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Select item 107657091.

PDE4D single nucleotide polymorphism rs918592 is associated with ischemic Stroke risk in Chinese populations: a meta-analysis

Xinrui Yu, Guiying Zhang, Xuelei Tang, Rong Lin

BMC Cardiovasc Disord. 2024; 24: 17. Published online 2024 Jan 3. doi: 10.1186/s12872-023-03681-2

PMCID:: PMC10765709

Abstract Article PDF–1.9M

Select item 103713482.

Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth

Mi-Hyeon Jeong, Greg Urquhart, Cheryl Lewis, Zhikai Chi, Jenna L. Jewell

JCI Insight. 2023 Jul 10; 8(13): e158098. Published online 2023 Jul 10. doi: 10.1172/jci.insight.158098

PMCID:: PMC10371348

Abstract Article PDF–7.9M

Select item 80510373.

A novel variant in the PDE4D gene is the cause of Acrodysostosis type 2 in a Lithuanian patient: a case report

Gunda Petraitytė, Kamilė Šiaurytė, Violeta Mikštienė, Loreta Cimbalistienė, Dovilė Kriaučiūnienė, Aušra Matulevičienė, Algirdas Utkus, Eglė Preikšaitienė

BMC Endocr Disord. 2021; 21: 71. Published online 2021 Apr 15. doi: 10.1186/s12902-021-00741-6

PMCID:: PMC8051037

Abstract Article PDF–1.1M

Select item 78122504.

COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type‐2 and PDE4 gene expression in sputum

Dave Singh, Michele Bassi, Deborah Balzano, Germano Lucci, Aida Emirova, Marie Anna Nandeuil, Gera Jellema, Ebenezer K. Afolabi, Brian Leaker, Oliver Kornmann, Kai Michael Beeh, Henrik Watz, Mirco Govoni

J Cell Mol Med. 2021 Jan; 25(2): 905–918. Published online 2020 Dec 9. doi: 10.1111/jcmm.16146

PMCID:: PMC7812250

Abstract Article PDF–1.0M

Select item 70703055.

Insight into GEBR-32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition

Valeria Cavalloro, Katia Russo, Francesca Vasile, Luca Pignataro, Archimede Torretta, Stefano Donini, Marta S. Semrau, Paola Storici, Daniela Rossi, Federica Rapetti, Chiara Brullo, Emilio Parisini, Olga Bruno, Simona Collina

Molecules. 2020 Feb; 25(4): 935. Published online 2020 Feb 19. doi: 10.3390/molecules25040935

PMCID:: PMC7070305

Abstract Article PDF–4.3M

Select item 68075586.

PDE4D Gene Polymorphisms and Coronary Heart Disease: A Case‐Control Study in a North Indian Population

Ekata Sinha, Sanjenbam Yaiphaba Meitei, Priyanka Rani Garg, Kallur Nava Saraswathy

J Clin Lab Anal. 2013 Jul; 27(4): 297–300. Published online 2013 Jul 12. doi: 10.1002/jcla.21601

PMCID:: PMC6807558

Abstract Article PDF–57K

Select item 57856447.

Phenotypic Variability in a Family with Acrodysostosis Type 2 Caused by a Novel PDE4D Mutation Affecting the Serine Target of Protein Kinase-A Phosphorylation

Julia Hoppmann, Julia Gesing, Caroline Silve, Chrystel Leroy, Astrid Bertsche, Franz Wolfgang Hirsch, Wieland Kiess, Roland Pfäffle, Volker Schuster

J Clin Res Pediatr Endocrinol. 2017 Dec; 9(4): 360–365. Published online 2017 Dec 15. doi: 10.4274/jcrpe.4488

PMCID:: PMC5785644

Abstract Article PDF–675K

Select item 53425828.

Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases

René Böttcher, Kalyan Dulla, Dianne van Strijp, Natasja Dits, Esther I. Verhoef, George S. Baillie, Geert J.L.H. van Leenders, Miles D. Houslay, Guido Jenster, Ralf Hoffmann

Oncotarget. 2016 Oct 25; 7(43): 70669–70684. Published online 2016 Sep 23. doi: 10.18632/oncotarget.12204

PMCID:: PMC5342582

Abstract Article PDF–4.2M

Select item 53204949.

Phosphodiesterase 4D polymorphisms associate with the short-term outcome in ischemic stroke

Yan-li Song, Chun-juan Wang, Yi-ping Wu, Jie Lin, Peng-lian Wang, Wan-liang Du, Li Liu, Jin-xi Lin, Yi-long Wang, Yong-jun Wang, Gai-fen Liu

Sci Rep. 2017; 7: 42914. Published online 2017 Feb 22. doi: 10.1038/srep42914

PMCID:: PMC5320494

Abstract Article PDF–321K

Select item 509455910.

Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics

Pasqualina D'Ursi, Sara Guariento, Gabriele Trombetti, Alessandro Orro, Elena Cichero, Luciano Milanesi, Paola Fossa, Olga Bruno

Mol Inform. 2016 Sep; 35(8-9): 369–381. Published online 2016 Jun 20. doi: 10.1002/minf.201501033

PMCID:: PMC5094559

Abstract Article PDF–1.7M

Select item 482104311.

Aberrant DNA Methylation of Phosphodiestarase 4D Alters Airway Smooth Muscle Cell Phenotypes

Amanda H. Y. Lin, Yan Shang, Wayne Mitzner, James S. K. Sham, Wan-yee Tang

Am J Respir Cell Mol Biol. 2016 Feb; 54(2): 241–249. doi: 10.1165/rcmb.2015-0079OC

Correction in:: Am J Respir Cell Mol Biol. 2016 Apr; 54(4): 597.

PMCID:: PMC4821043

Abstract Article PDF–902K

Select item 462199112.

Phosphodiesterase 4D: an enzyme to remember

Roberta Ricciarelli, Ernesto Fedele

Br J Pharmacol. 2015 Oct; 172(20): 4785–4789. Published online 2015 Sep 22. doi: 10.1111/bph.13257

PMCID:: PMC4621991

Abstract Article PDF–448K

Select item 437841713.

Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4

Peder Cedervall, Ann Aulabaugh, Kieran F. Geoghegan, Thomas J. McLellan, Jayvardhan Pandit

Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12): E1414–E1422. Published online 2015 Mar 9. doi: 10.1073/pnas.1419906112

PMCID:: PMC4378417

Abstract Article PDF–1.4M

Select item 437179414.

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Graeme B. Bolger, Allan J. Dunlop, Dong Meng, Jon P. Day, Enno Klussmann, George S. Baillie, David R. Adams, Miles D. Houslay

Cell Signal. 2015 Apr; 27(4): 756–769. doi: 10.1016/j.cellsig.2014.12.009

PMCID:: PMC4371794

Abstract Article

Select item 434627215.

The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus

Ashleigh M. Byrne, Christina Elliott, Ralf Hoffmann, George S. Baillie

FEBS Lett. 2015 Mar 12; 589(6): 750–755. doi: 10.1016/j.febslet.2015.02.004

PMCID:: PMC4346272

Abstract Article

Select item 431250316.

Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential

Ginny L. Powers, Kimberly D.P. Hammer, Maribella Domenech, Katsiaryna Frantskevich, Rita L. Malinowski, Wade Bushman, David J. Beebe, Paul C. Marker

Mol Cancer Res. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Mol Cancer Res. 2015 Jan; 13(1): 149–160. Published online 2014 Aug 22. doi: 10.1158/1541-7786.MCR-14-0110

PMCID:: PMC4312503

Abstract Article PDF–1.6M

Select item 400496417.

A whole genome association study of neuroticism using DNA pooling

S Shifman, A Bhomra, S Smiley, NR Wray, MR James, NG Martin, JM Hettema, SS An, MC Neale, EJCG van den Oord, KS Kendler, X Chen, DI Boomsma, CM Middeldorp, JJ Hottenga, PE Slagboom, J Flint

Mol Psychiatry. Author manuscript; available in PMC 2014 Apr 30.

Published in final edited form as: Mol Psychiatry. 2008 Mar; 13(3): 302–312. Published online 2007 Jul 31. doi: 10.1038/sj.mp.4002048