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Select item 110503161.

The OTX2 Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas

Elisabet Ampudia-Mesias, Charles S. Cameron, Eunjae Yoo, Marcus Kelly, Sarah M. Anderson, Riley Manning, Juan E. Abrahante Lloréns, Christopher L. Moertel, Hyungshin Yim, David J. Odde, Nurten Saydam, Okay Saydam

Int J Mol Sci. 2024 Apr; 25(8): 4416. Published online 2024 Apr 17. doi: 10.3390/ijms25084416

PMCID:: PMC11050316

Abstract Article PDF–2.6M

Select item 69941532.

Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells

Ryusaku Matsumoto, Hidetaka Suga, Takashi Aoi, Hironori Bando, Hidenori Fukuoka, Genzo Iguchi, Satoshi Narumi, Tomonobu Hasegawa, Keiko Muguruma, Wataru Ogawa, Yutaka Takahashi

J Clin Invest. 2020 Feb 3; 130(2): 641–654. Published online 2019 Dec 17. doi: 10.1172/JCI127378

PMCID:: PMC6994153

Abstract Article PDF–13M

Select item 61357533.

Methylation in OTX2 and related genes, maltreatment, and depression in children

Joan Kaufman, Nicholas F. Wymbs, Janitza L. Montalvo-Ortiz, Catherine Orr, Matthew D. Albaugh, Robert Althoff, Kerry O’Loughlin, Hannah Holbrook, Hugh Garavan, Catherine Kearney, Bao-Zhu Yang, Hongyu Zhao, Catherine Peña, Eric J. Nestler, Richard S. Lee, Stewart Mostofsky, Joel Gelernter, James Hudziak

Neuropsychopharmacology. 2018 Oct; 43(11): 2204–2211. Published online 2018 Jul 21. doi: 10.1038/s41386-018-0157-y

PMCID:: PMC6135753

Abstract Article PDF–1.5M

Select item 58910394.

Characterization of a novel OTX2‐driven stem cell program in Group 3 and Group 4 medulloblastoma

Margaret Stromecki, Nazanin Tatari, Ludivine Coudière Morrison, Ravinder Kaur, Jamie Zagozewski, Gareth Palidwor, Vijay Ramaswamy, Patryk Skowron, Matthias Wölfl, Till Milde, Marc R. Del Bigio, Michael D. Taylor, Tamra E. Werbowetski‐Ogilvie

Mol Oncol. 2018 Apr; 12(4): 495–513. Published online 2018 Mar 1. doi: 10.1002/1878-0261.12177

PMCID:: PMC5891039

Abstract Article PDF–1.6M

Select item 57629845.

Otx2-Genetically Modified Retinal Pigment Epithelial Cells Rescue Photoreceptors after Transplantation

Christo Kole, Laurence Klipfel, Ying Yang, Vanessa Ferracane, Frederic Blond, Sacha Reichman, Géraldine Millet-Puel, Emmanuelle Clérin, Najate Aït-Ali, Delphine Pagan, Hawa Camara, Marie-Noëlle Delyfer, Emeline F. Nandrot, Jose-Alain Sahel, Olivier Goureau, Thierry Léveillard

Mol Ther. 2018 Jan 3; 26(1): 219–237. Published online 2017 Sep 8. doi: 10.1016/j.ymthe.2017.09.007

PMCID:: PMC5762984

Abstract Article PDF–6.3M

Select item 56930236.

Heterozygous mutation in OTX2 associated with early-onset retinal dystrophy with atypical maculopathy

Maram EA Abdalla-Elsayed, Patrik Schatz, Christine Neuhaus, Arif O. Khan

Mol Vis. 2017; 23: 778–784. Published online 2017 Nov 13.

PMCID:: PMC5693023

Abstract Article PDF–1.4M

Select item 53405877.

OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma

Gaylor Boulay, Mary E. Awad, Nicolo Riggi, Tenley C. Archer, Sowmya Iyer, Wannaporn E. Boonseng, Nikki E Rossetti, Beverly Naigles, Shruthi Rengarajan, Angela Volorio, James C. Kim, Jill P. Mesirov, Pablo Tamayo, Scott L. Pomeroy, Martin J. Aryee, Miguel N. Rivera

Cancer Discov. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Cancer Discov. 2017 Mar; 7(3): 288–301. Published online 2017 Feb 17. doi: 10.1158/2159-8290.CD-16-0844

PMCID:: PMC5340587

Abstract Article PDF–810K

Select item 46102338.

OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells

Ravinder Kaur, Christopher Aiken, Ludivine Coudière Morrison, Radhika Rao, Marc R. Del Bigio, Shravanti Rampalli, Tamra Werbowetski-Ogilvie

Dis Model Mech. 2015 Oct 1; 8(10): 1295–1309. doi: 10.1242/dmm.020594

PMCID:: PMC4610233

Abstract Article

Select item 41578459.

Chromatin Accessibility Mapping Identifies Mediators of Basal Transcription and Retinoid-Induced Repression of OTX2 in Medulloblastoma

Matthew Wortham, Changcun Guo, Monica Zhang, Lingyun Song, Bum-Kyu Lee, Vishwanath R. Iyer, Terrence S. Furey, Gregory E. Crawford, Hai Yan, Yiping He

PLoS One. 2014; 9(9): e107156. Published online 2014 Sep 8. doi: 10.1371/journal.pone.0107156

PMCID:: PMC4157845

Abstract Article PDF–1.8M

Select item 401600810.

OTX2 Duplication Is Implicated in Hemifacial Microsomia

Dina Zielinski, Barak Markus, Mona Sheikh, Melissa Gymrek, Clement Chu, Marta Zaks, Balaji Srinivasan, Jodi D. Hoffman, Dror Aizenbud, Yaniv Erlich

PLoS One. 2014; 9(5): e96788. Published online 2014 May 9. doi: 10.1371/journal.pone.0096788

PMCID:: PMC4016008

Abstract Article PDF–685K

Select item 301765911.

OTX2 microphthalmia syndrome: four novel mutations and delineation of a phenotype

Kala Schilter, Adele Schneider, Tanya Bardakjian, Jean-François Soucy, Rebecca C. Tyler, Linda M. Reis, Elena V. Semina

Clin Genet. Author manuscript; available in PMC 2012 Feb 1.

Published in final edited form as: Clin Genet. 2011 Feb; 79(2): 158–168. doi: 10.1111/j.1399-0004.2010.01450.x

PMCID:: PMC3017659

Abstract Article PDF–525K

Select item 294373612.

OTX2 is critical for the maintenance and progression of classic medulloblastoma

David C. Adamson, Qun Shi, Matthew Wortham, Paul A. Northcott, Chunhui Di, Christopher G. Duncan, Jianjun Li, Roger E. McLendon, Darell D. Bigner, Michael D. Taylor, Hai Yan

Cancer Res. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Cancer Res. 2010 Jan 1; 70(1): 181–191. Published online 2009 Dec 22. doi: 10.1158/0008-5472.CAN-09-2331

PMCID:: PMC2943736

Abstract Article PDF–2.1M

Select item 278688813.

A rare de novo nonsense mutation in OTX2 causes early onset retinal dystrophy and pituitary dysfunction

Robert H. Henderson, Kathleen A. Williamson, Joanna S. Kennedy, Andrew R. Webster, Graham E. Holder, Anthony G. Robson, David R. FitzPatrick, Veronica van Heyningen, Anthony T. Moore

Mol Vis. 2009; 15: 2442–2447. Published online 2009 Nov 21.

PMCID:: PMC2786888

Abstract Article PDF–1.6M

Select item 119643914.

Heterozygous Mutations of OTX2 Cause Severe Ocular Malformations

Nicola K. Ragge, Alison G. Brown, Charlotte M. Poloschek, Birgit Lorenz, R. Alex Henderson, Michael P. Clarke, Isabelle Russell-Eggitt, Alistair Fielder, Dianne Gerrelli, Juan Pedro Martinez-Barbera, Piers Ruddle, Jane Hurst, J. Richard O. Collin, Alison Salt, Simon T. Cooper, Pamela J. Thompson, Sanjay M. Sisodiya, Kathleen A. Williamson, David R. FitzPatrick, Veronica van Heyningen, Isabel M. Hanson

Am J Hum Genet. 2005 Jun; 76(6): 1008–1022. Published online 2005 Apr 21. doi: 10.1086/430721

Correction in:: Am J Hum Genet. 2005 Aug; 77(2): 334.

PMCID:: PMC1196439

Abstract Article PDF–3.8M

Select item 1122711815.

OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis-regulatory elements

Jenny L. Kerschner, Alekh Paranjapye, Monali NandyMazumdar, Shiyi Yin, Shih-Hsing Leir, Ann Harris

Dev Dyn. Author manuscript; available in PMC 2024 Jul 6.

Published in final edited form as: Dev Dyn. 2021 May; 250(5): 684–700. Published online 2021 Jan 26. doi: 10.1002/dvdy.293

PMCID:: PMC11227118

Abstract Article PDF–2.2M

Select item 980747116.

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas: “it’s a numbers game”—implications for WNT medulloblastoma dose-reduction clinical trials

Nicholas G. Gottardo

Acta Neuropathol. 2023; 145(1): 145–147. Published online 2022 Nov 20. doi: 10.1007/s00401-022-02518-0

PMCID:: PMC9807471

Article PDF–422K

Select item 586825617.

Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition

Zhenghui Su, Yanqi Zhang, Baojian Liao, Xiaofen Zhong, Xin Chen, Haitao Wang, Yiping Guo, Yongli Shan, Lihui Wang, Guangjin Pan

J Biol Chem. 2018 Mar 23; 293(12): 4445–4455. Published online 2018 Jan 31. doi: 10.1074/jbc.M117.815449

PMCID:: PMC5868256

Abstract Article PDF–3.6M

Select item 530426718.

OTX1 and OTX2 as Possible Molecular Markers of Sinonasal Carcinomas and Olfactory Neuroblastomas

Cristina Pirrone, Anna M. Chiaravalli, Alessandro Marando, Andrea Conti, Alessia Rainero, Andrea Pistochini, Francesco Lo Curto, Francesco Pasquali, Paolo Castelnuovo, Carlo Capella, Giovanni Porta

Eur J Histochem. 2017 Jan 23; 61(1): 2730. Published online 2017 Feb 9. doi: 10.4081/ejh.2017.2730

PMCID:: PMC5304267

Abstract Article PDF–252K

Select item 486124019.

OTX2 Represses Myogenic and Neuronal Differentiation in Medulloblastoma Cells

Ren-Yuan Bai, Verena Staedtke, Hart G. Lidov, Charles G. Eberhart, Gregory J. Riggins

Cancer Res. Author manuscript; available in PMC 2016 May 9.

Published in final edited form as: Cancer Res. 2012 Nov 15; 72(22): 5988–6001. Published online 2012 Sep 17. doi: 10.1158/0008-5472.CAN-12-0614

PMCID:: PMC4861240

Abstract Article PDF–2.6M

Select item 469406320.

OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development

Ramona Palombo, Giovanni Porta, Ernesto Bruno, Paolo Provero, Valeria Serra, Karthik Neduri, Andrea Viziano, Marco Alessandrini, Alessandro Micarelli, Fabrizio Ottaviani, Gerry Melino, Alessandro Terrinoni

Aging (Albany NY) 2015 Nov; 7(11): 928–936. Published online 2015 Nov 10. doi: 10.18632/aging.100839

PMCID:: PMC4694063

Abstract Article PDF–1.6M

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