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Select item 109380551.

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant–negative effect

Verónica Palma-Barqueros, Marilena Crescente, María Eugenia de la Morena, Melissa V Chan, Elena Almarza, Nuria Revilla, Natalia Bohdan, Antonia Miñano, José Padilla, Harriet E Allan, Tania Maffucci, Matthew L. Edin, Darryl. C. Zeldin, Cristina Mesa-Nuñez, Carlos Damian, Ana Marín-Quilez, Rocío Benito, Irene Martínez-Martínez, Nuria Bermejo, Ignacio Casas-Aviles, Agustín Rodríguez Alen, José Ramón González-Porras, Jesús María Hernández-Rivas, Vicente Vicente, Javier Corral, María Luisa Lozano, Timothy D. Warner, José María Bastida, José Rivera

Am J Hematol. Author manuscript; available in PMC 2024 Mar 14.

Published in final edited form as: Am J Hematol. 2021 Mar 1; 96(3): E83–E88. Published online 2021 Jan 5. doi: 10.1002/ajh.26076

PMCID:: PMC10938055

Article PDF–671K

Select item 91434722.

Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study

Kim-Oanh Pham, Akinori Hara, Hiromasa Tsujiguchi, Keita Suzuki, Fumihiko Suzuki, Sakae Miyagi, Takayuki Kannon, Takehiro Sato, Kazuyoshi Hosomichi, Hirohito Tsuboi, Thao Thi Thu Nguyen, Yukari Shimizu, Yasuhiro Kambayashi, Masaharu Nakamura, Chie Takazawa, Haruki Nakamura, Toshio Hamagishi, Aki Shibata, Tadashi Konoshita, Atsushi Tajima, Hiroyuki Nakamura

Nutrients. 2022 May; 14(10): 2082. Published online 2022 May 16. doi: 10.3390/nu14102082

PMCID:: PMC9143472

Abstract Article PDF–893K

Select item 80941083.

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

Melissa V. Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O’Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner

Haematologica. 2021 May 1; 106(5): 1423–1432. Published online 2020 Apr 16. doi: 10.3324/haematol.2019.235895

PMCID:: PMC8094108

Abstract Article PDF–1.3M

Select item 71801094.

Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1

Michael S. Garshick, Michael Tawil, Tessa J. Barrett, Charissa M. Salud-Gnilo, Michael Eppler, Angela Lee, Jose U. Scher, Andrea L. Neimann, Sanja Jelic, Nehal N. Mehta, Edward A. Fisher, James G. Krueger, Jeffrey S. Berger

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 May; 40(5): 1340–1351. Published online 2020 Mar 5. doi: 10.1161/ATVBAHA.119.314008

PMCID:: PMC7180109

Abstract Article PDF–1.7M

Select item 57654175.

Epithelial Cells Induce a Cyclo-Oxygenase-1–Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype

Michael J. O’Sullivan, Elizabeth Gabriel, Alice Panariti, Chan Y. Park, Gijs Ijpma, Jeffrey J. Fredberg, Anne-Marie Lauzon, James G. Martin

Am J Respir Cell Mol Biol. 2017 Dec; 57(6): 683–691. doi: 10.1165/rcmb.2016-0427OC

PMCID:: PMC5765417

Abstract Article PDF–860K

Select item 50612936.

Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E₂ in Normal Human Colon Tissue

ElKhansa Sidahmed, Ananda Sen, Jianwei Ren, Arsh Patel, D. Kim Turgeon, Mack T. Ruffin, Dean Brenner, Zora Djuric

Nutr Cancer. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Nutr Cancer. 2016 Oct; 68(7): 1192–1201. Published online 2016 Aug 22. doi: 10.1080/01635581.2016.1213866

PMCID:: PMC5061293

Abstract Article PDF–682K

Select item 49194337.

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A₃, a Neutrophil-activating Eicosanoid

Christine Hinz, Maceler Aldrovandi, Charis Uhlson, Lawrence J. Marnett, Hilary J. Longhurst, Timothy D. Warner, Saydul Alam, David A. Slatter, Sarah N. Lauder, Keith Allen-Redpath, Peter W. Collins, Robert C. Murphy, Christopher P. Thomas, Valerie B. O'Donnell

J Biol Chem. 2016 Jun 24; 291(26): 13448–13464. Published online 2016 Apr 22. doi: 10.1074/jbc.M115.700609

PMCID:: PMC4919433

Abstract Article PDF–3.4M

Select item 46732708.

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

Andrew J. Wilson, Oluwole Fadare, Alicia Beeghly-Fadiel, Deok-Soo Son, Qi Liu, Shilin Zhao, Jeanette Saskowski, Md. Jashim Uddin, Cristina Daniel, Brenda Crews, Brian D. Lehmann, Jennifer A. Pietenpol, Marta A. Crispens, Lawrence J. Marnett, Dineo Khabele

Oncotarget. 2015 Aug 28; 6(25): 21353–21368. Published online 2015 May 4. doi: 10.18632/oncotarget.3860

PMCID:: PMC4673270

Abstract Article PDF–3.7M

Select item 44094249.

Fatty acids and TxA₂ generation, in the absence of platelet-COX-1 activity

A.P. DeFilippis, S.N. Rai, A. Cambon, R.J. Miles, A.S. Jaffe, A.B. Moser, R.O. Jones, R. Bolli, S.P. Schulman

Nutr Metab Cardiovasc Dis. Author manuscript; available in PMC 2015 Apr 24.

Published in final edited form as: Nutr Metab Cardiovasc Dis. 2014 Apr; 24(4): 428–433. Published online 2013 Oct 23. doi: 10.1016/j.numecd.2013.08.012

PMCID:: PMC4409424

Abstract Article PDF–181K

Select item 429729910.

Cyclooxygenase-1 as the Main Source of Proinflammatory Factors After Sodium Orthovanadate Treatment

Jan Korbecki, Irena Baranowska-Bosiacka, Izabela Gutowska, Katarzyna Piotrowska, Dariusz Chlubek

Biol Trace Elem Res. 2015; 163(1): 103–111. Published online 2014 Nov 15. doi: 10.1007/s12011-014-0176-4

PMCID:: PMC4297299

Abstract Article PDF–1.7M

Select item 416346711.

Impact of Blood Type, Functional Polymorphism (T-1676C) of the COX-1 Gene Promoter and Clinical Factors on the Development of Peptic Ulcer during Cardiovascular Prophylaxis with Low-Dose Aspirin

Pin-Yao Wang, Hsiu-Ping Chen, Angela Chen, Feng-Woei Tsay, Kwok-Hung Lai, Sung-Shuo Kao, Wen-Chi Chen, Chao-Hung Kuo, Nan-Jing Peng, Hui-Hwa Tseng, Ping-I Hsu

Biomed Res Int. 2014; 2014: 616018. Published online 2014 Aug 27. doi: 10.1155/2014/616018

PMCID:: PMC4163467

Abstract Article PDF–512K

Select item 394681012.

Suboptimal inhibition of platelet cyclo-oxygenase-1 (COX-1) by aspirin in lupus erythematosus: Association with metabolic syndrome

Vivian K. Kawai, Ingrid Avalos, Annette Oeser, John A. Oates, Ginger L. Milne, Joseph F. Solus, Cecilia P. Chung, C. Michael Stein

Arthritis Care Res (Hoboken) Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Arthritis Care Res (Hoboken). 2014 Feb; 66(2): 285–292. doi: 10.1002/acr.22169

PMCID:: PMC3946810

Abstract Article PDF–269K

Select item 204186113.

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1)

Craig R. Lee, Frank G. Bottone, Jr, Joseph M. Krahn, Leping Li, Harvey W. Mohrenweiser, Molly E. Cook, Robert M. Petrovich, Douglas A. Bell, Thomas E. Eling, Darryl C. Zeldin

Pharmacogenet Genomics. Author manuscript; available in PMC 2007 Oct 24.

Published in final edited form as: Pharmacogenet Genomics. 2007 Feb; 17(2): 145–160. doi: 10.1097/01.fpc.0000236340.87540.e3

PMCID:: PMC2041861

Abstract Article PDF–1.2M

Select item 122068914.

Characterization of a novel transcript of prostaglandin endoperoxide H synthase 1 with a tissue-specific profile of expression.

M H Plant, O Laneuville

Biochem J. 1999 Dec 15; 344(Pt 3): 677–685.

PMCID:: PMC1220689

Summary PDF–296K

Select item 113467315.

Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities

Claus Schneider, William E. Boeglin, Alan R. Brash

Biochem J. 2005 Jan 1; 385(Pt 1): 57–64. Prepublished online 2004 Sep 13. Published online 2004 Dec 14. doi: 10.1042/BJ20041115

PMCID:: PMC1134673

Abstract Article PDF–598K

Select item 961370016.

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

Franziska Nadler, Elena Lavdovskaia, Angelique Krempler, Luis Daniel Cruz-Zaragoza, Sven Dennerlein, Ricarda Richter-Dennerlein

Nat Commun. 2022; 13: 6406. Published online 2022 Oct 27. doi: 10.1038/s41467-022-34088-w

PMCID:: PMC9613700

Abstract Article PDF–1.9M

Select item 799833617.

MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women

Hye-Won Cho, Hyun-Seok Jin, Yong-Bin Eom

Genes (Basel) 2021 Mar; 12(3): 378. Published online 2021 Mar 6. doi: 10.3390/genes12030378

PMCID:: PMC7998336

Abstract Article PDF–1.0M

Select item 707165618.

Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas

Nasrin Akbari, Mohammad Ghorbani, Vahid Salimi, Alimohammad Alimohammadi, Mohammad E. Khamseh, Hamideh Akbari, Mitra Nourbakhsh, Alireza Sheikhi, S. Fahimeh Taghavi, Masoumeh Tavakoli-Yaraki

BMC Endocr Disord. 2020; 20: 39. Published online 2020 Mar 14. doi: 10.1186/s12902-020-0515-8

PMCID:: PMC7071656

Abstract Article PDF–1.3M

Select item 685961019.

Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population

Lei Zhao, Jinghuan Fang, Muke Zhou, Jie Zhou, Lihua Yu, Ning Chen, Li He

BMC Neurol. 2019; 19: 291. Published online 2019 Nov 17. doi: 10.1186/s12883-019-1505-1

PMCID:: PMC6859610

Abstract Article PDF–569K

Select item 637516020.

Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling

Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang, Yongsheng Zhou

Stem Cell Res Ther. 2019; 10: 57. Published online 2019 Feb 13. doi: 10.1186/s13287-019-1167-3

PMCID:: PMC6375160

Abstract Article PDF–4.0M

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