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Items: 1 to 20 of 182

1.
Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
eLife. 2021; 10: e64691. Published online 2021 Mar 4. doi: 10.7554/eLife.64691
PMCID:
PMC7955810
AbstractArticlePDF–3.7M
2.
Quassinoid analogs with enhanced efficacy for treatment of hematologic malignancies target the PI3Kγ isoform
Yonggang Pei, Nicky Hwang, Fengchao Lang, Lanlan Zhou, Josiah Hiu-yuen Wong, Rajnish Kumar Singh, Hem Chandra Jha, Wafik S. El-Deiry, Yanming Du, Erle S. Robertson
Commun Biol. 2020; 3: 267. Published online 2020 May 27. doi: 10.1038/s42003-020-0996-z
PMCID:
PMC7253423
AbstractArticlePDF–3.9M
3.
PIK3CG single nucleotide polymorphisms are associated with poor responsiveness to clopidogrel and increased risk of ischemia in patients with coronary heart disease
Ke-Cheng Li, Shu-Hong Yu, Bao-Zhong Zhuge
Medicine (Baltimore) 2017 Sep; 96(36): e7566. Published online 2017 Sep 8. doi: 10.1097/MD.0000000000007566
PMCID:
PMC6392743
AbstractArticlePDF–366K
4.
Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers
Martin Kächele, Anita M. Hennige, Jürgen Machann, Anja Hieronimus, Apostolia Lamprinou, Fausto Machicao, Fritz Schick, Andreas Fritsche, Norbert Stefan, Bernd Nürnberg, Hans-Ulrich Häring, Harald Staiger
PLoS One. 2015; 10(12): e0144494. Published online 2015 Dec 10. doi: 10.1371/journal.pone.0144494
PMCID:
PMC4675530
AbstractArticlePDF–840K
5.
Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development
Adam M. Gustafson, Raffaella Soldi, Christina Anderlind, Mary Beth Scholand, Jun Qian, Xiaohui Zhang, Kendal Cooper, Darren Walker, Annette McWilliams, Gang Liu, Eva Szabo, Jerome Brody, Pierre P. Massion, Marc E. Lenburg, Stephen Lam, Andrea H. Bild, Avrum Spira
Sci Transl Med. Author manuscript; available in PMC 2013 Jun 27.
Published in final edited form as: Sci Transl Med. 2010 Apr 7; 2(26): 26ra25. doi: 10.1126/scitranslmed.3000251
PMCID:
PMC3694402
AbstractArticlePDF–2.6M
6.
Identification of upregulated phosphoinositide 3-kinase γ as a target to suppress breast cancer cell migration and invasion
Yan Xie, Peter W. Abel, Joseph K. Kirui, Caishu Deng, Poonam Sharma, Dennis W. Wolff, Myron L. Toews, Yaping Tu
Biochem Pharmacol. Author manuscript; available in PMC 2014 May 15.
Published in final edited form as: Biochem Pharmacol. 2013 May 15; 85(10): 1454–1462. Published online 2013 Mar 13. doi: 10.1016/j.bcp.2013.03.001
PMCID:
PMC3637857
AbstractArticlePDF–3.3M
7.
Phosphoinositide 3 kinase signalling may affect multiple steps during herpes simplex virus type-1 entry
Vaibhav Tiwari, Deepak Shukla
J Gen Virol. 2010 Dec; 91(Pt 12): 3002–3009. doi: 10.1099/vir.0.024166-0
PMCID:
PMC3052565
AbstractArticlePDF–465K
8.
Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells
Bernhard Kloo, Daniel Nagel, Matthias Pfeifer, Michael Grau, Michael Düwel, Michelle Vincendeau, Bernd Dörken, Peter Lenz, Georg Lenz, Daniel Krappmann
Proc Natl Acad Sci U S A. 2011 Jan 4; 108(1): 272–277. Published online 2010 Dec 20. doi: 10.1073/pnas.1008969108
PMCID:
PMC3017191
AbstractArticlePDF–835K
9.
mRNA Degradation Plays a Significant Role in the Program of Gene Expression Regulated by Phosphatidylinositol 3-Kinase Signaling
Julie R. Graham, Melissa C. Hendershott, Jolyon Terragni, Geoffrey M. Cooper
Mol Cell Biol. 2010 Nov; 30(22): 5295–5305. Published online 2010 Sep 20. doi: 10.1128/MCB.00303-10
PMCID:
PMC2976374
AbstractArticlePDF–589K
10.
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions
Marta M. Lipinski, Greg Hoffman, Aylwin Ng, Wen Zhou, Bénédicte F. Py, Emily Hsu, Xuxin Liu, Jason Eisenberg, Jun Liu, John Blenis, Ramnik J. Xavier, Junying Yuan
Dev Cell. Author manuscript; available in PMC 2011 Jun 15.
Published in final edited form as: Dev Cell. 2010 Jun 15; 18(6): 1041–1052. doi: 10.1016/j.devcel.2010.05.005
PMCID:
PMC2935848
AbstractArticlePDF–2.4M
11.
Distinct Patterns of DNA Damage Response and Apoptosis Correlate with Jak/Stat and PI3Kinase Response Profiles in Human Acute Myelogenous Leukemia
David B. Rosen, Santosh Putta, Todd Covey, Ying-Wen Huang, Garry P. Nolan, Alessandra Cesano, Mark D. Minden, Wendy J. Fantl
PLoS One. 2010; 5(8): e12405. Published online 2010 Aug 25. doi: 10.1371/journal.pone.0012405
PMCID:
PMC2928279
AbstractArticlePDF–1.4M
12.
Negative regulation of Vps34 by Cdk mediated phosphorylation
Tsuyoshi Furuya, Minsu Kim, Marta Lipinski, Juying Li, Dohoon Kim, Tao Lu, Yong Shen, Lucia Rameh, Bruce Yankner, Li-Huei Tsai, Junying Yuan
Mol Cell. Author manuscript; available in PMC 2011 May 28.
Published in final edited form as: Mol Cell. 2010 May 28; 38(4): 500–511. doi: 10.1016/j.molcel.2010.05.009
PMCID:
PMC2888511
AbstractArticlePDF–1.8M
13.
Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): differential interactions with the regulatory subunit p85 and with RAS
Li Zhao, Peter K. Vogt
Cell Cycle. Author manuscript; available in PMC 2011 Feb 1.
Published in final edited form as: Cell Cycle. 2010 Feb; 9(3): 596–600. doi: 10.4161/cc.9.3.10599
PMCID:
PMC2835815
AbstractArticlePDF–144K
14.
PI3-kinase dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation
Sam M. Janes, Tyler A. Ofstad, Douglas H. Campbell, Ayad Eddaoudi, Gary Warnes, Derek Davies, Fiona M. Watt
Cell Res. Author manuscript; available in PMC 2009 Sep 1.
Published in final edited form as: Cell Res. 2009 Mar; 19(3): 328–339. doi: 10.1038/cr.2008.281
PMCID:
PMC2650684
AbstractArticlePDF–2.9M
15.
Dysregulation of the Phosphatidylinositol 3-kinase Pathway in Thyroid Neoplasia
John E. Paes, Matthew D. Ringel
Endocrinol Metab Clin North Am. Author manuscript; available in PMC 2009 Jun 1.
Published in final edited form as: Endocrinol Metab Clin North Am. 2008 Jun; 37(2): 375–387. doi: 10.1016/j.ecl.2008.01.001
PMCID:
PMC2446602
AbstractArticlePDF–354K
16.
NMR characterizations of an amyloidogenic conformational ensemble of the PI3K SH3 domain
Hee-Chul Ahn, Yen T.H. Le, Partha S. Nagchowdhuri, Eugene F. DeRose, Cindy Putnam-Evans, Robert E. London, John L. Markley, Kwang Hun Lim
Protein Sci. 2006 Nov; 15(11): 2552–2557. doi: 10.1110/ps.062154306
PMCID:
PMC2242406
AbstractArticlePDF–364K
17.
Targeted Molecular Therapy of the PI3K Pathway: Therapeutic Significance of PI3K Subunit Targeting in Colorectal Carcinoma
Piotr G. Rychahou, Lindsey N. Jackson, Scott R. Silva, Srinivasan Rajaraman, B Mark Evers
Ann Surg. 2006 Jun; 243(6): 833–844. doi: 10.1097/01.sla.0000220040.66012.a9
PMCID:
PMC1570577
AbstractArticlePDF–2.0M
18.
Acanthamoeba castellanii Induces Host Cell Death via a Phosphatidylinositol 3-Kinase-Dependent Mechanism
James Sissons, Kwang Sik Kim, Monique Stins, Samantha Jayasekera, Selwa Alsam, Naveed Ahmed Khan
Infect Immun. 2005 May; 73(5): 2704–2708. doi: 10.1128/IAI.73.5.2704-2708.2005
PMCID:
PMC1087316
AbstractArticlePDF–105K
19.
v-Crk Activates the Phosphoinositide 3-Kinase/AKT Pathway by Utilizing Focal Adhesion Kinase and H-Ras
Tsuyoshi Akagi, Kazutaka Murata, Tomoyuki Shishido, Hidesaburo Hanafusa
Mol Cell Biol. 2002 Oct; 22(20): 7015–7023. doi: 10.1128/MCB.22.20.7015-7023.2002
PMCID:
PMC139810
AbstractArticlePDF–438K
20.
Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1
R. Azar, S. Najib, H. Lahlou, C. Susini, S. Pyronnet
Cell Mol Life Sci. 2008 Oct; 65(19): 3110–3117. Published online 2008 Sep 23. doi: 10.1007/s00018-008-8418-2
PMCID:
PMC11131698
AbstractArticlePDF–755K

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