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Select item 56638741.

Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels

Kyle A. Lyman, Ye Han, Robert J. Heuermann, Xiangying Cheng, Jonathan E. Kurz, Reagan E. Lyman, Paul P. Van Veldhoven, Dane M. Chetkovich

J Biol Chem. 2017 Oct 27; 292(43): 17718–17730. Published online 2017 Sep 8. doi: 10.1074/jbc.M117.802256

PMCID:: PMC5663874

Abstract Article PDF–2.4M

Select item 56638792.

Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b

John R. Bankston, Hannah A. DeBerg, Stefan Stoll, William N. Zagotta

J Biol Chem. 2017 Oct 27; 292(43): 17794–17803. Published online 2017 Sep 1. doi: 10.1074/jbc.M117.800722

PMCID:: PMC5663879

Abstract Article PDF–1.5M

Select item 51452433.

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Ye Han, Kyle A. Lyman, Matt Clutter, Gary E. Schiltz, Quratul-Ain Ismail, Xiangying Cheng, Chi-Hao Luan, Dane M. Chetkovich

J Vis Exp. 2016; (117): 54540. Published online 2016 Nov 11. doi: 10.3791/54540

PMCID:: PMC5145243

Abstract Article PDF–311K

Select item 42100224.

Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function

Andrea Saponaro, Sofia R. Pauleta, Francesca Cantini, Manolis Matzapetakis, Christian Hammann, Chiara Donadoni, Lei Hu, Gerhard Thiel, Lucia Banci, Bina Santoro, Anna Moroni

Proc Natl Acad Sci U S A. 2014 Oct 7; 111(40): 14577–14582. Published online 2014 Sep 2. doi: 10.1073/pnas.1410389111

PMCID:: PMC4210022

Abstract Article PDF–1.0M

Select item 41044725.

TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels

Zhuo Huang, Rafael Lujan, Jose Martinez-Hernandez, Alan S. Lewis, Dane M. Chetkovich, Mala M. Shah

J Neurosci. 2012 Oct 17; 32(42): 14835–14848. doi: 10.1523/JNEUROSCI.1544-12.2012

PMCID:: PMC4104472

Abstract Article PDF–4.1M

Select item 33566376.

Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels

John R. Bankston, Stacey S. Camp, Frank DiMaio, Alan S. Lewis, Dane M. Chetkovich, William N. Zagotta

Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7899–7904. Published online 2012 May 1. doi: 10.1073/pnas.1201997109

PMCID:: PMC3356637

Abstract Article PDF–1.1M

Select item 43352317.

Mechanistic Insights into PTS2-mediated Peroxisomal Protein Import: THE CO-RECEPTOR PEX5L DRASTICALLY INCREASES THE INTERACTION STRENGTH BETWEEN THE CARGO PROTEIN AND THE RECEPTOR PEX7

Markus Kunze, Naila Malkani, Sebastian Maurer-Stroh, Christoph Wiesinger, Johannes A. Schmid, Johannes Berger

J Biol Chem. 2015 Feb 20; 290(8): 4928–4940. Published online 2014 Dec 23. doi: 10.1074/jbc.M114.601575

PMCID:: PMC4335231

Abstract Article PDF–2.2M

Select item 31215008.

Trafficking and Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels Are Regulated by Interaction with Tetratricopeptide Repeat-containing Rab8b-interacting Protein (TRIP8b) and Cyclic AMP at Distinct Sites

Ye Han, Yoav Noam, Alan S. Lewis, Johnie J. Gallagher, Wytse J. Wadman, Tallie Z. Baram, Dane M. Chetkovich

J Biol Chem. 2011 Jun 10; 286(23): 20823–20834. Published online 2011 Apr 19. doi: 10.1074/jbc.M111.236125

PMCID:: PMC3121500

Abstract Article PDF–2.1M

Select item 12219949.

Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals.

L Amery, H Sano, G P Mannaerts, J Snider, J Van Looy, M Fransen, P P Van Veldhoven

Biochem J. 2001 Aug 1; 357(Pt 3): 635–646. doi: 10.1042/0264-6021:3570635

PMCID:: PMC1221994

Summary PDF–597K

Select item 307236610.

Transferability of Type 2 Diabetes Implicated Loci in Multi-Ethnic Cohorts from Southeast Asia

Xueling Sim, Rick Twee-Hee Ong, Chen Suo, Wan-Ting Tay, Jianjun Liu, Daniel Peng-Keat Ng, Michael Boehnke, Kee-Seng Chia, Tien-Yin Wong, Mark Seielstad, Yik-Ying Teo, E-Shyong Tai

PLoS Genet. 2011 Apr; 7(4): e1001363. Published online 2011 Apr 7. doi: 10.1371/journal.pgen.1001363

PMCID:: PMC3072366

Abstract Article PDF–1.0M

Select item 791045911.

Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams

Nat Commun. 2021; 12: 1302. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21478-9

PMCID:: PMC7910459

Abstract Article PDF–3.3M

Select item 406425412.

An atlas of genetic influences on human blood metabolites

So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo

Nat Genet. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982

PMCID:: PMC4064254

Abstract Article PDF–2.4M

Select item 274057213.

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

Man Lung Yeung, Laurent Houzet, Venkat S. R. K. Yedavalli, Kuan-Teh Jeang

J Biol Chem. 2009 Jul 17; 284(29): 19463–19473. Published online 2009 May 20. doi: 10.1074/jbc.M109.010033

PMCID:: PMC2740572

Abstract Article PDF–2.5M

Select item 358195414.

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Rajesh Ghai, Andrea Bugarcic, Huadong Liu, Suzanne J. Norwood, Sune Skeldal, Elizabeth J. Coulson, Shawn Shun-Cheng Li, Rohan D. Teasdale, Brett M. Collins

Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8): E643–E652. Published online 2013 Feb 4. doi: 10.1073/pnas.1216229110

PMCID:: PMC3581954

Abstract Article PDF–2.3M

Select item 289646415.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 616668216.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 1023742217.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 135612918.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

Select item 52892819.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 13924120.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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