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Select item 74109231.

Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity

Yuan Zhou, Ping Wang, Bing-Xi Yan, Xue-Yan Chen, Lilla Landeck, Zhao-Yuan Wang, Xin-Xin Li, Jing Zhang, Min Zheng, Xiao-Yong Man

Front Immunol. 2020; 11: 1432. Published online 2020 Jul 31. doi: 10.3389/fimmu.2020.01432

PMCID:: PMC7410923

Abstract Article PDF–2.5M

Select item 72648522.

Structural and Hydrodynamic Characterization of Dimeric Human Oligoadenylate Synthetase 2

Amit Koul, Darren Gemmill, Nikhat Lubna, Markus Meier, Natalie Krahn, Evan P. Booy, Jörg Stetefeld, Trushar R. Patel, Sean A. McKenna

Biophys J. 2020 Jun 2; 118(11): 2726–2740. Published online 2020 May 1. doi: 10.1016/j.bpj.2020.04.025

PMCID:: PMC7264852

Abstract Article PDF–2.5M

Select item 50041443.

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

Xiaolian Gu, Linda Boldrup, Philip J. Coates, Robin Fahraeus, Elisabet Nylander, Christos Loizou, Katarina Olofsson, Lena Norberg-Spaak, Ola Gärskog, Karin Nylander

Sci Rep. 2016; 6: 32579. Published online 2016 Aug 30. doi: 10.1038/srep32579

PMCID:: PMC5004144

Abstract Article PDF–693K

Select item 61104964.

Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively

Jin Cheon Kim, Ye Jin Ha, Ka Hee Tak, Seon Ae Roh, Yi Hong Kwon, Chan Wook Kim, Yong Sik Yoon, Jong Lyul Lee, Yangsoon Park, Seon-Kyu Kim, Seon-Young Kim, Dong-Hyung Cho, Yong Sung Kim

PLoS One. 2018; 13(8): e0202856. Published online 2018 Aug 27. doi: 10.1371/journal.pone.0202856

PMCID:: PMC6110496

Abstract Article PDF–5.7M

Select item 88067835.

Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2’-5’-oligoadenylate synthetase 2 axis in acute myeloid leukemia

Hong Zhou, Xiaofeng Jia, Fan Yang, Pengfei Shi

Bioengineered. 2021; 12(1): 6403–6417. Published online 2021 Sep 13. doi: 10.1080/21655979.2021.1971508

PMCID:: PMC8806783

Abstract Article PDF–5.2M

Select item 76931196.

Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19

Hibah Shaath, Radhakrishnan Vishnubalaji, Eyad Elkord, Nehad M. Alajez

Cells. 2020 Nov; 9(11): 2374. Published online 2020 Oct 29. doi: 10.3390/cells9112374

PMCID:: PMC7693119

Abstract Article PDF–6.0M

Select item 51292497.

Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans

Aaron J. Sams, Anne Dumaine, Yohann Nédélec, Vania Yotova, Carolina Alfieri, Jerome E. Tanner, Philipp W. Messer, Luis B. Barreiro

Genome Biol. 2016; 17: 246. Published online 2016 Nov 29. doi: 10.1186/s13059-016-1098-6

PMCID:: PMC5129249

Abstract Article PDF–1.3M

Select item 47172388.

Extracellular 2′5′‐oligoadenylate synthetase 2 mediates T‐cell receptor CD3‐ζ chain down‐regulation via caspase‐3 activation in oral cancer

Asif A. Dar, Trupti N. Pradhan, Dakshayni P. Kulkarni, Sagar U. Shah, Kanury V. Rao, Devendra A. Chaukar, Anil K. D'Cruz, Shubhada V. Chiplunkar

Immunology. 2016 Feb; 147(2): 251–264. Published online 2015 Dec 27. doi: 10.1111/imm.12560

PMCID:: PMC4717238

Abstract Article PDF–880K

Select item 27879669.

Nucleotide Oligomerization Domain-2 Interacts with 2’-5’- Oligoadenylate Synthetase Type 2 and Enhances RNase-L Function in THP-1 Cells

Jae W. Dugan, Amador Albor, Larry David, Jonathan Fowlkes, Marc T. Blackledge, Tammy M. Martin, Stephen R. Planck, Holly L. Rosenzweig, James T. Rosenbaum, Michael P. Davey

Mol Immunol. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Mol Immunol. 2009 Dec; 47(2-3): 560–566. Published online 2009 Oct 23. doi: 10.1016/j.molimm.2009.09.025

PMCID:: PMC2787966

Abstract Article PDF–978K

Select item 256462710.

Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?

M‐C Tessier, H‐Q Qu, R Fréchette, F Bacot, R Grabs, S P Taback, M L Lawson, S E Kirsch, T J Hudson, C Polychronakos

J Med Genet. 2006 Feb; 43(2): 129–132. Published online 2005 Jul 13. doi: 10.1136/jmg.2005.035212

PMCID:: PMC2564627

Abstract Article PDF–272K

Select item 55392911.

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.

A G Hovanessian, A G Laurent, J Chebath, J Galabru, N Robert, J Svab

EMBO J. 1987 May; 6(5): 1273–1280. doi: 10.1002/j.1460-2075.1987.tb02364.x

PMCID:: PMC553929

Summary Page Browse PDF–1.8M

Select item 1114685112.

Gene structure and function of the 2′-5′-oligoadenylate synthetase family

J. Justesen, R. Hartmann, N.O. Kjeldgaard

Cell Mol Life Sci. 2000 Oct; 57(11): 1593–1612. doi: 10.1007/PL00000644

PMCID:: PMC11146851

Abstract Article PDF–1.2M

Select item 528251813.

Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study

Mónica García-Álvarez, Juan Berenguer, María A. Jiménez-Sousa, Daniel Pineda-Tenor, Teresa Aldámiz-Echevarria, Francisco Tejerina, Cristina Diez, Sonia Vázquez-Morón, Salvador Resino

Sci Rep. 2017; 7: 41516. Published online 2017 Jan 31. doi: 10.1038/srep41516

PMCID:: PMC5282518

Abstract Article PDF–1.4M

Select item 711274914.

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection

Jeffery T. Kwock, Chelsea Handfield, Jutamas Suwanpradid, Peter Hoang, Michael J. McFadden, Kevin F. Labagnara, Lauren Floyd, Jessica Shannon, Ranjitha Uppala, Mrinal K. Sarkar, Johann E. Gudjonsson, David L. Corcoran, Helen M. Lazear, Gregory Sempowski, Stacy M. Horner, Amanda S. MacLeod

Sci Adv. 2020 Apr; 6(14): eaay3245. Published online 2020 Apr 1. doi: 10.1126/sciadv.aay3245

PMCID:: PMC7112749

Abstract Article PDF–621K

Select item 357813115.

Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network

S Aslibekyan, P An, AC Frazier-Wood, EK Kabagambe, MR Irvin, RJ Straka, HK Tiwari, MY Tsai, PN Hopkins, IB Borecki, JM Ordovas, DK Arnett

Nutr Metab Cardiovasc Dis. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Nutr Metab Cardiovasc Dis. 2013 Oct; 23(10): 10.1016/j.numecd.2012.07.010. Published online 2012 Nov 11. doi: 10.1016/j.numecd.2012.07.010

PMCID:: PMC3578131

Abstract Article PDF–548K

Select item 625137016.

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

Fabian Christoph Franke, Johannes Müller, Miguel Abal, Eduardo Domínguez Medina, Ulrich Nitsche, Henri Weidmann, Solenne Chardonnet, Ewa Ninio, Klaus-Peter Janssen

Cell Mol Gastroenterol Hepatol. 2019; 7(1): 33–53. Published online 2018 Sep 11. doi: 10.1016/j.jcmgh.2018.08.007

PMCID:: PMC6251370

Abstract Article PDF–5.6M

Select item 403683117.

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells

Sami Kukkonen, Maria Del Pilar Martinez-Viedma, Nayoung Kim, Mariana Manrique, Anna Aldovini

Retrovirology. 2014; 11: 30. Published online 2014 Apr 17. doi: 10.1186/1742-4690-11-30

PMCID:: PMC4036831

Abstract Article PDF–1.8M

Select item 295089818.

Dengue hemorrhagic fever is associated with polymorphisms in JAK1

Luciano K Silva, Ronald E Blanton, Antonio R Parrado, Paulo S Melo, Vanessa G Morato, Eliana AG Reis, Juarez P Dias, Jesuina M Castro, Pedro FC Vasconcelos, Katrina AB Goddard, Maurício L Barreto, Mitermayer G Reis, M Glória Teixeira

Eur J Hum Genet. 2010 Nov; 18(11): 1221–1227. Published online 2010 Jun 30. doi: 10.1038/ejhg.2010.98

PMCID:: PMC2950898

Abstract Article PDF–446K

Select item 334973419.

Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

Caroline S. Fox, Yongmei Liu, Charles C. White, Mary Feitosa, Albert V. Smith, Nancy Heard-Costa, Kurt Lohman, GIANT Consortium, MAGIC Consortium, GLGC Consortium, Andrew D. Johnson, Meredith C. Foster, Danielle M. Greenawalt, Paula Griffin, Jinghong Ding, Anne B. Newman, Fran Tylavsky, Iva Miljkovic, Stephen B. Kritchevsky, Lenore Launer, Melissa Garcia, Gudny Eiriksdottir, J. Jeffrey Carr, Vilmunder Gudnason, Tamara B. Harris, L. Adrienne Cupples, Ingrid B. Borecki

PLoS Genet. 2012 May; 8(5): e1002695. Published online 2012 May 10. doi: 10.1371/journal.pgen.1002695

PMCID:: PMC3349734

Abstract Article PDF–377K

Select item 631010220.

Interactome and proteome dynamics uncover immune modulatory associations of the pathogen sensing factor cGAS

Krystal K. Lum, Bokai Song, Joel D. Federspiel, Benjamin A. Diner, Timothy Howard, Ileana M. Cristea

Cell Syst. Author manuscript; available in PMC 2019 Dec 26.

Published in final edited form as: Cell Syst. 2018 Dec 26; 7(6): 627–642.e6. Published online 2018 Nov 21. doi: 10.1016/j.cels.2018.10.010

PMCID:: PMC6310102

Abstract Article PDF–3.5M

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PMC Links for Gene (Select 4939) (30)
PMC
Homo sapiens ArfGAP with dual PH domains 1 (ADAP1), transcript variant 2, mRNA
Homo sapiens ArfGAP with dual PH domains 1 (ADAP1), transcript variant 2, mRNA
gi|2199215530|ref|NM_001284308.2|

Nucleotide
Human mRNA encoding major histocompatibility complex gene HLA-DR beta-I
Human mRNA encoding major histocompatibility complex gene HLA-DR beta-I
gi|32122|emb|V00522.1|

Nucleotide
TGM3=transglutaminase 3 {5' region} [human, placenta, Genomic, 180 nt]
TGM3=transglutaminase 3 {5' region} [human, placenta, Genomic, 180 nt]
gi|558012|bbm|343850|bbs|150570|gb| 7.1|

Nucleotide

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