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Select item 106029241.

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery

Ze Liu, Justin Wang, Yi Shi, Brian A Yee, Markus Terrey, Qian Zhang, Jenq-Chang Lee, Kuo-I Lin, Andrew H-J Wang, Susan L Ackerman, Gene W Yeo, Haissi Cui, Xiang-Lei Yang

Nucleic Acids Res. 2023 Oct 27; 51(19): 10768–10781. Published online 2023 Sep 22. doi: 10.1093/nar/gkad773

PMCID:: PMC10602924

Abstract Article PDF–1.2M

Select item 96918312.

Loss of seryl-tRNA synthetase (SARS1) causes complex spastic paraplegia and cellular senescence

Edgard Verdura, Bruno Senger, Miquel Raspall-Chaure, Agatha Schlüter, Nathalie Launay, Montserrat Ruiz, Carlos Casasnovas, Agustí Rodriguez-Palmero, Alfons Macaya, Hubert Dominique Becker, Aurora Pujol

J Med Genet. 2022 Dec; 59(12): 1227–1233. Published online 2022 Aug 30. doi: 10.1136/jmg-2022-108529

PMCID:: PMC9691831

Abstract Article PDF–692K

Select item 56480363.

Insights into substrate promiscuity of human seryl-tRNA synthetase

Kaitlyn M. Holman, Anupama K. Puppala, Jonathan W. Lee, Hyun Lee, Miljan Simonović

RNA. 2017 Nov; 23(11): 1685–1699. doi: 10.1261/rna.061069.117

PMCID:: PMC5648036

Abstract Article PDF–11M

Select item 38471964.

A new mutation in the gene encoding mitochondrial seryl-tRNA synthetase as a cause of HUPRA syndrome

Henry Rivera, Elena Martín-Hernández, Aitor Delmiro, María Teresa García-Silva, Pilar Quijada-Fraile, Rafael Muley, Joaquín Arenas, Miguel A Martín, Francisco Martínez-Azorín

BMC Nephrol. 2013; 14: 195. Published online 2013 Sep 13. doi: 10.1186/1471-2369-14-195

PMCID:: PMC3847196

Abstract Article PDF–1.9M

Select item 30016645.

Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase

Jean-Baptiste Artero, Susana C. M. Teixeira, Edward P. Mitchell, Michael A. Kron, V. Trevor Forsyth, Michael Haertlein

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1; 66(Pt 11): 1521–1524. Published online 2010 Oct 29. doi: 10.1107/S1744309110037346

PMCID:: PMC3001664

Abstract Article PDF–263K

Select item 83680636.

Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer

Jin Zhao, Hangming Bai, Xiaoyu Li, Jie Yan, Gengyi Zou, Longlong Wang, Xiru Li, Ze Liu, Rong Xiang, Xiang-Lei Yang, Yi Shi

Signal Transduct Target Ther. 2021; 6: 303. Published online 2021 Aug 16. doi: 10.1038/s41392-021-00714-0

PMCID:: PMC8368063

Abstract Article PDF–6.0M

Select item 46664017.

SerRS-tRNA^Sec complex structures reveal mechanism of the first step in selenocysteine biosynthesis

Caiyan Wang, Yu Guo, Qingnan Tian, Qian Jia, Yuanzhu Gao, Qinfen Zhang, Chun Zhou, Wei Xie

Nucleic Acids Res. 2015 Dec 2; 43(21): 10534–10545. Published online 2015 Oct 3. doi: 10.1093/nar/gkv996

PMCID:: PMC4666401

Abstract Article PDF–6.8M

Select item 38258328.

Crystal structure of human seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes

Xiaoling Xu, Yi Shi, Xiang-Lei Yang

Structure. Author manuscript; available in PMC 2014 Nov 5.

Published in final edited form as: Structure. 2013 Nov 5; 21(11): 10.1016/j.str.2013.08.021. Published online 2013 Oct 3. doi: 10.1016/j.str.2013.08.021

PMCID:: PMC3825832

Abstract Article PDF–2.1M

Select item 30357109.

Mutations in the Mitochondrial Seryl-tRNA Synthetase Cause Hyperuricemia, Pulmonary Hypertension, Renal Failure in Infancy and Alkalosis, HUPRA Syndrome

Ruth Belostotsky, Efrat Ben-Shalom, Choni Rinat, Rachel Becker-Cohen, Sofia Feinstein, Sharon Zeligson, Reeval Segel, Orly Elpeleg, Suheir Nassar, Yaacov Frishberg

Am J Hum Genet. 2011 Feb 11; 88(2): 193–200. doi: 10.1016/j.ajhg.2010.12.010

PMCID:: PMC3035710

Abstract Article PDF–1020K

Select item 272671510.

Genetic evidence for a non-canonical function of seryl-tRNA Synthetase in vascular development

Wiebke Herzog, Katja Müller, Jan Huisken, Didier Y. R. Stainier

Circ Res. Author manuscript; available in PMC 2010 Jun 5.

Published in final edited form as: Circ Res. 2009 Jun 5; 104(11): 1260–1266. Published online 2009 May 7. doi: 10.1161/CIRCRESAHA.108.191718

Correction in:: volume 105 on page e54

PMCID:: PMC2726715

Abstract Article PDF–2.1M

Select item 959685611.

Bladder Cancer‐Derived Small Extracellular Vesicles Promote Tumor Angiogenesis by Inducing HBP‐Related Metabolic Reprogramming and SerRS O‐GlcNAcylation in Endothelial Cells

Xinyuan Li, Xiang Peng, Chunlin Zhang, Xuesong Bai, Yang Li, Guo Chen, Huixia Guo, Weiyang He, Xiang Zhou, Xin Gou

Adv Sci (Weinh) 2022 Oct; 9(30): 2202993. Published online 2022 Aug 31. doi: 10.1002/advs.202202993

PMCID:: PMC9596856

Abstract Article PDF–7.9M

Select item 329341212.

Unique domain appended to vertebrate tRNA synthetase is essential for vascular development

Xiaoling Xu, Yi Shi, Hui-Min Zhang, Eric C. Swindell, Alan G. Marshall, Min Guo, Shuji Kishi, Xiang-Lei Yang

Nat Commun. 2012 Feb 21; 3: 681. Published online 2012 Feb 21. doi: 10.1038/ncomms1686

PMCID:: PMC3293412

Abstract Article PDF–1.3M

Select item 837306513.

Mutually exclusive substrate selection strategy by human m³C RNA transferases METTL2A and METTL6

Xue-Ling Mao, Zi-Han Li, Meng-Han Huang, Jin-Tao Wang, Jing-Bo Zhou, Qing-Run Li, Hong Xu, Xi-Jin Wang, Xiao-Long Zhou

Nucleic Acids Res. 2021 Aug 20; 49(14): 8309–8323. Published online 2021 Jul 15. doi: 10.1093/nar/gkab603

PMCID:: PMC8373065

Abstract Article PDF–3.9M

Select item 729506614.

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription

Gengyi Zou, Xiaotong Zhang, Lun Wang, Xiyang Li, Tianyu Xie, Jin Zhao, Jie Yan, Longlong Wang, Haoyu Ye, Shunchang Jiao, Rong Xiang, Yi Shi

Theranostics. 2020; 10(15): 6839–6853. Published online 2020 May 22. doi: 10.7150/thno.43622

PMCID:: PMC7295066

Abstract Article PDF–2.5M

Select item 538971615.

Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis

Chuan-Yang Fu, Po-Chun Wang, Huai-Jen Tsai

Nucleic Acids Res. 2017 Mar 17; 45(5): 2423–2437. Published online 2016 Nov 29. doi: 10.1093/nar/gkw1187

PMCID:: PMC5389716

Abstract Article PDF–4.7M

Select item 405778216.

tRNA synthetase counteracts c-Myc to develop functional vasculature

Yi Shi, Xiaoling Xu, Qian Zhang, Guangsen Fu, Zhongying Mo, George S Wang, Shuji Kishi, Xiang-Lei Yang

eLife. 2014; 3: e02349. Published online 2014 Jun 17. doi: 10.7554/eLife.02349

PMCID:: PMC4057782

Abstract Article PDF–6.5M

Select item 558285917.

Three distinct 3-methylcytidine (m³C) methyltransferases modify tRNA and mRNA in mice and humans

Luang Xu, Xinyu Liu, Na Sheng, Kyaw Soe Oo, Junxin Liang, Yok Hian Chionh, Juan Xu, Fuzhou Ye, Yong-Gui Gao, Peter C. Dedon, Xin-Yuan Fu

J Biol Chem. 2017 Sep 1; 292(35): 14695–14703. Published online 2017 Jun 27. doi: 10.1074/jbc.M117.798298

PMCID:: PMC5582859

Abstract Article PDF–696K

Select item 851323718.

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA

Rulan Ma, Kun Zhu, Dawei Yuan, Meijun Gong, Yijun Li, Kang Li, Lei Meng

J Transl Med. 2021; 19: 425. Published online 2021 Oct 13. doi: 10.1186/s12967-021-03100-0

PMCID:: PMC8513237

Abstract Article PDF–4.3M

Select item 293164519.

Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population

B. Fontaine-Bisson, F. Renström, O. Rolandsson, The MAGIC investigators, F. Payne, G. Hallmans, I. Barroso, P. W. Franks

Diabetologia. 2010; 53(10): 2155–2162. Published online 2010 Jun 23. doi: 10.1007/s00125-010-1792-y

PMCID:: PMC2931645

Abstract Article PDF–688K

Select item 637646820.

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway

Yin-Li Zheng, Lei Li, Yong-Xun Jia, Bao-Zhu Zhang, Jiang-Chao Li, Ying-Hui Zhu, Meng-Qing Li, Jiao-Zi He, Ting-Ting Zeng, Xiao-Jiao Ban, Yun-Fei Yuan, Yan Li, Xin-Yuan Guan

Theranostics. 2019; 9(3): 796–810. Published online 2019 Jan 24. doi: 10.7150/thno.28992