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Select item 88579311.

WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15

Aamir Ali Khan, Hua Huang, Yue Zhao, Huan Li, Ruining Pan, Sijia Wang, Xinhui Liu

Int J Oncol. 2022 Mar; 60(3): 24. Published online 2022 Jan 25. doi: 10.3892/ijo.2022.5314

PMCID:: PMC8857931

Abstract Article PDF–1.9M

Select item 85999012.

THUMPD3–TRMT112 is a m²G methyltransferase working on a broad range of tRNA substrates

Wen-Qing Yang, Qing-Ping Xiong, Jian-Yang Ge, Hao Li, Wen-Yu Zhu, Yan Nie, Xiuying Lin, Daizhu Lv, Jing Li, Huan Lin, Ru-Juan Liu

Nucleic Acids Res. 2021 Nov 18; 49(20): 11900–11919. Published online 2021 Oct 20. doi: 10.1093/nar/gkab927

PMCID:: PMC8599901

Abstract Article PDF–8.4M

Select item 67968633.

Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase

Wenjing Li, Yu Shi, Tianlong Zhang, Jie Ye, Jianping Ding

Cell Discov. 2019; 5: 51. Published online 2019 Sep 10. doi: 10.1038/s41421-019-0121-y

PMCID:: PMC6796863

Abstract Article PDF–3.9M

Select item 67968294.

Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112

Clayton B. Woodcock, Dan Yu, Xing Zhang, Xiaodong Cheng

Cell Discov. 2019; 5: 50. Published online 2019 Sep 10. doi: 10.1038/s41421-019-0119-5

PMCID:: PMC6796829

Article PDF–474K

Select item 67696525.

The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells

Lilian Leetsi, Kadri Õunap, Aare Abroi, Reet Kurg

Biomolecules. 2019 Sep; 9(9): 422. Published online 2019 Aug 28. doi: 10.3390/biom9090422

PMCID:: PMC6769652

Abstract Article PDF–1.6M

Select item 88574816.

The METTL5-TRMT112 N⁶-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation

Caraline Sepich-Poore, Zhong Zheng, Emily Schmitt, Kailong Wen, Zijie Scott Zhang, Xiao-Long Cui, Qing Dai, Allen C. Zhu, Linda Zhang, Arantxa Sanchez Castillo, Haiyan Tan, Junmin Peng, Xiaoxi Zhuang, Chuan He, Sigrid Nachtergaele

J Biol Chem. 2022 Mar; 298(3): 101590. Published online 2022 Jan 14. doi: 10.1016/j.jbc.2022.101590

PMCID:: PMC8857481

Abstract Article PDF–2.3M

Select item 45163537.

The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway

Kadri Õunap, Lilian Leetsi, Maarja Matsoo, Reet Kurg

PLoS One. 2015; 10(7): e0133841. Published online 2015 Jul 27. doi: 10.1371/journal.pone.0133841

PMCID:: PMC4516353

Abstract Article PDF–2.9M

Select item 28636998.

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

Dragony Fu, Jennifer A. N. Brophy, Clement T. Y. Chan, Kyle A. Atmore, Ulrike Begley, Richard S. Paules, Peter C. Dedon, Thomas J. Begley, Leona D. Samson

Mol Cell Biol. 2010 May; 30(10): 2449–2459. Published online 2010 Mar 22. doi: 10.1128/MCB.01604-09

PMCID:: PMC2863699

Abstract Article PDF–2.0M

Select item 28380689.

Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding

Lene Songe-Møller, Erwin van den Born, Vibeke Leihne, Cathrine B. Vågbø, Terese Kristoffersen, Hans E. Krokan, Finn Kirpekar, Pål Ø. Falnes, Arne Klungland

Mol Cell Biol. 2010 Apr; 30(7): 1814–1827. Published online 2010 Feb 1. doi: 10.1128/MCB.01602-09

PMCID:: PMC2838068

Abstract Article PDF–3.4M

Select item 673586510.

The human 18S rRNA m⁶A methyltransferase METTL5 is stabilized by TRMT112

Nhan van Tran, Felix G M Ernst, Ben R Hawley, Christiane Zorbas, Nathalie Ulryck, Philipp Hackert, Katherine E Bohnsack, Markus T Bohnsack, Samie R Jaffrey, Marc Graille, Denis L J Lafontaine

Nucleic Acids Res. 2019 Sep 5; 47(15): 7719–7733. Published online 2019 Jul 22. doi: 10.1093/nar/gkz619

PMCID:: PMC6735865

Abstract Article PDF–4.3M

Select item 870861511.

Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor

Baiba Brūmele, Margit Mutso, Lilian Telanne, Kadri Õunap, Karīna Spunde, Aare Abroi, Reet Kurg

Int J Mol Sci. 2021 Dec; 22(24): 13593. Published online 2021 Dec 18. doi: 10.3390/ijms222413593

PMCID:: PMC8708615

Abstract Article PDF–2.7M

Select item 447201812.

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis

Christiane Zorbas, Emilien Nicolas, Ludivine Wacheul, Emmeline Huvelle, Valérie Heurgué-Hamard, Denis L. J. Lafontaine

Mol Biol Cell. 2015 Jun 1; 26(11): 2080–2095. doi: 10.1091/mbc.E15-02-0073

PMCID:: PMC4472018

Abstract Article PDF–6.8M

Select item 878559013.

Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells

Hongyan Li, Hong Zhang, Guomin Huang, Zhitong Bing, Duling Xu, Jiadi Liu, Hongtao Luo, Xiaoli An

J Exp Clin Cancer Res. 2022; 41: 33. Published online 2022 Jan 24. doi: 10.1186/s13046-021-02230-z

PMCID:: PMC8785590

Abstract Article PDF–9.6M

Select item 972361914.

The nucleoplasmic phase of pre-40S formation prior to nuclear export

Jingdong Cheng, Benjamin Lau, Matthias Thoms, Michael Ameismeier, Otto Berninghausen, Ed Hurt, Roland Beckmann

Nucleic Acids Res. 2022 Nov 11; 50(20): 11924–11937. Published online 2022 Nov 2. doi: 10.1093/nar/gkac961

PMCID:: PMC9723619

Abstract Article PDF–11M

Select item 349950715.

Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus

Mohamed Ali Jarboui, Carlo Bidoia, Elena Woods, Barbara Roe, Kieran Wynne, Giuliano Elia, William W. Hall, Virginie W. Gautier

PLoS One. 2012; 7(11): e48702. Published online 2012 Nov 15. doi: 10.1371/journal.pone.0048702

PMCID:: PMC3499507

Abstract Article PDF–1.5M

Select item 1690116.

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning

R.-M. Hu, Z.-G. Han, H.-D. Song, Y.-D. Peng, Q.-H. Huang, S.-X. Ren, Y.-J. Gu, C.-H. Huang, Y.-B. Li, C.-L. Jiang, G. Fu, Q.-H. Zhang, B.-W. Gu, M. Dai, Y.-F. Mao, G.-F. Gao, R. Rong, M. Ye, J. Zhou, S.-H. Xu, J. Gu, J.-X. Shi, W.-R. Jin, C.-K. Zhang, T.-M. Wu, G.-Y. Huang, Z. Chen, M.-D. Chen, J.-L. Chen

Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17): 9543–9548. Published online 2000 Aug 8. doi: 10.1073/pnas.160270997

PMCID:: PMC16901

Abstract Article PDF–801K

Select item 866666517.

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre

iScience. 2021 Dec 17; 24(12): 103538. Published online 2021 Dec 1. doi: 10.1016/j.isci.2021.103538

PMCID:: PMC8666665

Abstract Article PDF–3.2M

Select item 702912318.

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival

Yuanming He, Siyu Wang, Jiefei Tong, Shuoyi Jiang, Ye Yang, Zubin Zhang, Yujia Xu, Yuanying Zeng, Biyin Cao, Michael F. Moran, Xinliang Mao

J Biol Chem. 2020 Feb 14; 295(7): 2084–2096. Published online 2019 Dec 10. doi: 10.1074/jbc.RA119.010724

PMCID:: PMC7029123

Abstract Article PDF–3.6M

Select item 827460319.

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome

Jérémy A. Ferreira Barbosa, Samantha Sparapani, Jonathan Boulais, Robert Lodge, Éric A. Cohen

J Virol. 2021 Aug; 95(15): e00971-20. Prepublished online 2021 May 19. Published online 2021 Jul 12. doi: 10.1128/JVI.00971-20

PMCID:: PMC8274603

Abstract Article PDF–4.2M

Select item 31093420.

Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells

Qing-Hua Zhang, Min Ye, Xin-Yan Wu, Shuang-Xi Ren, Meng Zhao, Chun-Jun Zhao, Gang Fu, Yu Shen, Hui-Yong Fan, Gang Lu, Ming Zhong, Xiang-Ru Xu, Ze-Guang Han, Ji-Wang Zhang, Jiong Tao, Qiu-Hua Huang, Jun Zhou, Geng-Xi Hu, Jian Gu, Sai-Juan Chen, Zhu Chen

Genome Res. 2000 Oct; 10(10): 1546–1560. doi: 10.1101/gr.140200