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Select item 111601631.

Up‐regulation of DNA‐dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma

Satoru Shintani, Mariko Mihara, Chunnan Li, Yuuji Nakahara, Satoshi Hino, Koh‐ichi Nakashiro, Hiroyuki Hamakawa

Cancer Sci. 2003 Oct; 94(10): 894–900. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01372.x

PMCID:: PMC11160163

Abstract Article PDF–1.8M

Select item 111099642.

DNA-PKcs suppresses illegitimate chromosome rearrangements

Jinglong Wang, Cheyenne A Sadeghi, Richard L Frock

Nucleic Acids Res. 2024 May 22; 52(9): 5048–5066. Published online 2024 Feb 27. doi: 10.1093/nar/gkae140

PMCID:: PMC11109964

Abstract Article PDF–2.9M

Select item 110844403.

PRKDC-Mediated NHEJ May Play a Crucial Role in Aneuploidy of Chromosome 8-Driven Progression of Ovarian Cancer

Wenqing Luan, Hongyan Cheng, Haoling Xie, Huiping Liu, Yicheng Wang, Shang Wang, Xue Ye, Honglan Zhu, Fuchou Tang, Yi Li, Xiaohong Chang

Int J Mol Sci. 2024 May; 25(9): 4825. Published online 2024 Apr 28. doi: 10.3390/ijms25094825

PMCID:: PMC11084440

Abstract Article PDF–12M

Select item 101837024.

Up‐regulation of PRKDC was associated with poor renal dysfunction after renal transplantation: A multi‐centre analysis

Zhijun Cao, Hao Jiang, Chunchun Zhao, Huifeng Zhou, Zheng Ma, Chen Xu, Jianglei Zhang, Minjun Jiang, Zhenfan Wang

J Cell Mol Med. 2023 May; 27(10): 1362–1372. Published online 2023 Apr 1. doi: 10.1111/jcmm.17737

PMCID:: PMC10183702

Abstract Article PDF–4.0M

Select item 98832515.

DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease

Sara E. F. Kost, Ali Saleh, Shek H. Yuan, Bozena Kuzio, Spencer B. Gibson, Lin Yang, Versha Banerji, James B. Johnston, Sachin Katyal

Blood Cancer J. 2023 Dec; 13(1): 20. Published online 2023 Jan 27. doi: 10.1038/s41408-022-00781-8

PMCID:: PMC9883251

Article PDF–2.1M

Select item 92591066.

Potential value of PRKDC as a therapeutic target and prognostic biomarker in pan-cancer

Xiawei Yang, Feng Yang, Liugen Lan, Ning Wen, Haibin Li, Xuyong Sun

Medicine (Baltimore) 2022 Jul 8; 101(27): e29628. Published online 2022 Jul 8. doi: 10.1097/MD.0000000000029628

PMCID:: PMC9259106

Abstract Article PDF–3.8M

Select item 90387227.

PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA

Yao Fan, Yi Liang, Yu Liu, Hui Fan

Cell Death Dis. 2022 Apr; 13(4): 404. Published online 2022 Apr 25. doi: 10.1038/s41419-022-04852-3

PMCID:: PMC9038722

Abstract Article PDF–4.5M

Select item 89161198.

Autophosphorylation Transforms DNA-PK from protecting to processing DNA ends

Lan Liu, Xuemin Chen, Jun Li, Huaibin Wang, Christopher J. Buehl, Noah J. Goff, Katheryn Meek, Wei Yang, Martin Gellert

Mol Cell. Author manuscript; available in PMC 2023 Jan 6.

Published in final edited form as: Mol Cell. 2022 Jan 6; 82(1): 177–189.e4. Published online 2021 Dec 21. doi: 10.1016/j.molcel.2021.11.025

PMCID:: PMC8916119

Abstract Article PDF–3.1M

Select item 87758309.

Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer

Hajnalka Laura Pálinkás, Lőrinc Pongor, Máté Balajti, Ádám Nagy, Kinga Nagy, Angéla Békési, Giampaolo Bianchini, Beáta G. Vértessy, Balázs Győrffy

Int J Mol Sci. 2022 Jan; 23(2): 633. Published online 2022 Jan 6. doi: 10.3390/ijms23020633

PMCID:: PMC8775830

Abstract Article PDF–1.7M

Select item 858210810.

Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs

Cholpon S. Djuzenova, Thomas Fischer, Astrid Katzer, Dmitri Sisario, Tessa Korsa, Gudrun Steussloff, Vladimir L. Sukhorukov, Michael Flentje

BMC Cancer. 2021; 21: 1201. Published online 2021 Nov 11. doi: 10.1186/s12885-021-08930-1

PMCID:: PMC8582108

Abstract Article PDF–4.6M

Select item 850875711.

Role of DNA-Dependent Protein Kinase in Mediating Cyst Growth in Autosomal Dominant Polycystic Kidney Disease

Ashley N. Chandra, Sayanthooran Saravanabavan, Gopala K. Rangan

Int J Mol Sci. 2021 Oct; 22(19): 10512. Published online 2021 Sep 29. doi: 10.3390/ijms221910512

PMCID:: PMC8508757

Abstract Article PDF–1.9M

Select item 810703412.

miRNA‐218‐5p increases cell sensitivity by inhibiting PRKDC activity in radiation‐resistant lung carcinoma cells

Xiaoke Chen, Yuanyuan Xu, Long Jiang, Qiang Tan

Thorac Cancer. 2021 May; 12(10): 1549–1557. Published online 2021 Mar 23. doi: 10.1111/1759-7714.13939

PMCID:: PMC8107034

Abstract Article PDF–4.0M

Select item 789727913.

Structure of an activated DNA-PK and its implications for NHEJ

Xuemin Chen, Xiang Xu, Yun Chen, Joyce C. Cheung, Huaibin Wang, Jiansen Jiang, Natalia de Val, Tara Fox, Martin Gellert, Wei Yang

Mol Cell. Author manuscript; available in PMC 2022 Feb 18.

Published in final edited form as: Mol Cell. 2021 Feb 18; 81(4): 801–810.e3. Published online 2020 Dec 31. doi: 10.1016/j.molcel.2020.12.015

PMCID:: PMC7897279

Abstract Article PDF–1.5M

Select item 746334614.

Prevalence of PRKDC mutations and association with response to immune checkpoint inhibitors in solid tumors

Yu Chen, Yi Li, Yanfang Guan, Yingying Huang, Jing Lin, Lizhu Chen, Jin Li, Gang Chen, Leong Kin Pan, Xuefeng Xia, Ning Xu, Lianpeng Chang, Zengqing Guo, Jianji Pan, Xin Yi, Chuanben Chen

Mol Oncol. 2020 Sep; 14(9): 2096–2110. Published online 2020 Jun 30. doi: 10.1002/1878-0261.12739

PMCID:: PMC7463346

Abstract Article PDF–1.1M

Select item 733681715.

Relationship between thyroid tumor radiosensitivity and nuclear localization of DNA-dependent protein kinase catalytic subunit

Makoto Ihara, Kazuko Shichijo, Kiyoto Ashizawa, Katsuya Matsuda, Ryota Otsubo, Ichiro Horie, Masahiro Nakashima, Takashi Kudo

J Radiat Res. 2020 Jul; 61(4): 511–516. Published online 2020 Jun 22. doi: 10.1093/jrr/rraa032

PMCID:: PMC7336817

Abstract Article PDF–727K

Select item 682131816.

Simultaneous precise editing of multiple genes in human cells

Stephan Riesenberg, Manjusha Chintalapati, Dominik Macak, Philipp Kanis, Tomislav Maricic, Svante Pääbo

Nucleic Acids Res. 2019 Nov 4; 47(19): e116. Published online 2019 Aug 8. doi: 10.1093/nar/gkz669

PMCID:: PMC6821318

Abstract Article PDF–4.2M

Select item 675515717.

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response

Yang Han, Feng Jin, Ying Xie, Yike Liu, Sai Hu, Xiao-Dan Liu, Hua Guan, Yongqing Gu, Teng Ma, Ping-Kun Zhou

Mol Med Rep. 2019 Oct; 20(4): 3609–3616. Published online 2019 Sep 2. doi: 10.3892/mmr.2019.10640

PMCID:: PMC6755157

Abstract Article PDF–1.1M

Select item 671194818.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) contributes to incorporation of histone variant H2A.Z into nucleosomes

Ling-Yao Wang, Yun-xiao He, Min Li, Jian Ding, Yi Sui, Joan W. Conaway, Ronald C. Conaway, Fei Wang, Jingji Jin, Yong Cai

Protein Cell. 2019 Sep; 10(9): 694–699. Published online 2019 May 20. doi: 10.1007/s13238-019-0632-1

PMCID:: PMC6711948

Article PDF–912K

Select item 643025519.

Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines

Makoto Ihara, Kiyoto Ashizawa, Kazuko Shichijo, Takashi Kudo

J Radiat Res. 2019 Mar; 60(2): 171–177. Published online 2018 Nov 23. doi: 10.1093/jrr/rry097

PMCID:: PMC6430255

Abstract Article PDF–349K

Select item 617742220.

Tumor DNA-dependent protein kinase catalytic subunit expression is associated with hepatitis B surface antigen status and tumor progression in patients with hepatocellular carcinoma

Takayuki Shimizu, Taku Aoki, Shozo Mori, Yukihiro Iso, Masato Kato, Mitsuru Ishizuka, Keiichi Kubota

Sci Rep. 2018; 8: 15019. Published online 2018 Oct 9. doi: 10.1038/s41598-018-33427-6

PMCID:: PMC6177422

Abstract Article PDF–1.2M

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PMC Links for Gene (Select 5591) (523)
PMC
PREDICTED: Canis lupus familiaris tropomyosin 1 (TPM1), transcript variant X17, ...
PREDICTED: Canis lupus familiaris tropomyosin 1 (TPM1), transcript variant X17, mRNA
gi|1953363580|ref|XM_038442548.1|

Nucleotide
PREDICTED: Canis lupus familiaris tropomyosin 1 (TPM1), transcript variant X7, m...
PREDICTED: Canis lupus familiaris tropomyosin 1 (TPM1), transcript variant X7, mRNA
gi|1953363560|ref|XM_038442537.1|

Nucleotide
tropomyosin alpha-1 chain isoform X19 [Canis lupus familiaris]
tropomyosin alpha-1 chain isoform X19 [Canis lupus familiaris]
gi|1953363587|ref|XP_038298479.1|

Protein
tropomyosin alpha-1 chain isoform X3 [Canis lupus familiaris]
tropomyosin alpha-1 chain isoform X3 [Canis lupus familiaris]
gi|1953047852|ref|XP_038436535.1|

Protein

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