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Select item 65909871.

Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP

Mufeng Li, Yao Wang, Rahul Banerjee, Fabrizio Marinelli, Shai Silberberg, José D Faraldo-Gómez, Motoyuki Hattori, Kenton Jon Swartz

eLife. 2019; 8: e47060. Published online 2019 Jun 24. doi: 10.7554/eLife.47060

PMCID:: PMC6590987

Abstract Article PDF–4.3M

Select item 59806142.

P2X receptor channels in chronic pain pathways

Louis‐Philippe Bernier, Ariel R Ase, Philippe Séguéla

Br J Pharmacol. 2018 Jun; 175(12): 2219–2230. Published online 2017 Aug 17. doi: 10.1111/bph.13957

PMCID:: PMC5980614

Abstract Article PDF–1.1M

Select item 59489983.

Druggable negative allosteric site of P2X3 receptors

Jin Wang, Yao Wang, Wen-Wen Cui, Yichen Huang, Yang Yang, Yan Liu, Wen-Shan Zhao, Xiao-Yang Cheng, Wang-Sheng Sun, Peng Cao, Michael X. Zhu, Rui Wang, Motoyuki Hattori, Ye Yu

Proc Natl Acad Sci U S A. 2018 May 8; 115(19): 4939–4944. Published online 2018 Apr 19. doi: 10.1073/pnas.1800907115

PMCID:: PMC5948998

Abstract Article PDF–1.6M

Select item 55953294.

P2X3 receptor involvement in endometriosis pain via ERK signaling pathway

Shaojie Ding, Libo Zhu, Yonghong Tian, Tianhong Zhu, Xiufeng Huang, Xinmei Zhang

PLoS One. 2017; 12(9): e0184647. Published online 2017 Sep 12. doi: 10.1371/journal.pone.0184647

PMCID:: PMC5595329

Abstract Article PDF–10M

Select item 49380275.

P2X receptors

R. Alan North

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5; 371(1700): 20150427. doi: 10.1098/rstb.2015.0427

PMCID:: PMC4938027

Abstract Article PDF–793K

Select item 48548356.

Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating

Gabriele Stephan, Maria Kowalski-Jahn, Christopher Zens, Günther Schmalzing, Peter Illes, Ralf Hausmann

Purinergic Signal. 2016 Jun; 12(2): 221–233. Published online 2016 Jan 29. doi: 10.1007/s11302-016-9496-5

PMCID:: PMC4854835

Abstract Article PDF–917K

Select item 47473977.

P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients

Janielle P. Maynard, Ju-Seog Lee, Bo Hwa Sohn, Xiaoying Yu, Dolores Lopez-Terrada, Milton J. Finegold, John A. Goss, Sundararajah Thevananther

Oncotarget. 2015 Dec 1; 6(38): 41162–41179. Published online 2015 Oct 26. doi: 10.18632/oncotarget.6240

PMCID:: PMC4747397

Abstract Article PDF–11M

Select item 45298558.

Purinergic signalling during development and ageing

Geoffrey Burnstock, Nicholas Dale

Purinergic Signal. 2015 Sep; 11(3): 277–305. Published online 2015 May 20. doi: 10.1007/s11302-015-9452-9

PMCID:: PMC4529855

Abstract Article PDF–1.4M

Select item 42534589.

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening

M Kowalski, R Hausmann, A Dopychai, M Grohmann, H Franke, K Nieber, G Schmalzing, P Illes, T Riedel

Br J Pharmacol. 2014 Nov; 171(22): 5093–5112. Published online 2014 Sep 5. doi: 10.1111/bph.12830

PMCID:: PMC4253458

Abstract Article PDF–2.6M

Select item 403792910.

Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model: ATP-gated P2X₃ Channels in EC are Downregulated in Ulcerative Colitis

Andrómeda Liñán-Rico, Jacqueline E. Wunderlich, Iveta S. Grants, Wendy L. Frankel, Jianjing Xue, Kent C. Williams, Alan E. Harzman, Joshua T. Enneking, Helen J. Cooke, Fievos L. Christofi

Inflamm Bowel Dis. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Inflamm Bowel Dis. 2013 Oct; 19(11): 2366–2379. doi: 10.1097/MIB.0b013e31829ecf4d

PMCID:: PMC4037929

Abstract Article PDF–5.0M

Select item 381516011.

Agonist Antagonist Interactions at the Rapidly Desensitizing P2X3 Receptor

Nick Helms, Maria Kowalski, Peter Illes, Thomas Riedel

PLoS One. 2013; 8(11): e79213. Published online 2013 Nov 1. doi: 10.1371/journal.pone.0079213

PMCID:: PMC3815160

Abstract Article PDF–1.4M

Select item 335058312.

P2X3 receptor expression by HEK cells conditions their survival

Lucio Apicella, Elsa Fabbretti

Purinergic Signal. 2012 Jun; 8(2): 295–300. Published online 2011 Dec 8. doi: 10.1007/s11302-011-9285-0

PMCID:: PMC3350583

Abstract Article PDF–408K

Select item 335057913.

Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion

Aihua Pan, Haiping Wu, Ming Li, Dahua Lu, Xu He, Xinan Yi, Xiao-Xin Yan, Zhiyuan Li

Purinergic Signal. 2012 Jun; 8(2): 245–254. Published online 2011 Nov 4. doi: 10.1007/s11302-011-9277-0

PMCID:: PMC3350579

Abstract Article PDF–1003K

Select item 302477014.

Amino Acid Residues Constituting the Agonist Binding Site of the Human P2X3 Receptor

Mandy Bodnar, Haihong Wang, Thomas Riedel, Stefan Hintze, Erzsebet Kato, Ghada Fallah, Helke Gröger-Arndt, Rashid Giniatullin, Marcus Grohmann, Ralf Hausmann, Günther Schmalzing, Peter Illes, Patrizia Rubini

J Biol Chem. 2011 Jan 28; 286(4): 2739–2749. Published online 2010 Nov 22. doi: 10.1074/jbc.M110.167437

PMCID:: PMC3024770

Abstract Article PDF–3.7M

Select item 285196615.

ATP-gated P2X₃ receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell

M. Caroline Jacques-Silva, Mayrin Correa-Medina, Over Cabrera, Rayner Rodriguez-Diaz, Natalia Makeeva, Alberto Fachado, Juan Diez, Dora M. Berman, Norma S. Kenyon, Camillo Ricordi, Antonello Pileggi, R. Damaris Molano, Per-Olof Berggren, Alejandro Caicedo

Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14): 6465–6470. Published online 2010 Mar 22. doi: 10.1073/pnas.0908935107

PMCID:: PMC2851966

Abstract Article PDF–745K

Select item 186182816.

Protein kinase C regulation of P2X₃ receptors is unlikely to involve direct receptor phosphorylation

David A. Brown, David I. Yule

Biochim Biophys Acta. Author manuscript; available in PMC 2007 May 2.

Published in final edited form as: Biochim Biophys Acta. 2007 Feb; 1773(2): 166–175. Published online 2006 Sep 19. doi: 10.1016/j.bbamcr.2006.09.020

PMCID:: PMC1861828

Abstract Article PDF–736K

Select item 516164117.

X-ray structures define human P2X3 receptor gating cycle and antagonist action

Steven E. Mansoor, Wei Lü, Wout Oosterheert, Mrinal Shekhar, Emad Tajkhorshid, Eric Gouaux

Nature. Author manuscript; available in PMC 2017 Apr 6.

Published in final edited form as: Nature. 2016 Oct 6; 538(7623): 66–71. Published online 2016 Sep 14. doi: 10.1038/nature19367

PMCID:: PMC5161641

Abstract Article PDF–5.7M

Select item 493327418.

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies

Anatoly Shcherbatko, Davide Foletti, Kris Poulsen, Pavel Strop, Guoyun Zhu, Adela Hasa-Moreno, Jody Melton Witt, Carole Loo, Stellanie Krimm, Ariel Pios, Jessica Yu, Colleen Brown, John K. Lee, Robert Stroud, Arvind Rajpal, David Shelton

J Biol Chem. 2016 Jun 3; 291(23): 12254–12270. Published online 2016 Apr 20. doi: 10.1074/jbc.M116.722330