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Items: 1 to 20 of 38

1.
Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity, confirming the gene’s candidacy in 6q16.1 deletions
Ria Schönauer, Wenjun Jin, Christin Findeisen, Irene Valenzuela, Laura Alice Devlin, Jill Murrell, Emma C. Bedoukian, Linda Pöschla, Elena Hantmann, Korbinian M. Riedhammer, Julia Hoefele, Konrad Platzer, Ronald Biemann, Philipp M. Campeau, Johannes Münch, Henrike Heyne, Anne Hoffmann, Adhideb Ghosh, Wenfei Sun, Hua Dong, Falko Noé, Christian Wolfrum, Emily Woods, Michael J. Parker, Ruxandra Neatu, Gwenael Le Guyader, Ange-Line Bruel, Laurence Perrin, Helena Spiewak, Genomics England Research Consortium, Isabelle Missotte, Melanie Fourgeaud, Vincent Michaud, Didier Lacombe, Sarah A. Paolucci, Jillian G. Buchan, Margaret Glissmeyer, Bernt Popp, Matthias Blüher, John A. Sayer, Jan Halbritter
Am J Hum Genet. 2023 Jun 1; 110(6): 998–1007. Published online 2023 May 18. doi: 10.1016/j.ajhg.2023.04.010
PMCID:
PMC10257002
AbstractArticlePDF–3.4M
2.
Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder
Kunling Huang, Yuchang Wu, Junha Shin, Ye Zheng, Alireza Fotuhi Siahpirani, Yupei Lin, Zheng Ni, Jiawen Chen, Jing You, Sunduz Keles, Daifeng Wang, Sushmita Roy, Qiongshi Lu
PLoS Genet. 2021 Feb; 17(2): e1009309. Published online 2021 Feb 4. doi: 10.1371/journal.pgen.1009309
PMCID:
PMC7888619
AbstractArticlePDF–2.7M
3.
POU3F2 is a regulator of a gene coexpression network in brain tissue from patients with neuropsychiatric disorders
Chao Chen, Qingtuan Meng, Yan Xia, Chaodong Ding, Le Wang, Rujia Dai, Lijun Cheng, Preethi Gunaratne, Richard A. Gibbs, Shishi Min, Cristian Coarfa, Jeffrey G. Reid, Chunling Zhang, Chuan Jiao, Yi Jiang, Gina Giase, Amber Thomas, Dominic Fitzgerald, Tonya Brunetti, Annie Shieh, Cuihua Xia, Yongjun Wang, Yunpeng Wang, Judith A. Badner, Elliot S. Gershon, Kevin P White, Chunyu Liu
Sci Transl Med. Author manuscript; available in PMC 2019 May 1.
Published in final edited form as: Sci Transl Med. 2018 Dec 19; 10(472): eaat8178. Published online 2018 Dec 13. doi: 10.1126/scitranslmed.aat8178
PMCID:
PMC6494100
AbstractArticlePDF–1.4M
4.
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
Katharine Herbert, Romuald Binet, Jean-Philippe Lambert, Pakavarin Louphrasitthiphol, Halime Kalkavan, Laura Sesma-Sanz, Carla Daniela Robles-Espinoza, Sovan Sarkar, Eda Suer, Sarah Andrews, Jagat Chauhan, Nicola D. Roberts, Mark R. Middleton, Anne-Claude Gingras, Jean-Yves Masson, Lionel Larue, Paola Falletta, Colin R. Goding
Genes Dev. 2019 Mar 1; 33(5-6): 310–332. doi: 10.1101/gad.314633.118
PMCID:
PMC6411009
AbstractArticlePDF–8.5M
5.
Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.
E Schreiber, K Harshman, I Kemler, U Malipiero, W Schaffner, A Fontana
Nucleic Acids Res. 1990 Sep 25; 18(18): 5495–5503. doi: 10.1093/nar/18.18.5495
PMCID:
PMC332229
SummaryPage BrowsePDF–2.5M
6.
cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif.
E Schreiber, A Tobler, U Malipiero, W Schaffner, A Fontana
Nucleic Acids Res. 1993 Jan 25; 21(2): 253–258. doi: 10.1093/nar/21.2.253
PMCID:
PMC309100
SummaryPage BrowsePDF–1.6M
7.
CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury
Yanbing Kao, Hanming Zhu, Yu Yang, Wenyuan Shen, Wei Song, Renjie Zhang, Yanchun Liu, Haoyun Liu, Xiaohong Kong
Cells. 2024 Jan; 13(1): 67. Published online 2023 Dec 28. doi: 10.3390/cells13010067
PMCID:
PMC10778540
AbstractArticlePDF–9.8M
8.
Transcription factor POU3F2 regulates TRIM8 expression contributing to cellular functions implicated in schizophrenia
Chaodong Ding, Chunling Zhang, Richard Kopp, Liz Kuney, Qingtuan Meng, Le Wang, Yan Xia, Yi Jiang, Rujia Dai, Shishi Min, Wei-Dong Yao, Ma-Li Wong, Hongyu Ruan, Chunyu Liu, Chao Chen
Mol Psychiatry. Author manuscript; available in PMC 2021 Oct 13.
Published in final edited form as: Mol Psychiatry. 2021 Jul; 26(7): 3444–3460. Published online 2020 Sep 14. doi: 10.1038/s41380-020-00877-2
PMCID:
PMC7956165
AbstractArticlePDF–1.5M
9.
Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma
Takashi Sato, Seungyeul Yoo, Ranran Kong, Abhilasha Sinha, Prashanth Chandramani-Shivalingappa, Ayushi Patel, Maya Fridrikh, Osamu Nagano, Takashi Masuko, Mary Beth Beasley, Charles A. Powell, Jun Zhu, Hideo Watanabe
Cancer Res. Author manuscript; available in PMC 2020 Jun 15.
Published in final edited form as: Cancer Res. 2019 Dec 15; 79(24): 6084–6100. Published online 2019 Sep 24. doi: 10.1158/0008-5472.CAN-19-2132
PMCID:
PMC6911633
AbstractArticlePDF–4.0M
10.
BRN4 is a novel driver of neuroendocrine differentiation in castration-resistant prostate cancer and is selectively released in extracellular vesicles with BRN2
Divya Bhagirath, Thao Ly Yang, Z Laura Tabatabai, Shahana Majid, Rajvir Dahiya, Yuichiro Tanaka, Sharanjot Saini
Clin Cancer Res. Author manuscript; available in PMC 2020 May 1.
Published in final edited form as: Clin Cancer Res. 2019 Nov 1; 25(21): 6532–6545. Published online 2019 Aug 1. doi: 10.1158/1078-0432.CCR-19-0498
PMCID:
PMC6825556
AbstractArticlePDF–924K
11.
Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2
Hung Yen Chen, Yi Hui Lee, Huei Yu Chen, Chia An Yeh, Pin Ju Chueh, Yi-Mei J. Lin
Molecules. 2016 Jun; 21(6): 733. Published online 2016 Jun 4. doi: 10.3390/molecules21060733
PMCID:
PMC6273514
AbstractArticlePDF–4.9M
12.
Bi-allelic loss of CDKN2A initiates melanoma invasion via BRN2 activation
Hanlin Zeng, Aparna Jorapur, A. Hunter Shain, Ursula E. Lang, Rodrigo Torres, Yuntian Zhang, Andrew S. McNeal, Thomas Botton, Jue Lin, Matthew Donne, Ingmar N. Bastian, Richard Yu, Jeffrey P. North, Laura Pincus, Beth S. Ruben, Nancy M Joseph, Iwei Yeh, Boris C. Bastian, Robert L. Judson
Cancer Cell. Author manuscript; available in PMC 2019 Jul 9.
Published in final edited form as: Cancer Cell. 2018 Jul 9; 34(1): 56–68.e9. doi: 10.1016/j.ccell.2018.05.014
PMCID:
PMC6084788
AbstractArticlePDF–3.1M
13.
MITF and BRN2 contribute to metastatic growth after dissemination of melanoma
Jacinta L. Simmons, Carly J. Pierce, Fares Al-Ejeh, Glen M. Boyle
Sci Rep. 2017; 7: 10909. Published online 2017 Sep 7. doi: 10.1038/s41598-017-11366-y
PMCID:
PMC5589904
AbstractArticlePDF–7.4M
14.
Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway
A.E. Thurber, G. Douglas, E.C. Sturm, S.E. Zabierowski, D.J. Smit, S.N. Ramakrishnan, E. Hacker, J.H. Leonard, M. Herlyn, R.A. Sturm
Oncogene. Author manuscript; available in PMC 2013 Mar 8.
Published in final edited form as: Oncogene. 2011 Jul 7; 30(27): 3036–3048. Published online 2011 Feb 28. doi: 10.1038/onc.2011.33
PMCID:
PMC3591523
AbstractArticlePDF–3.3M
15.
Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells
David Cobrinik, Richard O Francis, David H Abramson, Thomas C Lee
Mol Cancer. 2006; 5: 72. Published online 2006 Dec 12. doi: 10.1186/1476-4598-5-72
PMCID:
PMC1764425
AbstractArticlePDF–560K
16.
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
Wonyoung Choi, Mu Seog Choe, Su Min Kim, So Jin Kim, Jiyeon Lee, Yeongun Lee, Sun-Min Lee, So Hee Dho, Min-Young Lee, Lark Kyun Kim
Cell Mol Life Sci. 2024 Dec; 81(1): 99. Published online 2024 Feb 22. doi: 10.1007/s00018-024-05129-y
PMCID:
PMC10884155
AbstractArticlePDF–6.0M
17.
A Phosphatidylinositol 3-Kinase–Pax3 Axis Regulates Brn-2 Expression in Melanoma
Elise Bonvin, Paola Falletta, Heather Shaw, Veronique Delmas, Colin R. Goding
Mol Cell Biol. 2012 Nov; 32(22): 4674–4683. doi: 10.1128/MCB.01067-12
PMCID:
PMC3486186
AbstractArticlePDF–2.0M
18.
The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation
Jane Goodall, Claudia Wellbrock, Timothy J. Dexter, Karen Roberts, Richard Marais, Colin R. Goding
Mol Cell Biol. 2004 Apr; 24(7): 2923–2931. doi: 10.1128/MCB.24.7.2923-2931.2004
PMCID:
PMC371133
AbstractArticlePDF–288K
19.
BRN2 is a non-canonical melanoma tumor-suppressor
Michael Hamm, Pierre Sohier, Valérie Petit, Jérémy H. Raymond, Véronique Delmas, Madeleine Le Coz, Franck Gesbert, Colin Kenny, Zackie Aktary, Marie Pouteaux, Florian Rambow, Alain Sarasin, Nisamanee Charoenchon, Alfonso Bellacosa, Luis Sanchez-del-Campo, Laura Mosteo, Martin Lauss, Dies Meijer, Eirikur Steingrimsson, Göran B. Jönsson, Robert A. Cornell, Irwin Davidson, Colin R. Goding, Lionel Larue
Nat Commun. 2021; 12: 3707. Published online 2021 Jun 17. doi: 10.1038/s41467-021-23973-5
PMCID:
PMC8211827
AbstractArticlePDF–1.9M
20.
NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation
Yi-Mei J. Lin, I-Lun Hsin, H. Sunny Sun, Shankung Lin, Yen-Ling Lai, Hsuan-Ying Chen, Ting-Yu Chen, Ya-Ping Chen, Yi-Ting Shen, Hung-Ming Wu
Mol Neurobiol. 2018; 55(11): 8403–8413. Published online 2018 Mar 16. doi: 10.1007/s12035-018-0995-y
PMCID:
PMC6153716
AbstractArticlePDF–4.7M

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