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Select item 106252631.

Expanding the clinical spectrum of cytosolic phosphoenolpyruvate carboxykinase deficiency: novel PCK1 variants in four Arabian Gulf families

Marwa Al Busaidi, Feda E. Mohamed, Eiman Al-Ajmi, Nadia Al Hashmi, Khalid Al-Thihli, Amna Al Futaisi, Watfa Al Mamari, Fathiya Al-Murshedi, Fatma Al-Jasmi

Orphanet J Rare Dis. 2023; 18: 344. Published online 2023 Nov 3. doi: 10.1186/s13023-023-02946-5

PMCID:: PMC10625263

Abstract Article PDF–1.2M

Select item 79484132.

Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity

Pedro Latorre-Muro, Josue Baeza, Ramon Hurtado-Guerrero, Thomas Hicks, Ignacio Delso, Cristina Hernández-Ruiz, Adrian Velázquez-Campoy, Alexis J. Lawton, Jesús Angulo, John M. Denu, José A. Carrodeguas

J Biol Chem. 2021 Jan-Jun; 296: 100205. Published online 2021 Jan 21. doi: 10.1074/jbc.RA120.015103

PMCID:: PMC7948413

Abstract Article PDF–3.0M

Select item 63606963.

PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27^Kip1 axis

Lin Tuo, Jin Xiang, Xuanming Pan, Jieli Hu, Hua Tang, Li Liang, Jie Xia, Yuan Hu, Wenlu Zhang, Ailong Huang, Kai Wang, Ni Tang

J Exp Clin Cancer Res. 2019; 38: 50. Published online 2019 Feb 4. doi: 10.1186/s13046-019-1029-y

PMCID:: PMC6360696

Abstract Article PDF–7.4M

Select item 58609304.

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Meng-Xi Liu, Lei Jin, Si-Jia Sun, Peng Liu, Xu Feng, Zhou-Li Cheng, Wei-Ren Liu, Kun-Liang Guan, Ying-Hong Shi, Hai-Xin Yuan, Yue Xiong

Oncogene. Author manuscript; available in PMC 2018 Jul 16.

Published in final edited form as: Oncogene. 2018 Mar; 37(12): 1637–1653. Published online 2018 Jan 16. doi: 10.1038/s41388-017-0070-6

PMCID:: PMC5860930

Abstract Article PDF–2.2M

Select item 50541235.

Identification of Conserved Regulatory Elements in Mammalian Promoter Regions: A Case Study Using the PCK1 Promoter

George E. Liu, Matthew T. Weirauch, Curtis P. Van Tassell, Robert W. Li, Tad S. Sonstegard, Lakshmi K. Matukumalli, Erin E. Connor, Richard W. Hanson, Jianqi Yang

Genomics Proteomics Bioinformatics. 2008; 6(3-4): 129–143. Published online 2009 Mar 27. doi: 10.1016/S1672-0229(09)60001-2

PMCID:: PMC5054123

Abstract Article PDF–678K

Select item 46313756.

Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft

Shashank Prakash Katiyar, Arpit Jain, Jaspreet Kaur Dhanjal, Durai Sundar

PLoS One. 2015; 10(11): e0141987. Published online 2015 Nov 3. doi: 10.1371/journal.pone.0141987

PMCID:: PMC4631375

Abstract Article PDF–4.3M

Select item 42199337.

Three Rare Diseases in One Sib Pair: RAI1, PCK1, GRIN2B Mutations Associated with Smith-Magenis Syndrome, Cytosolic PEPCK Deficiency and NMDA Receptor Glutamate Insensitivity

David R Adams, Hongjie Yuan, Todd Holyoak, Katrina H. Arajs, Parvin Hakimi, Thomas C Markello, Lynne A Wolfe, Thierry Vilboux, Barbara K Burton, Karin Fuentes Fajardo, George Grahame, Conisha Holloman, Murat Sincan, Ann C M Smith, Gordon A Wells, Yan Huang, Hugo Vega, James P Snyder, Gretchen A Golas, Cynthia J Tifft, Cornelius F Boerkoel, Richard W Hanson, Stephen F Traynelis, Douglas S Kerr, William A Gahl

Mol Genet Metab. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: Mol Genet Metab. 2014 Nov; 113(3): 161–170. Published online 2014 Apr 13. doi: 10.1016/j.ymgme.2014.04.001

PMCID:: PMC4219933

Abstract Article PDF–1.0M

Select item 29949398.

A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis

Zongqi Xia, Lori B. Chibnik, Bonnie I. Glanz, Maria Liguori, Joshua M. Shulman, Dong Tran, Samia J. Khoury, Tanuja Chitnis, Todd Holyoak, Howard L. Weiner, Charles R. G. Guttmann, Philip L. De Jager

PLoS One. 2010; 5(11): e14169. Published online 2010 Nov 30. doi: 10.1371/journal.pone.0014169

PMCID:: PMC2994939

Abstract Article PDF–269K

Select item 27490229.

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population

Simon D Rees, Abigail C Britten, Srikanth Bellary, J Paul O'Hare, Sudhesh Kumar, Anthony H Barnett, M Ann Kelly

BMC Med Genet. 2009; 10: 83. Published online 2009 Sep 2. doi: 10.1186/1471-2350-10-83

PMCID:: PMC2749022

Abstract Article PDF–267K

Select item 1031336210.

Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression

Dongmei Gou, Rui Liu, Xiaoqun Shan, Haijun Deng, Chang Chen, Jin Xiang, Yi Liu, Qingzhu Gao, Zhi Li, Ailong Huang, Kai Wang, Ni Tang

J Clin Invest. 2023 Jul 3; 133(13): e161713. Published online 2023 Jul 3. doi: 10.1172/JCI161713

PMCID:: PMC10313362

Abstract Article PDF–26M

Select item 819047811.

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis

Shuo Yu, Simin Meng, Meixiang Xiang, Hong Ma

Mol Metab. 2021 Nov; 53: 101257. Published online 2021 May 18. doi: 10.1016/j.molmet.2021.101257

PMCID:: PMC8190478

Abstract Article PDF–3.1M

Select item 729934012.

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

Norihiro Yamaguchi, Ethan M Weinberg, Alexander Nguyen, Maria V Liberti, Hani Goodarzi, Yelena Y Janjigian, Philip B Paty, Leonard B Saltz, T Peter Kingham, Jia Min Loo, Elisa de Stanchina, Sohail F Tavazoie

eLife. 2019; 8: e52135. Published online 2019 Dec 16. doi: 10.7554/eLife.52135

PMCID:: PMC7299340

Abstract Article PDF–3.1M

Select item 631088413.

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5

Qingya Shen, Zhiyu Qiu, Wenping Wu, Jimin Zheng, Zongchao Jia

Biol Open. 2018 Dec 15; 7(12): bio037366. Published online 2018 Dec 15. doi: 10.1242/bio.037366

PMCID:: PMC6310884

Abstract Article PDF–1.4M

Select item 1054264714.

Suppression of SLC39A6‐CREB1 axis in liver cancer causes PCK1‐mediated mitochondrial dysfunction

Ze Yu, Cheng Chen, Hongpeng Gu, Jinliang Dong, Yingjie Zhang, Jie Wang, Haijie Ma, Guoqiang Zhang

Cell Prolif. 2023 Oct; 56(10): e13527. Published online 2023 Jul 12. doi: 10.1111/cpr.13527

PMCID:: PMC10542647

Article PDF–1.5M

Select item 1040331615.

Structure of the human UBR5 E3 ubiquitin ligase

Feng Wang, Qing He, Wenhu Zhan, Ziqi Yu, Efrat Finkin-Groner, Xiaojing Ma, Gang Lin, Huilin Li

Structure. Author manuscript; available in PMC 2023 Aug 4.

Published in final edited form as: Structure. 2023 May 4; 31(5): 541–552.e4. Published online 2023 Apr 10. doi: 10.1016/j.str.2023.03.010

PMCID:: PMC10403316

Abstract Article PDF–1.7M

Select item 888875316.

PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer

Yu-Ching Wen, Chien-Liang Liu, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Van Thi Ngoc Tram, Michael Hsiao, Jiaoti Huang, Wei-Yu Chen, Yen-Nien Liu

Br J Cancer. 2022 Mar 23; 126(5): 778–790. Published online 2021 Nov 24. doi: 10.1038/s41416-021-01631-3

PMCID:: PMC8888753

Abstract Article PDF–3.2M

Select item 636324117.

Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population

Shimin Hu, Shujuan Ma, Xun Li, Zhengwen Tian, Huiling Liang, Junxia Yan, Mengshi Chen, Hongzhuan Tan

Biomed Res Int. 2019; 2019: 7398063. Published online 2019 Jan 20. doi: 10.1155/2019/7398063

PMCID:: PMC6363241

Abstract Article PDF–721K

Select item 548248118.

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α

Pedro Latorre, Luis Varona, Carmen Burgos, José A. Carrodeguas, Pascual López-Buesa

PLoS One. 2017; 12(6): e0179988. Published online 2017 Jun 23. doi: 10.1371/journal.pone.0179988

Correction in:: PLoS One. 2017; 12(8): e0183566.

Correction in:: PLoS One. 2017; 12(8): e0183735.

PMCID:: PMC5482481

Abstract Article PDF–3.4M

Select item 371316719.

Toll-like receptor 4 signaling is required for induction of gluconeogenic gene expression by palmitate in human hepatic carcinoma cells

Laman K. Mamedova, Kai Yuan, Amber N. Laudick, Sherry D. Fleming, Douglas G. Mashek, Barry J. Bradford

J Nutr Biochem. Author manuscript; available in PMC 2014 Aug 1.

Published in final edited form as: J Nutr Biochem. 2013 Aug; 24(8): 1499–1507. Published online 2013 Mar 1. doi: 10.1016/j.jnutbio.2012.12.009

PMCID:: PMC3713167

Abstract Article PDF–1.4M

Select item 239115820.

The estrogen hypothesis of Schizophrenia implicates glucose metabolism: Association study in three independent samples

Line Olsen, Thomas Hansen, Klaus D Jakobsen, Srdjan Djurovic, Ingrid Melle, Ingrid Agartz, Haakan Hall, Henrik Ullum, Sally Timm, August G Wang, Erik G Jönsson, Ole A Andreassen, Thomas Werge

BMC Med Genet. 2008; 9: 39. Published online 2008 May 6. doi: 10.1186/1471-2350-9-39

PMCID:: PMC2391158

Abstract Article PDF–348K

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