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Select item 111363291.

How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?

T. Edouard, A. Montagner, M. Dance, F. Conte, A. Yart, B. Parfait, M. Tauber, J. P. Salles, P. Raynal

Cell Mol Life Sci. 2007 Jul; 64(13): 1585–1590. Published online 2007 Apr 23. doi: 10.1007/s00018-007-6509-0

PMCID:: PMC11136329

Abstract Article PDF–123K

Select item 109702862.

Spectrum of Mutations in PTPN11 in Russian Cohort

Anna Orlova, Daria Guseva, Nina Demina, Aleksander Polyakov, Oksana Ryzhkova

Genes (Basel) 2024 Mar; 15(3): 345. Published online 2024 Mar 7. doi: 10.3390/genes15030345

PMCID:: PMC10970286

Abstract Article PDF–942K

Select item 109385173.

Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals

Ruken Yıldırım, Edip Ünal, Şervan Özalkak, Akçahan Akalın, Ayça Aykut, Nevzat Yılmaz

J Clin Res Pediatr Endocrinol. 2024 Mar; 16(1): 76–83. Published online 2024 Mar 11. doi: 10.4274/jcrpe.galenos.2023.2023-5-16

PMCID:: PMC10938517

Abstract Article PDF–503K

Select item 107269034.

The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China

Jinjun Yang, Lei Zhao, Yu Wu, Ting Niu, Yuping Gong, Xinchuan Chen, Xiaoou Huang, Jiazhuo Liu, Yang Dai, Hongbing Ma

Cancer Med. 2023 Dec; 12(23): 21111–21117. Published online 2023 Nov 8. doi: 10.1002/cam4.6669

PMCID:: PMC10726903

Abstract Article PDF–1.2M

Select item 106029175.

PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma

Satyamaanasa Polubothu, Nicole Bender, Siobhan Muthiah, Davide Zecchin, Charalambos Demetriou, Sara Barberan Martin, Sony Malhotra, Jana Travnickova, Zhiqiang Zeng, Markus Böhm, Sebastien Barbarot, Catherine Cottrell, Olivia Davies, Eulalia Baselga, Nigel P. Burrows, Virginie Carmignac, Joey Santiago Diaz, Christine Fink, Holger A. Haenssle, Rudolf Happle, Mark Harland, Jacquelyn Majerowski, Pierre Vabres, Marie Vincent, Julia A. Newton-Bishop, D. Tim Bishop, Dawn Siegel, E. Elizabeth Patton, Maya Topf, Neil Rajan, Beth Drolet, Veronica A. Kinsler

J Invest Dermatol. 2023 Jun; 143(6): 1042–1051.e3. doi: 10.1016/j.jid.2022.09.661

PMCID:: PMC10602917

Abstract Article PDF–2.8M

Select item 100997746.

Germline selection of PTPN11 (HGNC:9644) variants make a major contribution to both Noonan syndrome's high birth rate and the transmission of sporadic cancer variants resulting in fetal abnormality

Jordan Eboreime, Soo‐Kyung Choi, Song‐Ro Yoon, Anastasiia Sadybekov, Vsevolod Katritch, Peter Calabrese, Norman Arnheim

Hum Mutat. 2022 Dec; 43(12): 2205–2221. Published online 2022 Nov 24. doi: 10.1002/humu.24493

PMCID:: PMC10099774

Abstract Article PDF–1.5M

Select item 99279467.

SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis

Yiqing Li, Hui Zhou, Pan Liu, Dandan Lv, Yichun Shi, Bufu Tang, Jiaqi Xu, Tingting Zhong, Wangting Xu, Jie Zhang, Jianying Zhou, Kejing Ying, Yongchao Zhao, Yi Sun, Zhinong Jiang, Hongqiang Cheng, Xue Zhang, Yuehai Ke

J Clin Invest. 2023 Feb 15; 133(4): e162870. Published online 2023 Feb 15. doi: 10.1172/JCI162870

PMCID:: PMC9927946

Abstract Article PDF–28M

Select item 92394328.

Targeting SHP2 phosphatase in hematological malignancies

Rahul Kanumuri, Santhosh Kumar Pasupuleti, Sarah S Burns, Baskar Ramdas, Reuben Kapur

Expert Opin Ther Targets. Author manuscript; available in PMC 2023 May 3.

Published in final edited form as: Expert Opin Ther Targets. 2022 Apr; 26(4): 319–332. Published online 2022 May 3. doi: 10.1080/14728222.2022.2066518

PMCID:: PMC9239432

Abstract Article PDF–1.6M

Select item 91486759.

Oxygen-induced conformational changes in the PAS-heme domain of the Pseudomonas aeruginosa Aer2 receptor

Emilie Orillard, Selina Anaya, Mark S. Johnson, Kylie J. Watts

Biochemistry. Author manuscript; available in PMC 2022 May 29.

Published in final edited form as: Biochemistry. 2021 Aug 31; 60(34): 2610–2622. Published online 2021 Aug 12. doi: 10.1021/acs.biochem.1c00452

PMCID:: PMC9148675

Abstract Article PDF–2.7M

Select item 890570710.

Molecular, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia

Sydney Fobare, Jessica Kohlschmidt, Hatice Gulcin Ozer, Krzysztof Mrózek, Deedra Nicolet, Alice S. Mims, Ramiro Garzon, James S. Blachly, Shelley Orwick, Andrew J. Carroll, Richard M. Stone, Eunice S. Wang, Jonathan E. Kolitz, Bayard L. Powell, Christopher C. Oakes, Ann-Kathrin Eisfeld, Erin Hertlein, John C. Byrd

Blood Adv. 2022 Mar 8; 6(5): 1371–1380. Published online 2022 Feb 25. doi: 10.1182/bloodadvances.2021006242

PMCID:: PMC8905707

Abstract Article PDF–1.5M

Select item 878232111.

Prognostic significance of SHP2 (PTPN11) expression in solid tumors: A meta-analysis

Jiupeng Zhou, Hui Guo, Yongfeng Zhang, Heng Liu, Quanli Dou

PLoS One. 2022; 17(1): e0262931. Published online 2022 Jan 21. doi: 10.1371/journal.pone.0262931

PMCID:: PMC8782321

Abstract Article PDF–1.4M

Select item 844629412.

Juvenile Xanthogranuloma in Noonan Syndrome

Marwan M. Ali, Amy E. Gilliam, Beth S. Ruben, William E. Tidyman, Katherine A. Rauen

Am J Med Genet A. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Am J Med Genet A. 2021 Oct; 185(10): 3048–3052. Published online 2021 May 25. doi: 10.1002/ajmg.a.62353

PMCID:: PMC8446294

Abstract Article PDF–739K

Select item 841066413.

Targeted degradation of the oncogenic phosphatase SHP2

Vidyasiri Vemulapalli, Katherine A. Donovan, Tom C.M. Seegar, Julia M. Rogers, Munhyung Bae, Ryan J. Lumpkin, Ruili Cao, Matthew T. Henke, Soumya Ray, Eric S. Fischer, Gregory D. Cuny, Stephen C. Blacklow

Biochemistry. Author manuscript; available in PMC 2021 Nov 30.

Published in final edited form as: Biochemistry. 2021 Aug 31; 60(34): 2593–2609. Published online 2021 Aug 19. doi: 10.1021/acs.biochem.1c00377

PMCID:: PMC8410664

Abstract Article PDF–2.5M

Select item 839428114.

Data-driven computational modeling identifies determinants of glioblastoma response to SHP2 inhibition

Evan K. Day, Qing Zhong, Benjamin Purow, Matthew J. Lazzara

Cancer Res. Author manuscript; available in PMC 2021 Oct 15.

Published in final edited form as: Cancer Res. 2021 Apr 15; 81(8): 2056–2070. Published online 2021 Feb 11. doi: 10.1158/0008-5472.CAN-20-1756

PMCID:: PMC8394281

Abstract Article PDF–2.9M

Select item 835450415.

Association of protein tyrosine phosphatase 1B gene polymorphism with the effects of weight reduction therapy on bodyweight and glycolipid profiles in obese patients

Hajime Yamakage, Yousuke Konishi, Kazuya Muranaka, Kikuko Hotta, Yoshihiro Miyamoto, Hiroko Morisaki, Takayuki Morisaki, Noriko Satoh‐Asahara

J Diabetes Investig. 2021 Aug; 12(8): 1462–1470. Published online 2021 Feb 5. doi: 10.1111/jdi.13492

PMCID:: PMC8354504

Abstract Article PDF–253K

Select item 794456116.

Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin

Yuefei Zhang, Yiqing Li, Pan Liu, Dacheng Gong, Hui Zhou, Wenjuan Li, Huilun Zhang, Wenfang Zheng, Jiaqi Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke

J Extracell Vesicles. 2021 Mar; 10(5): e12078. Published online 2021 Mar 10. doi: 10.1002/jev2.12078

PMCID:: PMC7944561

Abstract Article PDF–9.7M

Select item 786908917.

PTPN11 Mutations in the Ras-MAPK Signaling Pathway Affect Human White Matter Microstructure

Mustafa Fattah, Mira M Raman, Allan L Reiss, Tamar Green

Cereb Cortex. 2021 Mar; 31(3): 1489–1499. Published online 2020 Oct 29. doi: 10.1093/cercor/bhaa299

PMCID:: PMC7869089

Abstract Article PDF–1.0M

Select item 771469018.

SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer

Hao Chen, Sarah Libring, Kasi Viswanatharaju Ruddraraju, Jinmin Miao, Luis Solorio, Zhong-Yin Zhang, Michael K. Wendt

Oncogene. 2020; 39(49): 7166–7180. Published online 2020 Oct 8. doi: 10.1038/s41388-020-01488-5

PMCID:: PMC7714690

Abstract Article PDF–4.9M

Select item 768253619.

Congenital heart defects in Noonan syndrome: Diagnosis, management, and treatment

Léa Linglart, Bruce D. Gelb

Am J Med Genet C Semin Med Genet. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Am J Med Genet C Semin Med Genet. 2020 Mar; 184(1): 73–80. Published online 2020 Feb 5. doi: 10.1002/ajmg.c.31765

PMCID:: PMC7682536

Abstract Article PDF–860K

Select item 757290420.

Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation

Guangya Zhu, Jingjing Xie, Wenna Kong, Jingfei Xie, Yichen Li, Lin Du, Qiangang Zheng, Lin Sun, Mingfeng Guan, Huan Li, Tianxin Zhu, Hao He, Zhenying Liu, Xi Xia, Chen Kan, Youqi Tao, Hong C. Shen, Dan Li, Siying Wang, Yongguo Yu, Zhi-Hong Yu, Zhong-Yin Zhang, Cong Liu, Jidong Zhu

Cell. Author manuscript; available in PMC 2021 Oct 15.

Published in final edited form as: Cell. 2020 Oct 15; 183(2): 490–502.e18. Published online 2020 Sep 30. doi: 10.1016/j.cell.2020.09.002

PMCID:: PMC7572904

Abstract Article PDF–2.4M

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