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Select item 108166991.

PP2A complex disruptor SET prompts widespread hypertranscription of growth-essential genes in the pancreatic cancer cells

He Xu, Di Wu, Mingming Xiao, Yubin Lei, Yalan Lei, Xianjun Yu, Si Shi

Sci Adv. 2024 Jan 26; 10(4): eadk6633. Published online 2024 Jan 26. doi: 10.1126/sciadv.adk6633

PMCID:: PMC10816699

Abstract Article PDF–2.6M

Select item 94896312.

Structural mechanism of TAF-Iβ chaperone function on linker histone H1.10

Haniqao Feng, Bing-Rui Zhou, Charles D. Schwieters, Yawen Bai

J Mol Biol. Author manuscript; available in PMC 2023 Oct 15.

Published in final edited form as: J Mol Biol. 2022 Oct 15; 434(19): 167755. Published online 2022 Jul 21. doi: 10.1016/j.jmb.2022.167755

PMCID:: PMC9489631

Abstract Article PDF–1.8M

Select item 83756703.

SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia

Danielle M. Brander, Daphne R. Friedman, Alicia D. Volkheimer, Dale J. Christensen, Laura Z. Rassenti, Thomas J. Kipps, Eross Guadalupe, Youwei Chen, Dadong Zhang, Xi Wang, Carter Davis, Kouros Owzar, J. Brice Weinberg

Br J Haematol. Author manuscript; available in PMC 2021 Aug 19.

Published in final edited form as: Br J Haematol. 2019 Feb; 184(4): 605–615. Published online 2018 Nov 15. doi: 10.1111/bjh.15677

PMCID:: PMC8375670

Abstract Article PDF–2.0M

Select item 83515444.

SET levels contribute to cohesion fatigue

Lu Yang, Qian Zhang, Tianhua Niu, Hong Liu

Mol Biol Cell. 2021 Jun 15; 32(13): 1256–1266. doi: 10.1091/mbc.E20-12-0778

PMCID:: PMC8351544

Abstract Article PDF–4.6M

Select item 69492225.

A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia

Elena Arriazu, Carmen Vicente, Raffaella Pippa, Irene Peris, Elena Martínez-Balsalobre, Patricia García-Ramírez, Nerea Marcotegui, Ana Igea, Diego Alignani, José Rifón, María C. Mateos, María L. Cayuela, Angel R. Nebreda, María D. Odero

Blood Cancer J. 2020 Jan; 10(1): 3. Published online 2020 Jan 8. doi: 10.1038/s41408-019-0270-0

PMCID:: PMC6949222

Abstract Article PDF–3.4M

Select item 61173296.

SET de novo frameshift variants associated with developmental delay and intellectual disabilities

Ruth Richardson, Miranda Splitt, Ruth Newbury-Ecob, Alice Hulbert, Joanna Kennedy, Astrid Weber, DDD Study

Eur J Hum Genet. 2018 Sep; 26(9): 1306–1311. Published online 2018 Jun 15. doi: 10.1038/s41431-018-0199-y

PMCID:: PMC6117329

Abstract Article PDF–553K

Select item 55222807.

SET mediates TCE-induced liver cell apoptosis through dephosphorylation and upregulation of nucleolin

Xiaohu Ren, Xinfeng Huang, Xifei Yang, Yungang Liu, Wei Liu, Haiyan Huang, Desheng Wu, Fei Zou, Jianjun Liu

Oncotarget. 2017 Jun 20; 8(25): 40958–40966. Published online 2017 Apr 3. doi: 10.18632/oncotarget.16785

PMCID:: PMC5522280

Abstract Article PDF–2.2M

Select item 54322988.

SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation

Luciana O. Almeida, Marinaldo P.C. Neto, Lucas O. Sousa, Maryna A. Tannous, Carlos Curti, Andreia M. Leopoldino

Oncotarget. 2017 Apr 18; 8(16): 26802–26818. Published online 2017 Mar 1. doi: 10.18632/oncotarget.15818

PMCID:: PMC5432298

Abstract Article PDF–6.8M

Select item 40285069.

Regulating Set-β's Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration

Ephraim F. Trakhtenberg, Yan Wang, Melina I. Morkin, Stephanie G. Fernandez, Gregory M. Mlacker, Jesse M. Shechter, Xiongfei Liu, Karan H. Patel, Allison Lapins, Steven Yang, Susan M. Dombrowski, Jeffrey L. Goldberg

J Neurosci. 2014 May 21; 34(21): 7361–7374. doi: 10.1523/JNEUROSCI.3658-13.2014

PMCID:: PMC4028506

Abstract Article PDF–2.9M

Select item 398942010.

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcome drug resistance in myeloid leukemia

Anupriya Agarwal, Ryan J. MacKenzie, Raffaella Pippa, Christopher A. Eide, Jessica Oddo, Jeffrey W. Tyner, Rosalie Sears, Michael P. Vitek, María D. Odero, Dale Christensen, Brian J. Druker

Clin Cancer Res. Author manuscript; available in PMC 2015 Apr 15.

Published in final edited form as: Clin Cancer Res. 2014 Apr 15; 20(8): 2092–2103. Published online 2014 Jan 16. doi: 10.1158/1078-0432.CCR-13-2575

PMCID:: PMC3989420

Abstract Article PDF–1.5M

Select item 393688711.

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

Lays M Sobral, Lucas O Sousa, Ricardo D Coletta, Hamilton Cabral, Lewis J Greene, Eloiza H Tajara, J Silvio Gutkind, Carlos Curti, Andréia M Leopoldino

Mol Cancer. 2014; 13: 32. Published online 2014 Feb 20. doi: 10.1186/1476-4598-13-32

PMCID:: PMC3936887

Abstract Article PDF–2.8M

Select item 392689312.

Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment

Archana Mukhopadhyay, Kayann Tabanor, Rathnam Chaguturu, Jane V Aldrich

Cancer Biol Ther. 2013 Oct 1; 14(10): 962–972. Published online 2013 Aug 5. doi: 10.4161/cbt.25943

PMCID:: PMC3926893

Abstract Article PDF–1.5M

Select item 334767513.

Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia

Ion Cristóbal, Laura Garcia-Orti, Cristina Cirauqui, Xabier Cortes-Lavaud, María A. García-Sánchez, María J. Calasanz, María D. Odero

Haematologica. 2012 Apr; 97(4): 543–550. doi: 10.3324/haematol.2011.050542

PMCID:: PMC3347675

Abstract Article PDF–798K

Select item 320473214.

SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target

Dale J. Christensen, Youwei Chen, Jessica Oddo, Karen M. Matta, Jessica Neil, Evan D. Davis, Alicia D. Volkheimer, Mark C. Lanasa, Daphne R. Friedman, Barbara K. Goodman, Jon P. Gockerman, Louis F. Diehl, Carlos M. de Castro, Joseph O. Moore, Michael P. Vitek, J. Brice Weinberg

Blood. 2011 Oct 13; 118(15): 4150–4158. Prepublished online 2011 Aug 15. doi: 10.1182/blood-2011-04-351072

PMCID:: PMC3204732

Abstract Article

Select item 291729315.

Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of SET/TAF-Iβ ΔN from Homo sapiens

Zhen Xu, Weili Yang, Nuo Shi, Yongxiang Gao, Maikun Teng, Liwen Niu

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1; 66(Pt 8): 926–928. Published online 2010 Jul 29. doi: 10.1107/S1744309110021779

PMCID:: PMC2917293

Abstract Article PDF–143K

Select item 265398816.

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

Archana Mukhopadhyay, Sahar A. Saddoughi, Pengfei Song, Iyad Sultan, Suriyan Ponnusamy, Can E. Senkal, Christopher F. Snook, Hugh K. Arnold, Rosalie C. Sears, Yusuf A. Hannun, Besim Ogretmen

FASEB J. 2009 Mar; 23(3): 751–763. doi: 10.1096/fj.08-120550