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Items: 1 to 20 of 158

1.
Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome
Ashley Y. Gao, Ana M. Diaz Espinosa, Fiorenza Gianì, Tho X. Pham, Chase M. Carver, Aja Aravamudhan, Colleen M. Bartman, Giovanni Ligresti, Nunzia Caporarello, Marissa J. Schafer, Andrew J. Haak
Am J Physiol Lung Cell Mol Physiol. 2022 Dec 1; 323(6): L685–L697. Published online 2022 Oct 12. doi: 10.1152/ajplung.00023.2022
PMCID:
PMC9744654
AbstractArticle
2.
Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis
He Li, Lihui Xie, Lei Zhu, Zhaohuai Li, Rong Wang, Xiuxing Liu, Zhaohao Huang, Binyao Chen, Yuehan Gao, Lai Wei, Chang He, Rong Ju, Yizhi Liu, Xialin Liu, Yingfeng Zheng, Wenru Su
Nat Commun. 2022; 13: 5866. Published online 2022 Oct 4. doi: 10.1038/s41467-022-33502-7
PMCID:
PMC9532430
AbstractArticlePDF–6.1M
3.
PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest
Yangyang Yuan, Chenwei Wang, Xuran Zhuang, Shaofeng Lin, Miaomiao Luo, Wankun Deng, Jiaqi Zhou, Lihui Liu, Lina Mao, Wenbo Peng, Jian Chen, Qiangsong Wang, Yilai Shu, Yu Xue, Pengyu Huang
Nat Commun. 2022; 13: 5237. Published online 2022 Sep 6. doi: 10.1038/s41467-022-32976-9
PMCID:
PMC9448736
AbstractArticlePDF–3.9M
4.
Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy
Xavier León, Jacinto García, Albert Pujol, Julia de Juan, Rosselin Vásquez, Miquel Quer, Mercedes Camacho
Eur Arch Otorhinolaryngol. 2022; 279(7): 3679–3684. Published online 2022 Jan 6. doi: 10.1007/s00405-021-07223-4
PMCID:
PMC9130163
AbstractArticlePDF–466K
5.
PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity
Fanghang Zhou, Qianya Wan, Ying Chen, Sheng Chen, Ming-liang He
Signal Transduct Target Ther. 2021; 6: 207. Published online 2021 Jun 2. doi: 10.1038/s41392-021-00539-x
PMCID:
PMC8169747
ArticlePDF–970K
6.
PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma
Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D. Willey, Elizabeth A. Beierle
Sci Rep. 2021; 11: 5984. Published online 2021 Mar 16. doi: 10.1038/s41598-021-85289-0
PMCID:
PMC7966748
AbstractArticlePDF–2.4M
7.
Coexistence of two quadruplex–duplex hybrids in the PIM1 gene
Derrick J Y Tan, Fernaldo Richtia Winnerdy, Kah Wai Lim, Anh Tuân Phan
Nucleic Acids Res. 2020 Nov 4; 48(19): 11162–11171. Published online 2020 Sep 25. doi: 10.1093/nar/gkaa752
PMCID:
PMC7641742
AbstractArticlePDF–5.9M
8.
PIM Kinases Alter Mitochondrial Dynamics and Chemosensitivity in Lung Cancer
Shailender S. Chauhan, Rachel K. Toth, Corbin C. Jensen, Andrea L. Casillas, David F. Kashatus, Noel A. Warfel
Oncogene. Author manuscript; available in PMC 2020 Oct 9.
Published in final edited form as: Oncogene. 2020 Mar; 39(12): 2597–2611. Published online 2020 Jan 28. doi: 10.1038/s41388-020-1168-9
PMCID:
PMC7545584
AbstractArticlePDF–1.2M
9.
Virtual Screening and Design with Machine Intelligence Applied to Pim‐1 Kinase Inhibitors
Dr. Petra Schneider, Dr. Martin Welin, Dr. Bo Svensson, Dr. Björn Walse, Prof. Dr. Gisbert Schneider
Mol Inform. 2020 Sep; 39(9): 2000109. Published online 2020 Jul 9. doi: 10.1002/minf.202000109
PMCID:
PMC7539333
AbstractArticlePDF–3.2M
10.
Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma
Tatevik R. Broutian, Bo Jiang, Jingfeng Li, Keiko Akagi, Shanying Gui, Zhengqiu Zhou, Weihong Xiao, David E. Symer, Maura L. Gillison
Cancer Lett. Author manuscript; available in PMC 2020 May 21.
Published in final edited form as: Cancer Lett. 2020 Apr 28; 476: 23–33. Published online 2020 Jan 17. doi: 10.1016/j.canlet.2020.01.012
PMCID:
PMC7239795
AbstractArticlePDF–712K
11.
PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer
Sabina Luszczak, Christopher Kumar, Vignesh Krishna Sathyadevan, Benjamin S. Simpson, Kathy A. Gately, Hayley C. Whitaker, Susan Heavey
Signal Transduct Target Ther. 2020; 5: 7. Published online 2020 Jan 31. doi: 10.1038/s41392-020-0109-y
PMCID:
PMC6992635
AbstractArticlePDF–1.0M
12.
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Nat Commun. 2019; 10: 5428. Published online 2019 Nov 28. doi: 10.1038/s41467-019-13315-x
PMCID:
PMC6883072
AbstractArticlePDF–1.7M
13.
PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation
Xueqiang Gao, Xiangping Liu, Yangyong Lu, Yu Wang, Weihong Cao, Xiaoyi Liu, Haiyan Hu, Haibo Wang
Breast Cancer. 2019; 26(5): 663–671. Published online 2019 Apr 15. doi: 10.1007/s12282-019-00966-3
PMCID:
PMC6694096
AbstractArticlePDF–7.3M
14.
Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect
Meng Zhang, Tingting Liu, Hui Sun, Weiwei Weng, Qiongyan Zhang, Chenchen Liu, Yang Han, Weiqi Sheng
Cancer Sci. 2018 May; 109(5): 1468–1479. Published online 2018 Apr 10. doi: 10.1111/cas.13562
PMCID:
PMC5980151
AbstractArticlePDF–2.3M
15.
AZD1208, a pan‐Pim kinase inhibitor, inhibits adipogenesis and induces lipolysis in 3T3‐L1 adipocytes
Yu‐Kyoung Park, Brice Wilfried Obiang‐Obounou, Kyung‐Bok Lee, Jong‐Soon Choi, Byeong‐Churl Jang
J Cell Mol Med. 2018 Apr; 22(4): 2488–2497. Published online 2018 Feb 14. doi: 10.1111/jcmm.13559
PMCID:
PMC5867077
AbstractArticlePDF–754K
16.
PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia
Hui Cheng, Chongmei Huang, Xiaoqian Xu, Xiaoxia Hu, Shenglan Gong, Gusheng Tang, Xianmin Song, Weiping Zhang, Jianmin Wang, Li Chen, Jianmin Yang
J Transl Med. 2017; 15: 179. Published online 2017 Aug 29. doi: 10.1186/s12967-017-1287-4
PMCID:
PMC5576275
AbstractArticlePDF–1.1M
17.
PIM1 kinase regulates cell death, tumor growth and chemotherapy response revealing a novel target in triple-negative breast cancer
Fara Brasó-Maristany, Simone Filosto, Steven Catchpole, Rebecca Marlow, Jelmar Quist, Erika Francesch-Domenech, Darren A. Plumb, Leila Zakka, Patrycja Gazinska, Gianmaria Liccardi, Pascal Meier, Albert Gris-Oliver, Maggie Chon U Cheang, Anna Perdrix-Rosell, Manar Shafat, Elodie Noël, Nirmesh Patel, Kristen McEachern, Maurizio Scaltriti, Pau Castel, Farzana Noor, Richard Buus, Sumi Mathew, Johnathan Watkins, Violeta Serra, Pierfrancesco Marra, Anita Grigoriadis, Andrew N. Tutt
Nat Med. Author manuscript; available in PMC 2017 Aug 10.
Published in final edited form as: Nat Med. 2016 Nov; 22(11): 1303–1313. Published online 2016 Oct 24. doi: 10.1038/nm.4198
Correction in:
Nat Med. 2017 Apr 7; 23(4): 526.
Correction in:
Nat Med. 2017 Jun 6; 23(6): 788.
PMCID:
PMC5552044
AbstractArticlePDF–2.7M
18.
Cytoplasmic Irradiation Induces Metabolic Shift in Human Small Airway Epithelial Cells via Activation of Pim-1 Kinase
Jinhua Wu, Qin Zhang, Yen-Ruh Wuu, Sirui Zou, Tom K. Hei
Radiat Res. Author manuscript; available in PMC 2017 Aug 2.
Published in final edited form as: Radiat Res. 2017 Apr; 187(4): 441–453. Published online 2017 Feb 7. doi: 10.1667/RR0006CC.1
PMCID:
PMC5539528
AbstractArticlePDF–1.7M
19.
PIM kinase inhibition presents a novel targeted therapy against triple-negative breast tumors with elevated MYC expression
Dai Horiuchi, Roman Camarda, Alicia Y. Zhou, Christina Yau, Olga Momcilovic, Sanjeev Balakrishnan, Alexandra N. Corella, Henok Eyob, Kai Kessenbrock, Devon A. Lawson, Lindsey A. Marsh, Brittany N. Anderton, Julia Rohrberg, Ratika Kunder, Alexey V. Bazarov, Paul Yaswen, Michael T. McManus, Hope S. Rugo, Zena Werb, Andrei Goga
Nat Med. Author manuscript; available in PMC 2017 Mar 8.
Published in final edited form as: Nat Med. 2016 Nov; 22(11): 1321–1329. Published online 2016 Oct 24. doi: 10.1038/nm.4213
PMCID:
PMC5341692
AbstractArticlePDF–3.3M
20.
Systematic functional characterization of resistance to PI3K inhibition in breast cancer
Xiuning Le, Rajee Antony, Pedram Razavi, Daniel J. Treacy, Flora Luo, Mahmoud Ghandi, Pau Castel, Maurizio Scaltriti, Jose Baselga, Levi A. Garraway
Cancer Discov. Author manuscript; available in PMC 2017 Oct 1.
Published in final edited form as: Cancer Discov. 2016 Oct; 6(10): 1134–1147. Published online 2016 Sep 7. doi: 10.1158/2159-8290.CD-16-0305
PMCID:
PMC5050154
AbstractArticlePDF–1.0M

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