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Select item 102631321.

PCSK6 and Survival in Idiopathic Pulmonary Fibrosis

Justin M. Oldham, Richard J. Allen, Jose M. Lorenzo-Salazar, Philip L. Molyneaux, Shwu-Fan Ma, Chitra Joseph, John S. Kim, Beatriz Guillen-Guio, Tamara Hernández-Beeftink, Jonathan A. Kropski, Yong Huang, Cathryn T. Lee, Ayodeji Adegunsoye, Janelle Vu Pugashetti, Angela L. Linderholm, Vivian Vo, Mary E. Strek, Jonathan Jou, Adrian Muñoz-Barrera, Luis A. Rubio-Rodriguez, Richard Hubbard, Nik Hirani, Moira K. B. Whyte, Simon Hart, Andrew G. Nicholson, Lisa Lancaster, Helen Parfrey, Doris Rassl, William Wallace, Eleanor Valenzi, Yingze Zhang, Josyf Mychaleckyj, Amy Stockwell, Naftali Kaminski, Paul J. Wolters, Maria Molina-Molina, Nicholas E. Banovich, William A. Fahy, Fernando J. Martinez, Ian P. Hall, Martin D. Tobin, Toby M. Maher, Timothy S. Blackwell, Brian L. Yaspan, R. Gisli Jenkins, Carlos Flores, Louise V. Wain, Imre Noth

Am J Respir Crit Care Med. 2023 Jun 1; 207(11): 1515–1524. Published online 2023 Feb 13. doi: 10.1164/rccm.202205-0845OC

PMCID:: PMC10263132

Abstract Article PDF–1.4M

Select item 91373522.

Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma

Carsten WEISHAUPT, Arianna MASTROFRANCESCO, Dieter METZE, Björn KEMPER, Agatha STEGEMANN, Mauro PICARDO, Andres J. P. KLEIN-SZANTO, Markus BÖHM

Acta Derm Venereol. 2020; 100(10): 5779. Published online 2020 May 29. doi: 10.2340/00015555-3525

PMCID:: PMC9137352

Abstract Article PDF–9.4M

Select item 90016533.

PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer

Frédéric Couture, Luojun Wang, Frédérik Dufour, Keena Chabot-Maheux, Nadia Ekindi Ndongo, Robert Sabbagh, Robert Day

Sci Rep. 2022; 12: 6066. Published online 2022 Apr 11. doi: 10.1038/s41598-022-09778-6

PMCID:: PMC9001653

Abstract Article PDF–2.9M

Select item 46395194.

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

Zhiyong Yao, Bin Sun, Quan Hong, Jingmin Yan, Dawei Mu, Jianye Li, Haibo Sheng, Heqing Guo

Drug Des Devel Ther. 2015; 9: 5911–5923. Published online 2015 Nov 5. doi: 10.2147/DDDT.S86881

PMCID:: PMC4639519

Abstract Article PDF–2.2M

Select item 44656545.

Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity

Frédéric Couture, Kévin Ly, Christine Levesque, Anna Kwiatkowska, Samia Ait-Mohand, Roxane Desjardins, Brigitte Guérin, Robert Day

Biomed Res Int. 2015; 2015: 824014. Published online 2015 May 31. doi: 10.1155/2015/824014

PMCID:: PMC4465654

Abstract Article PDF–1.1M

Select item 36950886.

PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness

Larissa Arning, Sebastian Ocklenburg, Stefanie Schulz, Vanessa Ness, Wanda M. Gerding, Jan G. Hengstler, Michael Falkenstein, Jörg T. Epplen, Onur Güntürkün, Christian Beste

PLoS One. 2013; 8(6): e67251. Published online 2013 Jun 27. doi: 10.1371/journal.pone.0067251

PMCID:: PMC3695088

Abstract Article PDF–179K

Select item 35147437.

Role of Proprotein Convertases in Prostate Cancer Progression

Frédéric Couture, François D'Anjou, Roxane Desjardins, François Boudreau, Robert Day

Neoplasia. 2012 Nov; 14(11): 1032–1042. doi: 10.1593/neo.121368

PMCID:: PMC3514743

Abstract Article PDF–2.3M

Select item 30169058.

PCSK6 is associated with handedness in individuals with dyslexia

Thomas S. Scerri, William M. Brandler, Silvia Paracchini, Andrew P. Morris, Susan M. Ring, Alex J. Richardson, Joel B. Talcott, John Stein, Anthony P. Monaco

Hum Mol Genet. 2011 Feb 1; 20(3): 608–614. Published online 2010 Nov 4. doi: 10.1093/hmg/ddq475

PMCID:: PMC3016905

Abstract Article PDF–144K

Select item 12202009.

Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.

J F Sucic, J M Moehring, N M Inocencio, J W Luchini, T J Moehring

Biochem J. 1999 May 1; 339(Pt 3): 639–647.

PMCID:: PMC1220200

Summary PDF–219K

Select item 829957810.

Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome

Xiaolan Zhao, Xun Zhang, Zhao Wu, Jie Mei, Lingling Li, Yujue Wang

Mol Med. 2021; 27: 82. Published online 2021 Jul 23. doi: 10.1186/s10020-021-00335-x

PMCID:: PMC8299578

Abstract Article PDF–7.6M

Select item 574525811.

Functional Analysis of Corin Protein Domains Required for PCSK6-mediated Activation

Shenghan Chen, Hao Wang, Heng Li, Yue Zhang, Qingyu Wu

Int J Biochem Cell Biol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Int J Biochem Cell Biol. 2018 Jan; 94: 31–39. Published online 2017 Nov 24. doi: 10.1016/j.biocel.2017.11.010

PMCID:: PMC5745258

Abstract Article PDF–1.5M

Select item 498633112.

The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts

Robert Shore, Laura Covill, Kerry A. Pettigrew, William M. Brandler, Rebeca Diaz, Yiwang Xu, Javier A. Tello, Joel B. Talcott, Dianne F. Newbury, John Stein, Anthony P. Monaco, Silvia Paracchini

Hum Mol Genet. 2016 May 1; 25(9): 1771–1779. Published online 2016 Feb 21. doi: 10.1093/hmg/ddw047

PMCID:: PMC4986331

Abstract Article PDF–466K

Select item 360314413.

A Role for PACE4 in Osteoarthritis Pain: Evidence from Human Genetic Association and Null Mutant Phenotype

Anne-Marie Malfait, Albert B. Seymour, Feng Gao, Micky D. Tortorella, Marie-Pierre Hellio Le Graverand-Gastineau, Linda S. Wood, Michael Doherty, Sally Doherty, Weiya Zhang, Nigel K. Arden, Frances L. Vaughn, Paul L. Leaverton, Tim D. Spector, Deborah J. Hart, Rose A. Maciewicz, Kenneth R. Muir, Rosalina Das, Robert E. Sorge, Susanna G. Sotocinal, Ara Schorscher-Petcu, Ana M. Valdes, Jeffrey S. Mogil

Ann Rheum Dis. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Ann Rheum Dis. 2012 Jun; 71(6): 1042–1048. Published online 2012 Mar 22. doi: 10.1136/annrheumdis-2011-200300

PMCID:: PMC3603144

Abstract Article PDF–1.2M

Select item 415574414.

Subtilisin-like Proprotein Convertase Expression, Localization, and Activity in the Human Retina and Optic Nerve Head

John A. Fuller, Anne-Marie Brun-Zinkernagel, Abbot F. Clark, Robert J. Wordinger

Invest Ophthalmol Vis Sci. Author manuscript; available in PMC 2014 Sep 5.

Published in final edited form as: Invest Ophthalmol Vis Sci. 2009 Dec; 50(12): 5759–5768. Published online 2009 Apr 1. doi: 10.1167/iovs.08-2616

PMCID:: PMC4155744

Abstract Article PDF–4.0M

Select item 395518615.

Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases

Yong Xiao, Gang Chen, Jonathan Richard, Nicole Rougeau, Hongshan Li, Nabil G. Seidah, Éric A. Cohen

Virology. Author manuscript; available in PMC 2014 Mar 15.

Published in final edited form as: Virology. 2008 Mar 15; 372(2): 384–397. Published online 2007 Dec 3. doi: 10.1016/j.virol.2007.10.036

PMCID:: PMC3955186

Abstract Article PDF–1.2M

Select item 122227316.

Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1.

I Yoshida, S Koide, S I Hasegawa, A Nakagawara, A Tsuji, Y Matsuda

Biochem J. 2001 Dec 15; 360(Pt 3): 683–689. doi: 10.1042/0264-6021:3600683

PMCID:: PMC1222273

Summary PDF–245K

Select item 471051717.

PCSK6-mediated corin activation is essential for normal blood pressure

Shenghan Chen, Pengxiu Cao, Ningzheng Dong, Jianhao Peng, Chunyi Zhang, Hao Wang, Tiantian Zhou, Junhua Yang, Yue Zhang, Elizabeth E Martelli, Sathyamangla V Naga Prasad, Rachel E Miller, Anne-Marie Malfait, Yiqing Zhou, Qingyu Wu

Nat Med. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Nat Med. 2015 Sep; 21(9): 1048–1053. Published online 2015 Aug 10. doi: 10.1038/nm.3920

PMCID:: PMC4710517

Abstract Article PDF–438K

Select item 256740418.

Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

Marie-Hélène Blanchet, J Ann Le Good, Daniel Mesnard, Viola Oorschot, Stéphane Baflast, Gabriella Minchiotti, Judith Klumperman, Daniel B Constam

EMBO J. 2008 Oct 8; 27(19): 2580–2591. Published online 2008 Sep 4. doi: 10.1038/emboj.2008.174

PMCID:: PMC2567404

Abstract Article PDF–1.8M

Select item 144999219.

A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4

Akihiko Tsuji, Yayoi Kikuchi, Yukimi Sato, Shizuyo Koide, Keizo Yuasa, Masami Nagahama, Yoshiko Matsuda

Biochem J. 2006 May 15; 396(Pt 1): 51–59. Prepublished online 2006 Jan 24. Published online 2006 Apr 26. doi: 10.1042/BJ20051524

PMCID:: PMC1449992

Abstract Article PDF–766K

Select item 121708120.

Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.

F Vollenweider, S Benjannet, E Decroly, D Savaria, C Lazure, G Thomas, M Chrétien, N G Seidah

Biochem J. 1996 Mar 1; 314(Pt 2): 521–532. doi: 10.1042/bj3140521

PMCID:: PMC1217081

Summary PDF–620K

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