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Select item 99851381.

Mediator subunit MED1 differentially modulates mutant thyroid hormone receptor intracellular dynamics in Resistance to Thyroid Hormone syndrome

Moyao Wang, Vincent R. Roggero, Lizabeth A. Allison

Mol Cell Endocrinol. Author manuscript; available in PMC 2023 Mar 4.

Published in final edited form as: Mol Cell Endocrinol. 2023 Jan 1; 559: 111781. Published online 2022 Oct 1. doi: 10.1016/j.mce.2022.111781

PMCID:: PMC9985138

Abstract Article PDF–1.7M

Select item 90714942.

Phosphorylated MED1 links transcription recycling and cancer growth

Zhong Chen, Zhenqing Ye, Raymond E Soccio, Tomoyoshi Nakadai, William Hankey, Yue Zhao, Furong Huang, Fuwen Yuan, Hongyan Wang, Zhifen Cui, Benjamin Sunkel, Dayong Wu, Richard K Dzeng, Jennifer M Thomas-Ahner, Tim H M Huang, Steven K Clinton, Jiaoti Huang, Mitchell A Lazar, Victor X Jin, Robert G Roeder, Qianben Wang

Nucleic Acids Res. 2022 May 6; 50(8): 4450–4463. Published online 2022 Apr 8. doi: 10.1093/nar/gkac246

PMCID:: PMC9071494

Abstract Article PDF–4.7M

Select item 88069163.

Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure

Jinwei Guo, Zhixiang Zhang, Jincan Zhu

Bioengineered. 2021; 12(1): 7600–7615. Published online 2021 Oct 6. doi: 10.1080/21655979.2021.1981756

PMCID:: PMC8806916

Abstract Article PDF–2.8M

Select item 80179274.

Mediator subunit MED1 is required for E2A-PBX1–mediated oncogenic transcription and leukemic cell growth

Yu-Ling Lee, Keiichi Ito, Wen-Chieh Pi, I-Hsuan Lin, Chi-Shuen Chu, Sohail Malik, I-Hsin Cheng, Wei-Yi Chen, Robert G. Roeder

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e1922864118. Published online 2021 Feb 4. doi: 10.1073/pnas.1922864118

PMCID:: PMC8017927

Abstract Article PDF–2.9M

Select item 66199215.

PML–RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1

Tomoya Fukuoka, Asami Kawai, Taku Takahara, Mahiro Mori, Robert G. Roeder, Natsumi Hasegawa, Mitsuhiro Ito

Transcription. 2019; 10(3): 147–156. Published online 2019 Jun 5. doi: 10.1080/21541264.2019.1624467

PMCID:: PMC6619921

Abstract Article PDF–1.7M

Select item 65682276.

Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer

Marissa Leonard, Xiaoting Zhang

J Zhejiang Univ Sci B. 2019 May; 20(5): 381–390. doi: 10.1631/jzus.B1900163

PMCID:: PMC6568227

Abstract Article PDF–1.1M

Select item 60814507.

Essential role of MED1 in the transcriptional regulation of ER-dependent oncogenic miRNAs in breast cancer

Neha Nagpal, Shivani Sharma, Sourobh Maji, Giorgio Durante, Manuela Ferracin, Jitendra K. Thakur, Ritu Kulshreshtha

Sci Rep. 2018; 8: 11805. Published online 2018 Aug 7. doi: 10.1038/s41598-018-29546-9

PMCID:: PMC6081450

Abstract Article PDF–2.7M

Select item 43815958.

MED1 mediates androgen receptor splice variant induced gene expression in the absence of ligand

Gang Liu, Cynthia Sprenger, Pin-Jou Wu, Shihua Sun, Takuma Uo, Kathleen Haugk, Kathryn Soriano Epilepsia, Stephen Plymate

Oncotarget. 2015 Jan; 6(1): 288–304. Published online 2014 Dec 3. doi: 10.18632/oncotarget.2672

PMCID:: PMC4381595

Abstract Article PDF–4.2M

Select item 37283229.

Silencing MED1 Sensitizes Breast Cancer Cells to Pure Anti-Estrogen Fulvestrant In Vitro and In Vivo

Lijiang Zhang, Jiajun Cui, Marissa Leonard, Kenneth Nephew, Yongquan Li, Xiaoting Zhang

PLoS One. 2013; 8(7): e70641. Published online 2013 Jul 30. doi: 10.1371/journal.pone.0070641

PMCID:: PMC3728322

Abstract Article PDF–1.6M

Select item 357933810.

Vitamin D Receptor Fok-I Polymorphism Modulates Diabetic Host Response to Vitamin D Intake: Need for a nutrigenetic approach

Tirang R. Neyestani, Abolghassem Djazayery, Sakineh Shab-Bidar, Mohammad Reza Eshraghian, Ali Kalayi, Nastaran Shariátzadeh, Niloufar Khalaji, Malihe Zahedirad, A’zam Gharavi, Anahita Houshiarrad, Maryam Chamari, Sepideh Asadzadeh

Diabetes Care. 2013 Mar; 36(3): 550–556. Published online 2013 Feb 13. doi: 10.2337/dc12-0919

PMCID:: PMC3579338

Abstract Article PDF–143K

Select item 268389911.

Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer

J. Harrison Howard, Andrey Frolov, Ching-Wei D. Tzeng, Ashley Stewart, Andrew Midzak, Amar Majmundar, Andrew K. Godwin, Martin J. Heslin, Alfonso Bellacosa, J. Pablo Arnoletti

Cancer Biol Ther. Author manuscript; available in PMC 2010 Jan 1.

Published in final edited form as: Cancer Biol Ther. 2009 Jan; 8(1): 1–7. Published online 2009 Jan 20. doi: 10.4161/cbt.8.1.7469

PMCID:: PMC2683899

Abstract Article PDF–597K

Select item 1797112.

Amplification and overexpression of peroxisome proliferatoractivated receptor binding protein (PBP/PPARBP) gene in breast cancer

Yijun Zhu, Chao Qi, Sanjay Jain, Michelle M. Le Beau, Rafael Espinosa, III, G. Brandon Atkins, Mitchell A. Lazar, Anjana V. Yeldandi, M. Sambasiva Rao, Janardan K. Reddy

Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19): 10848–10853. doi: 10.1073/pnas.96.19.10848

PMCID:: PMC17971

Abstract Article PDF–266K

Select item 1098304213.

Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation

Shuvam M. Chaudhuri, Samuel E. Weinberg, Dongmei Wang, Lenore K. Yalom, Elena Montauti, Radhika Iyer, Amy Y. Tang, Manuel A. Torres Acosta, Jian Shen, Nikita L. Mani, Shengnan Wang, Kun Liu, Weiyuan Lu, Triet M. Bui, Laura D. Manzanares, Zeinab Dehghani, Ching Man Wai, Beixue Gao, Juncheng Wei, Feng Yue, Weiguo Cui, Benjamin D. Singer, Ronen Sumagin, Yana Zhang, Deyu Fang

Cell Rep Med. 2024 Mar 19; 5(3): 101441. Published online 2024 Feb 29. doi: 10.1016/j.xcrm.2024.101441

PMCID:: PMC10983042

Abstract Article PDF–8.5M

Select item 841899414.

Structural Mechanism Underlying Ligand Binding and Activation of PPARγ

Jinsai Shang, Douglas J. Kojetin

Structure. Author manuscript; available in PMC 2022 Sep 2.

Published in final edited form as: Structure. 2021 Sep 2; 29(9): 940–950.e4. Published online 2021 Mar 12. doi: 10.1016/j.str.2021.02.006

PMCID:: PMC8418994

Abstract Article PDF–2.3M

Select item 745651915.

Mediator Subunit MED1 Modulates Intranuclear Dynamics of the Thyroid Hormone Receptor

Matthew R. Femia, Rochelle M. Evans, Jibo Zhang, Xiaopeng Sun, Caroline J. Lebegue, Vincent R. Roggero, Lizabeth A. Allison

J Cell Biochem. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: J Cell Biochem. 2020 Apr; 121(4): 2909–2926. Published online 2019 Nov 6. doi: 10.1002/jcb.29532

PMCID:: PMC7456519

Abstract Article PDF–1.8M

Select item 685907016.

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage response factors

Fabio Pessina, Fabio Giavazzi, Yandong Yin, Ubaldo Gioia, Valerio Vitelli, Alessandro Galbiati, Sara Barozzi, Massimiliano Garre, Amanda Oldani, Andrew Flaus, Roberto Cerbino, Dario Parazzoli, Eli Rothenberg, Fabrizio d’Adda di Fagagna

Nat Cell Biol. Author manuscript; available in PMC 2020 Mar 30.

Published in final edited form as: Nat Cell Biol. 2019 Oct; 21(10): 1286–1299. Published online 2019 Sep 30. doi: 10.1038/s41556-019-0392-4