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Select item 110732001.

Re-expression of epigenetically silenced PTPRR by histone acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2 inhibition

Tingting Du, Xiaowen Hu, Zhenyan Hou, Weida Wang, Shen You, Mingjin Wang, Ming Ji, Nina Xue, Xiaoguang Chen

Cell Mol Life Sci. 2024 Dec; 81(1): 64. Published online 2024 Jan 28. doi: 10.1007/s00018-023-05034-w

PMCID:: PMC11073200

Abstract Article PDF–13M

Select item 68856122.

Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin

Yuetong Wang, Jian Cao, Weiwei Liu, Jiali Zhang, Zuo Wang, Yiqun Zhang, Linjun Hou, Shengmiao Chen, Piliang Hao, Liye Zhang, Min Zhuang, Yang Yu, Dake Li, Gaofeng Fan

J Biol Chem. 2019 Nov 29; 294(48): 18306–18323. Published online 2019 Oct 25. doi: 10.1074/jbc.RA119.010348

PMCID:: PMC6885612

Abstract Article PDF–5.8M

Select item 43024423.

Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells

Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan, David J Elliott

BMC Cancer. 2015; 15: 9. Published online 2015 Jan 16. doi: 10.1186/s12885-015-1012-8

PMCID:: PMC4302442

Abstract Article PDF–1.3M

Select item 28016614.

The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis

Mirco Menigatti, Elisa Cattaneo, Jacob Sabates-Bellver, Valery V Ilinsky, Philip Went, Federico Buffoli, Victor E Marquez, Josef Jiricny, Giancarlo Marra

Mol Cancer. 2009; 8: 124. Published online 2009 Dec 16. doi: 10.1186/1476-4598-8-124

PMCID:: PMC2801661

Abstract Article PDF–1.4M

Select item 70860115.

Identification of PTPRR and JAG1 as key genes in castration-resistant prostate cancer by integrated bioinformatics methods^#

Ji-li Wang, Yan Wang, Guo-ping Ren

J Zhejiang Univ Sci B. 2020 Mar; 21(3): 246–255. doi: 10.1631/jzus.B1900329

PMCID:: PMC7086011

Abstract Article PDF–1.3M

Select item 14626986.

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases

Jeyanthy Eswaran, Jens Peter von Kries, Brian Marsden, Emma Longman, Judit É. Debreczeni, Emilie Ugochukwu, Andrew Turnbull, Wen Hwa Lee, Stefan Knapp, Alastair J. Barr

Biochem J. 2006 May 1; 395(Pt 3): 483–491. Prepublished online 2006 Jan 30. Published online 2006 Apr 11. doi: 10.1042/BJ20051931

PMCID:: PMC1462698

Abstract Article PDF–984K

Select item 36215057.

Association Mapping of the High-Grade Myopia MYP3 Locus Reveals Novel Candidates UHRF1BP1L, PTPRR, and PPFIA2

Felicia Hawthorne, Sheng Feng, Ravikanth Metlapally, Yi-Ju Li, Khanh-Nhat Tran-Viet, Jeremy A. Guggenheim, Francois Malecaze, Patrick Calvas, Thomas Rosenberg, David A. Mackey, Cristina Venturini, Pirro G. Hysi, Christopher J. Hammond, Terri L. Young

Invest Ophthalmol Vis Sci. 2013 Mar; 54(3): 2076–2086. Published online 2013 Mar 21. doi: 10.1167/iovs.12-11102

PMCID:: PMC3621505

Abstract Article PDF–441K

Select item 21681018.

A Novel Regulatory Mechanism of Map Kinases Activation and Nuclear Translocation Mediated by Pka and the Ptp-Sl Tyrosine Phosphatase

Carmen Blanco-Aparicio, Josema Torres, Rafael Pulido

J Cell Biol. 1999 Dec 13; 147(6): 1129–1136. doi: 10.1083/jcb.147.6.1129

PMCID:: PMC2168101

Abstract Article PDF–183K

Select item 11710799.

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

R Pulido, A Zúñiga, A Ullrich

EMBO J. 1998 Dec 15; 17(24): 7337–7350. doi: 10.1093/emboj/17.24.7337

PMCID:: PMC1171079

Summary PDF–556K

Select item 313408410.

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the ‘PTP-ome'

Guang Lin, Victoria Aranda, Senthil K. Muthuswamy, Nicholas K. Tonks

Genes Dev. 2011 Jul 1; 25(13): 1412–1425. doi: 10.1101/gad.2018911

PMCID:: PMC3134084

Abstract Article PDF–1.5M

Select item 832170111.

CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada, Shigeki Higashiyama

Life Sci Alliance. 2021 Sep; 4(9): e202101095. Published online 2021 Jun 29. doi: 10.26508/lsa.202101095

PMCID:: PMC8321701

Abstract Article PDF–4.8M

Select item 374056812.

Genome-wide meta-analyses of multi-ethnic cohorts identify multiple new susceptibility loci for refractive error and myopia

Virginie J.M. Verhoeven, Pirro G. Hysi, Robert Wojciechowski, Qiao Fan, Jeremy A. Guggenheim, René Höhn, Stuart MacGregor, Alex W. Hewitt, Abhishek Nag, Ching-Yu Cheng, Ekaterina Yonova-Doing, Xin Zhou, M. Kamran Ikram, Gabriëlle H.S. Buitendijk, George McMahon, John P. Kemp, Beate St. Pourcain, Claire L. Simpson, Kari-Matti Mäkelä, Terho Lehtimäki, Mika Kähönen, Andrew D. Paterson, S. Mohsen Hosseini, Hoi Suen Wong, Liang Xu, Jost B. Jonas, Olavi Pärssinen, Juho Wedenoja, Shea Ping Yip, Daniel W. H. Ho, Chi Pui Pang, Li Jia Chen, Kathryn P. Burdon, Jamie E. Craig, Barbara E. K. Klein, Ronald Klein, Toomas Haller, Andres Metspalu, Chiea-Chuen Khor, E-Shyong Tai, Tin Aung, Eranga Vithana, Wan-Ting Tay, Veluchamy A. Barathi, CREAM, Peng Chen, Ruoying Li, Jiemin Liao, Yingfeng Zheng, Rick T. Ong, Angela Döring, DCCT/EDIC Research Group, David M. Evans, Nicholas J. Timpson, Annemieke J.M.H. Verkerk, Thomas Meitinger, Olli Raitakari, Felicia Hawthorne, Tim D. Spector, Lennart C. Karssen, Mario Pirastu, Federico Murgia, Wei Ang, WTCCC2, Aniket Mishra, Grant W. Montgomery, Craig E. Pennell, Phillippa M. Cumberland, Ioana Cotlarciuc, Paul Mitchell, Jie Jin Wang, Maria Schache, Sarayut Janmahasathian, Robert P. Igo, Jr, Jonathan H. Lass, Emily Chew, Sudha K. Iyengar, the Fuchs’ Genetics Multi-Center Study Group, Theo G.M.F. Gorgels, Igor Rudan, Caroline Hayward, Alan F. Wright, Ozren Polasek, Zoran Vatavuk, James F. Wilson, Brian Fleck, Tanja Zeller, Alireza Mirshahi, Christian Müller, Andre’ G. Uitterlinden, Fernando Rivadeneira, Johannes R. Vingerling, Albert Hofman, Ben A. Oostra, Najaf Amin, Arthur A.B. Bergen, Yik-Ying Teo, Jugnoo S. Rahi, Veronique Vitart, Cathy Williams, Paul N. Baird, Tien-Yin Wong, Konrad Oexle, Norbert Pfeiffer, David A. Mackey, Terri L. Young, Cornelia M. van Duijn, Seang-Mei Saw, Joan E. Bailey Wilson, Dwight Stambolian, Caroline C. Klaver, Christopher J. Hammond

Nat Genet. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: Nat Genet. 2013 Mar; 45(3): 314–318. Published online 2013 Feb 10. doi: 10.1038/ng.2554

Correction in:: volume 45 on page 712

PMCID:: PMC3740568

Abstract Article PDF–575K

Select item 263802013.

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

Alastair J. Barr, Emilie Ugochukwu, Wen Hwa Lee, Oliver N.F. King, Panagis Filippakopoulos, Ivan Alfano, Pavel Savitsky, Nicola A. Burgess-Brown, Susanne Müller, Stefan Knapp

Cell. 2009 Jan 23; 136(2): 352–363. doi: 10.1016/j.cell.2008.11.038

PMCID:: PMC2638020

Abstract Article

Select item 356108414.

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Gordan Lauc, Jennifer E. Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N. van Leeuwen, L. Renee Ruhaak, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom, Marian Beekman, Anton J. M. de Craen, André M. Deelder, Qiang Zeng, Wei Wang, Nicholas D. Hastie, Ulf Gyllensten, James F. Wilson, Manfred Wuhrer, Alan F. Wright, Pauline M. Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan

PLoS Genet. 2013 Jan; 9(1): e1003225. Published online 2013 Jan 31. doi: 10.1371/journal.pgen.1003225

PMCID:: PMC3561084

Abstract Article PDF–1.0M

Select item 358351715.

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

DANIEL BÖHM, KSENIA KELLER, JULIA PIETER, NILS BOEHM, DOMINIK WOLTERS, WULF SIGGELKOW, ANTJE LEBRECHT, MARCUS SCHMIDT, HEINZ KÖLBL, NORBERT PFEIFFER, FRANZ-HERMANN GRUS

Oncol Rep. 2012 Aug; 28(2): 429–438. Published online 2012 Jun 1. doi: 10.3892/or.2012.1849

PMCID:: PMC3583517

Abstract Article PDF–501K

Select item 566346516.

A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome

Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar

Mol Cell. Author manuscript; available in PMC 2017 Oct 31.

Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004

PMCID:: PMC5663465

Abstract Article PDF–2.1M

Select item 501331517.

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family

Xu Li, Kim My Tran, Kathryn E. Aziz, Alexey V. Sorokin, Junjie Chen, Wenqi Wang

Mol Cell Proteomics. 2016 Sep; 15(9): 3030–3044. Published online 2016 Jul 18. doi: 10.1074/mcp.M116.060277

PMCID:: PMC5013315

Abstract Article PDF–3.2M

Select item 554841318.

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling

Parveen Kumar, Prathyusha Munnangi, KVS Rammohan Chowdary, Varun J. Shah, Swapnil R. Shinde, Nanci R. Kolli, Rachita R. Halehalli, Hampapathalu A. Nagarajaram, Subbareddy Maddika

J Proteome Res. 2017 Aug 4; 16(8): 2789–2801. Published online 2017 Jul 4. doi: 10.1021/acs.jproteome.7b00065

PMCID:: PMC5548413

Abstract Article PDF–5.2M

Select item 549522519.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 698120620.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

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