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Select item 68509701.

Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

Susanna Norrbacka, Dan Lindholm, Timo T. Myöhänen

J Cell Mol Med. 2019 Dec; 23(12): 8511–8515. Published online 2019 Sep 29. doi: 10.1111/jcmm.14675

PMCID:: PMC6850970

Article PDF–830K

Select item 50707362.

Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line

Da Zhou, Bing-Hang Li, Jing Wang, Yong-Nian Ding, Yan Dong, Yuan-Wen Chen, Jian-Gao Fan

PLoS One. 2016; 11(10): e0165224. Published online 2016 Oct 19. doi: 10.1371/journal.pone.0165224

PMCID:: PMC5070736

Abstract Article PDF–1.5M

Select item 45891963.

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

Jofre Tenorio-Laranga, Carmina Montoliu, Amparo Urios, Vicente Hernandez-Rabaza, Hanan Ahabrach, J. Arturo García-Horsman, Vicente Felipo

J Neuroinflammation. 2015; 12: 183. Published online 2015 Sep 30. doi: 10.1186/s12974-015-0404-7

PMCID:: PMC4589196

Abstract Article PDF–2.7M

Select item 42585404.

Mechanism of oxidative inactivation of human presequence protease (hPreP) by hydrogen peroxide

Jue Chen, Pedro Filipe Teixeira, Elzbieta Glaser, Rodney L. Levine

Free Radic Biol Med. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Free Radic Biol Med. 2014 Dec; 0: 57–63. Published online 2014 Sep 16. doi: 10.1016/j.freeradbiomed.2014.08.016

PMCID:: PMC4258540

Abstract Article PDF–641K

Select item 38944055.

Prolyl Endopeptidase Activity Is Correlated with Colorectal Cancer Prognosis

Gorka Larrinaga, Itxaro Perez, Lorena Blanco, Begoña Sanz, Peio Errarte, Maider Beitia, María C. Etxezarraga, Alberto Loizate, Javier Gil, Jon Irazusta, José I. López

Int J Med Sci. 2014; 11(2): 199–208. Published online 2014 Jan 10. doi: 10.7150/ijms.7178

PMCID:: PMC3894405

Abstract Article PDF–579K

Select item 35245556.

Distribution of Prolyl Oligopeptidase in Human Peripheral Tissues and in Ovarian and Colorectal Tumors

Timo T. Myöhänen, Elisa Pyykkö, Pekka T. Männistö, Olli Carpen

J Histochem Cytochem. 2012 Sep; 60(9): 706–715. doi: 10.1369/0022155412453051

PMCID:: PMC3524555

Abstract Article PDF–4.0M

Select item 28642377.

Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis

Jofre Tenorio-Laranga, Francisco Coret-Ferrer, Buenaventura Casanova-Estruch, María Burgal, J Arturo García-Horsman

J Neuroinflammation. 2010; 7: 23. Published online 2010 Apr 6. doi: 10.1186/1742-2094-7-23

PMCID:: PMC2864237

Abstract Article PDF–1.0M

Select item 18105348.

No association between the PREP gene and lithium responsive bipolar disorder

Firoza Mamdani, Adolfo Sequeira, Martin Alda, Paul Grof, Guy Rouleau, Gustavo Turecki

BMC Psychiatry. 2007; 7: 9. Published online 2007 Feb 26. doi: 10.1186/1471-244X-7-9

PMCID:: PMC1810534

Abstract Article PDF–248K

Select item 83474989.

Preliminary Investigation on the Involvement of Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular Disorders

Massimo Venditti, Davide Arcaniolo, Marco De Sio, Sergio Minucci

Int J Mol Sci. 2021 Aug; 22(15): 8094. Published online 2021 Jul 28. doi: 10.3390/ijms22158094

PMCID:: PMC8347498

Abstract Article PDF–3.3M

Select item 791678310.

Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner

Ulrika H. Julku, Maria Jäntti, Reinis Svarcbahs, Timo T. Myöhänen

Int J Mol Sci. 2021 Feb; 22(4): 1777. Published online 2021 Feb 10. doi: 10.3390/ijms22041777

PMCID:: PMC7916783

Abstract Article PDF–1.6M

Select item 643734311.

Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm

Massimo Venditti, Sergio Minucci

J Histochem Cytochem. 2019 Apr; 67(4): 229–243. Published online 2018 Oct 31. doi: 10.1369/0022155418810064

PMCID:: PMC6437343

Abstract Article PDF–8.7M

Select item 350062212.

Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein α

Kalyani Jambunathan, Douglas S. Watson, Aaron N. Endsley, Krishna Kodukula, Amit K. Galande

FEBS Lett. Author manuscript; available in PMC 2013 Jul 30.

Published in final edited form as: FEBS Lett. 2012 Jul 30; 586(16): 2507–2512. Published online 2012 Jun 27. doi: 10.1016/j.febslet.2012.06.015

PMCID:: PMC3500622

Abstract Article PDF–1.1M

Select item 322316313.

Structural Analysis of Prolyl Oligopeptidases Using Molecular Docking and Dynamics: Insights into Conformational Changes and Ligand Binding

Swati Kaushik, Ramanathan Sowdhamini

PLoS One. 2011; 6(11): e26251. Published online 2011 Nov 23. doi: 10.1371/journal.pone.0026251

PMCID:: PMC3223163

Abstract Article PDF–1.4M

Select item 412808814.

Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

John V. King, Wenguang G. Liang, Kathryn P. Scherpelz, Alexander B. Schilling, Stephen C. Meredith, Wei-Jen Tang

Structure. Author manuscript; available in PMC 2015 Jul 8.

Published in final edited form as: Structure. 2014 Jul 8; 22(7): 996–1007. Published online 2014 Jun 12. doi: 10.1016/j.str.2014.05.003

PMCID:: PMC4128088

Abstract Article PDF–1.8M

Select item 545567815.

Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes

Tomasz Szul, Preston E. Bratcher, Kyle B. Fraser, Michele Kong, Rabindra Tirouvanziam, Sarah Ingersoll, Elizabeth Sztul, Sunil Rangarajan, J. Edwin Blalock, Xin Xu, Amit Gaggar

Am J Respir Cell Mol Biol. 2016 Mar; 54(3): 359–369. doi: 10.1165/rcmb.2015-0108OC

PMCID:: PMC5455678

Abstract Article PDF–1.7M

Select item 433524616.

Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

Mari H. Savolainen, Xu Yan, Timo T. Myöhänen, Henri J. Huttunen

J Biol Chem. 2015 Feb 20; 290(8): 5117–5126. Published online 2015 Jan 2. doi: 10.1074/jbc.M114.592931

PMCID:: PMC4335246

Abstract Article PDF–1.0M

Select item 282906217.

Genome-Wide Association Study Reveals Multiple Loci Associated with Primary Tooth Development during Infancy

Demetris Pillas, Clive J. Hoggart, David M. Evans, Paul F. O'Reilly, Kirsi Sipilä, Raija Lähdesmäki, Iona Y. Millwood, Marika Kaakinen, Gopalakrishnan Netuveli, David Blane, Pimphen Charoen, Ulla Sovio, Anneli Pouta, Nelson Freimer, Anna-Liisa Hartikainen, Jaana Laitinen, Sarianna Vaara, Beate Glaser, Peter Crawford, Nicholas J. Timpson, Susan M. Ring, Guohong Deng, Weihua Zhang, Mark I. McCarthy, Panos Deloukas, Leena Peltonen, Paul Elliott, Lachlan J. M. Coin, George Davey Smith, Marjo-Riitta Jarvelin

PLoS Genet. 2010 Feb; 6(2): e1000856. Published online 2010 Feb 26. doi: 10.1371/journal.pgen.1000856

Correction in:: PLoS Genet. 2010 Mar; 6(3): 10.1371/annotation/e2a4252d-f903-4d2a-8acf-95d30a32a76c.

PMCID:: PMC2829062

Abstract Article PDF–250K

Select item 278357718.

Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations; significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes (FIND) Research Group

Alka Malhotra, Robert P. Igo, Jr., Farook Thameem, W.H. Linda Kao, Hanna E. Abboud, Sharon G. Adler, Nedal H. Arar, Donald W. Bowden, Ravindranath Duggirala, Barry I. Freedman, Katrina A.B. Goddard, Eli Ipp, Sudha K. Iyengar, Paul L. Kimmel, William C. Knowler, Orly Kohn, David Leehey, Lucy A. Meoni, Robert G. Nelson, Susanne B. Nicholas, Rulan S. Parekh, Stephen S. Rich, Yii-Der I. Chen, Mohammed F. Saad, Marina Scavini, Jeffrey R. Schelling, John R. Sedor, Vallabh O. Shah, Kent D. Taylor, Denyse Thornley-Brown, Philip G. Zager, Amanda Horvath, Robert L. Hanson

Diabetes Metab Res Rev. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Diabetes Metab Res Rev. 2009 Nov; 25(8): 740–747. doi: 10.1002/dmrr.1031

PMCID:: PMC2783577

Abstract Article PDF–354K

Select item 296315419.

Association Study of 182 Candidate Genes in Anorexia Nervosa

Andrea Poyastro Pinheiro, Cynthia M. Bulik, Laura M. Thornton, Patrick F. Sullivan, Tammy L. Root, Cinnamon S. Bloss, Wade H. Berrettini, Nicholas J. Schork, Walter H. Kaye, Andrew W. Bergen, Pierre Magistretti, Harry Brandt, Steve Crawford, Scott Crow, Manfred M. Fichter, David Goldman, Katherine A. Halmi, Craig Johnson, Allan S. Kaplan, Pamela K. Keel, Kelly L. Klump, Maria La Via, James E. Mitchell, Michael Strober, Alessandro Rotondo, Janet Treasure, D. Blake Woodside

Am J Med Genet B Neuropsychiatr Genet. Author manuscript; available in PMC 2010 Oct 25.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2010 Jul; 153B(5): 1070–1080. doi: 10.1002/ajmg.b.31082

PMCID:: PMC2963154

Abstract Article PDF–315K

Select item 711512820.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

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