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Select item 72435961.

Selective PP2A enhancement through biased heterotrimer stabilization

Daniel Leonard, Wei Huang, Sudeh Izadmehr, Caitlin M. O’Connor, Danica D. Wiredja, Zhizhi Wang, Nilesh Zaware, Yinghua Chen, Daniela M. Schlatzer, Janna Kiselar, Nikhil Vasireddi, Stefan Schüchner, Abbey L. Perl, Matthew D. Galsky, Wenqing Xu, David L. Brautigan, Egon Ogris, Derek J. Taylor, Goutham Narla

Cell. Author manuscript; available in PMC 2021 Apr 30.

Published in final edited form as: Cell. 2020 Apr 30; 181(3): 688–701.e16. Published online 2020 Apr 20. doi: 10.1016/j.cell.2020.03.038

PMCID:: PMC7243596

Article PDF–2.9M

Select item 56529452.

MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway

Zehang Zhuang, Fengchun Hu, Jing Hu, Cheng Wang, Jinsong Hou, Zhiqiang Yu, Tony T. Wang, Xiqiang Liu, Hongzhang Huang

Oncol Rep. 2017 Oct; 38(4): 2051–2061. Published online 2017 Aug 11. doi: 10.3892/or.2017.5899

PMCID:: PMC5652945

Article PDF–802K

Select item 31868383.

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

Emily A. Foley, Maria Maldonado, Tarun M. Kapoor

Nat Cell Biol. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: Nat Cell Biol. 2011 Oct; 13(10): 1265–1271. Published online 2011 Aug 28. doi: 10.1038/ncb2327

PMCID:: PMC3186838

Article PDF–1.9M

Select item 30407164.

Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage

Alyson K. Freeman, Virna Dapic, Alvaro N.A. Monteiro

Cell Cycle. Author manuscript; available in PMC 2011 Feb 17.

Published in final edited form as: Cell Cycle. 2010 Feb 15; 9(4): 736–747. Published online 2010 Feb 12. doi: 10.4161/cc.9.4.10613

PMCID:: PMC3040716

Article PDF–868K

Select item 84846055.

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

Sara M. Ambjørn, Julien P. Duxin, Emil P. T. Hertz, Isha Nasa, Joana Duro, Thomas Kruse, Blanca Lopez-Mendez, Beata Rymarczyk, Lauren E. Cressey, Thomas van Overeem Hansen, Arminja N. Kettenbach, Vibe H. Oestergaard, Michael Lisby, Jakob Nilsson

Nat Commun. 2021; 12: 5748. Published online 2021 Sep 30. doi: 10.1038/s41467-021-26079-0

PMCID:: PMC8484605

Article PDF–2.2M

Select item 69033956.

HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

Daniel J. Salamango, Terumasa Ikeda, Seyed Arad Moghadasi, Jiayi Wang, Jennifer L. McCann, Artur A. Serebrenik, Diako Ebrahimi, Matthew C. Jarvis, William L. Brown, Reuben S. Harris

Cell Rep. Author manuscript; available in PMC 2019 Dec 10.

Published in final edited form as: Cell Rep. 2019 Oct 29; 29(5): 1057–1065.e4. doi: 10.1016/j.celrep.2019.09.057

PMCID:: PMC6903395

Article PDF–1.9M

Select item 67155877.

PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore

Richard J. Smith, Marilia H. Cordeiro, Norman E. Davey, Giulia Vallardi, Andrea Ciliberto, Fridolin Gross, Adrian T. Saurin

Cell Rep. 2019 Aug 20; 28(8): 2206–2219.e8. Published online 2019 Aug 20. doi: 10.1016/j.celrep.2019.07.067

PMCID:: PMC6715587

Article PDF–4.1M

Select item 50856078.

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

Edward JD Greenwood, Nicholas J Matheson, Kim Wals, Dick JH van den Boomen, Robin Antrobus, James C Williamson, Paul J Lehner

eLife. 2016; 5: e18296. Published online 2016 Sep 30. doi: 10.7554/eLife.18296

PMCID:: PMC5085607

Article PDF–4.0M

Select item 49307729.

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

Jiao Wang, Zhizhi Wang, Tingting Yu, Huan Yang, David M. Virshup, Geert J. P. L. Kops, Sang Hyun Lee, Weihong Zhou, Xin Li, Wenqing Xu, Zihe Rao

Protein Cell. 2016 Jul; 7(7): 516–526. Published online 2016 Jun 28. doi: 10.1007/s13238-016-0283-4

PMCID:: PMC4930772

Article PDF–3.9M

Select item 439872710.

Screening and identification of proteins interacting with nucleostemin

Hai-Xia Yang, Geng-Lin Jin, Ling Meng, Jian-Zhi Zhang, Wen-Bin Liu, Cheng-Chao Shou

World J Gastroenterol. 2005 Aug 21; 11(31): 4812–4814. Published online 2005 Aug 21. doi: 10.3748/wjg.v11.i31.4812

PMCID:: PMC4398727

Article PDF–353K

Select item 387954111.

Protein Phosphatase 2A Is Regulated by Protein Kinase Cα (PKCα)-dependent Phosphorylation of Its Targeting Subunit B56α at Ser⁴¹

Uwe Kirchhefer, Alexander Heinick, Simone König, Torsten Kristensen, Frank U. Müller, Matthias D. Seidl, Peter Boknik

J Biol Chem. 2014 Jan 3; 289(1): 163–176. Published online 2013 Nov 13. doi: 10.1074/jbc.M113.507996

PMCID:: PMC3879541

Article PDF–3.3M

Select item 288173812.

Nuclear Export and Centrosome Targeting of the Protein Phosphatase 2A Subunit B56α: ROLE OF B56α IN NUCLEAR EXPORT OF THE CATALYTIC SUBUNIT

Cameron P. Flegg, Manisha Sharma, Cahora Medina-Palazon, Cara Jamieson, Melanie Galea, Mariana G. Brocardo, Kate Mills, Beric R. Henderson

J Biol Chem. 2010 Jun 11; 285(24): 18144–18154. Published online 2010 Apr 8. doi: 10.1074/jbc.M109.093294

PMCID:: PMC2881738

Article PDF–2.8M

Select item 8597813.

The B56α Regulatory Subunit of Protein Phosphatase 2A Is a Target for Regulation by Double-Stranded RNA-Dependent Protein Kinase PKR

Zan Xu, Bryan R. G. Williams

Mol Cell Biol. 2000 Jul; 20(14): 5285–5299. doi: 10.1128/mcb.20.14.5285-5299.2000

PMCID:: PMC85978

Article PDF–4.2M

Select item 518020914.

Expanding the PP2A Interactome by Defining a B56-specific SLiM

Xinru Wang, Rakhi Bajaj, Mathieu Bollen, Wolfgang Peti, Rebecca Page

Structure. Author manuscript; available in PMC 2017 Dec 6.

Published in final edited form as: Structure. 2016 Dec 6; 24(12): 2174–2181. Published online 2016 Oct 27. doi: 10.1016/j.str.2016.09.010

PMCID:: PMC5180209

Article PDF–1.1M

Select item 299792015.

Over-expression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor

Nengwang Yu, James M. Kozlowski, Irwin I. Park, Lin Chen, Qiang Zhang, Danfeng Xu, Jennifer A. Doll, Susan E. Crawford, Charles B. Brendler, Chung Lee

Urology. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Urology. 2010 Dec; 76(6): 1519.e8–1519.e13. Published online 2010 Oct 27. doi: 10.1016/j.urology.2010.03.061

PMCID:: PMC2997920

Article PDF–759K

Select item 274596716.

The Bα and Bδ Regulatory Subunits of PP2A are Necessary for Assembly of the CaMKIV•PP2A Signaling Complex

Kelie M. Reece, Matthew D. Mazalouskasa, Brian E. Wadzinskia

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Sep 4.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Sep 4; 386(4): 582–587. Published online 2009 Jun 16. doi: 10.1016/j.bbrc.2009.06.062

PMCID:: PMC2745967

Article PDF–702K

Select item 260290017.

PKR Regulates B56α-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells

Vivian R. Ruvolo, Svitlana M. Kurinna, Kul B. Karanjeet, Todd F. Schuster, Alberto M. Martelli, James A. McCubrey, Peter P. Ruvolo

J Biol Chem. 2008 Dec 19; 283(51): 35474–35485. doi: 10.1074/jbc.M800951200

PMCID:: PMC2602900

Article PDF–658K

Select item 756561218.

Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling

Daniel J. Salamango, Jennifer L. McCann, Özlem Demir, Jordan T. Becker, Jiayi Wang, Jairam R. Lingappa, Nuri A. Temiz, William L. Brown, Rommie E. Amaro, Reuben S. Harris

J Virol. 2020 Nov; 94(21): e00631-20. Prepublished online 2020 Aug 26. Published online 2020 Oct 14. doi: 10.1128/JVI.00631-20

PMCID:: PMC7565612

Article PDF–3.0M

Select item 537663619.

The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific Dephosphorylation

Ryan J. Davis, Jherek Swanger, Bridget T. Hughes, Bruce E. Clurman

Mol Cell Biol. 2017 Apr 15; 37(8): e00657-16. Prepublished online 2017 Jan 30. Published online 2017 Mar 31. doi: 10.1128/MCB.00657-16

PMCID:: PMC5376636

Article PDF–1.7M

Select item 377095420.

PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7

Maud Martin, Ilse Geudens, Jonathan Bruyr, Michael Potente, Anouk Bleuart, Marielle Lebrun, Nicolas Simonis, Christophe Deroanne, Jean-Claude Twizere, Philippe Soubeyran, Paul Peixoto, Denis Mottet, Veerle Janssens, Wolf-Karsten Hofmann, Filip Claes, Peter Carmeliet, Richard Kettmann, Holger Gerhardt, Franck Dequiedt

EMBO J. 2013 Sep 11; 32(18): 2491–2503. Published online 2013 Aug 16. doi: 10.1038/emboj.2013.187

PMCID:: PMC3770954

Article PDF–1.7M

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