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Select item 45368881.

Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation

René Köffel, Anastasia Meshcheryakova, Joanna Warszawska, Annika Hennig, Karin Wagner, Almut Jörgl, Daniela Gubi, Doris Moser, Anastasiya Hladik, Ulrike Hoffmann, Michael B. Fischer, Wim van den Berg, Marije Koenders, Clemens Scheinecker, Bernhard Gesslbauer, Sylvia Knapp, Herbert Strobl

Blood. 2014 Oct 23; 124(17): 2713–2724. Prepublished online 2014 Sep 11. doi: 10.1182/blood-2014-07-588178

PMCID:: PMC4536888

Article

Select item 241482.

c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation

Feng Cong, Stephen P. Goff

Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24): 13819–13824. doi: 10.1073/pnas.96.24.13819

PMCID:: PMC24148

Article PDF–247K

Select item 95962123.

APEX1 promotes the oncogenicity of hepatocellular carcinoma via regulation of MAP2K6

Zhipeng Sun, Guangyang Chen, Liang Wang, Qing Sang, Guangzhong Xu, Nengwei Zhang

Aging (Albany NY) 2022 Oct 15; 14(19): 7959–7971. Published online 2022 Oct 4. doi: 10.18632/aging.204325

PMCID:: PMC9596212

Article PDF–1.2M

Select item 79805014.

The interaction of p38 with its upstream kinase MKK6

Ganesan Senthil Kumar, Rebecca Page, Wolfgang Peti

Protein Sci. 2021 Apr; 30(4): 908–913. Published online 2021 Feb 16. doi: 10.1002/pro.4039

PMCID:: PMC7980501

Article PDF–1.8M

Select item 39096775.

Helicobacter pylori activates NF-κB by inducing Ubc13-mediated ubiquitination of lysine 158 of TAK1

Acacia Lamb, JinJing Chen, Steven R. Blanke, Lin-Feng Chen

J Cell Biochem. Author manuscript; available in PMC 2014 Feb 2.

Published in final edited form as: J Cell Biochem. 2013 Oct; 114(10): 2284–2292. doi: 10.1002/jcb.24573

PMCID:: PMC3909677

Article PDF–1.4M

Select item 36916796.

Overexpression of Mitogen-activated Protein Kinase Kinase 6 in the Heart Improves Functional Recovery from Ischemia in Vitro and Protects against Myocardial Infarction in Vivo

Joshua J. Martindale, Jason A. Wall, Diana M. Martinez-Longoria, Prafulla Aryal, Howard A. Rockman, Yiru Guo, Roberto Bolli, Christopher C. Glembotski

J Biol Chem. Author manuscript; available in PMC 2013 Jun 25.

Published in final edited form as: J Biol Chem. 2005 Jan 7; 280(1): 669–676. Published online 2004 Oct 18. doi: 10.1074/jbc.M406690200

PMCID:: PMC3691679

Article PDF–2.1M

Select item 36895397.

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

Xiaoshan Min, Radha Akella, Haixia He, John M. Humphreys, Susan E. Tsutakawa, Seung-Jae Lee, John A. Tainer, Melanie H. Cobb, Elizabeth J. Goldsmith

Structure. Author manuscript; available in PMC 2013 Jun 21.

Published in final edited form as: Structure. 2009 Jan 14; 17(1): 96–104. doi: 10.1016/j.str.2008.11.007

PMCID:: PMC3689539

Article PDF–1.8M

Select item 30003088.

Oxidation-induced intramolecular disulfide bond inactivates mitogen-activated protein kinase kinase 6 by inhibiting ATP binding

Yarui Diao, Wei Liu, Catherine C. L. Wong, Xi Wang, Kaman Lee, Po-yan Cheung, Lifeng Pan, Tao Xu, Jiahuai Han, John R. Yates, III, Mingjie Zhang, Zhenguo Wu

Proc Natl Acad Sci U S A. 2010 Dec 7; 107(49): 20974–20979. Published online 2010 Nov 15. doi: 10.1073/pnas.1007225107

PMCID:: PMC3000308

Article PDF–1.0M

Select item 4521389.

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

A Cuenda, G Alonso, N Morrice, M Jones, R Meier, P Cohen, A R Nebreda

EMBO J. 1996 Aug 15; 15(16): 4156–4164.

PMCID:: PMC452138

Summary Page Browse PDF–1.7M

Select item 15153410.

p38 Mitogen-Activated Protein Kinase-Dependent and -Independent Signaling of mRNA Stability of AU-Rich Element-Containing Transcripts

Mathias A. E. Frevel, Tala Bakheet, Aristobolo M. Silva, John G. Hissong, Khalid S. A. Khabar, Bryan R. G. Williams

Mol Cell Biol. 2003 Jan; 23(2): 425–436. doi: 10.1128/MCB.23.2.425-436.2003

PMCID:: PMC151534

Article PDF–361K

Select item 8584011.

Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest

Xiaofei Wang, Clare H. McGowan, Ming Zhao, Liusheng He, Jocelyn S. Downey, Colleen Fearns, Yibin Wang, Shi Huang, Jiahuai Han

Mol Cell Biol. 2000 Jul; 20(13): 4543–4552. doi: 10.1128/mcb.20.13.4543-4552.2000

PMCID:: PMC85840

Article PDF–1.0M

Select item 499069912.

miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells

Mads Heilskov Rasmussen, Iben Lyskjær, Rosa Rakownikow Jersie-Christensen, Line Schmidt Tarpgaard, Bjarke Primdal-Bengtson, Morten Muhlig Nielsen, Jakob Skou Pedersen, Tine Plato Hansen, Flemming Hansen, Jesper Velgaard Olsen, Per Pfeiffer, Torben Falck Ørntoft, Claus Lindbjerg Andersen

Nat Commun. 2016; 7: 12436. Published online 2016 Aug 16. doi: 10.1038/ncomms12436

PMCID:: PMC4990699

Article PDF–2.0M

Select item 456378613.

Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1

Y-C Cho, J E Park, B C Park, J-H Kim, D G Jeong, S G Park, S Cho

Cell Death Differ. 2015 Oct; 22(10): 1605–1617. Published online 2015 Jan 30. doi: 10.1038/cdd.2015.2

PMCID:: PMC4563786

Article PDF–1.2M

Select item 411811214.

F-Box Only Protein 31 (FBXO31) Negatively Regulates p38 Mitogen-activated Protein Kinase (MAPK) Signaling by Mediating Lysine 48-linked Ubiquitination and Degradation of Mitogen-activated Protein Kinase Kinase 6 (MKK6)

Jia Liu, Liang Han, Bin Li, Jie Yang, Michael S. Y. Huen, Xin Pan, Sai Wah Tsao, Annie L. M. Cheung

J Biol Chem. 2014 Aug 1; 289(31): 21508–21518. Published online 2014 Jun 16. doi: 10.1074/jbc.M114.560342

PMCID:: PMC4118112

Article PDF–2.3M

Select item 322958615.

Balance between MKK6 and MKK3 Mediates p38 MAPK Associated Resistance to Cisplatin in NSCLC

Eva M. Galan-Moya, Miguel A. de la Cruz-Morcillo, Maria Llanos Valero, Juan L. Callejas-Valera, Pedro Melgar-Rojas, Javier Hernadez Losa, Mayte Salcedo, Antonio Fernández-Aramburo, Santiago Ramon y. Cajal, Ricardo Sánchez-Prieto

PLoS One. 2011; 6(12): e28406. Published online 2011 Dec 2. doi: 10.1371/journal.pone.0028406