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Items: 1 to 20 of 57

1.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux
Jiaying Fu, Sihang Yu, Xiyao Zhao, Chaoke Zhang, Luyan Shen, Yanan Liu, Huimei Yu
Int J Mol Sci. 2022 Dec; 23(24): 16034. Published online 2022 Dec 16. doi: 10.3390/ijms232416034
PMCID:
PMC9786130
AbstractArticlePDF–2.9M
2.
Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma
Jiahui Chu, Xiangjie Niu, Jiang Chang, Mingming Shao, Linna Peng, Yiyi Xi, Ai Lin, Chengcheng Wang, Qionghua Cui, Yingying Luo, Wenyi Fan, Yamei Chen, Yanxia Sun, Wenjia Guo, Wen Tan, Dongxin Lin, Chen Wu
Theranostics. 2020; 10(8): 3488–3502. Published online 2020 Feb 10. doi: 10.7150/thno.41427
PMCID:
PMC7069087
AbstractArticlePDF–2.9M
3.
Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide
Gabriele D. Maurer, Sonja Heller, Christina Wanka, Johannes Rieger, Joachim P. Steinbach
Int J Mol Sci. 2019 Mar; 20(5): 1061. Published online 2019 Mar 1. doi: 10.3390/ijms20051061
PMCID:
PMC6429390
AbstractArticlePDF–2.7M
4.
TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation
Wenjuan Zhou, Tiantian Zhao, Jingyi Du, Guangyu Ji, Xinyue Li, Shufang Ji, Wenyu Tian, Xu Wang, Aijun Hao
Cell Death Dis. 2019 Mar; 10(3): 198. Published online 2019 Feb 27. doi: 10.1038/s41419-019-1434-3
PMCID:
PMC6393469
AbstractArticlePDF–2.6M
5.
The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30II and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma
Tetiana Hutchison, Aditi Malu, Laçin Yapindi, Rachel Bergeson, Kendra Peck, Megan Romeo, Carolyn Harrod, Jordan Pope, Louisa Smitherman, Wesleigh Gwinn, Lee Ratner, Courtney Yates, Robert Harrod
Virology. Author manuscript; available in PMC 2019 Jul 1.
Published in final edited form as: Virology. 2018 Jul; 520: 39–58. Published online 2018 May 26. doi: 10.1016/j.virol.2018.05.007
PMCID:
PMC6082153
AbstractArticlePDF–1.7M
6.
TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport
Yushuo Zhang, Fei Chen, Guomei Tai, Jiaojiao Wang, Jun Shang, Bing Zhang, Ping Wang, Baoxing Huang, Jie Du, Jiahua Yu, Haowen Zhang, Fenju Liu
Sci Rep. 2017; 7: 42928. Published online 2017 Mar 24. doi: 10.1038/srep42928
PMCID:
PMC5364507
AbstractArticlePDF–3.0M
7.
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer
Ying-Hui Ko, Marina Domingo-Vidal, Megan Roche, Zhao Lin, Diana Whitaker-Menezes, Erin Seifert, Claudia Capparelli, Madalina Tuluc, Ruth C. Birbe, Patrick Tassone, Joseph M. Curry, Àurea Navarro-Sabaté, Anna Manzano, Ramon Bartrons, Jaime Caro, Ubaldo Martinez-Outschoorn
J Biol Chem. 2016 Dec 16; 291(51): 26291–26303. Published online 2016 Nov 1. doi: 10.1074/jbc.M116.740209
PMCID:
PMC5159492
AbstractArticlePDF–2.8M
8.
TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia
Sixuan Qian, Jianyong Li, Ming Hong, Yu Zhu, Huihui Zhao, Yue Xie, Jiayu Huang, Yun Lian, Yanru Li, Shuai Wang, Jianping Mao, Yaoyu Chen
J Hematol Oncol. 2016; 9: 128. Published online 2016 Nov 25. doi: 10.1186/s13045-016-0360-4
PMCID:
PMC5123356
AbstractArticlePDF–2.3M
9.
Identification of the TP53-induced glycolysis and apoptosis regulator in various stages of colorectal cancer patients
KHAYAL AL-KHAYAL, MAHA ABDULLA, OMAR AL-OBEED, WAEL AL KATTAN, AHMAD ZUBAIDI, MANSOOR-ALI VAALI-MOHAMMED, ABDULMALIK ALSHEIKH, REHAN AHMAD
Oncol Rep. 2016 Mar; 35(3): 1281–1286. Published online 2015 Dec 17. doi: 10.3892/or.2015.4494
PMCID:
PMC4750753
AbstractArticlePDF–518K
10.
TIGAR overexpression diminishes radiosensitivity of parotid gland fibroblast cells and inhibits IR-induced cell autophagy
Guomei Tai, Haowen Zhang, Jie Du, Guojian Chen, Jianfeng Huang, Jiahua Yu, Jing Cai, Fenju Liu
Int J Clin Exp Pathol. 2015; 8(5): 4823–4829. Published online 2015 May 1.
PMCID:
PMC4503045
AbstractArticlePDF–1.0M
11.
TIGAR Is Correlated with Maximal Standardized Uptake Value on FDG-PET and Survival in Non-Small Cell Lung Cancer
Xiang Zhou, Wenhui Xie, Qian Li, Yifan Zhang, Jie Zhang, Xiaoping Zhao, Jianjun Liu, Gang Huang
PLoS One. 2013; 8(12): e80576. Published online 2013 Dec 10. doi: 10.1371/journal.pone.0080576
PMCID:
PMC3868468
AbstractArticlePDF–465K
12.
ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα
S Sinha, R Ghildiyal, V S Mehta, E Sen
Cell Death Dis. 2013 May; 4(5): e615. Published online 2013 May 2. doi: 10.1038/cddis.2013.128
PMCID:
PMC3674344
AbstractArticlePDF–7.6M
13.
Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis
Christina Wanka, Joachim P. Steinbach, Johannes Rieger
J Biol Chem. 2012 Sep 28; 287(40): 33436–33446. Published online 2012 Aug 10. doi: 10.1074/jbc.M112.384578
PMCID:
PMC3460445
AbstractArticlePDF–1.8M
14.
Modulation of intracellular ROS levels by TIGAR controls autophagy
Karim Bensaad, Eric C Cheung, Karen H Vousden
EMBO J. 2009 Oct 7; 28(19): 3015–3026. Published online 2009 Aug 27. doi: 10.1038/emboj.2009.242
PMCID:
PMC2736014
AbstractArticlePDF–800K
15.
Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance
Hong Wang, Qianqian Wang, Guodi Cai, Zhijian Duan, Zoann Nugent, Jie Huang, Jianwei Zheng, Alexander D. Borowsky, Jian Jian Li, Peiqing Liu, Hsing-Jien Kung, Leigh Murphy, Hong-Wu Chen, Junjian Wang
Acta Pharm Sin B. 2022 Apr; 12(4): 1871–1884. Published online 2021 Oct 21. doi: 10.1016/j.apsb.2021.10.015
PMCID:
PMC9279715
AbstractArticlePDF–3.4M
16.
Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer
Mengqin Shen, Xiaoping Zhao, Li Zhao, Liang Shi, Shuxian An, Gang Huang, Jianjun Liu
Mol Cancer. 2018; 17: 88. Published online 2018 May 12. doi: 10.1186/s12943-018-0839-4
PMCID:
PMC5948872
AbstractArticlePDF–5.7M
17.
Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death
Li Yin, Turner Kufe, David Avigan, Donald Kufe
Blood. 2014 May 8; 123(19): 2997–3006. Prepublished online 2014 Mar 14. doi: 10.1182/blood-2013-11-539395
PMCID:
PMC4014842
AbstractArticle
18.
Inhibition of c-Met Downregulates TIGAR Expression and Reduces NADPH Production Leading to Cell Death
Vivian Wai Yan Lui, Elaine Yue Ling Wong, Kakiu Ho, Patrick Kwok Shing Ng, Cecilia Pik Yuk Lau, Stephen Kwok Wing Tsui, Chi-Man Tsang, Sai-Wah Tsao, Suk Hang Cheng, Margaret Heung Ling Ng, Yuen Keng Ng, Emily Kai Yee Lam, Bo Hong, Kwok Wai Lo, Tony Shu Kam Mok, Anthony Tak Cheung Chan, Gordon B Mills
Oncogene. Author manuscript; available in PMC 2012 Aug 28.
Published in final edited form as: Oncogene. 2011 Mar 3; 30(9): 1127–1134. Published online 2010 Nov 8. doi: 10.1038/onc.2010.490
PMCID:
PMC3428712
AbstractArticlePDF–2.1M
19.
The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells
Helga Simon-Molas, Cristina Sánchez-de-Diego, Àurea Navarro-Sabaté, Esther Castaño, Francesc Ventura, Ramon Bartrons, Anna Manzano
Int J Mol Sci. 2022 Feb; 23(3): 1905. Published online 2022 Feb 8. doi: 10.3390/ijms23031905
PMCID:
PMC8836827
AbstractArticlePDF–3.6M
20.
The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR
Shenglan Zeng, Ze Zhao, Shengnan Zheng, Mengting Wu, Xiaomeng Song, Yiquan Li, Yi Zheng, Bingyu Liu, Lin Chen, Chengjiang Gao, Huiqing Liu
Redox Biol. 2021 Sep; 45: 102058. Published online 2021 Jun 29. doi: 10.1016/j.redox.2021.102058
PMCID:
PMC8260875
AbstractArticlePDF–12M

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