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Items: 1 to 20 of 123

1.
Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
Adrián Sánchez-Fdez, Sofía Matilla-Almazán, Sofía Del Carmen, Mar Abad, Elena Arconada-Luque, Jaime Jiménez-Suárez, Luis Miguel Chinchilla-Tábora, Mª José Ruíz-Hidalgo, Ricardo Sánchez-Prieto, Atanasio Pandiella, Azucena Esparís-Ogando
Exp Mol Med. 2023 Jun; 55(6): 1247–1257. Published online 2023 Jun 19. doi: 10.1038/s12276-023-01008-x
PMCID:
PMC10317974
AbstractArticlePDF–3.8M
2.
The Investigation of MAPK7 Gene Variations in Colorectal Cancer Risk
CANAN CACINA, ELIF ULU, SOYKAN ARIKAN, SAIME TURAN SURMEN, ILHAN YAYLIM
In Vivo. 2023 Mar-Apr; 37(2): 644–648. Published online 2023 Mar 3. doi: 10.21873/invivo.13123
PMCID:
PMC10026633
AbstractArticlePDF–561K
3.
Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity
Francesca Ippolito, Veronica Consalvi, Valeria Noce, Cecilia Battistelli, Carla Cicchini, Marco Tripodi, Laura Amicone, Alessandra Marchetti
Cell Death Dis. 2023 Jan; 14(1): 32. Published online 2023 Jan 17. doi: 10.1038/s41419-023-05569-7
PMCID:
PMC9845357
AbstractArticlePDF–2.3M
4.
Extracellular Signal‐Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells
Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Hepatology. 2021 Oct; 74(4): 2007–2020. Published online 2021 Jul 5. doi: 10.1002/hep.31888
PMCID:
PMC8518067
AbstractArticlePDF–941K
5.
Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation
Sivareddy Kotla, Aijun Zhang, Masaki Imanishi, Kyung Ae Ko, Steven H. Lin, Young Jin Gi, Margie Moczygemba, Sevinj Isgandarova, Keri L. Schadler, Caroline Chung, Sarah A. Milgrom, Jose Banchs, Syed Wamique Yusuf, Diana N. Amaya, Huifang Guo, Tamlyn N. Thomas, Ying H. Shen, Anita Deswal, Joerg Herrmann, Eugenie S. Kleinerman, Mark L. Entman, John P. Cooke, Giovanni Schifitto, Sanjay B. Maggirwar, Elena McBeath, Anisha A. Gupte, Sunil Krishnan, Zarana S. Patel, Yisang Yoon, Jared K. Burks, Keigi Fujiwara, Paul S. Brookes, Nhat-Tu Le, Dale J. Hamilton, Jun-ichi Abe
Redox Biol. 2021 Nov; 47: 102132. Published online 2021 Sep 20. doi: 10.1016/j.redox.2021.102132
PMCID:
PMC8502954
AbstractArticlePDF–12M
6.
Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition
Jingwei Zhang, Adam J. Pearson, Nitin Sabherwal, Brian A. Telfer, Nisha Ali, Karmern Kan, Qiuping Xu, Wei Zhang, Fuhui Chen, Shiyang Li, Jinhua Wang, Nathanael S. Gray, Blanca Risa-Ebrí, Katherine G. Finegan, Michael J. Cross, Emanuele Giurisato, Alan J. Whitmarsh, Cathy Tournier
Cancer Res Commun. 2022 Mar; 2(3): 131–145. Published online 2022 Mar 10. doi: 10.1158/2767-9764.CRC-21-0089
PMCID:
PMC7613885
AbstractArticlePDF–13M
7.
Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer
Darrell Green, Heather Eyre, Archana Singh, Jessica T. Taylor, Jason Chu, Lee Jeys, Vaiyapuri Sumathi, Aman Coonar, Doris Rassl, Muhammad Babur, Duncan Forster, Saba Alzabin, Frida Ponthan, Adam McMahon, Brian Bigger, Tristan Reekie, Michael Kassiou, Kaye Williams, Tamas Dalmay, William D. Fraser, Katherine G. Finegan
Oncogene. 2020; 39(33): 5553–5569. Published online 2020 Jul 13. doi: 10.1038/s41388-020-1379-0
PMCID:
PMC7426263
AbstractArticlePDF–3.1M
8.
Beyond Kinase Activity: ERK5 Nucleo-Cytoplasmic Shuttling as a Novel Target for Anticancer Therapy
Alessandro Tubita, Zoe Lombardi, Ignazia Tusa, Persio Dello Sbarba, Elisabetta Rovida
Int J Mol Sci. 2020 Feb; 21(3): 938. Published online 2020 Jan 31. doi: 10.3390/ijms21030938
PMCID:
PMC7038028
AbstractArticlePDF–857K
9.
Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5)
Adam J. Pearson, Paul Fullwood, Gabriela Toro Tapia, Ian Prise, Michael P. Smith, Qiuping Xu, Allan Jordan, Emanuele Giurisato, Alan J. Whitmarsh, Chiara Francavilla, Cathy Tournier
Int J Mol Sci. 2020 Feb; 21(3): 929. Published online 2020 Jan 31. doi: 10.3390/ijms21030929
PMCID:
PMC7037328
AbstractArticlePDF–4.0M
10.
Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response
Weiwei Jiang, Guanghui Jin, Fangfang Cai, Xiao Chen, Nini Cao, Xiangyu Zhang, Jia Liu, Fei Chen, Feng Wang, Wei Dong, Hongqin Zhuang, Zi-Chun Hua
Exp Mol Med. 2019 Feb; 51(2): 1–20. Published online 2019 Feb 21. doi: 10.1038/s12276-019-0209-3
Correction in:
Exp Mol Med. 2023 Jun; 55(6): 1272–1274.
PMCID:
PMC6389946
AbstractArticlePDF–6.8M
11.
Mitochondrial Complex I activity signals antioxidant response through ERK5
Abrar Ul Haq Khan, Nerea Allende-Vega, Delphine Gitenay, Johan Garaude, Dang-Nghiem Vo, Sana Belkhala, Sabine Gerbal-Chaloin, Claire Gondeau, Martine Daujat-Chavanieu, Cécile Delettre, Stefania Orecchioni, Giovanna Talarico, Francesco Bertolini, Alberto Anel, José M. Cuezva, Jose A. Enriquez, Guillaume Cartron, Charles-Henri Lecellier, Javier Hernandez, Martin Villalba
Sci Rep. 2018; 8: 7420. Published online 2018 May 9. doi: 10.1038/s41598-018-23884-4
PMCID:
PMC5943249
AbstractArticlePDF–2.1M
12.
Benzidine Induces Epithelial–Mesenchymal Transition of Human Bladder Cancer Cells through Activation of ERK5 Pathway
Xin Sun, Tao Zhang, Qifei Deng, Qirui Zhou, Xianchao Sun, Enlai Li, Dexin Yu, Caiyun Zhong
Mol Cells. 2018 Mar 31; 41(3): 188–197. Published online 2018 Feb 21. doi: 10.14348/molcells.2018.2113
PMCID:
PMC5881092
AbstractArticlePDF–6.4M
13.
Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells
Emma L. Wilkinson, James E. Sidaway, Michael J. Cross
J Cell Physiol. 2018 Jan; 233(1): 186–200. Published online 2017 Aug 3. doi: 10.1002/jcp.26064
PMCID:
PMC5655747
AbstractArticlePDF–4.8M
14.
Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes
Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu, Kazuhisa Takahashi
Respir Res. 2017; 18: 46. Published online 2017 Mar 11. doi: 10.1186/s12931-017-0529-6
PMCID:
PMC5346259
AbstractArticlePDF–1.4M
15.
Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
Hongming Chen, Julie Tucker, Xiaotao Wang, Paul R. Gavine, Chris Phillips, Martin A. Augustin, Patrick Schreiner, Stefan Steinbacher, Marian Preston, Derek Ogg
Acta Crystallogr D Struct Biol. 2016 May 1; 72(Pt 5): 682–693. Published online 2016 Apr 26. doi: 10.1107/S2059798316004502
PMCID:
PMC4854315
AbstractArticlePDF–2.3M
16.
Role of MAPK7 in cell proliferation and metastasis in ovarian cancer
Jinhua Dai, Tao Wang, Weihua Wang, Songhua Zhang, Yufeng Liao, Jie Chen
Int J Clin Exp Pathol. 2015; 8(9): 10444–10451. Published online 2015 Sep 1.
PMCID:
PMC4637568
AbstractArticlePDF–889K
17.
Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
Paul R. Gavine, Mei Wang, Dehua Yu, Eva Hu, Chunlei Huang, Jenny Xia, Xinying Su, Joan Fan, Tianwei Zhang, Qingqing Ye, Li Zheng, Guanshan Zhu, Ziliang Qian, Qingquan Luo, Ying Yong Hou, Qunsheng Ji
BMC Cancer. 2015; 15: 454. Published online 2015 Jun 4. doi: 10.1186/s12885-015-1455-y
PMCID:
PMC4453990
AbstractArticlePDF–1.6M
18.
THE MAPK ERK5, BUT NOT ERK1/2, INHIBITS THE PROGRESSION OF MONOCYTIC PHENOTYPE TO THE FUNCTIONING MACROPHAGE
Xuening Wang, Stella Pesakhov, Jonathan S Harrison, Michael Kafka, Michael Danilenko, George P Studzinski
Exp Cell Res. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: Exp Cell Res. 2015 Jan 1; 330(1): 199–211. Published online 2014 Oct 16. doi: 10.1016/j.yexcr.2014.10.003
PMCID:
PMC4364001
AbstractArticlePDF–3.4M
19.
ERK5 Pathway Regulates Transcription Factors Important for Monocytic Differentiation of Human Myeloid Leukemia Cells
Xuening Wang, Stella Pesakhov, Jonathan S Harrison, Michael Danilenko, George P Studzinski
J Cell Physiol. Author manuscript; available in PMC 2015 Jul 1.
Published in final edited form as: J Cell Physiol. 2014 Jul; 229(7): 856–867. doi: 10.1002/jcp.24513
PMCID:
PMC4363988
AbstractArticlePDF–1.7M
20.
Hydrogen Peroxide Activation of ERK5 Confers Resistance to Jurkat Cells Against Apoptosis Induced by the Extrinsic Pathway
Takeshi Suzuki, Jay Yang
Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Feb 7.
Published in final edited form as: Biochem Biophys Res Commun. 2014 Feb 7; 444(2): 248–253. Published online 2014 Jan 22. doi: 10.1016/j.bbrc.2014.01.058
PMCID:
PMC3974591
AbstractArticlePDF–1.1M

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