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Select item 110931971.

RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells

Linxiang Gong, Dominic Chih‐Cheng Voon, Joji Nakayama, Chiaki Takahashi, Susumu Kohno

Cancer Sci. 2024 May; 115(5): 1576–1586. Published online 2024 Mar 11. doi: 10.1111/cas.16122

PMCID:: PMC11093197

Abstract Article PDF–3.4M

Select item 105656432.

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

Sudarshan R Iyer, Kevin Nusser, Kristen Jones, Pushkar Shinde, Clare Keddy, Catherine Z Beach, Erin Aguero, Jeremy Force, Ujwal Shinde, Monika A Davare

EMBO Mol Med. 2023 Oct; 15(10): e17367. Published online 2023 Aug 17. doi: 10.15252/emmm.202217367

PMCID:: PMC10565643

Abstract Article PDF–2.6M

Select item 103804553.

Therapeutical Options in ROS1—Rearranged Advanced Non Small Cell Lung Cancer

Brigida Stanzione, Alessandro Del Conte, Elisa Bertoli, Elisa De Carlo, Alberto Revelant, Michele Spina, Alessandra Bearz

Int J Mol Sci. 2023 Jul; 24(14): 11495. Published online 2023 Jul 15. doi: 10.3390/ijms241411495

PMCID:: PMC10380455

Abstract Article PDF–533K

Select item 102245794.

“Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer”

Anne Pernille Harlem Dyrbekk, Abdirashid Ali Warsame, Pål Suhrke, Marianne Odnakk Ludahl, Joakim Oliu Moe, Inger Johanne Zwicky Eide, Marius Lund-Iversen, Odd Terje Brustugun

Diagn Pathol. 2023; 18: 70. Published online 2023 May 27. doi: 10.1186/s13000-023-01357-1

PMCID:: PMC10224579

Abstract Article PDF–1.1M

Select item 98044125.

ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer

Dilara Akhoundova, Saskia Hussung, Smruthy Sivakumar, Antonia Töpfer, Markus Rechsteiner, Abdullah Kahraman, Fabian Arnold, Florian Angst, Christian Britschgi, Martin Zoche, Holger Moch, Achim Weber, Ethan Sokol, Ralph M. Fritsch

Int J Cancer. 2022 Dec 15; 151(12): 2161–2171. Published online 2022 Aug 30. doi: 10.1002/ijc.34257

PMCID:: PMC9804412

Abstract Article PDF–4.2M

Select item 89338966.

Clinical and economic impact of ‘ROS1-testing’ strategy compared to a ‘no-ROS1-testing’ strategy in advanced NSCLC in Spain

Federico Rojo, Esther Conde, Héctor Torres, Luis Cabezón-Gutiérrez, Dolores Bautista, Inmaculada Ramos, David Carcedo, Natalia Arrabal, J. Francisco García, Raquel Galán, Ernest Nadal

BMC Cancer. 2022; 22: 292. Published online 2022 Mar 19. doi: 10.1186/s12885-022-09397-4

PMCID:: PMC8933896

Abstract Article PDF–1.9M

Select item 86574977.

Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations

Giorgia Guaitoli, Federica Bertolini, Stefania Bettelli, Samantha Manfredini, Michela Maur, Lucia Trudu, Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Massimo Dominici, Fausto Barbieri

Int J Mol Sci. 2021 Dec; 22(23): 12867. Published online 2021 Nov 28. doi: 10.3390/ijms222312867

PMCID:: PMC8657497

Abstract Article PDF–1.0M

Select item 85688558.

GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types

Philipp Sievers, Damian Stichel, Martin Sill, Daniel Schrimpf, Dominik Sturm, Florian Selt, Jonas Ecker, Daniel Kazdal, Evelina Miele, Mariëtte E. G. Kranendonk, Bastiaan B. J. Tops, Patricia Kohlhof-Meinecke, Rudi Beschorner, Christof M. Kramm, Martin Hasselblatt, Guido Reifenberger, David Capper, Pieter Wesseling, Albrecht Stenzinger, Till Milde, Andrey Korshunov, Olaf Witt, Stefan M. Pfister, Wolfgang Wick, Andreas von Deimling, David T. W. Jones, Felix Sahm

Acta Neuropathol. 2021; 142(6): 1065–1069. Published online 2021 Sep 18. doi: 10.1007/s00401-021-02369-1

PMCID:: PMC8568855

Article PDF–1.7M

Select item 83955159.

Reflex ROS1 IHC Screening with FISH Confirmation for Advanced Non-Small Cell Lung Cancer—A Cost-Efficient Strategy in a Public Healthcare System

Maisam Makarem, Doreen A. Ezeife, Adam C. Smith, Janice J. N. Li, Jennifer H. Law, Ming-Sound Tsao, Natasha B. Leighl

Curr Oncol. 2021 Oct; 28(5): 3268–3279. Published online 2021 Aug 25. doi: 10.3390/curroncol28050284

PMCID:: PMC8395515

Abstract Article PDF–2.9M

Select item 812738310.

Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion-Positive Lung Cancer

Jessica J. Lin, Noura J. Choudhury, Satoshi Yoda, Viola W. Zhu, Ted W. Johnson, Ramin Sakhtemani, Ibiayi Dagogo-Jack, Subba R. Digumarthy, Charlotte Lee, Andrew Do, Jennifer Peterson, Kylie Prutisto-Chang, Wafa Malik, Harper G. Hubbeling, Adam Langenbucher, Adam J. Schoenfeld, Christina J. Falcon, Jennifer S. Temel, Lecia V. Sequist, Beow Y. Yeap, Jochen K. Lennerz, Alice T. Shaw, Michael S. Lawrence, Sai-Hong Ignatius Ou, Aaron N. Hata, Alexander Drilon, Justin F. Gainor

Clin Cancer Res. Author manuscript; available in PMC 2021 Nov 15.

Published in final edited form as: Clin Cancer Res. 2021 May 15; 27(10): 2899–2909. Published online 2021 Mar 8. doi: 10.1158/1078-0432.CCR-21-0032

PMCID:: PMC8127383

Abstract Article PDF–1.5M

Select item 785500511.

Clinical, Morphologic and Genomic Findings in ROS1 Fusion Spitz Neoplasms.

Pedram Gerami, Daniel Kim, Elsy V. Compres, Bin Zhang, Ayesha U. Khan, Joel C. Sunshine, Victor L. Quan, Klaus Busam

Mod Pathol. Author manuscript; available in PMC 2021 Feb 28.

Published in final edited form as: Mod Pathol. 2021 Feb; 34(2): 348–357. Published online 2020 Aug 29. doi: 10.1038/s41379-020-00658-w

PMCID:: PMC7855005

Abstract Article PDF–2.2M

Select item 784836112.

Different Types of ROS1 Fusion Partners Yield Comparable Efficacy to Crizotinib

Yueming He, Wang Sheng, Weiguo Hu, Jing Lin, Junjun Liu, Bing Yu, Xinru Mao, Lu Zhang, Jin Huang, Guangsuo Wang

Oncol Res. 2019; 27(8): 901–910. Published online 2019 Aug 8. doi: 10.3727/096504019X15509372008132

PMCID:: PMC7848361

Abstract Article PDF–7.1M

Select item 760717513.

Molecular and clinicopathological characteristics of ROS1‐rearranged non‐small‐cell lung cancers identified by next‐generation sequencing

Meiying Cui, Yuchen Han, Pan Li, Jianying Zhang, Qiuxiang Ou, Xiaoling Tong, Ruiying Zhao, Nan Dong, Xue Wu, Wencai Li, Guozhong Jiang

Mol Oncol. 2020 Nov; 14(11): 2787–2795. Published online 2020 Sep 14. doi: 10.1002/1878-0261.12789

PMCID:: PMC7607175

Abstract Article PDF–431K

Select item 754098814.

Lorlatinib in previously treated anaplastic lymphoma kinase‐rearranged non–small cell lung cancer: Japanese subgroup analysis of a global study

Takashi Seto, Hidetoshi Hayashi, Miyako Satouchi, Yasushi Goto, Seiji Niho, Naoyuki Nogami, Toyoaki Hida, Toshiaki Takahashi, Jun Sakakibara‐Konishi, Masahiro Morise, Takashi Nagasawa, Mie Suzuki, Masayuki Ohkura, Kei Fukuhara, Holger Thurm, Gerson Peltz, Makoto Nishio

Cancer Sci. 2020 Oct; 111(10): 3726–3738. Published online 2020 Sep 11. doi: 10.1111/cas.14576

PMCID:: PMC7540988

Abstract Article PDF–700K

Select item 668899715.

The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models

Ryohei Katayama, Bo Gong, Noriko Togashi, Masaya Miyamoto, Masaki Kiga, Shiho Iwasaki, Yasuki Kamai, Yuichi Tominaga, Yasuyuki Takeda, Yoshiko Kagoshima, Yuki Shimizu, Yosuke Seto, Tomoko Oh-hara, Sumie Koike, Naoki Nakao, Hiroyuki Hanzawa, Kengo Watanabe, Satoshi Yoda, Noriko Yanagitani, Aaron N. Hata, Alice T. Shaw, Makoto Nishio, Naoya Fujita, Takeshi Isoyama

Nat Commun. 2019; 10: 3604. Published online 2019 Aug 9. doi: 10.1038/s41467-019-11496-z

PMCID:: PMC6688997

Abstract Article PDF–2.8M

Select item 635994416.

Differential subcellular localization regulates oncogenic signaling by ROS1 kinase fusion proteins

Dana S. Neel, David V. Allegakoen, Victor Olivas, Manasi K. Mayekar, Golzar Hemmati, Nilanjana Chatterjee, Collin M. Blakely, Caroline E. McCoach, Julia K. Rotow, Anh Le, Niki Karachaliou, Rafael Rosell, Jonathan W. Riess, Robert Nichols, Robert C. Doebele, Trever G. Bivona

Cancer Res. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Cancer Res. 2019 Feb 1; 79(3): 546–556. Published online 2018 Dec 11. doi: 10.1158/0008-5472.CAN-18-1492

PMCID:: PMC6359944

Abstract Article PDF–1.5M

Select item 629521417.

Rare but recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma

Monika A. Davare, Jacob J. Henderson, Anupriya Agarwal, Jacob P. Wagner, Sudarshan R. Iyer, Nameeta Shah, Randy Woltjer, Romel Somwar, Stephen W. Gilheeney, Ana DeCarvalo, Tom Mikkelson, Erwin G. Van Meir, Marc Ladanyi, Brian J. Druker

Clin Cancer Res. Author manuscript; available in PMC 2019 Dec 15.

Published in final edited form as: Clin Cancer Res. 2018 Dec 15; 24(24): 6471–6482. Published online 2018 Aug 31. doi: 10.1158/1078-0432.CCR-18-1052

PMCID:: PMC6295214

Abstract Article PDF–2.1M

Select item 620429018.

The incidence of brain metastases in stage IV ROS1-rearranged non-small cell lung cancer and rate of central nervous system progression on crizotinib.

Tejas Patil, Derek E. Smith, Paul A. Bunn, Dara L. Aisner, Anh T. Le, Mark Hancock, William T. Purcell, Daniel W. Bowles, D. Ross Camidge, Robert C. Doebele

J Thorac Oncol. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: J Thorac Oncol. 2018 Nov; 13(11): 1717–1726. Published online 2018 Jul 5. doi: 10.1016/j.jtho.2018.07.001

PMCID:: PMC6204290

Abstract Article PDF–854K

Select item 600064219.

非小细胞肺癌中ROS1基因重排及其临床意义

徐陆亭, 赵瑞景, 董增军, 朱铁年

Zhongguo Fei Ai Za Zhi. 2013 Dec 20; 16(12): 663–670. Chinese. doi: 10.3779/j.issn.1009-3419.2013.12.09

PMCID:: PMC6000642

Abstract Article PDF–1.2M

Select item 587415020.

Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors

Jason L. Hornick, Lynette M. Sholl, Paola Dal Cin, Merrida A. Childress, Christine M. Lovly

Mod Pathol. Author manuscript; available in PMC 2018 Mar 28.

Published in final edited form as: Mod Pathol. 2015 May; 28(5): 732–739. Published online 2015 Jan 23. doi: 10.1038/modpathol.2014.165

PMCID:: PMC5874150

Abstract Article PDF–756K

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