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Select item 90925721.

Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer

Igor Govorov, Sanaz Attarha, Larysa Kovalevska, Emil Andersson, Elena Kashuba, Miriam Mints

Cancer Control. 2022 Jan-Dec; 29: 10732748221094797. Published online 2022 May 9. doi: 10.1177/10732748221094797

PMCID:: PMC9092572

Abstract Article PDF–1.2M

Select item 67712592.

Protein Kinase N1 control of androgen-responsive Serum Response Factor action provides rationale for novel prostate cancer treatment strategy

Varadha Balaji Venkadakrishnan, Adam D. DePriest, Sangeeta Kumari, Dhirodatta Senapati, Salma Ben-Salem, Yixue Su, Giridhar Mudduluru, Qiang Hu, Eduardo Cortes, Elena Pop, James L. Mohler, Gissou Azabdaftari, Kristopher Attwood, Rajal B. Shah, Christina Jamieson, Scott M. Dehm, Cristina Magi-Galluzzi, Eric Klein, Nima Sharifi, Song Liu, Hannelore V. Heemers

Oncogene. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Oncogene. 2019 Jun; 38(23): 4496–4511. Published online 2019 Feb 11. doi: 10.1038/s41388-019-0732-7

PMCID:: PMC6771259

Abstract Article PDF–1.1M

Select item 66357693.

Characterization of the novel cardiolipin binding regions identified on the protease and lipid activated PKC‐related kinase 1

Jason L. J. Lin

Protein Sci. 2019 Aug; 28(8): 1473–1486. Published online 2019 Jun 19. doi: 10.1002/pro.3663

PMCID:: PMC6635769

Abstract Article PDF–1.5M

Select item 45164144.

Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport

Catherine Manser, Alison Stevenson, Steven Banner, Jennifer Davies, Elizabeth L. Tudor, Yoshitaka Ono, P. Nigel Leigh, Declan M. McLoughlin, Christopher E. Shaw, Christopher C.J. Miller

FEBS Lett. Author manuscript; available in PMC 2015 Jul 27.

Published in final edited form as: FEBS Lett. 2008 Jun 25; 582(15): 2303–2308. Published online 2008 Jun 2. doi: 10.1016/j.febslet.2008.05.034

PMCID:: PMC4516414

Abstract Article PDF–1.1M

Select item 43503445.

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

Cordula A. Jilg, Anett Ketscher, Eric Metzger, Barbara Hummel, Dominica Willmann, Vanessa Rüsseler, Vanessa Drendel, Axel Imhof, Manfred Jung, Henriette Franz, Stefanie Hölz, Malte Krönig, Judith M. Müller, Roland Schüle

Oncotarget. 2014 Dec; 5(24): 12646–12664. Published online 2014 Dec 10. doi: 10.18632/oncotarget.2653

PMCID:: PMC4350344

Abstract Article PDF–4.4M

Select item 39115196.

Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase

Alexander F. A. Keszei, Xiaojing Tang, Craig McCormick, Elton Zeqiraj, John R. Rohde, Mike Tyers, Frank Sicheri

Mol Cell Biol. 2014 Feb; 34(3): 362–373. doi: 10.1128/MCB.01360-13

PMCID:: PMC3911519

Abstract Article PDF–2.6M

Select item 38430787.

Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells

Richard G. James, Katherine A. Bosch, Rima M. Kulikauskas, Peitzu T. Yang, Nick C. Robin, Rachel A. Toroni, Travis L. Biechele, Jason D. Berndt, Priska D. von Haller, Jimmy K. Eng, Alejandro Wolf-Yadlin, Andy J. Chien, Randall T. Moon

J Biol Chem. 2013 Nov 29; 288(48): 34658–34670. Published online 2013 Oct 10. doi: 10.1074/jbc.M113.500314

PMCID:: PMC3843078

Abstract Article PDF–1.5M

Select item 27448398.

PRK1 Distribution in Normal Tissues and Carcinomas: Overexpression and Activation in Ovarian Serous Carcinoma

Mary T. Galgano, Mark Conaway, Adam M. Spencer, Bryce M. Paschal, Henry F. Frierson, Jr.

Hum Pathol. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Hum Pathol. 2009 Oct; 40(10): 1434–1440. Published online 2009 May 7. doi: 10.1016/j.humpath.2009.02.008

PMCID:: PMC2744839

Abstract Article PDF–1.7M

Select item 383609.

Translocation of PKN from the cytosol to the nucleus induced by stresses.

H Mukai, M Miyahara, H Sunakawa, H Shibata, M Toshimori, M Kitagawa, M Shimakawa, H Takanaga, Y Ono

Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19): 10195–10199. doi: 10.1073/pnas.93.19.10195

PMCID:: PMC38360

Summary Page Browse PDF–1.6M

Select item 1455510.

PKN delays mitotic timing by inhibition of Cdc25C: Possible involvement of PKN in the regulation of cell division

Kazuyo Misaki, Hideyuki Mukai, Chiho Yoshinaga, Kumiko Oishi, Takayuki Isagawa, Mikiko Takahashi, Keita Ohsumi, Takeo Kishimoto, Yoshitaka Ono

Proc Natl Acad Sci U S A. 2001 Jan 2; 98(1): 125–129. Published online 2000 Dec 26. doi: 10.1073/pnas.021541498

PMCID:: PMC14555

Abstract Article PDF–257K

Select item 469491311.

Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer

Aine G. O'Sullivan, Eamon P. Mulvaney, Paula B. Hyland, B. Therese Kinsella

Oncotarget. 2015 Sep 22; 6(28): 26437–26456. Published online 2015 Jul 20. doi: 10.18632/oncotarget.4664

PMCID:: PMC4694913

Abstract Article PDF–2.2M

Select item 2578612.

Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton

Lily Q. Dong, Luis R. Landa, Michael J. Wick, Li Zhu, Hideyuki Mukai, Yoshitaka Ono, Feng Liu

Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5089–5094. Published online 2000 May 2. doi: 10.1073/pnas.090491897

PMCID:: PMC25786

Abstract Article PDF–230K

Select item 2168113.

Proteolytic activation of PKN by caspase-3 or related protease during apoptosis

Mikiko Takahashi, Hideyuki Mukai, Masanao Toshimori, Masaaki Miyamoto, Yoshitaka Ono

Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20): 11566–11571. doi: 10.1073/pnas.95.20.11566

PMCID:: PMC21681

Abstract Article PDF–305K

Select item 531976614.

RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

Fan Wang, Rixing Zhan, Liang Chen, Xia Dai, Wenping Wang, Rui Guo, Xiaoge Li, Zhe Li, Liang Wang, Shupeng Huang, Jie Shen, Shirong Li, Chuan Cao

PLoS One. 2017; 12(2): e0172613. Published online 2017 Feb 21. doi: 10.1371/journal.pone.0172613

PMCID:: PMC5319766

Abstract Article PDF–1.6M

Select item 395812915.

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Matthew D. Falk, Wei Liu, Ben Bolaños, Keziban Unsal-Kacmaz, Anke Klippel, Stephan Grant, Alexei Brooun, Sergei Timofeevski

Biosci Rep. 2014; 34(2): e00097. Prepublished online 2014 Jan 29. Published online 2014 Mar 18. doi: 10.1042/BSR20140010

PMCID:: PMC3958129

Abstract Article PDF–1.6M

Select item 14009816.

A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

Eric Metzger, Judith M. Müller, Stefano Ferrari, Reinhard Buettner, Roland Schüle

EMBO J. 2003 Jan 15; 22(2): 270–280. doi: 10.1093/emboj/cdg023

PMCID:: PMC140098

Abstract Article PDF–336K

Select item 705426717.

Novel roles of PRK1 and PRK2 in cilia and cancer biology

Hitesh Patel, Jun Li, Ana Herrero, Jakob Kroboth, Adam Byron, Alex Von Kriegsheim, Valerie Brunton, Neil Carragher, Toby Hurd, Margaret Frame

Sci Rep. 2020; 10: 3902. Published online 2020 Mar 3. doi: 10.1038/s41598-020-60604-3

PMCID:: PMC7054267

Abstract Article PDF–3.2M

Select item 261034018.

Transporter Molecules influence the Gene Expression in HeLa Cells

Waldemar Waldeck, Ruediger Pipkorn, Bernhard Korn, Gabriele Mueller, Matthias Schick, Katalin Tóth, Manfred Wiessler, Bernd Didinger, Klaus Braun

Int J Med Sci. 2009; 6(1): 18–27. Published online 2008 Dec 18. doi: 10.7150/ijms.6.18

PMCID:: PMC2610340

Abstract Article PDF–1.8M

Select item 418988219.

Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2

Sabrina Höfling, Julia Scharnert, Christoph Cromme, Jessica Bertrand, Thomas Pap, M Alexander Schmidt, Christian Rüter

Virulence. 2014 Oct 1; 5(7): 761–771. Published online 2014 May 15. doi: 10.4161/viru.29062

PMCID:: PMC4189882

Abstract Article PDF–2.8M

Select item 347629620.

Protein Kinase N1 Is a Novel Substrate of NFATc1-mediated Cyclin D1-CDK6 Activity and Modulates Vascular Smooth Muscle Cell Division and Migration Leading to Inward Blood Vessel Wall Remodeling

Nikhlesh K. Singh, Venkatesh Kundumani-Sridharan, Sanjay Kumar, Shailendra K. Verma, Sivareddy Kotla, Hideyuki Mukai, Mark R. Heckle, Gadiparthi N. Rao

J Biol Chem. 2012 Oct 19; 287(43): 36291–36304. Published online 2012 Aug 13. doi: 10.1074/jbc.M112.361220

PMCID:: PMC3476296

Abstract Article PDF–5.2M

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PMC Links for Gene (Select 5585) (70)
PMC
gacA2
gacA2

biosample
WTB3
WTB3

biosample
hemin ABC transporter substrate-binding protein [Echinicola pacifica]
hemin ABC transporter substrate-binding protein [Echinicola pacifica]
gi|517285413|ref|WP_018474231.1|

Protein
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

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