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Select item 83287321.

ARHGEF3 Associated with Invasion, Metastasis, and Proliferation in Human Osteosarcoma

Jie Gong, Wei Tang, Bin Lv, Shushu Zhang, Tingjuan Fan, Guangyu Gao, Dong Chen, Yulong Liu

Biomed Res Int. 2021; 2021: 3381957. Published online 2021 Jul 24. doi: 10.1155/2021/3381957

PMCID:: PMC8328732

Abstract Article PDF–2.0M

Select item 82826322.

Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

Nilmani Singh, Adriana Reyes-Ordoñez, Michael A. Compagnone, Jesus F. Moreno, Benjamin J. Leslie, Taekjip Ha, Jie Chen

Nat Commun. 2021; 12: 4339. Published online 2021 Jul 15. doi: 10.1038/s41467-021-24639-y

PMCID:: PMC8282632

Abstract Article PDF–2.4M

Select item 50419483.

The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis

Tian-Hao Liu, Fang Zheng, Mu-Yan Cai, Lin Guo, Huan-Xin Lin, Jie-Wei Chen, Yi-Ji Liao, Hsiang-Fu Kung, Yi-Xin Zeng, Dan Xie

Oncotarget. 2016 May 3; 7(18): 25836–25848. Published online 2016 Mar 23. doi: 10.18632/oncotarget.8283

PMCID:: PMC5041948

Abstract Article PDF–6.6M

Select item 46226974.

ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias

Loredana D’Amato, Carmela Dell’Aversana, Mariarosaria Conte, Alfonso Ciotta, Lucia Scisciola, Annamaria Carissimo, Angela Nebbioso, Lucia Altucci

Epigenetics. 2015 Jan; 10(1): 6–18. Published online 2015 Jan 27. doi: 10.4161/15592294.2014.988035

PMCID:: PMC4622697

Abstract Article PDF–891K

Select item 24272585.

Identification of a Role for the ARHGEF3 Gene in Postmenopausal Osteoporosis

Ben H. Mullin, Richard L. Prince, Ian M. Dick, Deborah J. Hart, Tim D. Spector, Frank Dudbridge, Scott G. Wilson

Am J Hum Genet. 2008 Jun 6; 82(6): 1262–1269. Published online 2008 May 30. doi: 10.1016/j.ajhg.2008.04.016

PMCID:: PMC2427258

Abstract Article PDF–349K

Select item 95686106.

ARHGEF3 regulates the stability of ACLY to promote the proliferation of lung cancer

Feifei Zhou, Wenqian Ai, Yixing Zhang, Qifan Hu, Mingxi Gan, Jian-Bin Wang, Tianyu Han

Cell Death Dis. 2022 Oct; 13(10): 870. Published online 2022 Oct 14. doi: 10.1038/s41419-022-05297-4

PMCID:: PMC9568610

Abstract Article PDF–5.7M

Select item 61429177.

DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies

Olivera Story Jovanova, Ivana Nedeljkovic, Derek Spieler, Rosie M. Walker, Chunyu Liu, Michelle Luciano, Jan Bressler, Jennifer Brody, Amanda J. Drake, Kathryn L. Evans, Rahul Gondalia, Sonja Kunze, Brigitte Kuhnel, Jari Lahti, Rozenn N. Lemaitre, Riccardo E. Marioni, Brenton Swenson, Jayandra Jung Himali, Hongsheng Wu, Yun Li, Allan F. McRae, Tom C. Russ, James Stewart, Zhiying Wang, Guosheng Zhang, Karl-Heinz Ladwig, Andre G. Uitterlinden, Xiuqing Guo, Annette Peters, Katri Räikkönen, John M. Starr, Melanie Waldenberger, Naomi R. Wray, Eric A. Whitsel, Nona Sotoodehnia, Sudha Seshadri, David J. Porteous, Joyce van Meurs, Thomas H. Mosley, Andrew M. McIntosh, Michael M. Mendelson, Daniel Levy, Lifang Hou, Johan G. Eriksson, Myriam Fornage, Ian J. Deary, Andrea Baccarelli, Henning Tiemeier, Najaf Amin

JAMA Psychiatry. 2018 Sep; 75(9): 949–959. Published online 2018 Jul 11. doi: 10.1001/jamapsychiatry.2018.1725

Correction in:: JAMA Psychiatry. 2018 Nov; 75(11): 1206.

PMCID:: PMC6142917

Abstract Article

Select item 37917178.

XPLN is an endogenous inhibitor of mTORC2

Nidhi Khanna, Yimin Fang, Mee-Sup Yoon, Jie Chen

Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40): 15979–15984. Published online 2013 Sep 16. doi: 10.1073/pnas.1310434110

PMCID:: PMC3791717

Abstract Article PDF–1.0M

Select item 70931669.

Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant interaction networks, contribute to the risk of Hirschsprung disease

Yang Wang, Qian Jiang, Hao Cai, Ze Xu, Wenjie Wu, Beilin Gu, Long Li, Wei Cai

Aging (Albany NY) 2020 Mar 15; 12(5): 4379–4393. Published online 2020 Mar 6. doi: 10.18632/aging.102891

PMCID:: PMC7093166

Abstract Article PDF–1.3M

Select item 544159710.

SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume

Siying Zou, Alexandra M. Teixeira, Myrto Kostadima, William J. Astle, Aparna Radhakrishnan, Lukas Mikolaj Simon, Lucy Truman, Jennifer S. Fang, John Hwa, Ping-xia Zhang, Pim van der Harst, Paul F. Bray, Willem H. Ouwehand, Mattia Frontini, Diane S. Krause

PLoS One. 2017; 12(5): e0178095. Published online 2017 May 23. doi: 10.1371/journal.pone.0178095

PMCID:: PMC5441597

Abstract Article PDF–4.5M

Select item 402653211.

Influence of ARHGEF3 and RHOA Knockdown on ACTA2 and Other Genes in Osteoblasts and Osteoclasts

Benjamin H. Mullin, Cyril Mamotte, Richard L. Prince, Scott G. Wilson

PLoS One. 2014; 9(5): e98116. Published online 2014 May 19. doi: 10.1371/journal.pone.0098116

PMCID:: PMC4026532

Abstract Article PDF–534K

Select item 266803612.

A Genome-wide Association Study Identifies Three Loci Associated with Mean Platelet Volume

Christa Meisinger, Holger Prokisch, Christian Gieger, Nicole Soranzo, Divya Mehta, Dieter Rosskopf, Peter Lichtner, Norman Klopp, Jonathan Stephens, Nicholas A. Watkins, Panos Deloukas, Andreas Greinacher, Wolfgang Koenig, Matthias Nauck, Christian Rimmbach, Henry Völzke, Annette Peters, Thomas Illig, Willem H. Ouwehand, Thomas Meitinger, H.-Erich Wichmann, Angela Döring

Am J Hum Genet. 2009 Jan 9; 84(1): 66–71. doi: 10.1016/j.ajhg.2008.11.015

PMCID:: PMC2668036

Abstract Article PDF–472K

Select item 294657813.

Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women

G. H. Y. Li, A. W. C. Kung, Q.-Y. Huang

Osteoporos Int. 2010 Jun; 21(6): 1009–1020. Published online 2009 Sep 1. doi: 10.1007/s00198-009-1043-6

PMCID:: PMC2946578

Abstract Article PDF–379K

Select item 388060514.

A Genome- and Phenome-Wide Association Study to Identify Genetic Variants Influencing Platelet Count and Volume and their Pleiotropic Effects

Khader Shameer, Joshua C. Denny, Keyue Ding, Hayan Jouni, David R. Crosslin, Mariza de Andrade, Christopher G. Chute, Peggy Peissig, Jennifer A. Pacheco, Rongling Li, Lisa Bastarache, Abel N. Kho, Marylyn D Ritchie, Daniel R. Masys, Rex L. Chisholm, Eric B. Larson, Catherine A. McCarty, Dan M. Roden, Gail P. Jarvik, Iftikhar J. Kullo

Hum Genet. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Hum Genet. 2014 Jan; 133(1): 10.1007/s00439-013-1355-7. Published online 2013 Sep 12. doi: 10.1007/s00439-013-1355-7

PMCID:: PMC3880605

Abstract Article PDF–2.2M

Select item 310845915.

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Nicole Soranzo, Tim D Spector, Massimo Mangino, Brigitte Kühnel, Augusto Rendon, Alexander Teumer, Christina Willenborg, Benjamin Wright, Li Chen, Mingyao Li, Perttu Salo, Benjamin F Voight, Philippa Burns, Roman A Laskowski, Yali Xue, Stephan Menzel, David Altshuler, John R Bradley, Suzannah Bumpstead, Mary-Susan Burnett, Joseph Devaney, Angela Döring, Roberto Elosua, Stephen Epstein, Wendy Erber, Mario Falchi, Stephen F Garner, Mohammed J R Ghori, Alison H Goodall, Rhian Gwilliam, Hakon H Hakonarson, Alistair S Hall, Naomi Hammond, Christian Hengstenberg, Thomas Illig, Inke R König, Christopher W Knouff, Ruth McPherson, Olle Melander, Vincent Mooser, Matthias Nauck, Markku S Nieminen, Christopher J O’Donnell, Leena Peltonen, Simon C Potter, Holger Prokisch, Daniel J Rader, Catherine M Rice, Robert Roberts, Veikko Salomaa, Jennifer Sambrook, Stefan Schreiber, Heribert Schunkert, Stephen M Schwartz, Jovana Serbanovic-Canic, Juha Sinisalo, David S. Siscovick, Klaus Stark, Ida Surakka, Jonathan Stephens, John R Thompson, Uwe Völker, Henry Völzke, Nicholas A Watkins, George A Wells, H-Erich Wichmann, David A Van Heel, Chris Tyler-Smith, Swee Lay Thein, Sekar Kathiresan, Markus Perola, Muredach P Reilly, Alexandre F R Stewart, Jeanette Erdmann, Nilesh J Samani, Christa Meisinger, Andreas Greinacher, Panos Deloukas, Willem H Ouwehand, Christian Gieger

Nat Genet. Author manuscript; available in PMC 2011 Jun 6.

Published in final edited form as: Nat Genet. 2009 Nov; 41(11): 1182–1190. Published online 2009 Oct 11. doi: 10.1038/ng.467

PMCID:: PMC3108459

Abstract Article PDF–1.6M

Select item 365747516.

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children

Jin Li, Joseph T. Glessner, Haitao Zhang, Cuiping Hou, Zhi Wei, Jonathan P. Bradfield, Frank D. Mentch, Yiran Guo, Cecilia Kim, Qianghua Xia, Rosetta M. Chiavacci, Kelly A. Thomas, Haijun Qiu, Struan F.A. Grant, Susan L. Furth, Hakon Hakonarson, Patrick M.A. Sleiman

Hum Mol Genet. 2013 Apr 1; 22(7): 1457–1464. Published online 2012 Dec 20. doi: 10.1093/hmg/dds534

PMCID:: PMC3657475

Abstract Article PDF–147K

Select item 675758317.

Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

Anthony W. Harrington, Ju Young Kim, Sung Ok Yoon

J Neurosci. 2002 Jan 1; 22(1): 156–166. doi: 10.1523/JNEUROSCI.22-01-00156.2002

PMCID:: PMC6757583

Abstract Article PDF–582K

Select item 786343018.

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Lizhu Hu, Delong Wang, Ruiting Wang, Zhiyou Fang, Xueran Chen

Stem Cell Res Ther. 2021; 12: 107. Published online 2021 Feb 4. doi: 10.1186/s13287-021-02175-2

PMCID:: PMC7863430

Abstract Article PDF–6.5M

Select item 333529619.

New gene functions in megakaryopoiesis and platelet formation

Christian Gieger, Aparna Radhakrishnan, Ana Cvejic, Weihong Tang, Eleonora Porcu, Giorgio Pistis, Jovana Serbanovic-Canic, Ulrich Elling, Alison H. Goodall, Yann Labrune, Lorna M. Lopez, Reedik Mägi, Stuart Meacham, Yukinori Okada, Nicola Pirastu, Rossella Sorice, Alexander Teumer, Katrin Voss, Weihua Zhang, Ramiro Ramirez-Solis, Joshua C. Bis, David Ellinghaus, Martin Gögele, Jouke-Jan Hottenga, Claudia Langenberg, Peter Kovacs, Paul F. O’Reilly, So-Youn Shin, Tõnu Esko, Jaana Hartiala, Stavroula Kanoni, Federico Murgia, Afshin Parsa, Jonathan Stephens, Pim van der Harst, C. Ellen van der Schoot, Hooman Allayee, Antony Attwood, Beverley Balkau, François Bastardot, Saonli Basu, Sebastian E. Baumeister, Ginevra Biino, Lorenzo Bomba, Amélie Bonnefond, François Cambien, John C. Chambers, Francesco Cucca, Pio D’Adamo, Gail Davies, Rudolf A. de Boer, Eco J. C. de Geus, Angela Döring, Paul Elliott, Jeanette Erdmann, David M. Evans, Mario Falchi, Wei Feng, Aaron R. Folsom, Ian H. Frazer, Quince D. Gibson, Nicole L. Glazer, Chris Hammond, Anna-Liisa Hartikainen, Susan R. Heckbert, Christian Hengstenberg, Micha Hersch, Thomas Illig, Ruth J. F. Loos, Jennifer Jolley, Kay Tee Khaw, Brigitte Kühnel, Marie-Christine Kyrtsonis, Vasiliki Lagou, Heather Lloyd-Jones, Thomas Lumley, Massimo Mangino, Andrea Maschio, Irene Mateo Leach, Barbara McKnight, Yasin Memari, Braxton D. Mitchell, Grant W. Montgomery, Yusuke Nakamura, Matthias Nauck, Gerjan Navis, Ute Nöthlings, Ilja M. Nolte, David J. Porteous, Anneli Pouta, Peter P. Pramstaller, Janne Pullat, Susan M. Ring, Jerome I. Rotter, Daniela Ruggiero, Aimo Ruokonen, Cinzia Sala, Nilesh J. Samani, Jennifer Sambrook, David Schlessinger, Stefan Schreiber, Heribert Schunkert, James Scott, Nicholas L. Smith, Harold Snieder, John M. Starr, Michael Stumvoll, Atsushi Takahashi, W. H. Wilson Tang, Kent Taylor, Albert Tenesa, Swee Lay Thein, Anke Tönjes, Manuela Uda, Sheila Ulivi, Dirk J. van Veldhuisen, Peter M. Visscher, Uwe Völker, H.-Erich Wichmann, Kerri L. Wiggins, Gonneke Willemsen, Tsun-Po Yang, Jing Hua Zhao, Paavo Zitting, John R. Bradley, George V. Dedoussis, Paolo Gasparini, Stanley L. Hazen, Andres Metspalu, Mario Pirastu, Alan R. Shuldiner, L. Joost van Pelt, Jaap-Jan Zwaginga, Dorret I. Boomsma, Ian J. Deary, Andre Franke, Philippe Froguel, Santhi K. Ganesh, Marjo-Riitta Jarvelin, Nicholas G. Martin, Christa Meisinger, Bruce M. Psaty, Timothy D. Spector, Nicholas J. Wareham, Jan-Willem N. Akkerman, Marina Ciullo, Panos Deloukas, Andreas Greinacher, Steve Jupe, Naoyuki Kamatani, Jyoti Khadake, Jaspal S. Kooner, Josef Penninger, Inga Prokopenko, Derek Stemple, Daniela Toniolo, Lorenz Wernisch, Serena Sanna, Andrew A. Hicks, Augusto Rendon, Manuel A. Ferreira, Willem H. Ouwehand, Nicole Soranzo

Nature. Author manuscript; available in PMC 2012 Apr 24.

Published in final edited form as: Nature. 2011 Nov 30; 480(7376): 201–208. Published online 2011 Nov 30. doi: 10.1038/nature10659

PMCID:: PMC3335296

Abstract Article PDF–862K

Select item 436785720.

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing

Fernanda Luisa Basei, Gabriela Vaz Meirelles, Germanna Lima Righetto, Deivid Lucas dos Santos Migueleti, Juliana Helena Costa Smetana, Jörg Kobarg

Proteome Sci. 2015; 13: 11. Published online 2015 Feb 26. doi: 10.1186/s12953-015-0065-6

PMCID:: PMC4367857

Abstract Article PDF–3.1M

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