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Select item 101838321.

The EGFR phosphatase RPTPγ is a redox‐regulated suppressor of promigratory signaling

Maitreyi S Joshi, Angel Stanoev, Jan Huebinger, Birga Soetje, Veronika Zorina, Lisaweta Roßmannek, Kirsten Michel, Sven AH Müller, Philippe IH Bastiaens

EMBO J. 2023 May; 42(10): e111806. Published online 2023 Mar 29. doi: 10.15252/embj.2022111806

PMCID:: PMC10183832

Abstract Article PDF–3.0M

Select item 94564692.

Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG

Giulia Lombardi, Roberta Valeria Latorre, Alessandro Mosca, Diego Calvanese, Luisa Tomasello, Christian Boni, Manuela Ferracin, Massimo Negrini, Nader Al Dewik, Mohamed Yassin, Mohamed A. Ismail, Bruno Carpentieri, Claudio Sorio, Paola Lecca

Int J Mol Sci. 2022 Sep; 23(17): 9899. Published online 2022 Aug 31. doi: 10.3390/ijms23179899

PMCID:: PMC9456469

Abstract Article PDF–4.7M

Select item 87738353.

A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease

Christian Boni, Carlo Laudanna, Claudio Sorio

Biomolecules. 2022 Jan; 12(1): 84. Published online 2022 Jan 6. doi: 10.3390/biom12010084

PMCID:: PMC8773835

Abstract Article PDF–1.6M

Select item 80651064.

Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients

Mohamed A. Ismail, Marzia Vezzalini, Hisham Morsi, Ahmad Abujaber, Ali Al Sayab, Kodappully Siveen, Mohamed A. Yassin, Maria Monne, Muthanna Samara, Richard Cook, Claudio Sorio, Helmout Modjtahedi, Nader I. Al-Dewik

Sci Rep. 2021; 11: 8833. Published online 2021 Apr 23. doi: 10.1038/s41598-021-86875-y

PMCID:: PMC8065106

Abstract Article PDF–1.9M

Select item 75495745.

Aberrant DNA methylation of PTPRG as one possible mechanism of its under‐expression in CML patients in the State of Qatar

Mohamed A. Ismail, Muthanna Samara, Ali Al Sayab, Mohamed Alsharshani, Mohamed A. Yassin, Govindarajulu Varadharaj, Marzia Vezzalini, Luisa Tomasello, Maria Monne, Hisham Morsi, M. Walid Qoronfleh, Hatem Zayed, Richard Cook, Claudio Sorio, Helmout Modjtahedi, Nader I. Al‐Dewik

Mol Genet Genomic Med. 2020 Oct; 8(10): e1319. Published online 2020 Jul 23. doi: 10.1002/mgg3.1319

PMCID:: PMC7549574

Abstract Article PDF–890K

Select item 54790356.

A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients

Marzia Vezzalini, Andrea Mafficini, Luisa Tomasello, Erika Lorenzetto, Elisabetta Moratti, Zeno Fiorini, Tessa L. Holyoake, Francesca Pellicano, Mauro Krampera, Cristina Tecchio, Mohamed Yassin, Nader Al-Dewik, Mohamed A. Ismail, Ali Al Sayab, Maria Monne, Claudio Sorio

J Hematol Oncol. 2017; 10: 129. Published online 2017 Jun 21. doi: 10.1186/s13045-017-0494-z

PMCID:: PMC5479035

Abstract Article PDF–1.6M

Select item 47767547.

PTPRG inhibition By DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia

Jianqiao Xiao, Seung-Tae Lee, Yuanyuan Xiao, Xiaomei Ma, E. Andres Houseman, Ling-I Hsu, Ritu Roy, Margaret Wrensch, Adam J. de Smith, Anand Chokkalingam, Patricia Buffler, John K. Wiencke, Joseph L. Wiemels

Int J Cancer. Author manuscript; available in PMC 2016 Mar 3.

Published in final edited form as: Int J Cancer. 2014 Sep 1; 135(5): 1101–1109. Published online 2014 Feb 19. doi: 10.1002/ijc.28759

PMCID:: PMC4776754

Abstract Article PDF–1.1M

Select item 41712548.

Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer

Jian-Feng Wang, Dong-Qiu Dai

World J Gastroenterol. 2007 Nov 21; 13(43): 5692–5698. Published online 2007 Nov 21. doi: 10.3748/wjg.v13.i43.5692

PMCID:: PMC4171254

Abstract Article PDF–878K

Select item 31447929.

Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms

Kevin Kish, Patricia A. McDonnell, Valentina Goldfarb, Mian Gao, William J. Metzler, David R. Langley, James W. Bryson, Susan E. Kiefer, Brian Carpenter, Walter A. Kostich, Ryan S. Westphal, Steven Sheriff

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1; 67(Pt 7): 768–774. Published online 2011 Jun 30. doi: 10.1107/S1744309111017209

PMCID:: PMC3144792

Abstract Article PDF–625K

Select item 306199210.

Tumour-specific methylation of PTPRG intron 1 locus in sporadic and Lynch syndrome colorectal cancer

Eddy H J van Roon, Noël F C C de Miranda, Merlijn P van Nieuwenhuizen, Emile J de Meijer, Marjo van Puijenbroek, Pearlly S Yan, Tim H-M Huang, Tom van Wezel, Hans Morreau, Judith M Boer

Eur J Hum Genet. 2011 Mar; 19(3): 307–312. Published online 2010 Dec 8. doi: 10.1038/ejhg.2010.187

PMCID:: PMC3061992

Abstract Article PDF–435K

Select item 5180211.

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

S LaForgia, B Morse, J Levy, G Barnea, L A Cannizzaro, F Li, P C Nowell, L Boghosian-Sell, J Glick, A Weston, et al.

Proc Natl Acad Sci U S A. 1991 Jun 1; 88(11): 5036–5040. doi: 10.1073/pnas.88.11.5036

PMCID:: PMC51802

Summary Page Browse PDF–1.2M

Select item 951997912.

Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival

Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer

Br J Cancer. 2022 Oct 19; 127(7): 1226–1238. Published online 2022 Jul 11. doi: 10.1038/s41416-022-01911-6

PMCID:: PMC9519979

Abstract Article PDF–2.0M

Select item 754108413.

PTPRG is an ischemia risk locus essential for HCO₃^–-dependent regulation of endothelial function and tissue perfusion

Kristoffer B Hansen, Christian Staehr, Palle D Rohde, Casper Homilius, Sukhan Kim, Mette Nyegaard, Vladimir V Matchkov, Ebbe Boedtkjer

eLife. 2020; 9: e57553. Published online 2020 Sep 21. doi: 10.7554/eLife.57553

PMCID:: PMC7541084

Abstract Article PDF–4.9M

Select item 717763714.

Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia

Luisa Tomasello, Marzia Vezzalini, Christian Boni, Massimiliano Bonifacio, Luigi Scaffidi, Mohamed Yassin, Nader Al-Dewik, Paul Takam Kamga, Mauro Krampera, Claudio Sorio

Int J Mol Sci. 2020 Apr; 21(7): 2298. Published online 2020 Mar 26. doi: 10.3390/ijms21072298

PMCID:: PMC7177637

Abstract Article PDF–2.2M

Select item 653640215.

Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR‐567/PTPRG regulatory pathway

Chengtao Yu, Fang Tian, Jun Liu, Minhui Su, Min Wu, Xuejun Zhu, Wang Qian

Cell Prolif. 2019 May; 52(3): e12610. Published online 2019 Apr 22. doi: 10.1111/cpr.12610

PMCID:: PMC6536402

Abstract Article PDF–2.5M

Select item 593040116.

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors

Michal Kostas, Ellen Margrethe Haugsten, Yan Zhen, Vigdis Sørensen, Patrycja Szybowska, Elisa Fiorito, Susanne Lorenz, Nina Jones, Gustavo Antonio de Souza, Antoni Wiedlocha, Jørgen Wesche

Mol Cell Proteomics. 2018 May; 17(5): 850–870. Published online 2018 Jan 24. doi: 10.1074/mcp.RA117.000538

PMCID:: PMC5930401

Abstract Article PDF–6.2M

Select item 453702517.

PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma

Arthur Kwok Leung Cheung, Joseph Chok Yan Ip, Adrian Chi Hang Chu, Yue Cheng, Merrin Man Long Leong, Josephine Mun Yee Ko, Wai Ho Shuen, Hong Lok Lung, Maria Li Lung

Oncotarget. 2015 May 30; 6(15): 13434–13447. Published online 2015 Apr 19. doi: 10.18632/oncotarget.3876

PMCID:: PMC4537025

Abstract Article PDF–4.4M

Select item 436162518.

Identification of Protein Tyrosine Phosphatase Receptor Gamma Extracellular Domain (sPTPRG) as a Natural Soluble Protein in Plasma

Elisabetta Moratti, Marzia Vezzalini, Luisa Tomasello, Davide Giavarina, Claudio Sorio

PLoS One. 2015; 10(3): e0119110. Published online 2015 Mar 16. doi: 10.1371/journal.pone.0119110

PMCID:: PMC4361625

Abstract Article PDF–2.4M

Select item 419231719.

Association of Common Variants in TCF4 and PTPRG with Fuchs' Corneal Dystrophy: A Systematic Review and Meta-Analysis

Lawrence C. M. Lau, Li Ma, Alvin L. Young, Shi Song Rong, Vishal Jhanji, Marten E. Brelen, Chi Pui Pang, Li Jia Chen

PLoS One. 2014; 9(10): e109142. Published online 2014 Oct 9. doi: 10.1371/journal.pone.0109142

PMCID:: PMC4192317

Abstract Article PDF–1.0M

Select item 607321720.

The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer

Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy‐Nawathe, Gordon B Mills, Ruby Yun‐Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi

EMBO Rep. 2018 Aug; 19(8): e45670. Published online 2018 Jun 15. doi: 10.15252/embr.201745670