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Select item 65087381.

Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction

Dov Tiosano, Hagit N. Baris, Anlu Chen, Marrit M. Hitzert, Markus Schueler, Federico Gulluni, Antje Wiesener, Antonio Bergua, Adi Mory, Brett Copeland, Joseph G. Gleeson, Patrick Rump, Hester van Meer, Deborah A. Sival, Volker Haucke, Josh Kriwinsky, Karl X. Knaup, André Reis, Nadine N. Hauer, Emilio Hirsch, Ronald Roepman, Rolph Pfundt, Christian T. Thiel, Michael S. Wiesener, Mariam G. Aslanyan, David A. Buchner

PLoS Genet. 2019 Apr; 15(4): e1008088. Published online 2019 Apr 29. doi: 10.1371/journal.pgen.1008088

PMCID:: PMC6508738

Abstract Article PDF–2.3M

Select item 64560272.

Low expression of PIK3C2A gene: A potential biomarker to predict the risk of acute myocardial infarction

Buchuan Tan, Miao Liu, Yushuang Yang, Long Liu, Fanbo Meng

Medicine (Baltimore) 2019 Jun; 98(14): e15061. Published online 2019 Apr 5. doi: 10.1097/MD.0000000000015061

PMCID:: PMC6456027

Abstract Article PDF–234K

Select item 50081033.

High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions

William S. Polachek, Hanan F. Moshrif, Michael Franti, Donald M. Coen, Vattipally B. Sreenu, Blair L. Strang

J Virol. 2016 Sep 15; 90(18): 8360–8371. Prepublished online 2016 Jul 13. Published online 2016 Aug 26. doi: 10.1128/JVI.01134-16

PMCID:: PMC5008103

Abstract Article PDF–1.8M

Select item 43634054.

The Class II Phosphatidylinositol 3-Phosphate Kinase PIK3C2A Promotes Shigella flexneri Dissemination through Formation of Vacuole-Like Protrusions

Ana-Maria Dragoi, Hervé Agaisse

Infect Immun. 2015 Apr; 83(4): 1695–1704. Prepublished online 2015 Feb 9. Published online 2015 Mar 17. doi: 10.1128/IAI.03138-14

PMCID:: PMC4363405

Abstract Article PDF–1.5M

Select item 12186475.

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin.

J Domin, F Pages, S Volinia, S E Rittenhouse, M J Zvelebil, R C Stein, M D Waterfield

Biochem J. 1997 Aug 15; 326(Pt 1): 139–147. doi: 10.1042/bj3260139

PMCID:: PMC1218647

Summary PDF–876K

Select item 107175476.

The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells

Khin Thuzar Aung, Kazuaki Yoshioka, Sho Aki, Kazuhiro Ishimaru, Noriko Takuwa, Yoh Takuwa

J Physiol Sci. 2019 Mar; 69(2): 263–280. Published online 2018 Oct 29. doi: 10.1007/s12576-018-0644-2

PMCID:: PMC10717547

Abstract Article PDF–20M

Select item 99532877.

Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome

Shimaa E. Soliman, Mai A. H. Abouelenin, Neven I. Samy, Marwa M. Omar, Abeer A. Alrefai

Biomolecules. 2023 Feb; 13(2): 302. Published online 2023 Feb 6. doi: 10.3390/biom13020302

PMCID:: PMC9953287

Abstract Article PDF–1.4M

Select item 55990188.

PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles

Nathan M. Merrill, Joshua L. Schipper, Jonathan B. Karnes, Audra L. Kauffman, Katie R. Martin, Jeffrey P. MacKeigan

PLoS One. 2017; 12(9): e0184909. Published online 2017 Sep 14. doi: 10.1371/journal.pone.0184909

PMCID:: PMC5599018

Abstract Article PDF–23M

Select item 2806609.

Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation

Soha Salama El Sheikh, Jan Domin, Prakitpunthu Tomtitchong, Paul Abel, Gordon Stamp, El-Nasir Lalani

BMC Clin Pathol. 2003; 3: 4. Published online 2003 Oct 16. doi: 10.1186/1472-6890-3-4

PMCID:: PMC280660

Abstract Article PDF–740K

Select item 793315210.

Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells

Shota Shimizu, Kazuaki Yoshioka, Sho Aki, Yoh Takuwa

Sci Rep. 2021; 11: 5199. Published online 2021 Mar 4. doi: 10.1038/s41598-021-84548-4

PMCID:: PMC7933152

Abstract Article PDF–8.5M

Select item 718379011.

TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K–C2α-, and INPP4B-mediated phosphoinositide conversions

Sho Aki, Kazuaki Yoshioka, Noriko Takuwa, Yoh Takuwa

Mol Biol Cell. 2020 Mar 1; 31(5): 360–372. doi: 10.1091/mbc.E19-11-0662

PMCID:: PMC7183790

Abstract Article PDF–3.6M

Select item 519003012.

PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells

Tao Liu, Cai-Hua Zu, Shu-Sen Wang, Hong-Li Song, Zheng-Lu Wang, Xin-Nv Xu, Hong-Sheng Liu, Yu-Liang Wang, Zhong-Yang Shen

Oncotarget. 2016 Jul 12; 7(28): 43376–43389. Published online 2016 May 30. doi: 10.18632/oncotarget.9716

PMCID:: PMC5190030

Abstract Article PDF–13M

Select item 435825013.

Phosphatidylinositol 3-Kinase Class II α-Isoform PI3K-C2α Is Required for Transforming Growth Factor β-induced Smad Signaling in Endothelial Cells

Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, Noriko Takuwa, Yoh Takuwa

J Biol Chem. 2015 Mar 6; 290(10): 6086–6105. Published online 2015 Jan 22. doi: 10.1074/jbc.M114.601484

PMCID:: PMC4358250

Abstract Article PDF–7.8M

Select item 355490414.

Essential Role of Class II Phosphatidylinositol-3-kinase-C2α in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells

Kuntal Biswas, Kazuaki Yoshioka, Ken Asanuma, Yasuo Okamoto, Noriko Takuwa, Takehiko Sasaki, Yoh Takuwa

J Biol Chem. 2013 Jan 25; 288(4): 2325–2339. Published online 2012 Nov 28. doi: 10.1074/jbc.M112.409656

PMCID:: PMC3554904

Abstract Article PDF–3.8M

Select item 353999315.

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis

Gianpaolo Tibolla, Roberto Piñeiro, Daniela Chiozzotto, Ioanna Mavrommati, Ann P. Wheeler, Giuseppe Danilo Norata, Alberico Luigi Catapano, Tania Maffucci, Marco Falasca

PLoS One. 2013; 8(1): e53808. Published online 2013 Jan 8. doi: 10.1371/journal.pone.0053808

PMCID:: PMC3539993

Abstract Article PDF–997K

Select item 266076816.

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

H. B. Salvesen, S. L. Carter, M. Mannelqvist, A. Dutt, G. Getz, I. M. Stefansson, M. B. Raeder, M. L. Sos, I. B. Engelsen, J. Trovik, E. Wik, H. Greulich, T. H. Bø, I. Jonassen, R. K. Thomas, T. Zander, L. A. Garraway, A. M. Øyan, W. R. Sellers, K. H. Kalland, M. Meyerson, L. A. Akslen, R. Beroukhim

Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12): 4834–4839. Published online 2009 Mar 4. doi: 10.1073/pnas.0806514106

PMCID:: PMC2660768

Abstract Article PDF–682K

Select item 543803317.

Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder

F Lescai, T D Als, Q Li, M Nyegaard, G Andorsdottir, M Biskopstø, A Hedemand, A Fiorentino, N O'Brien, A Jarram, J Liang, J Grove, J Pallesen, E Eickhardt, M Mattheisen, L Bolund, D Demontis, A G Wang, A McQuillin, O Mors, J Wang, A D Børglum

Transl Psychiatry. 2017 Feb; 7(2): e1034. Published online 2017 Feb 14. doi: 10.1038/tp.2017.3

PMCID:: PMC5438033

Abstract Article PDF–1.3M

Select item 534772618.

A four-gene signature predicts survival in clear-cell renal-cell carcinoma

Jun Dai, Yuchao Lu, Jinyu Wang, Lili Yang, Yingyan Han, Ying Wang, Dan Yan, Qiurong Ruan, Shaogang Wang

Oncotarget. 2016 Dec 13; 7(50): 82712–82726. Published online 2016 Oct 13. doi: 10.18632/oncotarget.12631

PMCID:: PMC5347726

Abstract Article PDF–9.8M

Select item 284018419.

Pooled Analysis of Phosphatidylinositol 3-kinase Pathway Variants and Risk of Prostate Cancer

Stella Koutros, Fredrick R. Schumacher, Richard B. Hayes, Jing Ma, Wen-Yi Huang, Demetrius Albanes, Federico Canzian, Stephen J. Chanock, E. David Crawford, W. Ryan Diver, Heather Spencer Feigelson, Edward Giovanucci, Christopher A. Haiman, Brian E. Henderson, David J. Hunter, Rudolf Kaaks, Laurence N. Kolonel, Peter Kraft, Loïc Le Marchand, Elio Riboli, Afshan Siddiq, Mier J. Stampfer, Daniel O. Stram, Gilles Thomas, Ruth C. Travis, Michael J. Thun, Meredith Yeager, Sonja I. Berndt

Cancer Res. Author manuscript; available in PMC 2011 Mar 15.

Published in final edited form as: Cancer Res. 2010 Mar 15; 70(6): 2389–2396. Published online 2010 Mar 2. doi: 10.1158/0008-5472.CAN-09-3575

PMCID:: PMC2840184

Abstract Article PDF–326K

Select item 8570720.

Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors

Alexandre Arcaro, Marketa J. Zvelebil, Christian Wallasch, Axel Ullrich, Michael D. Waterfield, Jan Domin

Mol Cell Biol. 2000 Jun; 20(11): 3817–3830. doi: 10.1128/mcb.20.11.3817-3830.2000

PMCID:: PMC85707

Abstract Article PDF–4.2M

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