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Select item 92848901.

PPP2R5D promotes hepatitis C virus infection by binding to viral NS5B and enhancing viral RNA replication

Muhammad Ikram Anwar, Ni Li, Qing Zhou, Mingxiao Chen, Chengguang Hu, Tao Wu, Haihang Chen, Yi-Ping Li, Yuanping Zhou

Virol J. 2022; 19: 118. Published online 2022 Jul 14. doi: 10.1186/s12985-022-01848-5

PMCID:: PMC9284890

Abstract Article PDF–1.8M

Select item 90525552.

Early-Onset Parkinsonism Is a Manifestation of the PPP2R5D p.E200K Mutation

Christine Y. Kim, Thomas Wirth, Cécile Hubsch, Andrea H. Németh, Volkan Okur, Mathieu Anheim, Nathalie Drouot, Christine Tranchant, Gabrielle Rudolf, Jamel Chelly, Katrina Tatton-Brown, Cornelis Blauwendraat, Jean Paul G. Vonsattel, Etty Cortes, Roy N. Alcalay, Wendy K. Chung

Ann Neurol. Author manuscript; available in PMC 2022 Apr 29.

Published in final edited form as: Ann Neurol. 2020 Nov; 88(5): 1028–1033. Published online 2020 Aug 22. doi: 10.1002/ana.25863

PMCID:: PMC9052555

Abstract Article PDF–946K

Select item 73002493.

Parallel Tests of Whole Exome Sequencing and Copy Number Variant Sequencing Increase the Diagnosis Yields of Rare Pediatric Disorders

Xuyun Hu, Ruolan Guo, Jun Guo, Zhan Qi, Wei Li, Chanjuan Hao

Front Genet. 2020; 11: 473. Published online 2020 Jun 11. doi: 10.3389/fgene.2020.00473

PMCID:: PMC7300249

Abstract Article PDF–328K

Select item 71861684.

Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B′δ holoenzyme

Chian Ju Jong, Ronald A. Merrill, Emily M. Wilkerson, Laura E. Herring, Lee M. Graves, Stefan Strack

J Biol Chem. 2020 Apr 24; 295(17): 5654–5668. Published online 2020 Mar 10. doi: 10.1074/jbc.RA119.011270

PMCID:: PMC7186168

Abstract Article PDF–4.4M

Select item 47654935.

De Novo Missense Variants in PPP2R5D Are Associated with Intellectual Disability, Macrocephaly, Hypotonia, and Autism

Linshan Shang, Lindsay B. Henderson, Megan T. Cho, Donald S. Petrey, Chin-To Fong, Katrina M. Haude, Natasha Shur, Julie Lundberg, Natalie Hauser, Jason Carmichael, Jeffrey Innis, Jane Schuette, Yvonne W. Wu, Shailesh Asaikar, Margaret Pearson, Leandra Folk, Kyle Retterer, Kristin G. Monaghan, Wendy K. Chung

Neurogenetics. Author manuscript; available in PMC 2016 Feb 24.

Published in final edited form as: Neurogenetics. 2016 Jan; 17(1): 43–49. Published online 2015 Nov 17. doi: 10.1007/s10048-015-0466-9

PMCID:: PMC4765493

Abstract Article PDF–447K

Select item 46235706.

Gunnar Houge, Dorien Haesen, Lisenka E.L.M. Vissers, Sarju Mehta, Michael J. Parker, Michael Wright, Julie Vogt, Shane McKee, John L. Tolmie, Nuno Cordeiro, Tjitske Kleefstra, Marjolein H. Willemsen, Margot R.F. Reijnders, Siren Berland, Eli Hayman, Eli Lahat, Eva H. Brilstra, Koen L.I. van Gassen, Evelien Zonneveld-Huijssoon, Charlotte I. de Bie, Alexander Hoischen, Evan E. Eichler, Rita Holdhus, Vidar M. Steen, Stein Ove Døskeland, Matthew E. Hurles, David R. FitzPatrick, the Deciphering Developmental Disorders (DDD) study, Veerle Janssens

J Clin Invest. 2015 Aug 3; 125(8): 3051–3062. Published online 2015 Jul 13. doi: 10.1172/JCI79860

PMCID:: PMC4623570

Abstract Article PDF–3.0M

Select item 67769007.

PPM1G forms a PPP‐type phosphatase holoenzyme with B56δ that maintains adherens junction integrity

Parveen Kumar, Prajakta Tathe, Neelam Chaudhary, Subbareddy Maddika

EMBO Rep. 2019 Oct 4; 20(10): e46965. Published online 2019 Aug 21. doi: 10.15252/embr.201846965

PMCID:: PMC6776900

Abstract Article PDF–3.1M

Select item 34156668.

Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A–Glycogen Synthase Kinase 3β–Negative Feedback Pathway

Lingfeng Liu, Robert N. Eisenman

Genes Cancer. 2012 Jan; 3(1): 23–36. doi: 10.1177/1947601912448067

PMCID:: PMC3415666

Abstract Article PDF–4.4M

Select item 87018789.

Co-Occurrence of Fragile X Syndrome with a Second Genetic Condition: Three Independent Cases of Double Diagnosis

Elisabetta Tabolacci, Maria Grazia Pomponi, Laura Remondini, Roberta Pietrobono, Daniela Orteschi, Veronica Nobile, Cecilia Pucci, Elisa Musto, Marika Pane, Eugenio M. Mercuri, Giovanni Neri, Maurizio Genuardi, Pietro Chiurazzi, Marcella Zollino

Genes (Basel) 2021 Dec; 12(12): 1909. Published online 2021 Nov 27. doi: 10.3390/genes12121909

PMCID:: PMC8701878

Abstract Article PDF–1.6M

Select item 795213410.

Cinta M. Papke, Kali A. Smolen, Mark R. Swingle, Lauren Cressey, Richard A. Heng, Mourad Toporsian, Liyong Deng, Jacob Hagen, Yufeng Shen, Wendy K. Chung, Arminja N. Kettenbach, Richard E. Honkanen

J Biol Chem. 2021 Jan-Jun; 296: 100313. Published online 2021 Jan 20. doi: 10.1016/j.jbc.2021.100313

PMCID:: PMC7952134

Abstract Article PDF–4.9M

Select item 452748311.

Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth

Chey Loveday, Katrina Tatton-Brown, Matthew Clarke, Isaac Westwood, Anthony Renwick, Emma Ramsay, Andrea Nemeth, Jennifer Campbell, Shelagh Joss, McKinlay Gardner, Anna Zachariou, Anna Elliott, Elise Ruark, Rob van Montfort, The Childhood Overgrowth Collaboration, Nazneen Rahman

Hum Mol Genet. 2015 Sep 1; 24(17): 4775–4779. Published online 2015 May 13. doi: 10.1093/hmg/ddv182

Correction in:: Hum Mol Genet. 2019 May 1; 28(9): 1578.

PMCID:: PMC4527483

Abstract Article PDF–280K

Select item 417897012.

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing

Antonio Espert, Pelin Uluocak, Ricardo Nunes Bastos, Davinderpreet Mangat, Philipp Graab, Ulrike Gruneberg

J Cell Biol. 2014 Sep 29; 206(7): 833–842. doi: 10.1083/jcb.201406109

PMCID:: PMC4178970

Abstract Article PDF–2.8M

Select item 278979613.

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

Seth S. Margolis, Jennifer A. Perry, Craig M. Forester, Leta K. Nutt, Yanxiang Guo, Melanie J. Jardim, Michael J. Thomenius, Christopher D. Freel, Rashid Darbandi, Jung-Hyuck Ahn, Jason D. Arroyo, Xiao-Fan Wang, Shirish Shenolikar, Angus C. Nairn, William G. Dunphy, William C. Hahn, David M. Virshup, Sally Kornbluth

Cell. Author manuscript; available in PMC 2009 Dec 7.

Published in final edited form as: Cell. 2006 Nov 17; 127(4): 759–773. doi: 10.1016/j.cell.2006.10.035

PMCID:: PMC2789796

Abstract Article PDF–3.9M

Select item 274596714.

The Bα and Bδ Regulatory Subunits of PP2A are Necessary for Assembly of the CaMKIV•PP2A Signaling Complex

Kelie M. Reece, Matthew D. Mazalouskasa, Brian E. Wadzinskia

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Sep 4.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Sep 4; 386(4): 582–587. Published online 2009 Jun 16. doi: 10.1016/j.bbrc.2009.06.062

PMCID:: PMC2745967

Abstract Article PDF–702K

Select item 530867115.

Therapeutic relevance of the protein phosphatase 2A in cancer

Chelsea E. Cunningham, Shuangshuang Li, Frederick S. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Joo Sang Lee, Sreejit Parameswaran, Levi Furber, Omar Abuhussein, James M. Paul, Megan McDonald, Shaina D. Templeton, Hersh Shukla, Amr M. El Zawily, Frederick Boyd, Nezeka Alli, Darrell D. Mousseau, Ron Geyer, Keith Bonham, Deborah H. Anderson, Jiong Yan, Li-Yuan Yu-Lee, Beth A. Weaver, Maruti Uppalapati, Eytan Ruppin, Anna Sablina, Andrew Freywald, Franco J. Vizeacoumar

Oncotarget. 2016 Sep 20; 7(38): 61544–61561. Published online 2016 Aug 19. doi: 10.18632/oncotarget.11399

PMCID:: PMC5308671

Abstract Article PDF–12M

Select item 357571416.

A key phosphorylation site in AC8 mediates regulation of Ca²⁺-dependent cAMP dynamics by an AC8–AKAP79–PKA signalling complex

Debbie Willoughby, Michelle L. Halls, Katy L. Everett, Antonio Ciruela, Philipp Skroblin, Enno Klussmann, Dermot M. F. Cooper

J Cell Sci. 2012 Dec 1; 125(23): 5850–5859. doi: 10.1242/jcs.111427

PMCID:: PMC3575714

Abstract Article

Select item 281034717.

PME-1 protects ERK pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

Pietri Puustinen, Melissa R. Junttila, Sari Vanhatupa, Anna A. Sablina, Melissa E. Hector, Kaisa Teittinen, Olayinka Raheem, Kirsi Ketola, Shujun Lin, Juergen Kast, Hannu Haapasalo, William C. Hahn, Jukka Westermarck

Cancer Res. Author manuscript; available in PMC 2010 Apr 1.

Published in final edited form as: Cancer Res. 2009 Apr 1; 69(7): 2870–2877. Published online 2009 Mar 17. doi: 10.1158/0008-5472.CAN-08-2760

PMCID:: PMC2810347

Abstract Article PDF–1.0M

Select item 214838918.

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1

Craig M. Forester, Jessica Maddox, Justin V. Louis, Jozef Goris, David M. Virshup

Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50): 19867–19872. Published online 2007 Dec 4. doi: 10.1073/pnas.0709879104

PMCID:: PMC2148389

Abstract Article PDF–741K

Select item 632360919.

De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders

Sara Reynhout, Sandra Jansen, Dorien Haesen, Siska van Belle, Sonja A. de Munnik, Ernie M.H.F. Bongers, Jolanda H. Schieving, Carlo Marcelis, Jeanne Amiel, Marlène Rio, Heather Mclaughlin, Roger Ladda, Susan Sell, Marjolein Kriek, Cacha M.P.C.D. Peeters-Scholte, Paulien A. Terhal, Koen L. van Gassen, Nienke Verbeek, Sonja Henry, Jessica Scott Schwoerer, Saleem Malik, Nicole Revencu, Carlos R. Ferreira, Ellen Macnamara, Hilde M.H. Braakman, Elise Brimble, Maura R.Z. Ruznikov, Matias Wagner, Philip Harrer, Dagmar Wieczorek, Alma Kuechler, Barak Tziperman, Ortal Barel, Bert B.A. de Vries, Christopher T. Gordon, Veerle Janssens, Lisenka E.L.M. Vissers

Am J Hum Genet. 2019 Jan 3; 104(1): 139–156. Published online 2018 Dec 27. doi: 10.1016/j.ajhg.2018.12.002

Correction in:: Am J Hum Genet. 2019 Feb 7; 104(2): 357.

PMCID:: PMC6323609

Abstract Article PDF–1.8M

Select item 433853420.

A PP1/PP2A phosphatase relay controls mitotic progression

Agnes Grallert, Elvan Boke, Anja Hagting, Ben Hodgson, Yvonne Connolly, John. R. Griffiths, Duncan L. Smith, Jonathon Pines, Iain M. Hagan

Nature. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Nature. 2015 Jan 1; 517(7532): 94–98. Published online 2014 Dec 10. doi: 10.1038/nature14019

PMCID:: PMC4338534

Abstract Article PDF–4.4M

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