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Select item 106390661.

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release

Zhijia Wang, Samu V Himanen, Heidi M Haikala, Caroline C Friedel, Anniina Vihervaara, Matjaž Barborič

Nucleic Acids Res. 2023 Nov 10; 51(20): 10970–10991. Published online 2023 Oct 9. doi: 10.1093/nar/gkad792

PMCID:: PMC10639066

Abstract Article PDF–4.0M

Select item 96178772.

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux

Nat Commun. 2022; 13: 6457. Published online 2022 Oct 29. doi: 10.1038/s41467-022-34179-8

PMCID:: PMC9617877

Abstract Article PDF–6.4M

Select item 91998503.

CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation

Jingting Li, Manisha Tiwari, Yifang Chen, Sudjit Luanpitpong, George L Sen

Stem Cells. 2022 Apr; 40(4): 435–445. Published online 2022 Jan 28. doi: 10.1093/stmcls/sxac002

PMCID:: PMC9199850

Abstract Article PDF–11M

Select item 90529274.

Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas

Jing Gao, Michelle Y. Wang, Yuan Ren, Tint Lwin, Tao Li, Joy C. Yan, Eduardo M. Sotomayor, Derek R. Duckett, Bijal D. Shah, Kenneth H. Shain, Xiaohong Zhao, Jianguo Tao

Haematologica. 2022 May 1; 107(5): 1119–1130. Published online 2021 Jun 24. doi: 10.3324/haematol.2021.278743

PMCID:: PMC9052927

Abstract Article PDF–1.6M

Select item 83163675.

CRISPR screening identifies CDK12 as a conservative vulnerability of prostate cancer

Hanqi Lei, Zifeng Wang, Donggen Jiang, Fang Liu, Meiling Liu, Xinxing Lei, Yafei Yang, Bin He, Min Yan, Hai Huang, Quentin Liu, Jun Pang

Cell Death Dis. 2021 Aug; 12(8): 740. Published online 2021 Jul 27. doi: 10.1038/s41419-021-04027-6

PMCID:: PMC8316367

Abstract Article PDF–5.2M

Select item 78922356.

CDK12 Promotes Cervical Cancer Progression through Enhancing Macrophage Infiltration

Bikang Yang, Jing Chen, Yincheng Teng

J Immunol Res. 2021; 2021: 6645885. Published online 2021 Feb 11. doi: 10.1155/2021/6645885

PMCID:: PMC7892235

Abstract Article PDF–4.2M

Select item 76413117.

CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation

Michael Tellier, Justyna Zaborowska, Livia Caizzi, Eusra Mohammad, Taras Velychko, Björn Schwalb, Ivan Ferrer-Vicens, Daniel Blears, Takayuki Nojima, Patrick Cramer, Shona Murphy

Nucleic Acids Res. 2020 Aug 20; 48(14): 7712–7727. Published online 2020 Jun 17. doi: 10.1093/nar/gkaa514

PMCID:: PMC7641311

Abstract Article PDF–5.1M

Select item 75727478.

Pan-cancer Analysis of CDK12 Alterations Identifies a Subset of Prostate Cancers with Distinct Genomic and Clinical Characteristics

Bastien Nguyen, Jose Mauricio Mota, Subhiksha Nandakumar, Konrad H. Stopsack, Emily Weg, Dana Rathkopf, Michael J. Morris, Howard I. Scher, Philip W. Kantoff, Anuradha Gopalan, Dmitriy Zamarin, David B. Solit, Nikolaus Schultz, Wassim Abida

Eur Urol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Eur Urol. 2020 Nov; 78(5): 671–679. Published online 2020 Apr 19. doi: 10.1016/j.eururo.2020.03.024

PMCID:: PMC7572747

Abstract Article PDF–1.2M

Select item 73656099.

Clinical Outcomes in Cyclin-dependent Kinase 12 Mutant Advanced Prostate Cancer

Melissa A. Reimers, Steven M. Yip, Li Zhang, Marcin Cieslik, Mallika Dhawan, Bruce Montgomery, Alexander W. Wyatt, Kim N. Chi, Eric J. Small, Arul M. Chinnaiyan, Ajjai S. Alva, Felix Y. Feng, Jonathan Chou

Eur Urol. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Eur Urol. 2020 Mar; 77(3): 333–341. Published online 2019 Oct 20. doi: 10.1016/j.eururo.2019.09.036

PMCID:: PMC7365609

Abstract Article PDF–375K

Select item 734938010.

CDK12: A Potent Target and Biomarker for Human Cancer Therapy

Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian

Cells. 2020 Jun; 9(6): 1483. Published online 2020 Jun 18. doi: 10.3390/cells9061483

PMCID:: PMC7349380

Abstract Article PDF–866K

Select item 697594711.

Pan‐Cancer Analysis of CDK12 Loss‐of‐Function Alterations and Their Association with the Focal Tandem‐Duplicator Phenotype

Ethan S. Sokol, Dean Pavlick, Garrett M. Frampton, Jeffrey S. Ross, Vincent A. Miller, Siraj M. Ali, Tamara L. Lotan, Drew M. Pardoll, Jon H. Chung, Emmanuel S. Antonarakis

Oncologist. 2019 Dec; 24(12): 1526–1533. Published online 2019 Jul 10. doi: 10.1634/theoncologist.2019-0214

PMCID:: PMC6975947

Abstract Article PDF–2.1M

Select item 684407012.

CDK12 Activity-Dependent Phosphorylation Events in Human Cells

Bartlomiej Bartkowiak, Christopher M. Yan, Erik J. Soderblom, Arno L. Greenleaf

Biomolecules. 2019 Oct; 9(10): 634. Published online 2019 Oct 22. doi: 10.3390/biom9100634

PMCID:: PMC6844070

Abstract Article PDF–795K

Select item 677691413.

CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

Hee‐Joo Choi, Sora Jin, Hani Cho, Hee‐Young Won, Hee Woon An, Ga‐Young Jeong, Young‐Un Park, Hyung‐Yong Kim, Mi Kyung Park, Taekwon Son, Kyueng‐Whan Min, Ki‐Seok Jang, Young‐Ha Oh, Jeong‐Yeon Lee, Gu Kong

EMBO Rep. 2019 Oct 4; 20(10): e48058. Published online 2019 Aug 30. doi: 10.15252/embr.201948058

PMCID:: PMC6776914

Abstract Article PDF–4.5M

Select item 646537114.

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Malgorzata Krajewska, Ruben Dries, Andrew V. Grassetti, Sofia Dust, Yang Gao, Hao Huang, Bandana Sharma, Daniel S. Day, Nicholas Kwiatkowski, Monica Pomaville, Oliver Dodd, Edmond Chipumuro, Tinghu Zhang, Arno L. Greenleaf, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, Matthias Geyer, Scott A. Gerber, Rani E. George

Nat Commun. 2019; 10: 1757. Published online 2019 Apr 15. doi: 10.1038/s41467-019-09703-y

PMCID:: PMC6465371

Abstract Article PDF–2.1M

Select item 644653915.

CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability

Seung H. Choi, Thomas F. Martinez, Seongjae Kim, Cynthia Donaldson, Maxim N. Shokhirev, Alan Saghatelian, Katherine A. Jones

Genes Dev. 2019 Apr 1; 33(7-8): 418–435. doi: 10.1101/gad.322339.118

PMCID:: PMC6446539

Abstract Article PDF–5.6M

Select item 644236216.

Quantitative Mass Spectrometry to Interrogate Proteomic Heterogeneity in Metastatic Lung Adenocarcinoma and Validate a Novel Somatic Mutation CDK12-G879V

Xu Zhang, Khoa Dang Nguyen, Paul A. Rudnick, Nitin Roper, Emily Kawaler, Tapan K. Maity, Shivangi Awasthi, Shaojian Gao, Romi Biswas, Abhilash Venugopalan, Constance M. Cultraro, David Fenyö, Udayan Guha

Mol Cell Proteomics. 2019 Apr; 18(4): 622–641. Published online 2019 Jan 7. doi: 10.1074/mcp.RA118.001266

PMCID:: PMC6442362

Abstract Article PDF–5.5M

Select item 628478617.

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response Targeted Therapies in Breast Cancer

Kalnisha Naidoo, Patty T. Wai, Sarah L. Maguire, Frances Daley, Syed Haider, Divya Kriplani, James Campbell, Hasan Mirza, Anita Grigoriadis, Andrew Tutt, Paul M. Moseley, Tarek M.A. Abdel-Fatah, Stephen Y. Chan, Srinivasan Madhusudan, Emad A. Rhaka, Ian O. Ellis, Christopher J. Lord, Yinyin Yuan, Andrew R. Green, Rachael Natrajan

Mol Cancer Ther. Author manuscript; available in PMC 2018 Dec 7.

Published in final edited form as: Mol Cancer Ther. 2018 Jan; 17(1): 306–315. Published online 2017 Nov 13. doi: 10.1158/1535-7163.MCT-17-0760

PMCID:: PMC6284786

Abstract Article PDF–1.2M

Select item 549981218.

CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion

Jerry F. Tien, Alborz Mazloomian, S.-W. Grace Cheng, Christopher S. Hughes, Christalle C.T. Chow, Leanna T. Canapi, Arusha Oloumi, Genny Trigo-Gonzalez, Ali Bashashati, James Xu, Vicky C.-D. Chang, Sohrab P. Shah, Samuel Aparicio, Gregg B. Morin

Nucleic Acids Res. 2017 Jun 20; 45(11): 6698–6716. Published online 2017 Mar 17. doi: 10.1093/nar/gkx187

PMCID:: PMC5499812

Abstract Article PDF–3.6M

Select item 488609019.

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity

Ilirjana Bajrami, Jessica R. Frankum, Asha Konde, Rowan E. Miller, Farah L. Rehman, Rachel Brough, James Campbell, David Sims, Rumana Rafiq, Sean Hooper, Lina Chen, Iwanka Kozarewa, Ioannis Assiotis, Kerry Fenwick, Rachael Natrajan, Christopher J. Lord, Alan Ashworth

Cancer Res. Author manuscript; available in PMC 2016 May 31.

Published in final edited form as: Cancer Res. 2014 Jan 1; 74(1): 287–297. Published online 2013 Nov 15. doi: 10.1158/0008-5472.CAN-13-2541

PMCID:: PMC4886090

Abstract Article PDF–1.5M

Select item 434042020.

Expression, Purification, and Identification of Associated Proteins of the Full-length hCDK12/CyclinK Complex

Bartlomiej Bartkowiak, Arno L. Greenleaf

J Biol Chem. 2015 Jan 16; 290(3): 1786–1795. Published online 2014 Nov 26. doi: 10.1074/jbc.M114.612226

PMCID:: PMC4340420

Abstract Article PDF–1.3M

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PMC Links for Gene (Select 51755) (122)
PMC
cyclin-dependent kinase 12 isoform X3 [Homo sapiens]
cyclin-dependent kinase 12 isoform X3 [Homo sapiens]
gi|767995019|ref|XP_011523196.1|

Protein
PREDICTED: Homo sapiens cyclin dependent kinase 12 (CDK12), transcript variant X...
PREDICTED: Homo sapiens cyclin dependent kinase 12 (CDK12), transcript variant X25, mRNA
gi|2217312452|ref|XM_047436272.1|

Nucleotide
PREDICTED: Homo sapiens cyclin dependent kinase 12 (CDK12), transcript variant X...
PREDICTED: Homo sapiens cyclin dependent kinase 12 (CDK12), transcript variant X1, mRNA
gi|2462555938|ref|XM_054316449.1|

Nucleotide

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