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Select item 47664131.

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity

Jin-Yong Lee, Maki Tokumoto, Yasuyuki Fujiwara, Tatsuya Hasegawa, Yoshiyuki Seko, Akinori Shimada, Masahiko Satoh

Sci Rep. 2016; 6: 21968. Published online 2016 Feb 25. doi: 10.1038/srep21968

PMCID:: PMC4766413

Abstract Article PDF–2.2M

Select item 64685502.

Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H

Elisa Lazzari, Medhat S. El-Halawany, Matteo De March, Floriana Valentino, Francesco Cantatore, Chiara Migliore, Silvia Onesti, Germana Meroni

Cells. 2019 Mar; 8(3): 254. Published online 2019 Mar 16. doi: 10.3390/cells8030254

PMCID:: PMC6468550

Abstract Article PDF–5.1M

Select item 56386603.

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase

Daria M. Dawidziak, Jacint G. Sanchez, Jonathan M. Wagner, Barbie K. Ganser-Pornillos, Owen Pornillos

Proteins. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Proteins. 2017 Oct; 85(10): 1957–1961. Published online 2017 Jul 24. doi: 10.1002/prot.25348

PMCID:: PMC5638660

Abstract Article PDF–881K

Select item 37787094.

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

Michael H. Tatham, Anna Plechanovová, Ellis G. Jaffray, Helena Salmen, Ronald T. Hay

Biochem J. 2013 Jul 1; 453(Pt 1): 137–145. Prepublished online 2013 Apr 8. Published online 2013 Jun 13. doi: 10.1042/BJ20130244

PMCID:: PMC3778709

Abstract Article PDF–2.1M

Select item 55921405.

Osmotic and Heat Stress-dependent Regulation of MLK4β and MLK3 by the CHIP E3 Ligase in Ovarian Cancer Cells

Natalya A. Blessing, Srimathi Kasturirangan, Evan M. Zink, April L. Schroyer, Deborah N. Chadee

Cell Signal. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Cell Signal. 2017 Nov; 39: 66–73. Published online 2017 Jul 28. doi: 10.1016/j.cellsig.2017.07.021

PMCID:: PMC5592140

Abstract Article PDF–1.0M

Select item 31274286.

The IDOL–UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Li Zhang, Louise Fairall, Benjamin T. Goult, Anna C. Calkin, Cynthia Hong, Christopher J. Millard, Peter Tontonoz, John W.R. Schwabe

Genes Dev. 2011 Jun 15; 25(12): 1262–1274. doi: 10.1101/gad.2056211

PMCID:: PMC3127428

Abstract Article PDF–1.3M

Select item 97320517.

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity

Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, Katrin Rittinger

Nat Commun. 2022; 13: 7583. Published online 2022 Dec 8. doi: 10.1038/s41467-022-35300-7

PMCID:: PMC9732051

Abstract Article PDF–4.5M

Select item 56562678.

Ubiquitination of STING at lysine 224 controls IRF3 activation

Guoxin Ni, Hiroyasu Konno, Glen N. Barber

Sci Immunol. Author manuscript; available in PMC 2017 Oct 25.

Published in final edited form as: Sci Immunol. 2017 May 5; 2(11): eaah7119. doi: 10.1126/sciimmunol.aah7119

PMCID:: PMC5656267

Abstract Article PDF–2.2M

Select item 98604969.

Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method

Ryota Hayashida, Reika Kikuchi, Kenichiro Imai, Waka Kojima, Tatsuya Yamada, Miho Iijima, Hiromi Sesaki, Keiji Tanaka, Noriyuki Matsuda, Koji Yamano

J Biol Chem. 2023 Feb; 299(2): 102822. Published online 2022 Dec 21. doi: 10.1016/j.jbc.2022.102822

PMCID:: PMC9860496

Abstract Article PDF–6.6M

Select item 496747810.

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity

Nicolas Huguenin-Dezot, Virginia De Cesare, Julien Peltier, Axel Knebel, Yosua Adi Kristaryianto, Daniel T. Rogerson, Yogesh Kulathu, Matthias Trost, Jason W. Chin

Cell Rep. 2016 Jul 26; 16(4): 1180–1193. Published online 2016 Jul 14. doi: 10.1016/j.celrep.2016.06.064

PMCID:: PMC4967478

Abstract Article

Select item 616234611.

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway

Virginia De Cesare, Clare Johnson, Victoria Barlow, James Hastie, Axel Knebel, Matthias Trost

Cell Chem Biol. 2018 Sep 20; 25(9): 1117–1127.e4. doi: 10.1016/j.chembiol.2018.06.004

PMCID:: PMC6162346

Abstract Article

Select item 833109212.

Reconstitution of human CMG helicase ubiquitylation by CUL2^LRR1 and multiple E2 enzymes

Thanh Thi Le, Johanna Ainsworth, Cristian Polo Rivera, Thomas Macartney, Karim P.M. Labib

Biochem J. 2021 Jul 30; 478(14): 2825–2842. Prepublished online 2021 Jun 29. Published online 2021 Jul 23. doi: 10.1042/BCJ20210315

PMCID:: PMC8331092

Abstract Article PDF–1.9M

Select item 397140713.

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Agne Kazlauskaite, Van Kelly, Clare Johnson, Carla Baillie, C. James Hastie, Mark Peggie, Thomas Macartney, Helen I. Woodroof, Dario R. Alessi, Patrick G. A. Pedrioli, Miratul M. K. Muqit

Open Biol. 2014 Mar; 4(3): 130213. Published online 2014 Mar 19. doi: 10.1098/rsob.130213

PMCID:: PMC3971407

Abstract Article PDF–1.7M

Select item 608604014.

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

Joanna Koszela, Nhan T. Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F. J. Ceccarelli, Frank Sicheri, Mike Tyers, Manfred Auer

BMC Biol. 2018; 16: 88. Published online 2018 Aug 10. doi: 10.1186/s12915-018-0554-z

PMCID:: PMC6086040

Abstract Article PDF–1.4M

Select item 433911915.

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

Tobias Wauer, Kirby N Swatek, Jane L Wagstaff, Christina Gladkova, Jonathan N Pruneda, Martin A Michel, Malte Gersch, Christopher M Johnson, Stefan MV Freund, David Komander

EMBO J. 2015 Feb 3; 34(3): 307–325. Published online 2014 Dec 20. doi: 10.15252/embj.201489847

PMCID:: PMC4339119

Abstract Article PDF–4.5M

Select item 903410116.

Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates

Hanjie Jiang, Claire Y. Chiang, Zan Chen, Sara Nathan, Gabriel D’Agostino, Joao A. Paulo, Guang Song, Heng Zhu, Sandra B. Gabelli, Philip A. Cole

J Biol Chem. 2022 May; 298(5): 101854. Published online 2022 Mar 21. doi: 10.1016/j.jbc.2022.101854

PMCID:: PMC9034101

Abstract Article PDF–3.7M

Select item 283828117.

The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

Yael David, Tamar Ziv, Arie Admon, Ami Navon

J Biol Chem. 2010 Mar 19; 285(12): 8595–8604. Published online 2010 Jan 8. doi: 10.1074/jbc.M109.089003

PMCID:: PMC2838281

Abstract Article PDF–1.0M

Select item 510887218.

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

Monique P.C. Mulder, Katharina Witting, Ilana Berlin, Jonathan N. Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C.O. Vertegaal, Brenda A. Schulman, David Komander, Jacques Neefjes, Farid El Oualid, Huib Ovaa

Nat Chem Biol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Nat Chem Biol. 2016 Jul; 12(7): 523–530. Published online 2016 May 16. doi: 10.1038/nchembio.2084

PMCID:: PMC5108872

Abstract Article PDF–2.4M

Select item 273665219.

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

Sjoerd J L van Wijk, Sjoerd J de Vries, Patrick Kemmeren, Anding Huang, Rolf Boelens, Alexandre M J J Bonvin, H Th Marc Timmers

Mol Syst Biol. 2009; 5: 295. Published online 2009 Aug 18. doi: 10.1038/msb.2009.55

Correction in:: Mol Syst Biol. 2009; 5: 317.

PMCID:: PMC2736652

Abstract Article PDF–5.6M

Select item 276528020.

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Gabriel Markson, Christina Kiel, Russell Hyde, Stephanie Brown, Panagoula Charalabous, Anja Bremm, Jennifer Semple, Jonathan Woodsmith, Simon Duley, Kourosh Salehi-Ashtiani, Marc Vidal, David Komander, Luis Serrano, Paul Lehner, Christopher M. Sanderson

Genome Res. 2009 Oct; 19(10): 1905–1911. doi: 10.1101/gr.093963.109

PMCID:: PMC2765280

Abstract Article PDF–425K

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PMC Links for Gene (Select 51619) (37)
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Conserved Domain Links for Gene (Select 14525) (1)
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db82a08.y1 Wellcome CRC pSK animal cap Xenopus laevis cDNA clone IMAGE:3379478 5...
db82a08.y1 Wellcome CRC pSK animal cap Xenopus laevis cDNA clone IMAGE:3379478 5' similar to gb:X12671_rna1 HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (HUMAN); gb:M99167 Mouse rearranged RNA binding protein (MOUSE); gb:gb|L02957.1|XELRNPA3B Xenopus laevis ribonucleoprotein mRNA, complete (XENOPUS), mRNA sequence
gi|9726135|gnl|dbEST|5699601|gb|BE5 .1|

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