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Select item 110703901.

A study of the association between single nucleotide polymorphisms of the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and the risk of ankylosing spondylitis in Egyptians

Randa Mohamed Ibrahim Mesahel, Dina Salem Fotoh, Mahmoud Mohammed Hadhoud, Mohamed Farag Ali Assar

Mol Biol Rep. 2024; 51(1): 614. Published online 2024 May 5. doi: 10.1007/s11033-024-09404-w

PMCID:: PMC11070390

Abstract Article PDF–1.4M

Select item 107947812.

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

Wouter J. Venema, Sanne Hiddingh, Jorg van Loosdregt, John Bowes, Brunilda Balliu, Joke H. de Boer, Jeannette Ossewaarde-van Norel, Susan D. Thompson, Carl D. Langefeld, Aafke de Ligt, Lars T. van der Veken, Peter H.L. Krijger, Wouter de Laat, Jonas J.W. Kuiper

Cell Genom. 2024 Jan 10; 4(1): 100460. Published online 2023 Dec 5. doi: 10.1016/j.xgen.2023.100460

PMCID:: PMC10794781

Abstract Article PDF–4.2M

Select item 95962063.

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer

Pian Yu, Shifu Luo, Jiaxin Cai, Jie Li, Cong Peng

Aging (Albany NY) 2022 Oct 15; 14(19): 7941–7958. Published online 2022 Oct 8. doi: 10.18632/aging.204324

PMCID:: PMC9596206

Abstract Article PDF–1.5M

Select item 87259954.

ERAP2 Is Associated With Immune Infiltration and Predicts Favorable Prognosis in SqCLC

Zhenlin Yang, He Tian, Fenglong Bie, Jiachen Xu, Zheng Zhou, Junhui Yang, Renda Li, Yue Peng, Guangyu Bai, Yanhua Tian, Ying Chen, Lei Liu, Tao Fan, Chu Xiao, Yujia Zheng, Bo Zheng, Jie Wang, Chunxiang Li, Shugeng Gao, Jie He

Front Immunol. 2021; 12: 788985. Published online 2021 Dec 21. doi: 10.3389/fimmu.2021.788985

PMCID:: PMC8725995

Abstract Article PDF–23M

Select item 83953365.

Overexpression of ERAP2N in Human Trophoblast Cells Promotes Cell Death

Kristen Lospinoso, Mikhail Dozmorov, Nadine El Fawal, Rhea Raghu, Wook-Jin Chae, Eun D. Lee

Int J Mol Sci. 2021 Aug; 22(16): 8585. Published online 2021 Aug 10. doi: 10.3390/ijms22168585

PMCID:: PMC8395336

Abstract Article PDF–2.4M

Select item 79805286.

ERAPs Reduce In Vitro HIV Infection by Activating Innate Immune Response

Irma Saulle, Ivana Marventano, Marina Saresella, Claudia Vanetti, Micaela Garziano, Claudio Fenizia, Daria Trabattoni, Mario Clerici, Mara Biasin

J Immunol. 2021 Apr 1; 206(7): 1609–1617. Published online 2021 Feb 22. doi: 10.4049/jimmunol.2000991

PMCID:: PMC7980528

Abstract Article PDF–740K

Select item 79503167.

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

Wouter J. Venema, Sanne Hiddingh, Joke H. de Boer, Frans H. J. Claas, Arend Mulder, Anneke I. den Hollander, Efstratios Stratikos, Siranush Sarkizova, Lars T. van der Veken, George M. C. Janssen, Peter A. van Veelen, Jonas J. W. Kuiper

Front Immunol. 2021; 12: 634441. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.634441

PMCID:: PMC7950316

Abstract Article PDF–3.8M

Select item 75635228.

A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?

Irma Saulle, Claudia Vanetti, Sara Goglia, Chiara Vicentini, Enrico Tombetti, Micaela Garziano, Mario Clerici, Mara Biasin

Cells. 2020 Sep; 9(9): 1951. Published online 2020 Aug 24. doi: 10.3390/cells9091951

PMCID:: PMC7563522

Abstract Article PDF–1.8M

Select item 72618159.

Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2)

Elena Lorente, Miguel G. Fontela, Eilon Barnea, Antonio J. Martín-Galiano, Carmen Mir, Begoña Galocha, Arie Admon, Pilar Lauzurica, Daniel López

Mol Cell Proteomics. 2020 Jun; 19(6): 994–1004. Published online 2020 Apr 7. doi: 10.1074/mcp.RA120.002014

PMCID:: PMC7261815

Abstract Article PDF–1006K

Select item 664671310.

Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

Irma Saulle, Salomè Valentina Ibba, Enrica Torretta, Cecilia Vittori, Claudio Fenizia, Federica Piancone, Davide Minisci, Elisa Maria Lori, Daria Trabattoni, Cecilia Gelfi, Mario Clerici, Mara Biasin

Front Immunol. 2019; 10: 1648. Published online 2019 Jul 16. doi: 10.3389/fimmu.2019.01648

Correction in:: Front Immunol. 2019; 10: 2838.

PMCID:: PMC6646713

Abstract Article PDF–825K

Select item 628075711.

Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Rachel E. Gate, Meena Subramaniam, Tushar Bhangale, Mark N. Lee, Towfique Raj, Raktima Raychowdhury, Weibo Li, Noga Rogel, Sean Simmons, Selina H. Imboywa, Portia I. Chipendo, Cristin McCabe, Michelle H. Lee, Irene Y. Frohlich, Barbara E. Stranger, Philip L. De Jager, Aviv Regev, Tim Behrens, Nir Hacohen

Genome Res. 2018 Dec; 28(12): 1812–1825. doi: 10.1101/gr.240390.118

PMCID:: PMC6280757

Abstract Article PDF–15M

Select item 593961812.

The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma

Michelle D Warthan, Sonya L Washington, Samone E Franzese, Ronald M Ramus, Kyu-Rae Kim, Timothy P York, Efstratios Stratikos, Jerome F Strauss, III, Eun D Lee

Biol Reprod. 2018 Mar; 98(3): 309–322. Published online 2018 Jan 9. doi: 10.1093/biolre/ioy001

PMCID:: PMC5939618

Abstract Article PDF–5.8M

Select item 449899613.

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

Philip C Robinson, Mary-Ellen Costello, Paul Leo, Linda A Bradbury, Kelly Hollis, Adrian Cortes, Seunghun Lee, Kyung Bin Joo, Seung-Cheol Shim, Michael Weisman, Michael Ward, Xiaodong Zhou, Henri-Jean Garchon, Gilles Chiocchia, Johannes Nossent, Benedicte A Lie, Øystein Førre, Jaakko Tuomilehto, Kari Laiho, Lei Jiang, Yu Liu, Xin Wu, Dirk Elewaut, Ruben Burgos-Vargas, Lianne S Gensler, Simon Stebbings, Nigil Haroon, Juan Mulero, Jose Luis Fernandez-Sueiro, Miguel A Gonzalez-Gay, Carlos Lopez-Larrea, Paul Bowness, Karl Gafney, John S Hill Gaston, Dafna D Gladman, Proton Rahman, Walter P Maksymowych, Huji Xu, Irene E van der Horst-Bruinsma, Chung-Tei Chou, Raphael Valle-Oñate, María Consuelo Romero-Sánchez, Inger Myrnes Hansen, Fernando M Pimentel-Santos, Robert D Inman, Javier Martin, Maxime Breban, David Evans, John D Reveille, Tae-Hwan Kim, B Paul Wordsworth, Matthew A Brown

Ann Rheum Dis. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Ann Rheum Dis. 2015 Aug; 74(8): 1627–1629. Published online 2015 Apr 27. doi: 10.1136/annrheumdis-2015-207416

PMCID:: PMC4498996

Article PDF–395K

Select item 353040514.

A common SNP in ER aminopeptidase 2 induces a specificity switch that leads to altered antigen processing

Irini Evnouchidou, James Birtley, Sergey Seregin, Athanasios Papakyriakou, Efthalia Zervoudi, Martina Samiotaki, George Panayotou, Petros Giastas, Olivia Petrakis, Dimitris Georgiadis, Andrea Amalfitano, Emmanuel Saridakis, Irene M. Mavridis, Efstratios Stratikos

J Immunol. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: J Immunol. 2012 Sep 1; 189(5): 2383–2392. Published online 2012 Jul 25. doi: 10.4049/jimmunol.1200918

PMCID:: PMC3530405

Abstract Article PDF–2.5M

Select item 332582215.

Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2

David B. Ascher, Galina Polekhina, Michael W. Parker

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1; 68(Pt 4): 468–471. Published online 2012 Mar 28. doi: 10.1107/S1744309112006963

PMCID:: PMC3325822

Abstract Article PDF–204K

Select item 315763116.

A common functional variant of endoplasmic reticulum aminopeptidase 2 (ERAP2) that reduces major histocompatibility complex class I expression is not associated with ankylosing spondylitis

David Harvey, Jennifer J. Pointon, Tugce Karaderi, Louise H. Appleton, Claire Farrar, B. Paul Wordsworth

Rheumatology (Oxford) 2011 Sep; 50(9): 1720–1721. Published online 2011 Jun 29. doi: 10.1093/rheumatology/ker199

PMCID:: PMC3157631

Article PDF–45K

Select item 310341917.

Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study

Lori D Hill, DaShaunda D Hilliard, Timothy P York, Sindhu Srinivas, Juan P Kusanovic, Ricardo Gomez, Michal A Elovitz, Roberto Romero, Jerome F Strauss, III

BMC Med Genet. 2011; 12: 64. Published online 2011 May 11. doi: 10.1186/1471-2350-12-64

PMCID:: PMC3103419

Abstract Article PDF–237K

Select item 295482518.

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

Aida M. Andrés, Megan Y. Dennis, Warren W. Kretzschmar, Jennifer L. Cannons, Shih-Queen Lee-Lin, Belen Hurle, NISC Comparative Sequencing Program, Pamela L. Schwartzberg, Scott H. Williamson, Carlos D. Bustamante, Rasmus Nielsen, Andrew G. Clark, Eric D. Green

PLoS Genet. 2010 Oct; 6(10): e1001157. Published online 2010 Oct 14. doi: 10.1371/journal.pgen.1001157

PMCID:: PMC2954825

Abstract Article PDF–1.4M

Select item 1103055319.

Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma

Esther Kamphausen, Christiane Kellert, Tarish Abbas, Nadja Akkad, Stefan Tenzer, Graham Pawelec, Hansjoerg Schild, Peter van Endert, Barbara Seliger

Cancer Immunol Immunother. 2010 Aug; 59(8): 1273–1284. Published online 2010 Apr 24. doi: 10.1007/s00262-010-0856-7

PMCID:: PMC11030553

Abstract Article PDF–527K

Select item 996549220.

A Comparative Review of Pregnancy and Cancer and Their Association with Endoplasmic Reticulum Aminopeptidase 1 and 2

Brian Hur, Veronica Wong, Eun D. Lee

Int J Mol Sci. 2023 Feb; 24(4): 3454. Published online 2023 Feb 9. doi: 10.3390/ijms24043454

PMCID:: PMC9965492

Abstract Article PDF–323K

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