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Select item 102784391.

LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p

Zhaozhi Xia, Shuchao Zhao, Xin Gao, Hongrui Sun, Faji Yang, Huaqiang Zhu, Hengjun Gao, Jun Lu, Xu Zhou

Technol Cancer Res Treat. 2023; 22: 15330338231177807. Published online 2023 Jun 15. doi: 10.1177/15330338231177807

PMCID:: PMC10278439

Abstract Article PDF–2.9M

Select item 87418642.

As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma

Shanshan Liu, Wenzhen Gao, Yupu Lu, Qin Zhou, Rongjian Su, Tomoka Hasegawa, Juan Du, Minqi Li

Int J Biol Sci. 2022; 18(2): 491–506. Published online 2022 Jan 1. doi: 10.7150/ijbs.66841

PMCID:: PMC8741864

Abstract Article PDF–3.2M

Select item 77720403.

LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma

Xiaoting Zhang, Huaning Kang, Jing Xiao, Benyan Shi, Xiaofeng Li, Guihong Chen

Biomed Res Int. 2020; 2020: 7020924. Published online 2020 Dec 22. doi: 10.1155/2020/7020924

PMCID:: PMC7772040

Abstract Article PDF–2.5M

Select item 74695224.

LHPP inhibits hepatocellular carcinoma cell growth and metastasis

Lijuan Liao, Deyu Duan, Yanfeng Liu, Liang Chen

Cell Cycle. 2020; 19(14): 1846–1854. Published online 2020 Jun 24. doi: 10.1080/15384101.2020.1783472

PMCID:: PMC7469522

Abstract Article PDF–4.2M

Select item 71035875.

LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer

Fahong Wu, Yanling Chen, Jinhai Zhu

Biosci Rep. 2020 Mar 27; 40(3): BSR20194142. Published online 2020 Mar 27. doi: 10.1042/BSR20194142

PMCID:: PMC7103587

Abstract Article PDF–1.2M

Select item 69671596.

Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway

Bin Hou, Wenhan Li, Jianhui Li, Jia Ma, Peng Xia, Zhao Liu, Qingnuo Zeng, Xin Zhang, Dongmin Chang

Oncol Rep. 2020 Feb; 43(2): 536–548. Published online 2019 Dec 20. doi: 10.3892/or.2019.7442

PMCID:: PMC6967159

Abstract Article PDF–2.1M

Select item 52401757.

The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene

Renato Polimanti, Qian Wang, Shashwath A Meda, Krishna T Patel, Godfrey D Pearlson, Hongyu Zhao, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter

Neuropsychopharmacology. 2017 Feb; 42(3): 598–605. Prepublished online 2016 Aug 17. Published online 2016 Sep 14. doi: 10.1038/npp.2016.153

PMCID:: PMC5240175

Abstract Article PDF–253K

Select item 50978188.

Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder

Lingling Cui, Xiaohong Gong, Yanqing Tang, Lingtao Kong, Miao Chang, Haiyang Geng, Ke Xu, Fei Wang

Neural Plast. 2016; 2016: 9162590. Published online 2016 Oct 23. doi: 10.1155/2016/9162590

PMCID:: PMC5097818

Abstract Article PDF–1.5M

Select item 66677289.

LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway

Yansheng Li, Xin Zhang, Xiaoguang Zhou, Xiaodong Zhang

Biosci Rep. 2019 Jul 31; 39(7): BSR20182270. Prepublished online 2019 Jul 1. Published online 2019 Jul 30. doi: 10.1042/BSR20182270

PMCID:: PMC6667728

Abstract Article PDF–1.8M

Select item 703154510.

Clinical value of LHPP‐associated microRNAs combined with protein induced by vitamin K deficiency or antagonist‐II in the diagnosis of alpha‐fetoprotein‐negative hepatocellular carcinoma

Zeyu Tian, Tanbo Yu, Hongyan Wei, Ning Ning

J Clin Lab Anal. 2020 Feb; 34(2): e23071. Published online 2019 Nov 6. doi: 10.1002/jcla.23071

PMCID:: PMC7031545

Abstract Article PDF–1.1M

Select item 513184511.

Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Corina Lesseur, Brenda Diergaarde, Andrew F Olshan, Victor Wünsch-Filho, Andrew R Ness, Geoffrey Liu, Martin Lacko, José Eluf-Neto, Silvia Franceschi, Pagona Lagiou, Gary J Macfarlane, Lorenzo Richiardi, Stefania Boccia, Jerry Polesel, Kristina Kjaerheim, David Zaridze, Mattias Johansson, Ana M Menezes, Maria Paula Curado, Max Robinson, Wolfgang Ahrens, Cristina Canova, Ariana Znaor, Xavier Castellsagué, David I Conway, Ivana Holcátová, Dana Mates, Marta Vilensky, Claire M Healy, Neonila Szeszenia-Dabrowska, Eleonóra Fabiánová, Jolanta Lissowska, Jennifer R Grandis, Mark C Weissler, Eloiza H Tajara, Fabio D Nunes, Marcos B de Carvalho, Steve Thomas, Rayjean J Hung, Wilbert H M Peters, Rolando Herrero, Gabriella Cadoni, H Bas Bueno-de-Mesquita, Annika Steffen, Antonio Agudo, Oxana Shangina, Xiangjun Xiao, Valérie Gaborieau, Amélie Chabrier, Devasena Anantharaman, Paolo Boffetta, Christopher I Amos, James D McKay, Paul Brennan

Nat Genet. Author manuscript; available in PMC 2017 Apr 17.

Published in final edited form as: Nat Genet. 2016 Dec; 48(12): 1544–1550. Published online 2016 Oct 17. doi: 10.1038/ng.3685

PMCID:: PMC5131845

Abstract Article PDF–1.6M

Select item 864936512.

Three LHPP gene‐targeting co‐expressed microRNAs (microRNA‐765, microRNA‐21, and microRNA‐144) promote proliferation, epithelial‐mesenchymal transition, invasion, and are independent prognostic biomarkers in renal cell carcinomas patients

Kexin Meng, Zongda Li, Xiaoying Cui

J Clin Lab Anal. 2021 Dec; 35(12): e24077. Published online 2021 Oct 26. doi: 10.1002/jcla.24077

PMCID:: PMC8649365

Abstract Article PDF–1.6M

Select item 637698813.

The protein histidine phosphatase LHPP is a tumour suppressor

Sravanth K. Hindupur, Marco Colombi, Stephen R. Fuhs, Matthias S. Matter, Yakir Guri, Kevin Adam, Marion Cornu, Salvatore Piscuoglio, Charlotte K. Y. Ng, Charles Betz, Dritan Liko, Luca Quagliata, Suzette Moes, Paul Jenoe, Luigi M. Terracciano, Markus H. Heim, Tony Hunter, Michael N. Hall

Nature. Author manuscript; available in PMC 2019 Feb 15.

Published in final edited form as: Nature. 2018 Mar 29; 555(7698): 678–682. Published online 2018 Mar 21. doi: 10.1038/nature26140

PMCID:: PMC6376988

Abstract Article PDF–2.6M

Select item 766637114.

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination

Li Xing, Xiaolong Tang, Kaikai Wu, Xiong Huang, Yi Yi, Jinliang Huan

Mol Ther Nucleic Acids. 2020 Dec 4; 22: 910–923. Published online 2020 Oct 15. doi: 10.1016/j.omtn.2020.10.012

PMCID:: PMC7666371

Abstract Article PDF–4.6M

Select item 808585115.

LHPP impedes energy metabolism by inducing ubiquitin-mediated degradation of PKM2 in glioblastoma

Wen-Jin Chen, Li-Hua Chen, Ji Wang, Zhao-Tao Wang, Cui-Ying Wu, Kai Sun, Bo-Yun Ding, Ning Liu, Ru-Xiang Xu

Am J Cancer Res. 2021; 11(4): 1369–1390. Published online 2021 Apr 15.

PMCID:: PMC8085851

Abstract Article PDF–6.1M

Select item 765717916.

Genome‐wide association study of chemotherapeutic agent‐induced severe neutropenia/leucopenia for patients in Biobank Japan

Siew‐Kee Low, Suyoun Chung, Atsushi Takahashi, Hitoshi Zembutsu, Taisei Mushiroda, Michiaki Kubo, Yusuke Nakamura

Cancer Sci. 2013 Aug; 104(8): 1074–1082. Published online 2013 Jun 10. doi: 10.1111/cas.12186

PMCID:: PMC7657179

Abstract Article PDF–225K

Select item 334973417.

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Caroline S. Fox, Yongmei Liu, Charles C. White, Mary Feitosa, Albert V. Smith, Nancy Heard-Costa, Kurt Lohman, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Andrew D. Johnson, Meredith C. Foster, Danielle M. Greenawalt, Paula Griffin, Jinghong Ding, Anne B. Newman, Fran Tylavsky, Iva Miljkovic, Stephen B. Kritchevsky, Lenore Launer, Melissa Garcia, Gudny Eiriksdottir, J. Jeffrey Carr, Vilmunder Gudnason, Tamara B. Harris, L. Adrienne Cupples, Ingrid B. Borecki

PLoS Genet. 2012 May; 8(5): e1002695. Published online 2012 May 10. doi: 10.1371/journal.pgen.1002695

PMCID:: PMC3349734

Abstract Article PDF–377K

Select item 138022518.

A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease

Andrew Grupe, Yonghong Li, Charles Rowland, Petra Nowotny, Anthony L. Hinrichs, Scott Smemo, John S. K. Kauwe, Taylor J. Maxwell, Sara Cherny, Lisa Doil, Kristina Tacey, Ryan van Luchene, Amanda Myers, Fabienne Wavrant-De Vrièze, Mona Kaleem, Paul Hollingworth, Luke Jehu, Catherine Foy, Nicola Archer, Gillian Hamilton, Peter Holmans, Chris M. Morris, Joseph Catanese, John Sninsky, Thomas J. White, John Powell, John Hardy, Michael O’Donovan, Simon Lovestone, Lesley Jones, John C. Morris, Leon Thal, Michael Owen, Julie Williams, Alison Goate

Am J Hum Genet. 2006 Jan; 78(1): 78–88. Published online 2005 Nov 15. doi: 10.1086/498851

PMCID:: PMC1380225

Abstract Article PDF–329K

Select item 352258719.

Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population

Anthony G. Comuzzie, Shelley A. Cole, Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Richard A. Gibbs, Nancy F. Butte

PLoS One. 2012; 7(12): e51954. Published online 2012 Dec 14. doi: 10.1371/journal.pone.0051954

PMCID:: PMC3522587

Abstract Article PDF–130K

Select item 926261420.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

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