 Jul 5; 294(27): 10490–10502. Published online 2019 May 22. doi: 10.1074/jbc.RA119.007454

PMCID:: PMC6615694

Abstract Article PDF–2.3M

Select item 64866325.

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

Giulia Guiducci, Alessio Paone, Angela Tramonti, Giorgio Giardina, Serena Rinaldo, Amani Bouzidi, Maria C Magnifico, Marina Marani, Javier A Menendez, Alessandro Fatica, Alberto Macone, Alexandros Armaos, Gian G Tartaglia, Roberto Contestabile, Alessandro Paiardini, Francesca Cutruzzolà

Nucleic Acids Res. 2019 May 7; 47(8): 4240–4254. Published online 2019 Feb 27. doi: 10.1093/nar/gkz129

PMCID:: PMC6486632

Abstract Article PDF–6.1M

Select item 55095196.

Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression

R Gupta, Q Yang, S K Dogra, N Wajapeyee

Oncogene. 2017 Jul 13; 36(28): 4014–4024. Published online 2017 Mar 13. doi: 10.1038/onc.2017.37

PMCID:: PMC5509519

Abstract Article PDF–3.4M

Select item 46992937.

SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients

Yi-Wei Wang, Shao-Dan Zhang, Wen-Ji Xue, Mei-Ling Zhu, Lei-Zhen Zheng

Chin J Cancer. 2015; 34: 60. Published online 2015 Dec 14. doi: 10.1186/s40880-015-0065-z

PMCID:: PMC4699293

Abstract Article PDF–3.1M

Select item 32816278.

Competition between Sumoylation and Ubiquitination of Serine Hydroxymethyltransferase 1 Determines Its Nuclear Localization and Its Accumulation in the Nucleus

Donald D. Anderson, Jae Y. Eom, Patrick J. Stover

J Biol Chem. 2012 Feb 10; 287(7): 4790–4799. Published online 2011 Dec 21. doi: 10.1074/jbc.M111.302174

PMCID:: PMC3281627

Abstract Article PDF–3.4M

Select item 27815089.

Mechanism of the Internal Ribosome Entry Site-mediated Translation of Serine Hydroxymethyltransferase 1

Jennifer T. Fox, Patrick J. Stover

J Biol Chem. 2009 Nov 6; 284(45): 31085–31096. Published online 2009 Sep 4. doi: 10.1074/jbc.M109.035576

PMCID:: PMC2781508

Abstract Article PDF–3.4M

Select item 269301710.

Polymorphisms of cytosolic serine hydroxymethyltransferase and risk of lung cancer: a case–control analysis

Luo Wang, Jiachun Lu, Jiaze An, Qiuling Shi, Margaret R Spitz, Qingyi Wei

Lung Cancer. Author manuscript; available in PMC 2009 Jun 8.

Published in final edited form as: Lung Cancer. 2007 Aug; 57(2): 143–151. Published online 2007 Apr 8. doi: 10.1016/j.lungcan.2007.03.002

PMCID:: PMC2693017

Abstract Article PDF–435K

Select item 180142611.

Haploinsufficiency of cytosolic serine hydroxymethyltransferase in the Smith-Magenis syndrome.

S H Elsea, R C Juyal, S Jiralerspong, B M Finucane, M Pandolfo, F Greenberg, A Baldini, P Stover, P I Patel

Am J Hum Genet. 1995 Dec; 57(6): 1342–1350.

PMCID:: PMC1801426

Summary Page Browse PDF–1.8M

Select item 653639812.

MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1

Quanjun Yang, Jingjing Li, Yili Hu, Xiaofei Tang, Lili Yu, Lihua Dong, Diandian Chen

Yonsei Med J. 2019 Jun 1; 60(6): 500–508. Published online 2019 May 22. doi: 10.3349/ymj.2019.60.6.500

PMCID:: PMC6536398

Abstract Article PDF–320K

Select item 631482813.

IDH3α regulates one-carbon metabolism in glioblastoma

Jasmine L. May, Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, Andrea E. Calvert, Andrew Lee, Navdeep S. Chandel, Ramana V. Davuluri, Craig M. Horbinski, Jason W. Locasale, Alexander H. Stegh

Sci Adv. 2019 Jan; 5(1): eaat0456. Published online 2019 Jan 2. doi: 10.1126/sciadv.aat0456

PMCID:: PMC6314828

Abstract Article PDF–1.2M

Select item 566450914.

Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K. Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G. Manfredi, Zemer Gitai, Hahn Kim, Joshua D. Rabinowitz

Proc Natl Acad Sci U S A. 2017 Oct 24; 114(43): 11404–11409. Published online 2017 Oct 9. doi: 10.1073/pnas.1706617114

PMCID:: PMC5664509

Abstract Article PDF–923K

Select item 468452115.

Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes

Sara R. Zwart, Jesse F. Gregory, Steven H. Zeisel, Charles R. Gibson, Thomas H. Mader, Jason M. Kinchen, Per M. Ueland, Robert Ploutz-Snyder, Martina A. Heer, Scott M. Smith

FASEB J. 2016 Jan; 30(1): 141–148. Published online 2015 Aug 27. doi: 10.1096/fj.15-278457

PMCID:: PMC4684521

Abstract Article

Select item 426074016.

SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation

A Paone, M Marani, A Fiascarelli, S Rinaldo, G Giardina, R Contestabile, A Paiardini, F Cutruzzolà

Cell Death Dis. 2014 Nov; 5(11): e1525. Published online 2014 Nov 20. doi: 10.1038/cddis.2014.482

PMCID:: PMC4260740

Abstract Article PDF–1.9M

Select item 360960417.

DHFR 19-bp Deletion and SHMT C1420T Polymorphisms and Metabolite Concentrations of the Folate Pathway in Individuals with Down Syndrome

Cristiani Cortez Mendes, Aline Maria Zanchetta de Aquino Raimundo, Luciana Dutra Oliveira, Bruna Lancia Zampieri, Gustavo Henrique Marucci, Joice Matos Biselli, Eny Maria Goloni-Bertollo, Marcos Nogueira Eberlin, Renato Haddad, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Érika Cristina Pavarino

Genet Test Mol Biomarkers. 2013 Apr; 17(4): 274–277. doi: 10.1089/gtmb.2012.0293

PMCID:: PMC3609604

Abstract Article PDF–104K

Select item 329683618.

Serine Hydroxymethyltransferase 1 and 2: Gene Sequence Variation and Functional Genomic Characterization

Scott J. Hebbring, Yubo Chai, Yuan Ji, Ryan P. Abo, Gregory D. Jenkins, Brooke Fridley, Jianping Zhang, Bruce W. Eckloff, Eric D. Wieben, Richard M. Weinshilboum

J Neurochem. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: J Neurochem. 2012 Mar; 120(6): 881–890. Published online 2012 Feb 6. doi: 10.1111/j.1471-4159.2012.07646.x