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To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling

Pegah Javadpour, Leila Dargahi, Abolhassan Ahmadiani, Rasoul Ghasemi

Cell Mol Life Sci. 2019 Jun; 76(12): 2277–2297. Published online 2019 Mar 14. doi: 10.1007/s00018-019-03063-y

PMCID:: PMC11105459

Abstract Article PDF–1.5M

Select item 110879502.

Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes

Franziska Wachter, Radosław P. Nowak, Scott Ficarro, Jarrod Marto, Eric S. Fischer

J Biol Chem. 2024 May; 300(5): 107268. Published online 2024 Apr 4. doi: 10.1016/j.jbc.2024.107268

PMCID:: PMC11087950

Abstract Article PDF–2.5M

Select item 93960603.

A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation

Jean-Marie Sontag, Diana Schuhmacher, Goce Taleski, Anthony Jordan, Sarah Khan, Alexander Hoffman, Rey J. Gomez, Matthew D. Mazalouskas, Steven K. Hanks, Benjamin W. Spiller, Estelle Sontag, Brian E. Wadzinski

J Biol Chem. 2022 Aug; 298(8): 102248. Published online 2022 Jul 9. doi: 10.1016/j.jbc.2022.102248

PMCID:: PMC9396060

Abstract Article PDF–2.7M

Select item 65142984.

Hypoxia modulates protein phosphatase 2A through HIF‐1α dependent and independent mechanisms in human aortic smooth muscle cells and ventricular cardiomyocytes

Ismail Suliman Elgenaidi, James Paul Spiers

Br J Pharmacol. 2019 Jun; 176(11): 1745–1763. Published online 2019 Apr 22. doi: 10.1111/bph.14648

PMCID:: PMC6514298

Abstract Article PDF–3.1M

Select item 62221355.

Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling

Yang Mi, Rajendra Kumar Gurumurthy, Piotr K. Zadora, Thomas F. Meyer, Cindrilla Chumduri

mBio. 2018 Nov-Dec; 9(6): e01465-18. Published online 2018 Nov 6. doi: 10.1128/mBio.01465-18

PMCID:: PMC6222135

Abstract Article PDF–3.1M

Select item 61723676.

Protein phosphatase 2A regulates the p38 signaling pathway to affect the migration of astrocytes

Lijun Zhang, Pengju Ma, Qingkai Guan, Lei Meng, Linlin Su, Lina Wang, Jianhua Zhao, Sibei Ji

Mol Med Rep. 2018 Nov; 18(5): 4328–4334. Published online 2018 Aug 24. doi: 10.3892/mmr.2018.9425

PMCID:: PMC6172367

Abstract Article PDF–1.1M

Select item 59611177.

Protein phosphatase 2A inhibition enhances radiation sensitivity and reduces tumor growth in chordoma

Shuyu Hao, Hua Song, Wei Zhang, Ashlee Seldomridge, Jinkyu Jung, Amber J Giles, Marsha-Kay Hutchinson, Xiaoyu Cao, Nicole Colwell, Adrian Lita, Mioara Larion, Dragan Maric, Mones Abu-Asab, Martha Quezado, Tamalee Kramp, Kevin Camphausen, Zhengping Zhuang, Mark R Gilbert, Deric M Park

Neuro Oncol. 2018 May; 20(6): 799–809. Published online 2017 Dec 23. doi: 10.1093/neuonc/nox241

PMCID:: PMC5961117

Abstract Article PDF–825K

Select item 51616808.

Temporal Analysis of PP2A Phosphatase Activity During Insulin Stimulation Using a Direct Activity Probe

Jon R. Beck, Tiffany Truong, Cliff I. Stains

ACS Chem Biol. Author manuscript; available in PMC 2017 Dec 16.

Published in final edited form as: ACS Chem Biol. 2016 Dec 16; 11(12): 3284–3288. Published online 2016 Nov 7. doi: 10.1021/acschembio.6b00697

PMCID:: PMC5161680

Abstract Article PDF–816K

Select item 50044499.

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

Michael J. Cundell, Lukas H. Hutter, Ricardo Nunes Bastos, Elena Poser, James Holder, Shabaz Mohammed, Bela Novak, Francis A. Barr

J Cell Biol. 2016 Aug 29; 214(5): 539–554. doi: 10.1083/jcb.201606033

PMCID:: PMC5004449

Abstract Article PDF–3.9M

Select item 490557510.

PP2A as a master regulator of the cell cycle

Nathan Wlodarchak, Yongna Xing

Crit Rev Biochem Mol Biol. Author manuscript; available in PMC 2016 Jun 13.

Published in final edited form as: Crit Rev Biochem Mol Biol. 2016 May-Jun; 51(3): 162–184. Published online 2016 Feb 24. doi: 10.3109/10409238.2016.1143913

PMCID:: PMC4905575

Abstract Article PDF–1.9M

Select item 443495611.

Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin

Md. Mostafizur Rahman, Nowshin N. Rumzhum, Jonathan C. Morris, Andrew R. Clark, Nicole M. Verrills, Alaina J. Ammit

Sci Rep. 2015; 5: 10063. Published online 2015 May 18. doi: 10.1038/srep10063

PMCID:: PMC4434956

Abstract Article PDF–2.4M

Select item 411804612.

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length

Nana Naetar, Velmurugan Soundarapandian, Larisa Litovchick, Kelsey L. Goguen, Anna A. Sablina, Christian Bowman-Colin, Piotr Sicinski, William C. Hahn, James A. DeCaprio, David M. Livingston

Mol Cell. Author manuscript; available in PMC 2015 Jun 19.

Published in final edited form as: Mol Cell. 2014 Jun 19; 54(6): 932–945. Published online 2014 May 22. doi: 10.1016/j.molcel.2014.04.023

PMCID:: PMC4118046

Abstract Article PDF–1.8M

Select item 391590313.

Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone

Feng Guo, Vitali Stanevich, Nathan Wlodarchak, Rituparna Sengupta, Li Jiang, Kenneth A Satyshur, Yongna Xing

Cell Res. 2014 Feb; 24(2): 190–203. Published online 2013 Oct 8. doi: 10.1038/cr.2013.138

PMCID:: PMC3915903

Abstract Article PDF–2.1M

Select item 382348514.

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

R Liu, X-W Zhou, H Tanila, C Bjorkdahl, J-Z Wang, Z-Z Guan, Y Cao, J-Å Gustafsson, B Winblad, J-J Pei

J Cell Mol Med. 2008 Jan; 12(1): 241–257. Published online 2008 Jan 19. doi: 10.1111/j.1582-4934.2008.00249.x

PMCID:: PMC3823485

Abstract Article PDF–1.6M

Select item 375879715.

Protein Phosphatase 2A Activity Is Required for Functional Adherent Junctions in Endothelial Cells

Anita Kása, István Czikora, Alexander D. Verin, Pál Gergely, Csilla Csortos

Microvasc Res. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Microvasc Res. 2013 Sep; 89: 86–94. Published online 2013 May 28. doi: 10.1016/j.mvr.2013.05.003

PMCID:: PMC3758797

Abstract Article PDF–3.5M

Select item 367477416.

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

Y Yan, PT Cao, PM Greer, ES Nagengast, RH Kolb, MC Mumby, KH Cowan

Oncogene. Author manuscript; available in PMC 2013 Jun 6.

Published in final edited form as: Oncogene. 2010 Jul 29; 29(30): 4317–4329. Published online 2010 May 24. doi: 10.1038/onc.2010.187

PMCID:: PMC3674774

Abstract Article PDF–1.9M

Select item 338824617.

Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress

K H Tay, L Jin, H-Y Tseng, C C Jiang, Y Ye, R F Thorne, T Liu, S T Guo, N M Verrills, P Hersey, X D Zhang

Cell Death Dis. 2012 Jun; 3(6): e337. Published online 2012 Jun 28. doi: 10.1038/cddis.2012.79

PMCID:: PMC3388246

Abstract Article PDF–720K

Select item 335800918.

PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing

R Zimmerman, D-J Peng, H Lanz, Y-H Zhang, A Danen-Van Oorschot, S Qu, C Backendorf, M Noteborn

Cell Death Dis. 2012 Apr; 3(4): e291. Published online 2012 Apr 5. doi: 10.1038/cddis.2012.31

PMCID:: PMC3358009

Abstract Article PDF–499K

Select item 325619619.

Protein Phosphatase 2A Mediates Dormancy of Glioblastoma Multiforme-Derived Tumor Stem-Like Cells during Hypoxia

Christoph P. Hofstetter, Jan-Karl Burkhardt, Benjamin J. Shin, Demirkan B. Gürsel, Lynn Mubita, Ramana Gorrepati, Cameron Brennan, Eric C. Holland, John A. Boockvar

PLoS One. 2012; 7(1): e30059. Published online 2012 Jan 11. doi: 10.1371/journal.pone.0030059

PMCID:: PMC3256196

Abstract Article PDF–579K

Select item 274890620.

Raf-independent, PP2A-dependent MEK Activation in Response to ERK Silencing

Dongsoon Bae, Susan Ceryak

Biochem Biophys Res Commun. Author manuscript; available in PMC 2010 Aug 7.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Aug 7; 385(4): 523–527. Published online 2009 May 22. doi: 10.1016/j.bbrc.2009.05.082

PMCID:: PMC2748906

Abstract Article PDF–1.1M

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PMC Links for Gene (Select 5524) (142)
PMC
PREDICTED: Homo sapiens protein phosphatase 2 phosphatase activator (PTPA), tran...
PREDICTED: Homo sapiens protein phosphatase 2 phosphatase activator (PTPA), transcript variant X3, mRNA
gi|2217377700|ref|XM_011518836.3|

Nucleotide
serine/threonine-protein phosphatase 2A activator isoform a [Homo sapiens]
serine/threonine-protein phosphatase 2A activator isoform a [Homo sapiens]
gi|30065645|ref|NP_821068.1|

Protein

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