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Select item 103724061.

Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation

Wenxue Gu, Hongyan Zheng, Cecilia M. Canessa

J Biol Chem. 2023 Aug; 299(8): 104941. Published online 2023 Jun 19. doi: 10.1016/j.jbc.2023.104941

PMCID:: PMC10372406

Article PDF–3.3M

Select item 102286152.

Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Federica Giannetti, Miriam Barbieri, Assad Shiti, Simona Casini, Philip T Sager, Saumya Das, Sabindra Pradhananga, Dinesh Srinivasan, Saranda Nimani, Nicolò Alerni, Julien Louradour, Manuela Mura, Massimiliano Gnecchi, Paul Brink, Manfred Zehender, Gideon Koren, Antonio Zaza, Lia Crotti, Arthur A M Wilde, Peter J Schwartz, Carol Ann Remme, Lior Gepstein, Luca Sala, Katja E Odening

Europace. 2023 May; 25(5): euad094. Published online 2023 Apr 26. doi: 10.1093/europace/euad094

PMCID:: PMC10228615

Article PDF–1.6M

Select item 102258913.

SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells

Yannis Hara, Viktor T. Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard, Alexandra Hicks, David R. Light

Blood Adv. 2023 Jun 13; 7(11): 2317–2323. Published online 2023 Jan 31. doi: 10.1182/bloodadvances.2022008710

PMCID:: PMC10225891

Article PDF–1.3M

Select item 96754594.

Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation

Aneesh Bapat, Guoping Li, Ling Xiao, Ashish Yeri, Maarten Hulsmans, Jana Grune, Masahiro Yamazoe, Maximilian J. Schloss, Yoshiko Iwamoto, Justin Tedeschi, Xinyu Yang, Matthias Nahrendorf, Anthony Rosenzweig, Patrick T. Ellinor, Saumya Das, David Milan

JCI Insight. 2022 Oct 10; 7(19): e160885. Published online 2022 Oct 10. doi: 10.1172/jci.insight.160885

PMCID:: PMC9675459

Article PDF–5.7M

Select item 88947175.

SGK1 mutation status can further stratify patients with germinal center B‐cell‐like diffuse large B‐cell lymphoma into different prognostic subgroups

Baoping Guo, Yujie Huang, Ying Duan, Chengcheng Liao, Hong Cen

Cancer Med. 2022 Mar; 11(5): 1281–1291. Published online 2022 Feb 1. doi: 10.1002/cam4.4550

PMCID:: PMC8894717

Article PDF–1.2M

Select item 88666496.

SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease

Run-qing Lu, Yin-yin Zhang, Hai-qiu Zhao, Rong-qun Guo, Zhong-xing Jiang, Rong Guo

Front Immunol. 2022; 13: 822303. Published online 2022 Feb 10. doi: 10.3389/fimmu.2022.822303

PMCID:: PMC8866649

Article PDF–617K

Select item 75838137.

Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions

Florian Poetsch, Laura A. Henze, Misael Estepa, Barbara Moser, Burkert Pieske, Florian Lang, Kai-Uwe Eckardt, Ioana Alesutan, Jakob Voelkl

Int J Mol Sci. 2020 Oct; 21(19): 7207. Published online 2020 Sep 29. doi: 10.3390/ijms21197207

PMCID:: PMC7583813

Article PDF–1.0M

Select item 67666758.

SGK1 Attenuates Oxidative Stress-Induced Renal Tubular Epithelial Cell Injury by Regulating Mitochondrial Function

Daofang Jiang, Chensheng Fu, Jing Xiao, Zhenxing Zhang, Jianan Zou, Zhibin Ye, Xiaoli Zhang

Oxid Med Cell Longev. 2019; 2019: 2013594. Published online 2019 Sep 18. doi: 10.1155/2019/2013594

PMCID:: PMC6766675

Article PDF–2.3M

Select item 63368679.

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Xiuquan Ma, Luxi Zhang, Jiangning Song, Elizabeth Nguyen, Rachel S. Lee, Samuel J. Rodgers, Fuyi Li, Cheng Huang, Ralf B. Schittenhelm, Howard Chan, Chanly Chheang, Jianmin Wu, Kristin K. Brown, Christina A. Mitchell, Kaylene J. Simpson, Roger J. Daly

Nat Commun. 2019; 10: 296. Published online 2019 Jan 17. doi: 10.1038/s41467-018-08154-1

PMCID:: PMC6336867

Article PDF–3.4M

Select item 607071510.

Glioblastoma Multiforme: Fewer Tumor Copy Number Segments of the SGK1 Gene Are Associated with Poorer Survival

STEVEN LEHRER, PETER H RHEINSTEIN, KENNETH E ROSENZWEIG

Cancer Genomics Proteomics. 2018 Jul-Aug; 15(4): 273–278. Published online 2018 Jul 5. doi: 10.21873/cgp.20085

PMCID:: PMC6070715

Article PDF–238K

Select item 600082211.

Serum/Glucocorticoid-Regulated Kinase 1 Expression in Primary Human Prostate Cancers

Russell Z. Szmulewitz, Elizabeth Chung, Hikmat Al-Ahmadie, Silver Daniel, Masha Kocherginsky, Aria Razmaria, Gregory P. Zagaja, Charles B. Brendler, Walter M. Stadler, Suzanne D. Conzen

Prostate. Author manuscript; available in PMC 2018 Jun 14.

Published in final edited form as: Prostate. 2012 Feb 1; 72(2): 157–164. Published online 2011 May 11. doi: 10.1002/pros.21416

PMCID:: PMC6000822

Article PDF–665K

Select item 581709712.

Aldosterone, SGK1, and ion channels in the kidney

William C. Valinsky, Rhian M. Touyz, Alvin Shrier

Clin Sci (Lond) 2018 Jan 31; 132(2): 173–183. Published online 2018 Jan 19. doi: 10.1042/CS20171525

PMCID:: PMC5817097

Article PDF–925K

Select item 575257013.

A Large-scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells

Shreya Kulkarni, Surbhi Goel-Bhattacharya, Sejuti Sengupta, Brent H. Cochran

Mol Cancer Res. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Mol Cancer Res. 2018 Jan; 16(1): 103–114. Published online 2017 Oct 9. doi: 10.1158/1541-7786.MCR-17-0146

PMCID:: PMC5752570

Article PDF–1.6M

Select item 515556814.

Associations of the Serum/Glucocorticoid Regulated Kinase Genes With BP Changes and Hypertension Incidence: The Gensalt Study

Dingding Zhang, Dongfeng Gu, Jiang He, James E. Hixson, Dabeeru C. Rao, Changwei Li, Hua He, Jichun Chen, Jianfeng Huang, Jing Chen, Treva K. Rice, Shufeng Chen, Tanika N. Kelly

Am J Hypertens. 2017 Jan; 30(1): 95–101. Published online 2016 Sep 24. doi: 10.1093/ajh/hpw122

PMCID:: PMC5155568

Article PDF–395K

Select item 499147415.

Lnc-SGK1 induced by Helicobacter pylori infection and highsalt diet promote Th2 and Th17 differentiation in human gastric cancer by SGK1/Jun B signaling

Yongliang Yao, Qingbo Jiang, Lixing Jiang, Jianhong Wu, Qinghui Zhang, Jianjun Wang, Huang Feng, Panpan Zang

Oncotarget. 2016 Apr 12; 7(15): 20549–20560. Published online 2016 Mar 1. doi: 10.18632/oncotarget.7823

PMCID:: PMC4991474

Article PDF–4.8M

Select item 488851216.

Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia

Johann Matschke, Elisa Wiebeck, Sebastian Hurst, Justine Rudner, Verena Jendrossek

Radiat Oncol. 2016; 11: 75. Published online 2016 Jun 1. doi: 10.1186/s13014-016-0647-1

PMCID:: PMC4888512

Article PDF–2.9M

Select item 485323617.

Estrogen receptor β regulates endometriotic cell survival through SGK1 activation

Diana Monsivais, Matthew T. Dyson, Ping Yin, Antonia Navarro, John S Coon, Mary Ellen Pavone, Serdar E. Bulun

Fertil Steril. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Fertil Steril. 2016 May; 105(5): 1266–1273. Published online 2016 Jan 28. doi: 10.1016/j.fertnstert.2016.01.012

PMCID:: PMC4853236

Article PDF–589K

Select item 483428318.

SGK kinase activity in multiple myeloma cells protects against ER stress apoptosis via a SEK-dependent mechanism

Bao Hoang, Yijiang Shi, Patrick Frost, Veena Mysore, Carolyne Bardeleben, Alan Lichtenstein

Mol Cancer Res. Author manuscript; available in PMC 2017 Apr 1.

Published in final edited form as: Mol Cancer Res. 2016 Apr; 14(4): 397–407. Published online 2016 Feb 11. doi: 10.1158/1541-7786.MCR-15-0422

PMCID:: PMC4834283

Article PDF–1.8M

Select item 442092319.

Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway

Sarah Iqbal, Shannon Howard, Philip V. LoGrasso

Mol Cell Biol. 2015 Jun; 35(11): 1992–2006. Prepublished online 2015 Mar 30. Published online 2015 May 5. doi: 10.1128/MCB.01510-14

PMCID:: PMC4420923

Article PDF–2.7M

Select item 425416520.

Serum and Glucocorticoid-Regulated Kinase 1 Promotes Vascular Smooth Muscle Cell Proliferation via Regulation of β-catenin Dynamics

Wei Zhong, Babayewa Oguljahan, Yan Xiao, James Nelson, Liliana Hernandez, Minerva Garcia-Barrio, Sharon C. Francis

Cell Signal. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Cell Signal. 2014 Dec; 26(12): 2765–2772. Published online 2014 Aug 22. doi: 10.1016/j.cellsig.2014.08.002

PMCID:: PMC4254165

Article PDF–1.1M

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