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Select item 105312061.

Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype–Phenotype Analysis in Neurodevelopmentally Delayed Patients

Yanyan Qian, Yinmo Jiang, Ji Wang, Gang Li, Bingbing Wu, Yuanfeng Zhou, Xiu Xu, Huijun Wang

Genes (Basel) 2023 Sep; 14(9): 1750. Published online 2023 Sep 1. doi: 10.3390/genes14091750

PMCID:: PMC10531206

Article PDF–1.7M

Select item 78620672.

The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction

Lisa Lenaerts, Sara Reynhout, Iris Verbinnen, Frédéric Laumonnier, Annick Toutain, Frédérique Bonnet-Brilhault, Yana Hoorne, Shelagh Joss, Anna K. Chassevent, Constance Smith-Hicks, Bart Loeys, Pascal Joset, Katharina Steindl, Anita Rauch, Sarju G. Mehta, Wendy K. Chung, Koenraad Devriendt, Susan E. Holder, Tamison Jewett, Lauren M. Baldwin, William G. Wilson, Shelley Towner, Siddharth Srivastava, Hannah F. Johnson, Cornelia Daumer-Haas, Martina Baethmann, Anna Ruiz, Elisabeth Gabau, Vani Jain, Vinod Varghese, Ali Al-Beshri, Stephen Fulton, Oded Wechsberg, Naama Orenstein, Katrina Prescott, Anne-Marie Childs, Laurence Faivre, Sébastien Moutton, Jennifer A. Sullivan, Vandana Shashi, Suzanne M. Koudijs, Malou Heijligers, Emma Kivuva, Amy McTague, Alison Male, Yvette van Ierland, Barbara Plecko, Isabelle Maystadt, Rizwan Hamid, Vickie L. Hannig, Gunnar Houge, Veerle Janssens

Genet Med. 2021; 23(2): 352–362. Published online 2020 Oct 27. doi: 10.1038/s41436-020-00981-2

PMCID:: PMC7862067

Article PDF–1014K

Select item 69804873.

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

Caitlin M. O’Connor, Daniel Leonard, Danica Wiredja, Rita A. Avelar, Zhizhi Wang, Daniela Schlatzer, Benjamin Bryson, Eesha Tokala, Sarah E. Taylor, Aditya Upadhyay, Jaya Sangodkar, Anne-Claude Gingras, Jukka Westermarck, Wenqing Xu, Analisa DiFeo, David L. Brautigan, Shozeb Haider, Mark Jackson, Goutham Narla

Oncogene. Author manuscript; available in PMC 2020 Mar 20.

Published in final edited form as: Oncogene. 2020 Jan; 39(3): 703–717. Published online 2019 Sep 20. doi: 10.1038/s41388-019-1012-2

PMCID:: PMC6980487

Article PDF–2.0M

Select item 48953474.

Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway

Ae Lee Jeong, Sora Han, Sunyi Lee, Jeong Su Park, Yiling Lu, Shuangxing Yu, Jane Li, Kyung-Hee Chun, Gordon B. Mills, Young Yang

Sci Rep. 2016; 6: 27391. Published online 2016 Jun 7. doi: 10.1038/srep27391

PMCID:: PMC4895347

Article PDF–1.6M

Select item 42567165.

Multiple intermediates on the energy landscape of a 15-HEAT-repeat protein

Maksym Tsytlonok, Patricio O. Craig, Elin Sivertsson, David Serquera, Sarah Perrett, Robert B. Best, Peter G. Wolynes, Laura S. Itzhaki

Structure. Author manuscript; available in PMC 2014 Dec 5.

Published in final edited form as: Structure. 2013 Nov 5; 21(11): 1954–1965. Published online 2013 Oct 10. doi: 10.1016/j.str.2013.08.028

PMCID:: PMC4256716

Article PDF–2.7M

Select item 40587156.

Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiation

Tsung-I Chen, Hung-Wen Chiu, Yi-Chung Pan, Shih-Ting Hsu, Jian-Hong Lin, Kun-Ta Yang

J Biomed Sci. 2014; 21(1): 46. Published online 2014 May 16. doi: 10.1186/1423-0127-21-46

PMCID:: PMC4058715

Article PDF–2.0M

Select item 36120497.

Role of a Novel Functional Variant in the PPP2R1A Promoter on the Regulation of PP2A-Aalpha and the Risk of Hepatocellular Carcinoma

Hui-Feng Chen, Jian-Rong Mai, Jian-Xin Wan, Yan-fang Gao, Li-Na Lin, Song-Zi Wang, Yu-Xi Chen, Chen-Zi Zhang, Yu-Jing Zhang, Bin Xia, Kun Liao, Yu-Chun Lin, Zhong-Ning Lin

PLoS One. 2013; 8(3): e59574. Published online 2013 Mar 29. doi: 10.1371/journal.pone.0059574

PMCID:: PMC3612049

Article PDF–607K

Select item 30784498.

Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas

Ie-Ming Shih, Pradeep K. Panuganti, Kuan-Tin Kuo, Tsui-Lien Mao, Elisabetta Kuhn, Sian Jones, Victor E. Velculescu, Robert J. Kurman, Tian-Li Wang

Am J Pathol. 2011 Apr; 178(4): 1442–1447. doi: 10.1016/j.ajpath.2011.01.009

PMCID:: PMC3078449

Article PDF–704K

Select item 2983499.

Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein.

G Walter, F Ferre, O Espiritu, A Carbone-Wiley

Proc Natl Acad Sci U S A. 1989 Nov; 86(22): 8669–8672. doi: 10.1073/pnas.86.22.8669

PMCID:: PMC298349

Summary Page Browse PDF–935K

Select item 23627110.

Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens.

R Ruediger, M Hentz, J Fait, M Mumby, G Walter

J Virol. 1994 Jan; 68(1): 123–129. doi: 10.1128/jvi.68.1.123-129.1994

PMCID:: PMC236271

Summary Page Browse PDF–1.9M

Select item 5372111.

Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

G Walter, R Ruediger, C Slaughter, M Mumby

Proc Natl Acad Sci U S A. 1990 Apr; 87(7): 2521–2525. doi: 10.1073/pnas.87.7.2521

PMCID:: PMC53721

Summary Page Browse PDF–1.1M

Select item 885703312.

Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma

Caitlin M. O’Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla

Cancer Res. Author manuscript; available in PMC 2022 Aug 15.

Published in final edited form as: Cancer Res. 2022 Feb 15; 82(4): 721–733. doi: 10.1158/0008-5472.CAN-21-1987

PMCID:: PMC8857033

Article PDF–2.3M

Select item 565376013.

Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex

Susann Schweiger, Frank Matthes, Karen Posey, Eva Kickstein, Stephanie Weber, Moritz M. Hettich, Sandra Pfurtscheller, Dan Ehninger, Rainer Schneider, Sybille Krauß

Sci Rep. 2017; 7: 13753. Published online 2017 Oct 23. doi: 10.1038/s41598-017-12974-4

PMCID:: PMC5653760

Article PDF–2.6M

Select item 543165414.

Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression

Yang Liu, Zhong Zhang, Hui Liang, Xuyang Zhao, Ling Liang, Guangxi Wang, Jingyi Yang, Yan Jin, Michael A. McNutt, Yuxin Yin

Sci Rep. 2017; 7: 1630. Published online 2017 May 9. doi: 10.1038/s41598-017-01915-w

PMCID:: PMC5431654

Article PDF–2.1M

Select item 389737915.

PR65A Phosphorylation Regulates PP2A Complex Signaling

Kumar Kotlo, Yongna Xing, Sonia Lather, Jean Michel Grillon, Keven Johnson, Randal A. Skidgel, R. John Solaro, Robert S. Danziger

PLoS One. 2014; 9(1): e85000. Published online 2014 Jan 21. doi: 10.1371/journal.pone.0085000

PMCID:: PMC3897379

Article PDF–1.6M

Select item 381221216.

Functional Genetic Polymorphisms in PP2A Subunit Genes Confer Increased Risks of Lung Cancer in Southern and Eastern Chinese

Rongrong Yang, Lei Yang, Fuman Qiu, Lisha Zhang, Hui Wang, Xiaorong Yang, Jieqiong Deng, Wenxiang Fang, Yifeng Zhou, Jiachun Lu

PLoS One. 2013; 8(10): e77285. Published online 2013 Oct 29. doi: 10.1371/journal.pone.0077285

PMCID:: PMC3812212

Article PDF–219K

Select item 307689417.

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

Siân Jones, Tian-Li Wang, Ie-Ming Shih, Tsui-Lien Mao, Kentaro Nakayama, Richard Roden, Ruth Glas, Dennis Slamon, Luis A. Diaz, Jr, Bert Vogelstein, Kenneth W. Kinzler, Victor E. Velculescu, Nickolas Papadopoulos

Science. Author manuscript; available in PMC 2011 Apr 14.

Published in final edited form as: Science. 2010 Oct 8; 330(6001): 228–231. Published online 2010 Sep 8. doi: 10.1126/science.1196333

PMCID:: PMC3076894

Article PDF–598K

Select item 194933318.

Identification of the PP2A-interacting region of heat shock transcription factor 2

Hongyan Xing, Yiling Hong, Kevin D. Sarge

Cell Stress Chaperones. 2007 Jun; 12(2): 192–197. doi: 10.1379/CSC-249R.1

PMCID:: PMC1949333

Article PDF–358K

Select item 501714519.

A subset of RAB proteins modulates PP2A phosphatase activity

Francesca Sacco, Anna Mattioni, Karsten Boldt, Simona Panni, Elena Santonico, Luisa Castagnoli, Marius Ueffing, Gianni Cesareni

Sci Rep. 2016; 6: 32857. Published online 2016 Sep 9. doi: 10.1038/srep32857

PMCID:: PMC5017145

Article PDF–2.0M

Select item 496327120.

The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis

William J. Gibson, Erling A. Hoivik, Mari K. Halle, Amaro Taylor-Weiner, Andrew D. Cherniack, Anna Berg, Frederik Holst, Travis I. Zack, Henrica M. J. Werner, Kjersti M. Staby, Mara Rosenberg, Ingunn M. Stefansson, Kanthida Kusonmano, Aaron Chevalier, Karen K. Mauland, Jone Trovik, Camilla Krakstad, Marios Giannakis, Eran Hodis, Kathrine Woie, Line Bjorge, Olav K. Vintermyr, Jeremiah A. Wala, Michael S. Lawrence, Gad Getz, Scott L. Carter, Rameen Beroukhim, Helga B. Salvesen

Nat Genet. Author manuscript; available in PMC 2016 Dec 27.

Published in final edited form as: Nat Genet. 2016 Aug; 48(8): 848–855. Published online 2016 Jun 27. doi: 10.1038/ng.3602

PMCID:: PMC4963271

Article PDF–1.8M

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