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Select item 88983721.

CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability

Fei Liu, Qianying Han, Ting Zhang, Fen Chang, Jingcheng Deng, Xiaotian Huang, Weiping Wang, Yongjie Xu, Qin Li, Luzheng Xu, Bo Zhang, Wentong Li, Li Li, Yanrong Su, Yang Li, Genze Shao

Int J Biol Sci. 2022; 18(4): 1434–1450. Published online 2022 Jan 24. doi: 10.7150/ijbs.57178

PMCID:: PMC8898372

Article PDF–2.8M

Select item 87585082.

Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor

Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikołaj Słabicki, Dapeng Hao, Caroline J. Watson, Ayala Tovy, Jaime M. Reyes, Olga Dakhova, Brielle R. Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter J.M. Valk, Lionel Van Maldergem, Mathijs A. Sanders, Jamie R. Blundell, Wei Li, Benjamin L. Ebert, Margaret A. Goodell

Cancer Discov. 2022 Jan 1; 12(1): 220–235. Published online 2021 Aug 24. doi: 10.1158/2159-8290.CD-21-0560

PMCID:: PMC8758508

Article PDF–11M

Select item 39597563.

Ubiquitin ligase defect by DCAF8 mutation causes HMSN2 with giant axons

Christopher J. Klein, Yanhong Wu, Peter Vogel, Hans H. Goebel, Carsten Bönnemann, Kristen Zukosky, Maria-Victoria Botuyan, Xiaohui Duan, Sumit Middha, Elizabeth J. Atkinson, Georges Mer, Peter J. Dyck

Neurology. 2014 Mar 11; 82(10): 873–878. doi: 10.1212/WNL.0000000000000206

PMCID:: PMC3959756

Article PDF–728K

Select item 28232884.

A Promiscuous α-Helical Motif Anchors Viral Hijackers and Substrate Receptors to the CUL4-DDB1 Ubiquitin Ligase Machinery

Ti Li, Eva I. Robert, Pieter C. van Breugel, Michel Strubin, Ning Zheng

Nat Struct Mol Biol. Author manuscript; available in PMC 2010 Jul 1.

Published in final edited form as: Nat Struct Mol Biol. 2010 Jan; 17(1): 105. Published online 2009 Dec 6. doi: 10.1038/nsmb.1719

PMCID:: PMC2823288

Article PDF–1.3M

Select item 48775705.

A genome-scale CRISPR-Cas9 screening method for protein stability reveals novel regulators of Cdc25A

Yuanzhong Wu, Liwen Zhou, Xin Wang, Jinping Lu, Ruhua Zhang, Xiaoting Liang, Li Wang, Wuguo Deng, Yi-Xin Zeng, Haojie Huang, Tiebang Kang

Cell Discov. 2016; 2: 16014. Published online 2016 May 24. doi: 10.1038/celldisc.2016.14

PMCID:: PMC4877570

Article PDF–2.3M

Select item 93082186.

FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia

Hyun Mi Kang, Dae Hun Kim, Mijin Kim, Yoohong Min, Bohyeon Jeong, Kyung Hee Noh, Da Yong Lee, Hyun-Soo Cho, Nam-Soon Kim, Cho-Rok Jung, Jung Hwa Lim

Cell Biosci. 2022; 12: 110. Published online 2022 Jul 22. doi: 10.1186/s13578-022-00851-1

PMCID:: PMC9308218

Article PDF–2.8M

Select item 84877217.

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase

Shuai Zhao, Wafik S. El-Deiry

Oncotarget. 2021 Sep 28; 12(20): 1970–1979. Published online 2021 Sep 28. doi: 10.18632/oncotarget.28081

PMCID:: PMC8487721

Article PDF–3.1M

Select item 81669458.

CRL4^DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis

Daoyuan Huang, Qian Li, Xinpei Sun, Xiwen Sun, Yunyi Tang, Yanan Qu, Dawei Liu, Tingting Yu, Guodong Li, Tanjun Tong, Yu Zhang

Cell Death Differ. 2021 May; 28(5): 1593–1609. Published online 2020 Dec 7. doi: 10.1038/s41418-020-00689-5

PMCID:: PMC8166945

Article PDF–6.3M

Select item 66259219.

Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1

Luca Lignitto, Sarah E. LeBoeuf, Harrison Homer, Shaowen Jiang, Manor Askenazi, Triantafyllia R. Karakousi, Harvey I. Pass, Arjun J. Bhutkar, Aristotelis Tsirigos, Beatrix Ueberheide, Volkan I. Sayin, Thales Papagiannakopoulos, Michele Pagano

Cell. Author manuscript; available in PMC 2020 Jul 11.

Published in final edited form as: Cell. 2019 Jul 11; 178(2): 316–329.e18. Published online 2019 Jun 27. doi: 10.1016/j.cell.2019.06.003

PMCID:: PMC6625921

Article PDF–3.1M

Select item 658157410.

Cryptochromes-mediated Inhibition of the CRL4^Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

Luca Rizzini, Daniel C. Levine, Mark Perelis, Joseph Bass, Clara B. Peek, Michele Pagano

Curr Biol. Author manuscript; available in PMC 2020 Jun 17.

Published in final edited form as: Curr Biol. 2019 Jun 17; 29(12): 1954–1962.e4. Published online 2019 May 30. doi: 10.1016/j.cub.2019.04.073

PMCID:: PMC6581574

Article PDF–1.1M

Select item 406716911.

The Splicing Factor FUBP1 Is Required for the Efficient Splicing of Oncogene MDM2 Pre-mRNA

Aishwarya G. Jacob, Ravi K. Singh, Fuad Mohammad, Thomas W. Bebee, Dawn S. Chandler

J Biol Chem. 2014 Jun 20; 289(25): 17350–17364. Published online 2014 May 5. doi: 10.1074/jbc.M114.554717

PMCID:: PMC4067169

Article PDF–1.9M

Select item 887529712.

CRL4^AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi, Gergely Rona, Nan Zhou, Yeon-Tae Jeong, Shaowen Jiang, Giacomo Milletti, Arnaldo A. Arbini, Alfie O’Sullivan, Andrew A. Wang, Sorasicha Nithikasem, Sarah Keegan, Yik Siu, Valentina Cianfanelli, Emiliano Maiani, Francesca Nazio, Francesco Cecconi, Francesco Boccalatte, David Fenyö, Drew R. Jones, Luca Busino, Michele Pagano

Nature. Author manuscript; available in PMC 2022 Apr 14.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 789–793. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03445-y

PMCID:: PMC8875297

Article PDF–6.0M

Select item 893369913.

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation

Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein

J Biol Chem. 2022 Apr; 298(4): 101750. Published online 2022 Feb 23. doi: 10.1016/j.jbc.2022.101750

PMCID:: PMC8933699

Article PDF–1.6M

Select item 272093314.

An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases

Michael Hans Olma, Marcia Roy, Thierry Le Bihan, Izabela Sumara, Sarah Maerki, Brett Larsen, Manfredo Quadroni, Matthias Peter, Mike Tyers, Lionel Pintard

J Cell Sci. 2009 Apr 1; 122(7): 1035–1044. Published online 2009 Mar 18. doi: 10.1242/jcs.043539

PMCID:: PMC2720933

Article

Select item 644057715.

Isoform-specific GSK3A activity is negatively correlated with human sperm motility

M J Freitas, J V Silva, C Brothag, B Regadas-Correia, M Fardilha, S Vijayaraghavan

Mol Hum Reprod. 2019 Apr; 25(4): 171–183. Published online 2019 Mar 2. doi: 10.1093/molehr/gaz009

PMCID:: PMC6440577

Article PDF–1.0M

Select item 613844116.

CRL4^AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling

Si‐Han Chen, Gwendolyn M Jang, Ruth Hüttenhain, David E Gordon, Dan Du, Billy W Newton, Jeffrey R Johnson, Joseph Hiatt, Judd F Hultquist, Tasha L Johnson, Yi‐Liang Liu, Lily A Burton, Jordan Ye, Kurt M Reichermeier, Robert M Stroud, Alexander Marson, Jayanta Debnath, John D Gross, Nevan J Krogan

EMBO J. 2018 Sep 14; 37(18): e97508. Published online 2018 Aug 30. doi: 10.15252/embj.201797508

PMCID:: PMC6138441

Article PDF–1.7M

Select item 389378317.

Identification of proteins that interact with alpha A-crystallin using a human proteome microarray

Qi Fan, Lv-Zhen Huang, Xiang-Jia Zhu, Ke-Ke Zhang, Hong-Fei Ye, Yi Luo, Xing-Huai Sun, Peng Zhou, Yi Lu

Mol Vis. 2014; 20: 117–124. Published online 2014 Jan 14.

PMCID:: PMC3893783

Article PDF–1024K

Select item 711512818.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Article PDF–1.6M

Select item 794896419.

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1

Lee D. Harris, Janic Le Pen, Nico Scholz, Juliusz Mieszczanek, Natalie Vaughan, Simon Davis, Georgina Berridge, Benedikt M. Kessler, Mariann Bienz, Julien D.F. Licchesi

J Biol Chem. 2021 Jan-Jun; 296: 100246. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015162

PMCID:: PMC7948964

Article PDF–2.7M

Select item 287256120.

An empirical framework for binary interactome mapping

Kavitha Venkatesan, Jean-François Rual, Alexei Vazquez, Ulrich Stelzl, Irma Lemmens, Tomoko Hirozane-Kishikawa, Tong Hao, Martina Zenkner, Xiaofeng Xin, Kwang-II Goh, Muhammed A Yildirim, Nicolas Simonis, Kathrin Heinzmann, Fana Gebreab, Julie M Sahalie, Sebiha Cevik, Christophe Simon, Anne-Sophie de Smet, Elizabeth Dann, Alex Smolyar, Arunachalam Vinayagam, Haiyuan Yu, David Szeto, Heather Borick, Amélie Dricot, Niels Klitgord, Ryan R Murray, Chenwei Lin, Maciej Lalowski, Jan Timm, Kirstin Rau, Charles Boone, Pascal Braun, Michael E Cusick, Frederick P Roth, David E Hill, Jan Tavernier, Erich E Wanker, Albert-László Barabási, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2010 May 18.

Published in final edited form as: Nat Methods. 2009 Jan; 6(1): 83–90. Published online 2008 Dec 7. doi: 10.1038/nmeth.1280

PMCID:: PMC2872561

Article PDF–1.0M

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