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Select item 105206291.

Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization

Sunil Singh, Satoru Machida, Nikhil Kumar Tulsian, Yeu Khai Choong, Joel Ng, Srihari Shankar, Yaochen Liu, Krisha Vashdev Chandiramani, Jian Shi, J Sivaraman

Adv Sci (Weinh) 2023 Sep; 10(27): 2207672. Published online 2023 Aug 3. doi: 10.1002/advs.202207672

PMCID:: PMC10520629

Abstract Article PDF–3.7M

Select item 63251162.

HACE1 is a potential tumor suppressor in osteosarcoma

Amal M El-Naggar, Paul W. Clarkson, Gian Luca Negri, Busra Turgu, Fan Zhang, Michael S. Anglesio, Poul H. Sorensen

Cell Death Dis. 2019 Jan; 10(1): 21. Published online 2019 Jan 8. doi: 10.1038/s41419-018-1276-4

PMCID:: PMC6325116

Abstract Article PDF–3.2M

Select item 62195033.

Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells

Najla El-Hachem, Nadia Habel, Tanesha Naiken, Hanene Bzioueche, Yann Cheli, Guillaume E. Beranger, Emilie Jaune, Florian Rouaud, Nicolas Nottet, Frédéric Reinier, Céline Gaudel, Pascale Colosetti, Corine Bertolotto, Robert Ballotti

Cell Death Differ. 2018 Nov; 25(11): 2010–2022. Published online 2018 Mar 7. doi: 10.1038/s41418-018-0090-y

PMCID:: PMC6219503

Abstract Article PDF–3.7M

Select item 60109104.

Overexpression of HACE1 in gastric cancer inhibits tumor aggressiveness by impeding cell proliferation and migration

Ying‐ling Chen, Dong‐ping Li, Hong‐yue Jiang, Yang Yang, Li‐li Xu, Shun‐cai Zhang, Hong Gao

Cancer Med. 2018 Jun; 7(6): 2472–2484. Published online 2018 Apr 19. doi: 10.1002/cam4.1496

PMCID:: PMC6010910

Abstract Article PDF–1.2M

Select item 47174465.

HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome

Ronja Hollstein, David A Parry, Lisa Nalbach, Clare V Logan, Tim M Strom, Verity L Hartill, Ian M Carr, Georg C Korenke, Sandeep Uppal, Mushtaq Ahmed, Thomas Wieland, Alexander F Markham, Christopher P Bennett, Gabriele Gillessen-Kaesbach, Eamonn G Sheridan, Frank J Kaiser, David T Bonthron

J Med Genet. 2015 Dec; 52(12): 797–803. Published online 2015 Sep 30. doi: 10.1136/jmedgenet-2015-103344

PMCID:: PMC4717446

Abstract Article PDF–1.6M

Select item 35327106.

HACE1 Is a Tumor Suppressor Gene Candidate in Natural Killer Cell Neoplasms

Can Küçük, Xiaozhou Hu, Javeed Iqbal, Philippe Gaulard, David Klinkebiel, Adam Cornish, Bhavana J. Dave, Wing C. Chan

Am J Pathol. 2013 Jan; 182(1): 49–55. doi: 10.1016/j.ajpath.2012.09.012

PMCID:: PMC3532710

Abstract Article PDF–658K

Select item 31100537.

Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations

Elisabet Einarsdottir, Marianna R Bevova, Alexandra Zhernakova, Alienke Monsuur, Lotta LE Koskinen, Ruben van't Slot, Chris Mulder, M Luisa Mearin, Ilma R Korponay-Szabo, Katri Kaukinen, Kalle Kurppa, Juha Kere, Markku Mäki, Cisca Wijmenga, Päivi Saavalainen

Eur J Hum Genet. 2011 Jun; 19(6): 682–686. Published online 2011 Feb 16. doi: 10.1038/ejhg.2011.2

PMCID:: PMC3110053

Abstract Article PDF–280K

Select item 28262348.

Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type

Yenlin Huang, Aurélien de Reyniès, Laurence de Leval, Bouchra Ghazi, Nadine Martin-Garcia, Marion Travert, Jacques Bosq, Josette Brière, Barbara Petit, Emilie Thomas, Paul Coppo, Teresa Marafioti, Jean-François Emile, Marie-Hélène Delfau-Larue, Christian Schmitt, Philippe Gaulard

Blood. 2010 Feb 11; 115(6): 1226–1237. Prepublished online 2009 Nov 30. doi: 10.1182/blood-2009-05-221275

PMCID:: PMC2826234

Abstract Article

Select item 107560969.

HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Peiyi Yin, Yongbin Wu, Xiang Long, Shuqiang Zhu, Shiwei Chen, Feng Lu, Kun Lin, Jianjun Xu

Aging (Albany NY) 2023 Dec 15; 15(23): 13888–13900. Published online 2023 Dec 6. doi: 10.18632/aging.205272

PMCID:: PMC10756096

Abstract Article PDF–1.3M

Select item 879201910.

HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson’s disease models

Cai-xia Zang, Lu Wang, Han-yu Yang, Jun-mei Shang, Hui Liu, Zi-hong Zhang, Cheng Ju, Fang-yu Yuan, Fang-yuan Li, Xiu-qi Bao, Dan Zhang

Acta Pharmacol Sin. 2022 Feb; 43(2): 285–294. Published online 2021 Sep 30. doi: 10.1038/s41401-021-00778-2

PMCID:: PMC8792019

Abstract Article PDF–3.2M

Select item 733339311.

meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes

Diana M. Ciuculete, Sarah Voisin, Lara Kular, Jörgen Jonsson, Mathias Rask-Andersen, Jessica Mwinyi, Helgi B. Schiöth

Clin Epigenetics. 2020; 12: 99. Published online 2020 Jul 2. doi: 10.1186/s13148-020-00884-8

PMCID:: PMC7333393

Abstract Article PDF–1.4M

Select item 647579612.

HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi’s Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity

Binod Kumar, Arunava Roy, Kumari Asha, Neelam Sharma-Walia, Mairaj Ahmed Ansari, Bala Chandran

J Virol. 2019 May 1; 93(9): e01812-18. Prepublished online 2019 Feb 20. Published online 2019 Apr 17. doi: 10.1128/JVI.01812-18

PMCID:: PMC6475796

Abstract Article PDF–4.5M

Select item 535795713.

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

Emilie Andrio, Romain Lotte, Daniel Hamaoui, Jacqueline Cherfils, Anne Doye, Mads Daugaard, Poul H. Sorensen, Frédéric Bost, Raymond Ruimy, Amel Mettouchi, Emmanuel Lemichez

Sci Rep. 2017; 7: 44779. Published online 2017 Mar 20. doi: 10.1038/srep44779

PMCID:: PMC5357957

Abstract Article PDF–1.6M

Select item 463372114.

Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression

E T Goka, M E Lippman

Oncogene. 2015 Oct 16; 34(42): 5395–5405. Published online 2015 Feb 9. doi: 10.1038/onc.2014.468

PMCID:: PMC4633721

Abstract Article PDF–2.3M

Select item 393991915.

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Barak Rotblat, Amber L. Southwell, Dagmar E. Ehrnhoefer, Niels H. Skotte, Martina Metzler, Sonia Franciosi, Gabriel Leprivier, Syam Prakash Somasekharan, Adi Barokas, Yu Deng, Tiffany Tang, Joan Mathers, Naniye Cetinbas, Mads Daugaard, Brian Kwok, Liheng Li, Christopher J. Carnie, Dieter Fink, Roberto Nitsch, Jason D. Galpin, Christopher A. Ahern, Gerry Melino, Josef M. Penninger, Michael R. Hayden, Poul H. Sorensen

Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8): 3032–3037. Published online 2014 Feb 10. doi: 10.1073/pnas.1314421111

PMCID:: PMC3939919

Abstract Article PDF–1.0M

Select item 895835116.

Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer

Hong‐yue Jiang, Ying‐ling Chen, Xing‐xing Xu, Chuan‐yin Li, Yun Chen, Dong‐ping Li, Xiao‐qing Zeng, Hong Gao

Clin Transl Med. 2022 Mar; 12(3): e770. Published online 2022 Mar 28. doi: 10.1002/ctm2.770

PMCID:: PMC8958351

Abstract Article PDF–3.6M

Select item 861100317.

HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

Chenxing Da, Jun Pu, Zhe Liu, Jing Wei, Yiping Qu, Yongxing Wu, Bingyin Shi, Jian Yang, Nongyue He, Peng Hou

Signal Transduct Target Ther. 2021; 6: 399. Published online 2021 Nov 24. doi: 10.1038/s41392-021-00793-z

PMCID:: PMC8611003

Abstract Article PDF–3.4M

Select item 578049618.

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

Maria I. Acosta, Serge Urbach, Anne Doye, Yuen-Wai Ng, Jérôme Boudeau, Amel Mettouchi, Anne Debant, Edward Manser, Orane Visvikis, Emmanuel Lemichez

Sci Rep. 2018; 8: 1410. Published online 2018 Jan 23. doi: 10.1038/s41598-018-19471-2

PMCID:: PMC5780496

Abstract Article PDF–2.8M

Select item 488510119.

HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex

He-Ting Mao, Yan Wang, Juan Cai, Jun-Ling Meng, Yu Zhou, Yu Pan, Xiao-Ping Qian, Yu Zhang, Jun Zhang

Viruses. 2016 May; 8(5): 146. Published online 2016 May 21. doi: 10.3390/v8050146

PMCID:: PMC4885101

Abstract Article PDF–3.2M

Select item 797954220.

HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner

Busra Turgu, Fan Zhang, Amal El-Naggar, Gian Luca Negri, Melanie Kogler, Luigi Tortola, Fraser Johnson, Tony Ng, Amy Li, Donald Yapp, William Lockwood, Daniel Martinez, John M. Maris, Mads Daugaard, Josef M. Penninger, Christopher S. Hughes, Poul H. Sorensen

Oncogene. 2021; 40(11): 1988–2001. Published online 2021 Feb 18. doi: 10.1038/s41388-021-01680-1

PMCID:: PMC7979542

Abstract Article PDF–4.1M

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PMC Links for Gene (Select 57531) (45)
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ox06d09.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA clone IMAGE:1655...
ox06d09.s1 Soares_fetal_liver_spleen_1NFLS_S1 Homo sapiens cDNA clone IMAGE:1655537 3', mRNA sequence
gi|3254454|gnl|dbEST|1772769|gb|AI0 .1|

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