PMC Links for Gene (Select 4976) - PMC

Result Filters

Links from Gene

Items: 1 to 20 of 206

<< First< Prev

Page of 11

Select item 108759621.

Structural mechanism of mitochondrial membrane remodelling by human OPA1

Alexander von der Malsburg, Gracie M. Sapp, Kelly E. Zuccaro, Alexander von Appen, Frank R. Moss, III, Raghav Kalia, Jeremy A. Bennett, Luciano A. Abriata, Matteo Dal Peraro, Martin van der Laan, Adam Frost, Halil Aydin

Nature. Author manuscript; available in PMC 2024 Feb 23.

Published in final edited form as: Nature. 2023 Aug; 620(7976): 1101–1108. Published online 2023 Aug 23. doi: 10.1038/s41586-023-06441-6

PMCID:: PMC10875962

Abstract Article PDF–6.0M

Select item 108753472.

p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer: p32/OPA1 contributes to cisplatin resistance

Chun-Xia Yu, Zhe-Qing Peng, Tao Wang, Xin-Hui Qu, Ping Yang, Shao-Rong Huang, Li-Ping Jiang, Fang-Fang Tou, Xiao-Jian Han

Acta Biochim Biophys Sin (Shanghai) 2024 Jan 25; 56(1): 34–43. Published online 2023 Dec 26. doi: 10.3724/abbs.2023247

PMCID:: PMC10875347

Abstract Article PDF–1.7M

Select item 108286843.

Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function

Qiannan Lei, Kangjian Xiang, Lin Cheng, Mengqing Xiang

Stem Cell Reports. 2024 Jan 9; 19(1): 68–83. Published online 2023 Dec 14. doi: 10.1016/j.stemcr.2023.11.004

PMCID:: PMC10828684

Abstract Article PDF–7.8M

Select item 107134064.

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Ziyi Wu, Nuo Xu, Guoqing Li, Wen Yang, Chen Zhang, Hua Zhong, Gen Wu, Fei Chen, Dianqing Li

Aging (Albany NY) 2023 Nov 30; 15(22): 12982–12997. Published online 2023 Nov 16. doi: 10.18632/aging.205214

PMCID:: PMC10713406

Abstract Article PDF–2.8M

Select item 105382955.

OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases

Aurélie M. C. Millet, Corentin Coustham, Camille Champigny, Marlène Botella, Christine Demeilliers, Anne Devin, Anne Galinier, Pascale Belenguer, Joel Bordeneuve-Guibé, Noélie Davezac

Dis Model Mech. 2023 Sep 1; 16(9): dmm050266. Published online 2023 Sep 20. doi: 10.1242/dmm.050266

Correction in:: Dis Model Mech. 2024 Apr 1; 17(4): dmm050815.

PMCID:: PMC10538295

Abstract Article

Select item 102772436.

视神经萎缩因子1介导的线粒体动力学在骨骼系统疾病中的研究进展

凯博孙, 元刚吴, 羿曾, 明阳李, 立民武, 彬沈

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Jun; 37(6): 758–763. Chinese. doi: 10.7507/1002-1892.202302056

PMCID:: PMC10277243

Abstract Article PDF–531K

Select item 100484367.

Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Kim

Genes (Basel) 2023 Mar; 14(3): 566. Published online 2023 Feb 24. doi: 10.3390/genes14030566

PMCID:: PMC10048436

Abstract Article PDF–4.8M

Select item 100411218.

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion

Benjamín Cartes-Saavedra, Daniel Lagos, Josefa Macuada, Duxan Arancibia, Florence Burté, Marcela K. Sjöberg-Herrera, María Estela Andrés, Rita Horvath, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner

Proc Natl Acad Sci U S A. 2023 Mar 21; 120(12): e2207471120. Published online 2023 Mar 16. doi: 10.1073/pnas.2207471120

PMCID:: PMC10041121

Abstract Article PDF–4.0M

Select item 95588359.

Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells

Paul E Sladen, Katarina Jovanovic, Rosellina Guarascio, Daniele Ottaviani, Grace Salsbury, Tatiana Novoselova, J Paul Chapple, Patrick Yu-Wai-Man, Michael E Cheetham

Hum Mol Genet. 2022 Oct 15; 31(20): 3478–3493. Published online 2022 Jun 2. doi: 10.1093/hmg/ddac128

PMCID:: PMC9558835

Abstract Article PDF–2.2M

Select item 932724510.

Autosomal dominant optic atrophy caused by six novel pathogenic OPA1 variants and genotype–phenotype correlation analysis

Jinfeng Han, Ya Li, Ya You, Ke Fan, Bo Lei

BMC Ophthalmol. 2022; 22: 322. Published online 2022 Jul 26. doi: 10.1186/s12886-022-02546-0

PMCID:: PMC9327245

Abstract Article PDF–1.3M

Select item 889574711.

Mutations at a split codon in the GTPase-encoding domain of OPA1 cause dominant optic atrophy through different molecular mechanisms

Nicole Weisschuh, Valerio Marino, Karin Schäferhoff, Paul Richter, Joohyun Park, Tobias B Haack, Daniele Dell’Orco

Hum Mol Genet. 2022 Mar 1; 31(5): 761–774. Published online 2021 Sep 24. doi: 10.1093/hmg/ddab286

PMCID:: PMC8895747

Abstract Article PDF–1.5M

Select item 827042812.

Mutation spectrum of the OPA1 gene in a large cohort of patients with suspected dominant optic atrophy: Identification and classification of 48 novel variants

Nicole Weisschuh, Simone Schimpf-Linzenbold, Pascale Mazzola, Sinja Kieninger, Ting Xiao, Ulrich Kellner, Teresa Neuhann, Carina Kelbsch, Felix Tonagel, Helmut Wilhelm, Susanne Kohl, Bernd Wissinger

PLoS One. 2021; 16(7): e0253987. Published online 2021 Jul 9. doi: 10.1371/journal.pone.0253987

PMCID:: PMC8270428

Abstract Article PDF–1.3M

Select item 818554913.

High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts

Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu‐Wai‐Man, Pascal Reynier, Timothy Wai

EMBO Mol Med. 2021 Jun 8; 13(6): e13579. Published online 2021 May 20. doi: 10.15252/emmm.202013579

PMCID:: PMC8185549

Abstract Article PDF–4.8M

Select item 769537514.

OPA1, a new mitochondrial target in cancer therapy

Stephanie Herkenne, Luca Scorrano

Aging (Albany NY) 2020 Nov 15; 12(21): 20931–20933. Published online 2020 Nov 13. doi: 10.18632/aging.104207

PMCID:: PMC7695375

Article PDF–541K

Select item 733749415.

Structural insights into G domain dimerization and pathogenic mutation of OPA1

Caiting Yu, Jinghua Zhao, Liming Yan, Yuanbo Qi, Xiangyang Guo, Zhiyong Lou, Junjie Hu, Zihe Rao

J Cell Biol. 2020 Jul 6; 219(7): e201907098. Published online 2020 May 7. doi: 10.1083/jcb.201907098

PMCID:: PMC7337494

Abstract Article PDF–5.3M

Select item 729934316.

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

Yifan Ge, Xiaojun Shi, Sivakumar Boopathy, Julie McDonald, Adam W Smith, Luke H Chao

eLife. 2020; 9: e50973. Published online 2020 Jan 10. doi: 10.7554/eLife.50973

PMCID:: PMC7299343

Abstract Article PDF–4.5M

Select item 715626717.

Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding

Danyang Zhang, Yan Zhang, Jun Ma, Chunmei Zhu, Tongxin Niu, Wenbo Chen, Xiaoyun Pang, Yujia Zhai, Fei Sun

eLife. 2020; 9: e50294. Published online 2020 Mar 31. doi: 10.7554/eLife.50294

PMCID:: PMC7156267

Abstract Article PDF–7.4M

Select item 703477918.

OPA1 regulates respiratory supercomplexes assembly: the role of mitochondrial swelling

Sehwan Jang, Sabzali Javadov

Mitochondrion. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Mitochondrion. 2020 Mar; 51: 30–39. Published online 2019 Dec 20. doi: 10.1016/j.mito.2019.11.006

PMCID:: PMC7034779

Abstract Article PDF–1.3M

Select item 694122319.

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

Angelo Iannielli, Giovanni Stefano Ugolini, Chiara Cordiglieri, Simone Bido, Alicia Rubio, Gaia Colasante, Marco Valtorta, Tommaso Cabassi, Marco Rasponi, Vania Broccoli

Cell Rep. 2019 Dec 24; 29(13): 4646–4656.e4. Published online 2019 Dec 24. doi: 10.1016/j.celrep.2019.11.111